References included in TCDB:

1.A.1

Wu, L., S.L. Yong, C. Fan, Y. Ni, S. Yoo, T. Zhang, X. Zhang, C.A. Obejero-Paz, H.J. Rho, T. Ke, P. Szafranski, S.W. Jones, Q. Chen, and Q.K. Wang. (2008). Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav 1.5. J. Biol. Chem. 283(11): 6968-6978. 18184654

Wu, Y., Y. Yang, S. Ye, and Y. Jiang. (2010). Structure of the gating ring from the human large-conductance Ca²⁺-gated K⁺ channel. Nature 466: 393-397. 20574420

Xia, J., N. Yamaji, T. Kasai, and J.F. Ma. (2010). Plasma membrane-localized transporter for aluminum in rice. Proc. Natl. Acad. Sci. USA 107: 18381-18385. 20937890

Xia, X.-M., X. Zeng, and C.J. Lingle. (2002). Multiple regulatory sites in large-conductance calcium-activated potassium channels. Nature 418: 880-884. 12192411

Xicluna, J., B. Lacombe, I. Dreyer, C. Alcon, L. Jeanguenin, H. Sentenac, J.B. Thibaud, and I. Cherel. (2007). Increased functional diversity of plant K⁺ channels by preferential heteromerization of the shaker-like subunits AKT2 and KAT2. J. Biol. Chem. 282: 486-494. 17085433

Xu, T., L. Nie, Y. Zhang, J. Mo, W. Feng, D. Wei, E. Petrov, L.E. Calisto, B. Kachar, K.W. Beisel, A.E. Vazquez, and E.N. Yamoah. (2007). Roles of alternative splicing in the functional properties of inner ear-specific KCNQ4 channels. J. Biol. Chem. 282: 23899-23909. 17561493

Yang, H., L. Hu, J. Shi, K. Delaloye, F.T. Horrigan, and J. Cui. (2007). Mg²⁺ mediates interaction between the voltage sensor and cytosolic domain to activate BK channels. Proc. Natl. Acad. Sci. U.S.A. 104: 18270-18275. 17984060

Yang, J., G. Krishnamoorthy, A. Saxena, G. Zhang, J. Shi, H. Yang, K. Delaloye, D. Sept, and J. Cui. (2010). An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca²⁺ sensing. Neuron. 66: 871-883. 20620873

Yang, L., A. Katchman, J.P. Morrow, D. Doshi, and S.O. Marx. (2011). Cardiac L-type calcium channel (Cav1.2) associates with gamma subunits. FASEB J. 25: 928-936. 21127204

Ye, B. and J.M. Nerbonne. (2009). Proteolytic processing of HCN2 and co-assembly with HCN4 in the generation of cardiac pacemaker channels. J. Biol. Chem. 284: 25553-25559. 19574228

Yellen, G. (2002). The voltage-gated potassium channels and their relatives. Nature 419: 35-42. 12214225

Yellen, G. (1998). The moving parts of voltage-gated ion channels. Quat. Rev. Biophys. 31: 239-295. 10384687

Yuan A., C.M. Santi, A. Wei, Z.W. Wang, K. Pollak, M. Nonet, L. Kaczmarek, C.M. Crowder, L. Salkoff. (2003). The sodium-activated potassium channel is encoded by a member of the Slo gene family. Neuron. 37:765-773. 12628167

Yuan, P., M.D. Leonetti, Y. Hsiung, and R. MacKinnon. (2012). Open structure of the Ca²⁺ gating ring in the high-conductance Ca²⁺-activated K⁺ channel. Nature 481: 94-97. 22139424

Yusifov, T., N. Savalli, C.S. Gandhi, M. Ottolia, and R. Olcese. (2008). The RCK2 domain of the human BKCa channel is a calcium sensor. Proc. Natl. Acad. Sci. U.S.A. 105: 376-381. 18162557

Zhang, G., S.Y. Huang, J. Yang, J. Shi, X. Yang, A. Moller, X. Zou, and J. Cui. (2010). Ion sensing in the RCK1 domain of BK channels. Proc. Natl. Acad. Sci. USA 107: 18700-18705. 20937866

Zhao, G., Z.P. Neeb, M.D. Leo, J. Pachuau, A. Adebiyi, K. Ouyang, J. Chen, and J.H. Jaggar. (2010). Type 1 IP3 receptors activate BKCa channels via local molecular coupling in arterial smooth muscle cells. J Gen Physiol 136: 283-291. 20713546

Zhao, Y., T. Scheuer, and W.A. Catterall. (2004). Reversed voltage-dependent gating of a bacterial sodium channel with proline substitutions in the S6 transmembrane segment. Proc. Natl. Acad. Sci. USA 101: 17873-17878. 15583130

Zhong, H., L.L. Molday, R.S. Molday, and K.-W. Yau. (2002). The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry. Nature 420: 193-198. 12432397

Zimmermann, K., A. Leffler, A. Babes, C.M. Cendan, R.W. Carr, J. Kobayashi, C. Nau, J.N. Wood, and P.W. Reeh. (2007). Sensory neuron sodium channel Na_v1.8 is essential for pain at low temperatures. Nature. 447: 855-888. 17568746

1.A.2

Aguilar-Bryan, L., J.P. Clement IV, G. Gonzalez, K. Kunjilwar, A. Babenko, and J. Bryan. (1998). Toward understanding the assembly and structure of KATP channels. Physiol. Rev. 78: 227-245. 9457174

Ashen, M.D., B. O’Rourke, K.A. Kluge, D.C. Johns, and G.F. Tomaselli. (1995). Inward rectifier K⁺ channel from human heart and brain: cloning and stable expression in a human cell line. Am. J. Physiol. 268: H506-H511. 7840300

Babenko, A.P., G. Gonzalez, and J. Bryan. (1999). Two regions of sulfonylurea receptor specify the spontaneous bursting and ATP inhibition of KATP channel isoforms. J. Biol. Chem. 274: 11587-11592. 10206966

Bendahhou, S., M.R. Donaldson, N.M. Plaster, M. Tristani-Firouzi, Y.-H. Fu, and L.J. Ptácek. (2003). Defective potassium channel Kir2.1 trafficking underlies Andersen-Tawil Syndrome. J. Biol. Chem. 278: 51779-51785. 14522976

Boim, M.A., K. Ho, M.E. Shuck, M.J. Bienkowski, J.H. Block, J.L. Slightom, Y. Yang, B.M. Brenner, and S.C. Hebert. (1995). ROMK inwardly rectifying ATP-sensitive K+ channel. II. Cloning and distribution of alternative forms. Am. J. Physiol. 268: F1132-1140. 7611454

Caballero, R., P. Dolz-Gaitón, R. Gómez, I. Amorós, A. Barana, M. González de la Fuente, L. Osuna, J. Duarte, A. López-Izquierdo, I. Moraleda, E. Gálvez, J.A. Sánchez-Chapula, J. Tamargo, and E. Delpón. (2010). Flecainide increases Kir2.1 currents by interacting with cysteine 311, decreasing the polyamine-induced rectification. Proc. Natl. Acad. Sci. USA 107: 15631-15636. 20713726

Cheng, W.W., D. Enkvetchakul, and C.G. Nichols. (2009). KirBac1.1: it's an inward rectifying potassium channel. J Gen Physiol 133: 295-305. 19204189

Clement, J.P., IV, K. Kunjilwar, G. Gonzalez, M. Schwanstecher, U. Panten, L. Aguilar-Bryan, and J. Bryan. (1997). Association and stoichiometry of KATP channel subunits. Neuron 18: 827-838. 9182806

Coulson, E.J., L.M. May, S.L. Osborne, K. Reid, C.K. Underwood, F.A. Meunier, P.F. Bartlett, and P. Sah. (2008). p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol 4,5-bisphosphate. J. Neurosci. 28: 315-324. 18171948

Enkvetchakul, D., J. Bhattacharyya, I. Jeliazkova, D.K. Groesbeck, C.A. Cukras, and C.G. Nichols. (2004). Functional characterization of a prokaryotic Kir channel. J. Biol. Chem. 279: 47076-47080. 15448150

Epshtein, Y., A.P. Chopra, A. Rosenhouse-Dantsker, G.B. Kowalsky, D.E. Logothetis, and I. Levitan. (2009). Identification of a C-terminus domain critical for the sensitivity of Kir2.1 to cholesterol. Proc. Natl. Acad. Sci. USA 106: 8055-8060. 19416905

Hansen, S.B., X. Tao, and R. MacKinnon. (2011). Structural basis of PIP2 activation of the classical inward rectifier K⁺ channel Kir2.2. Nature 477: 495-498. 21874019

Hill, C.E., M.M. Briggs, J. Liu, and L. Magtanong. (2002). Cloning, expression, and localization of a rat hepatocyte inwardly rectifying potassium channel. Am. J. Physiol. Gastrointest. Liver Physiol. 282: G233-G240. 11804844

Hille, B. (1992). Ionic Channels of Excitable Membranes, 2nd ed. Sinaur Associates, Inc., Sunderland, MA.

Ho, I.H.M. and R.D. Murrell-Lagnado. (1999). Molecular determinants for sodium-dependent activation of G protein-gated K⁺ channels. J. Biol. Chem. 274: 8639-8648. 10085101

Inanobe, A., A. Nakagawa, and Y. Kurachi. (2011). Interactions of cations with the cytoplasmic pores of inward rectifier K⁺ channels in the closed state. J. Biol. Chem. 286: 41801-41811. 21982822

Ishihara, K., T. Yamamoto, and Y. Kubo. (2009). Heteromeric assembly of inward rectifier channel subunit Kir2.1 with Kir3.1 and with Kir3.4. Biochem. Biophys. Res. Commun. 380: 832-837. 19338762

Jaroslawski, S., B. Zadek, F. Ashcroft, C. Venien-Bryan, and S. Scheuring. (2007). Direct visualization of KirBac3.1 potassium channel gating by atomic force microscopy. J. Mol. Biol. 374(2):500-505. 17936299

Kuo, A., J.M. Gulbis, J.F. Antcliff, T. Rahman, E.D. Lowe, J. Zimmer, J. Cuthbertson, F.M. Ashcroft, T. Ezaki, and D.A. Doyle. (2003). Crystal structure of the potassium channel KirBac1.1 in the closed state. Science 300: 1922-1926. 12738871

Li, J., C.F. Kline, T.J. Hund, M.E. Anderson, and P.J. Mohler. (2010). Ankyrin-B regulates Kir6.2 membrane expression and function in heart. J. Biol. Chem. 285: 28723-28730. 20610380

Lin, Y.W., J.D. Bushman, F.F. Yan, S. Haidar, C. Macmullen, A. Ganguly, C.A. Stanley, and S.L. Shyng. (2008). Destabilization of ATP-sensitive potassium channel activity by novel KCNJ11 mutations identified in congenital hyperinsulinism. J. Biol. Chem. 283: 9146-9156. 18250167

Ma, D., X.D. Tang, T.B. Rogers, and P.A. Welling. (2007). An Andersen-Tawil syndrome mutation in Kir2.1 (V302M) alters the G-loop cytoplasmic K⁺ conduction pathway. J. Biol. Chem. 282: 5781-5789. 17166852

Minor, D.L., Jr., S.J. Masseling, Y.N. Jan, and L.Y. Jan. (1999). Transmembrane structure of an inwardly rectifying potassium channel. Cell 96: 879-891. 10102275

Partridge, C.J., D.J. Beech, and A. Sivaprasadarao. (2001). Identification and pharmacological correction of a membrane trafficking defect associated with a mutation in the sulfonylurea receptor causing familial hyperinsulinism. J. Biol. Chem. 276: 35947-35952. 11457841

Rodríguez-Menchaca, A.A., R.A. Navarro-Polanco, T. Ferrer-Villada, J. Rupp, F.B. Sachse, M. Tristani-Firouzi, and J.A. Sánchez-Chapula. (2008). The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel. Proc. Natl. Acad. Sci. U.S.A. 105: 1364-1368. 18216262

Ruknudin, A., D.H. Schulze, S.K. Sullivan, W.J. Lederer, and P.A. Welling. (1998). Novel subunit composition of a renal epithelial KATP channel. J. Biol. Chem. 273: 14165-14171. 9603917

Salkoff, L. and T. Jegla. (1995). Surfing the DNA databases for K⁺ channels nets yet more diversity. Neuron 15: 489-492. 7546728

Seino, S. (1999). ATP-sensitive potassium channels: a model of heteromultimeric potassium channel-receptor assemblies. Annu. Rev. Physiol. 61: 337-362. 10099692

Shuck, M.E., J.H. Bock, C.W. Benjamin, T.D. Tsai, K.S. Lee, J.L. Slightom, and M.J. Bienkowski. (1994). Cloning and characterization of multiple forms of the human kidney ROM-K potassium channel. J. Biol. Chem. 269: 24261-24270. 7929082

Suzuki, Y., M. Itakura, M. Kashiwagi, N. Nakamura, T. Matsuki, H. Sakuta, N. Naito, K. Takano, T. Fujita, and S. Hirose. (1999). Identification by differential display of a hypertonicity-inducible inward rectifier potassium channel highly expressed in chloride cells. J. Biol. Chem. 274: 11376-11382. 10196230

Tao, X., J.L. Avalos, J. Chen, and R. MacKinnon. (2009). Crystal structure of the eukaryotic strong inward-rectifier K⁺ channel Kir2.2 at 3.1 Ĺ resolution. Science 326: 1668-1674. 20019282

Töpert, C., F. Döring, E. Wischmeyer, C. Karschin, J. Brockhaus, K. Ballanyi, C. Derst, and A. Karschin. (1998). Kir2.4: a novel K⁺ inward rectifier channel associated with motoneurons of cranial nerve nuclei. J. Neurosci. 18: 4096-4105. 9592090

Zeng, W.-Z., X.-J. Li, D.W. Hilgemann, and C.-L. Huang. (2003). Protein kinase C inhibits ROMK1 channel activity via a phosphatidylinositol 4,5-bisphosphate-dependent mechanism. J. Biol. Chem. 278: 16852-16856. 12615924

Zhang, C., T. Miki, T. Shibasaki, M. Yokokura, A. Saraya, and S. Seino. (2005). Identification and characterization of a novel member of the ATP-sensitive K+ channel subunit family, Kir6.3, in zebrafish. Physiol Genomics. 24: 290-297. 16317080

1.A.3

Beutner, G., V.K. Sharma, D.R. Giovannucci, D.I. Yule and S.-S. Sheu (2001). Identification of a ryanodine receptor in rat heart mitochondria. J. Biol. Chem. 276: 21482-21488. 11297554

Bosanac, I., J.-R. Alattia, T.K. Mal, J. Chan, S. Talarico, F.K. Tong, K.I. Tong, F. Yoshikawa, T. Furuichi, M. Iwai, T. Michikawa, K. Mikoshiba, and M. Ikura. (2002). Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand. Nature 420: 696-700. 12442173

Chelu, M.G., and X.H. Wehrens. (2007). Sarcoplasmic reticulum calcium leak and cardiac arrhythmias. Biochem. Soc. Trans. 35: 952-956. 17956253

Du, G.G., B. Sandhu, B.K. Khanna, Z.H. Guo, and D.H. MacLennan. (2002). Topology of the Ca²⁺ release channel of skeletal muscle sarcoplasmic reticulum (RyR1). Proc. Natl. Acad. Sci. USA 99: 16725-16730. 12486242

Gaburjakova, M., J. Gaburjakova, S. Reiken, F. Huang, S.O. Marx, N. Rosemblit and A.R. Marks (2001). FKBP12 binding modulates ryanodine receptor channel gating. J. Biol. Chem. 276: 16931-16935. 11279144

Hasan, G. and M. Rosbash. (1992). Drosophila homologues of two mammalian Ca²⁺-release channels: identification and expression patterns of the inositol 1,4,5-triphosphate and the ryanodine receptor genes. Development 116: 967-975. 1338312

Jones, P.P., X. Meng, B. Xiao, S. Cai, J. Bolstad, T. Wagenknecht, Z. Liu, and S.R. Chen. (2008). Localization of PKA phosphorylation site, Ser(2030), in the three-dimensional structure of cardiac ryanodine receptor. Biochem. J. 410: 261-270. 17967164

Laver, D.R., T. Hamada, J.D. Fessenden, and N. Ikemoto. (2007). The ryanodine receptor pore blocker neomycin also inhibits channel activity via a previously undescribed high-affinity Ca²⁺ binding site. J. Membr. Biol. 220: 11-20. 17879109

Lee, A.G. (1996). The ryanodine receptor. In: Biomembranes, Vol. 6, Transmembrane Receptors and Channels (A.G. Lee, ed.), JAI Press, Denver, CO., pp. 291-326.

Lur, G., M.W. Sherwood, E. Ebisui, L. Haynes, S. Feske, R. Sutton, R.D. Burgoyne, K. Mikoshiba, O.H. Petersen, and A.V. Tepikin. (2011). InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences. Biochem. J. 436: 231-239. 21568942

Meng, X., G. Wang, C. Viero, Q. Wang, W. Mi, X.D. Su, T. Wagenknecht, A.J. Williams, Z. Liu, and C.C. Yin. (2009). CLIC2-RyR1 interaction and structural characterization by cryo-electron microscopy. J. Mol. Biol. 387: 320-334. 19356589

Michikawa, T., H. Hamanake, H. Otsu, A. Yamamoto, A. Miyawaki, T. Furuichi, Y. Tashiro and K. Mikoshiba (1994). Transmembrane topology and sites of N-glycosylation of inositol 1,4,5-triphosphate receptor. J. Biol. Chem. 269: 9184-9189. 8132655

Mikoshiba, K., T. Furuichi, and A. Miyawaki (1996). IP₃-sensitive calcium channel. J. Biochem. Biomem. 6: 273-289.

Saier, M.H., Jr., B.H. Eng, S. Fard, J. Garg, D.A. Haggerty, W.J. Hutchinson, D.L. Jack, E.C. Lai, H.J. Liu, D.P. Nusinew, A.M. Omar, S.S. Pao, I.T. Paulsen, J.A. Quan, M. Sliwinski, T.-T. Tseng, S. Wachi and G.B. Young (1999). Phylogenetic characterization of novel transport protein families revealed by genome analyses. Biochem. Biophys. Acta 1422: 1-56. 10082980

Schug, Z.T., P.C. da Fonseca, C.D. Bhanumathy, L. Wagner, 2nd, X. Zhang, B. Bailey, E.P. Morris, D.I. Yule, and S.K. Joseph. (2008). Molecular characterization of the inositol 1,4,5-trisphosphate receptor pore-forming segment. J. Biol. Chem. 283: 2939-2948. 18025085

Sun, Q.A., D.T. Hess, L. Nogueira, S. Yong, D.E. Bowles, J. Eu, K.R. Laurita, G. Meissner, and J.S. Stamler. (2011). Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor-Ca²⁺ release channel by NADPH oxidase 4. Proc. Natl. Acad. Sci. USA 108: 16098-16103. 21896730

Thomas, N.L., C.H. George, A.J. Williams, and F.A. Lai. (2007). Ryanodine receptor mutations in arrhythmias: advances in understanding the mechanisms of channel dysfunction. Biochem. Soc. Trans. 35:946-951. 17956252

Tunwell, R.E.A., C. Wickenden, B.M.A. Bertrand, V.I. Shevchenko, M.B. Walsh, P.D. Allen and F.A. Lai (1996). The human cardiac muscle ryanodine receptor-calcium release channel: identification, primary structure and topological analysis. Biochem. J. 318: 477-487. 8809036

Xia, R., T. Stangler and J.J. Abramson (2000). Skeletal muscle ryanodine receptor is a redox sensor with a well defined redox potential that is sensitive to channel modulators. J. Biol. Chem. 275: 36556-36561. 10952995

Xu, L., Y. Wang, N. Yamaguchi, D.A. Pasek, and G. Meissner. (2008). Single channel properties of heterotetrameric mutant RyR1 ion channels linked to core myopathies. J. Biol. Chem. 283: 6321-6329. 18171678

Zhao, M., P. Li, X. Li, L. Zhang, R.J. Winkfein and S.R.W. Chen (1999). Molecular identification of the ryanodine receptor pore-forming segment. J. Biol. Chem. 274: 25971-25974. 10473538

1.A.4

Barritt, G. and G. Rychkov. (2005). TRPs as mechanosensitive channels. Nat. Cell Biol. 7: 105-107. 15689975

Bautista D.M., J. Siemens, J.M. Glazer, P.R. Tsuruda, A.I. Basbaum, C.L. Stucky, S.E. Jordt, D. Julius. (2007). The menthol receptor TRPM8 is the principal detector of environmental cold. Nature. 448: 204-208. 17538622

Binshtok, A.M., B.P. Bean, and C.J. Woolf. (2007). Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers. Nature. 449(7162):607-610. 17914397

Bohlen, C.J., A. Priel, S. Zhou, D. King, J. Siemens, and D. Julius. (2010). A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain. Cell 141: 834-845. 20510930

Caterina, M.J., M.A. Schumacher, M. Tominaga, T.A. Rosen, J. D. Levine, and D. Julius. (1997). The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389: 816-824. 9349813

Chang, Y., G. Schlenstedt, V. Flockerzi, and A. Beck. (2009). Properties of the intracellular transient receptor potential (TRP) channel in yeast, Yvc1. FEBS Lett. [Epub: Ahead of Print] 20035756

Chen, J., X.F. Zhang, M.E. Kort, J.R. Huth, C. Sun, L.J. Miesbauer, S.C. Cassar, T. Neelands, V.E. Scott, R.B. Moreland, R.M. Reilly, P.J. Hajduk, P.R. Kym, C.W. Hutchins, and C.R. Faltynek. (2008). Molecular determinants of species-specific activation or blockade of TRPA1 channels. J. Neurosci. 28: 5063-5071. 18463259

Cheng Y., Nash H.A. (2007). Drosophila TRP channels require a protein with a distinctive motif encoded by the inaF locus. Proc. Natl. Acad. Sci. U.S.A. 104: 17730-17734. 17968007

Cheng, K.T., X. Liu, H.L. Ong, and I.S. Ambudkar. (2008). Functional requirement for Orai1 in store-operated TRPC1-STIM1 channels. J. Biol. Chem. 283: 12935-12940. 18326500

Chubanov, V., K.P. Schlingmann, J. Waring, J. Heinzinger, S. Kaske, S. Waldegger, M.M. Schnitzler, and T. Gudermann. (2007). Hypomagnesemia with secondary hypocalcemia due to a missense mutation in the putative pore-forming region of TRPM6. J. Biol. Chem. 282: 7656-7667. 17197439

Chubanov, V., S. Waldegger, M.M. y Schnitzler, H. Vitzthum, M.C. Sassen, H.W. Seyberth, M. Konrad, and T. Gudermann. (2004). Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia. Proc. Natl. Acad. Sci. USA 101: 2894-2899. 14976260

Clapham D.E. (2007). SnapShot: mammalian TRP channels. Cell. 129: 220. 17418797

Clapham, D.E. (1996). TRP is cracked, but is CRAC TRP? Neuron 16: 1069-1072. 8663982

Clapham, D.E. (2003). TRP channels as cellular sensors. Nature 426: 517-524. 14654832

Csanády, L. and B. Törocsik. (2009). Four Ca²⁺ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate. J Gen Physiol 133: 189-203. 19171771

D'hoedt, D., G. Owsianik, J. Prenen, M.P. Cuajungco, C. Grimm, S. Heller, T. Voets, and B. Nilius. (2008). Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3. J. Biol. Chem. 283(10): 6272-6280. 18174177

Dodier, Y., U. Banderali, H. Klein, O. Topalak, O. Dafi, M. Simoes, G. Bernatchez, R. Sauvé, and L. Parent. (2004). Outer pore topology of the ECaC-TRPV5 channel by cysteine scan mutagenesis. J. Biol. Chem. 279: 6853-6862. 14630907

Dohke, Y., Y.S. Oh, I.S. Ambudkar, and R.J. Turner. (2004). Biogenesis and topology of the transient receptor potential Ca²⁺ channel TRPC1. J. Biol. Chem. 279: 12242-12248. 14707123

Feng, Z., W. Li, A. Ward, B.J. Piggott, E.R. Larkspur, P.W. Sternberg, and X.Z. Xu. (2006). A C. elegans model of nicotine-dependent behavior: regulation by TRP-family channels. Cell 127: 621-633. 17081982

García-Martínez, C., C. Morenilla-Palao, R. Planells-Cases, J.M. Merino, and A. Ferrer-Montiel. (2000). Identification of an aspartic residue in the P-loop of the vanilloid receptor that modulates pore properties. J. Biol. Chem. 275: 32552-32558. 10931826

García-Sanz, N., P. Valente, A. Gomis, A. Fernández-Carvajal, G. Fernández-Ballester, F. Viana, C. Belmonte, and A. Ferrer-Montiel. (2007). A role of the transient receptor potential domain of vanilloid receptor I in channel gating. J. Neurosci. 27: 11641-11650. 17959807

Gevaert, T., J. Vriens, A. Segal, W. Everaerts, T. Roskams, K. Talavera, G. Owsianik, W. Liedtke, D. Daelemans, I. Dewachter, F. van Leuven, T. Voets, D. de Ridder, and B. Nilius. (2007). Deletion of the transient receptor potential cation channel TRPV4 (Trp12) impairs murine bladder voiding. J. Clin. Invest. 117(11): 3453-3462.

Hardie, R.C. and B. Minke. (1993). Novel Ca²⁺ channels underlying transduction in Drosophila photoreceptors: implications for phosphoinositide-mediated Ca²⁺ mobilization. Trends Neurosci 16: 371-376. 7694408

Hoenderop, J.G., A.W. van der Kemp, A. Hartog, S.F. van de Graaf, C.H. van Os, P.H. Willems, and R.J. Bindels. (1999). Molecular identification of the apical Ca²⁺ channel in 1, 25-dihydroxyvitamin D₃-responsive epithelia. J. Biol. Chem. 274: 8375-8378. 10085067

Hoenderop, J.G.J., T. Voets, S. Hoefs, F. Weidema, J. Prenen, B. Nilius, and R.J.M. Bindels. (2003). Homo- and heterotetrameric architecture of the epithelial Ca²⁺ channels TRPV5 and TRPV6. EMBO J. 22: 776-785. 12574114

Inoue, K., D. Branigan, and Z.G. Xiong. (2010). Zinc-induced neurotoxicity mediated by transient receptor potential melastatin 7 channels. J. Biol. Chem. 285: 7430-7439. 20048154

John Haynes, W., X.L. Zhou, Z.W. Su, S.H. Loukin, Y. Saimi, and C. Kung. (2008). Indole and other aromatic compounds activate the yeast TRPY1 channel. FEBS Lett. 582: 1514-1518. 18396169

Jordt, S.-E. and D. Julius. (2002). Molecular basis for species-specific sensitivity to "hot" chili peppers. Cell 108: 421-430. 11853675

Jordt, S.E., D.M. Bautista, H.H. Chuang, D.D. McKemy, P.M. Zygmunt, E.D. Hogestatt, I.D. Meng, and D. Julius. (2004). Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427: 260-265. 14712238

Kang, L., J. Gao, W.R. Schafer, Z. Xie, and X.Z. Xu. (2010). C. elegans TRP family protein TRP-4 is a pore-forming subunit of a native mechanotransduction channel. Neuron. 67: 381-391. 20696377

Kedei, N., T. Szabo, J.D. Lile, J.J. Treanor, Z. Olah, M.J. Iadarola, and P.M. Blumberg. (2001). Analysis of the native quaternary structure of vanilloid receptor 1. J. Biol. Chem. 276: 28613-28619. 11358970

Kim, J., Y.D. Chung, D. Park, S. Choi, D.W. Shin, H. Soh, H.W. Lee, W. Son, J. Yim, C.-S. Park, M.J. Kernan, and C. Kim. (2003). A TRPV family ion channel required for hearing in Drosophila. Nature 424: 81-82. 12819662

Kim, S.J., G.H. Park, D. Kim, J. Lee, H. Min, E. Wall, C.J. Lee, M.I. Simon, S.J. Lee, and S.K. Han. (2011). Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in transient receptor potential vanilloid 1 (TRPV1)-expressing neurons. Proc. Natl. Acad. Sci. USA 108: 3371-3376. 21300878

Kim, S.J., Y.S. Kim, J.P. Yuan, R.S. Petralia, P.F. Worley, and D.J. Linden. (2003). Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1. Nature 426: 285-291. 14614461

Kiselyov, K., X. Xu, G. Mozhayeva, T. Kuo, I. Pessah, G. Mignery, X. Zhu, L. Birnbaumer, and S. Muallem. (1998). Functional interaction between InsP3 receptors and store-operated Htrp3 channels. Nature 396: 478-482. 9853757

Knowles, H., J.W. Heizer, Y. Li, K. Chapman, C.A. Ogden, K. Andreasen, E. Shapland, G. Kucera, J. Mogan, J. Humann, L.L. Lenz, A.D. Morrison, and A.L. Perraud. (2011). Transient Receptor Potential Melastatin 2 (TRPM2) ion channel is required for innate immunity against Listeria monocytogenes. Proc. Natl. Acad. Sci. USA 108: 11578-11583. 21709234

Kühn, F.J., G. Knop, and A. Lückhoff. (2007). The transmembrane segment S6 determines cation versus anion selectivity of TRPM2 and TRPM8. J. Biol. Chem. 282: 27598-27609. 17604279

Latorre, R., C. Zaelzer, and S. Brauchi. (2009). Structure-functional intimacies of transient receptor potential channels. Q. Rev. Biophys. 42: 201-246. 20025796

Launay, P., A. Fleig, A.-L. Perraud, A.M. Scharenberg, R. Penner, and J.-P. Kinet. (2002). TRPM4 is a Ca²⁺-activated nonselective cation channel mediating cell membrane depolarization. Cell 109: 397-407. 12015988

Lee, Y., Y. Lee, J. Lee, S. Bang, S. Hyun, J. Kang, S.T. Hong, E. Bae, B.K. Kaang, and J. Kim. (2005). Pyrexia is a new thermal transient receptor potential channel endowing tolerance to high temperatures in Drosophila melanogaster. Nat. Genet. 37: 305-310. 15731759

Leffler, A., A. Lattrell, S. Kronewald, F. Niedermirtl, and C. Nau. (2011). Activation of TRPA1 by membrane permeable local anesthetics. Mol Pain 7: 62. 21861907

Leffler, A., M.J. Fischer, D. Rehner, S. Kienel, K. Kistner, S.K. Sauer, N.R. Gavva, P.W. Reeh, and C. Nau (2008). The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons. J Cl^- in Invest 118: 763-776. 18172555

Li, M., J. Du, J. Jiang, W. Ratzan, L.T. Su, L.W. Runnels, and L. Yue. (2007). Molecular Determinants of Mg²⁺ and Ca²⁺ Permeability and pH Sensitivity in TRPM6 and TRPM7. J. Biol. Chem. 282(35):25817-25830. 17599911

Liao, B.K., A.N. Deng, S.C. Chen, M.Y. Chou, and P.P. Hwang. (2007). Expression and water calcium dependence of calcium transporter isoforms in zebrafish gill mitochondrion-rich cells. BMC Genomics. 8: 354. 17915033

Liedtke, W., Y. Choe, M.A. Martí-Renom, A.M. Bell, C.S. Denis, A. Sali, A.J. Hudspeth, J.M. Friedman and S. Heller (2000). Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 103: 525-535. 11081638

Liu X., K.T. Cheng, B.C. Bandyopadhyay, B. Pani, A. Dietrich, B.C. Paria, W.D. Swaim, D. Beech, E. Yildrim, B.B. Singh, L. Birnbaumer, I.S. Ambudkar. (2007a). Attenuation of store-operated Ca₂₊ current impairs salivary gland fluid secretion in TRPC1(-/-) mice. Proc Natl Acad Sci U S A. 104: 17542-17547. 17956991

Liu, L., Y. Li, R. Wang, C. Yin, Q. Dong, H. Hing, C. Kim, and M.J. Welsh. (2007b). Drosophila hygrosensation requires the TRP channels water witch and nanchung. Nature. 450: 294-298. 17994098

Liu, X., B.B. Singh, and I.S. Ambudkar. (2003). TRPC1 is required for functional store-operated Ca²⁺ channels. Role of acidic amino acid residues in the S5-S6 region. J. Biol. Chem. 278: 11337-11343. 12536150

Liu, X., B.C. Bandyopadhyay, B.B. Singh, K. Groschner, and I.S. Ambudkar. (2005). Molecular analysis of a store-operated and 2-acetyl-sn-glycerol-sensitive non-selective cation channel. Heteromeric assembly of TRPC1-TRPC3. J. Biol. Chem. 280: 21600-21606. 15834157

Loukin, S., Z. Su, X. Zhou, and C. Kung. (2010). Forward genetic analysis reveals multiple gating mechanisms of TRPV4. J. Biol. Chem. 285: 19884-19890. 20424166

Ma, H.T., Z. Peng, T. Hiragun, S. Iwaki, A.M. Gilfillan, and M.A. Beaven. (2008). Canonical transient receptor potential 5 channel in conjunction with Orai1 and STIM1 allows Sr²⁺ entry, optimal influx of Ca²⁺, and degranulation in a rat mast cell line. J. Immunol. 180: 2233-2239. 18250430

Macpherson, L.J., A.E. Dubin, M.J. Evans, F. Marr, P.G. Schultz, B.F. Cravatt, and A. Patapoutian. (2007). Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature 445: 541-545. 17237762

Maruyama, Y., T. Ogura, K. Mio, S. Kiyonaka, K. Kato, Y. Mori, and C. Sato. (2007). Three-dimensional Reconstruction Using Transmission Electron Microscopy Reveals a Swollen, Bell-shaped Structure of Transient Receptor Potential Melastatin Type 2 Cation Channel. J. Biol. Chem. 282: 36961-36970. 17940282

Matta, J.A. and G.P. Ahern. (2007). Voltage is a partial activator of rat thermosensitive TRP channels. J. Physiol. 585(Pt 2):469-482. 17932142

Matta, J.A., P.M. Cornett, R.L. Miyares, K. Abe, N. Sahibzada, and G.P. Ahern. (2008). General anesthetics activate a nociceptive ion channel to enhance pain and inflammation. Proc. Natl. Acad. Sci. USA 105: 8784-8789. 18574153

McCleskey E.W. and M.S. Gold. (1999). Ion channels of nociception. Annu. Rev. Physiol. 61: 835-856. 10099712

Mederos y Schnitzler, M., J. Wäring, T. Gudermann, and V. Chubanov. (2008). Evolutionary determinants of divergent calcium selectivity of TRPM channels. FASEB J. 22(5): 1540-1551. 18073331

Mercado, J., A. Gordon-Shaag, W.N. Zagotta, and S.E. Gordon. (2010). Ca²⁺-dependent desensitization of TRPV2 channels is mediated by hydrolysis of phosphatidylinositol 4,5-bisphosphate. J. Neurosci. 30: 13338-13347. 20926660

Minke, B. and B. Cook. (2002). TRP channel proteins and signal transduction. Physiol. Rev. 82: 429-472. 11917094

Moiseenkova-Bell, V.Y., L.A. Stanciu, I.I. Serysheva, B.J. Tobe, and T.G. Wensel. (2008). Structure of TRPV1 channel revealed by electron cryomicroscopy. Proc. Natl. Acad. Sci. USA 105: 7451-7455. 18490661

Montell, C. (2005). The TRP superfamily of cation channels. Science STKE 272: 1-24. 15728426

Montell, C. and G.M. Rubin. (1989). Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction. Neuron 2: 1313-1323. 2516726

Montell, C., L. Birnbaumer, and V. Flockerzi. (2002). The TRP channels, a remarkably functional family. Cell 108: 595-598. 11893331

Moussaieff, A., N. Rimmerman, T. Bregman, A. Straiker, C.C. Felder, S. Shoham, Y. Kashman, S.M. Huang, H. Lee, E. Shohami, K. Mackie, M.J. Caterina, J.M. Walker, E. Fride, and R. Mechoulam. (2008). Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain. FASEB J. 22: 3024-3034. 18492727

Mukerji, N., T.V. Damodaran, and M.P. Winn. (2007). TRPC6 and FSGS: the latest TRP channelopathy. Biochim. Biophys. Acta. 1772: 859-868. 17459670

Nadler, M.J.S., M.C. Hermosura, K. Inabe, A.-L. Perraud, Q. Zhu, A.J. Stokes, T. Kurosaki, J.-P. Kinet, R. Penner, A.M. Scharenberg, and A. Fleig. (2001). LTRPC7 is a Mg·ATP-regulated divalent cation channel required for cell viability. Nature 411: 590-594. 11385574

Nilius, B., R. Vennekens, J. Prenen, J.G. Hoenderop, G. Droogmans, and R.J. Bindels. (2001). The single pore residue Asp542 determines Ca²⁺ permeation and Mg²⁺ block of the epithelial Ca²⁺ channel. J. Biol. Chem. 276: 1020-1025. 11035011

Numata, T. and Y. Okada. (2008). Proton Conductivity through the Human TRPM7 Channel and Its Molecular Determinants. J. Biol. Chem. 283: 15097-15103. 18390554

Olah, Z., L. Karai, and M.J. Iadarola. (2001). Anandamide activates vanilloid receptor 1 (VR1) at acidic pH in dorsal root ganglia neurons and cells ectopically expressing VR1. J. Biol. Chem. 276: 31163-31170. 11333266

Park, J.Y., E.M. Hwang, O. Yarishkin, J.H. Seo, E. Kim, J. Yoo, G.S. Yi, D.G. Kim, N. Park, C.M. Ha, J.H. La, D. Kang, J. Han, U. Oh, and S.G. Hong. (2008). TRPM4b channel suppresses store-operated Ca²⁺ entry by a novel protein-protein interaction with the TRPC3 channel. Biochem. Biophys. Res. Commun. 368: 677-683. 18262493

Peier, A.M., A. Moqrich, A.C. Hergarden, A.J. Reeve, D.A. Andersson, G.M. Story, T.J. Earley, I Dragoni, P. McIntyre, S. Bevan, and A. Patapoutian. (2002). A TRP channel that senses cold stimuli and menthol. Cell 108: 705-715. 11893340

Peng, J.B., X.Z. Chen, U.V. Berger, P.M. Vassilev, H. Tsukaguchi, E.M. Brown, and M.A. Hediger. (1999). Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption. J. Biol. Chem. 274: 22739-22746. 10428857

Perraud, A.-L., A. Fleig, C.A. Dunn, L.A. Bagley, P. Launay, C. Schmitz, A.J. Stokes, Q. Zhu, M.J. Bessman, R. Penner, J.-P. Kinet, and A.M. Scharenberg. (2001). ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Nature 411: 594-599. 11385575

Phelps, C.B., R.J. Huang, P.V. Lishko, R.R. Wang, and R. Gaudet (2008). Structural analyses of the ankyrin repeat domain of TRPV6 and related TRPV ion channels. Biochemistry 47: 2476-2484. 18232717

Premkumar, L.S. (2001). Interaction between vanilloid receptors and purinergic metabotropic receptors: pain perception and beyond. Proc. Natl. Acad. Sci. USA 98: 6537-6539. 11390988

Putney, J.W., Jr. and R.R. McKay. (1999). Capacitative calcium entry channels. BioEssays 21: 38-46. 10070252

Ramsey, I.S., M. Delling, and D.E. Clapham. ((2006)). An introduction to TRP channels. Annu. Rev. Physiol. 68: 619–647. 16460286

Rock, M.J., J. Prenen, V.A. Funari, T.L. Funari, B. Merriman, S.F. Nelson, R.S. Lachman, W.R. Wilcox, S. Reyno, R. Quadrelli, A. Vaglio, G. Owsianik, A. Janssens, T. Voets, S. Ikegawa, T. Nagai, D.L. Rimoin, B. Nilius, and D.H. Cohn. (2008). Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia. Nat. Genet. 40: 999-1003. 18587396

Runnels, L.W., L. Yue, and D.E. Clapham. (2001). TRP-PLIK, a bifunctional protein with kinase and ion channel activities. Science 291: 1043-1046. 11161216

Schmitz, C., F. Deason, and A.L. Perraud. (2007). Molecular components of vertebrate Mg²⁺-homeostasis regulation. Magnes. Res. 20: 6-18. 17536484

Schoeber, J.P., C.N. Topala, X. Wang, R.J. Diepens, T.T. Lambers, J.G. Hoenderop, and R.J. Bindels. (2006). RGS2 inhibits the epithelial Ca²⁺ channel TRPV6. J. Biol. Chem. 281: 29669-29674. 16895908

Sidi, S., R.W. Friedrich, and T. Nicolson. (2003). NompC TRP channel required for vertebrate sensory hair cell mechanotransduction. Science 301: 96-99. 12805553

Starkus, J.G., A. Fleig, and R. Penner. (2010). The calcium-permeable non-selective cation channel TRPM2 is modulated by cellular acidification. J. Physiol. 588: 1227-1240. 20194125

Story, G.M., A.M. Peier, A.J. Reeve, S.R. Eid, J. Mosbacher, T.R. Hricik, T.J. Earley, A.C. Hergarden, D.A. Andersson, S.W. Hwang, P. McIntyre, T. Jegla, S. Bevan, and A. Patapoutian. (2003). ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112: 819-829. 12654248

Studer, M. and P.A. McNaughton. (2010). Modulation of single-channel properties of TRPV1 by phosphorylation. J. Physiol. 588: 3743-3756. 20693293

Stumpf, T., Q. Zhang, D. Hirnet, U. Lewandrowski, A. Sickmann, U. Wissenbach, J. Dörr, C. Lohr, J.W. Deitmer, and C. Fecher-Trost. (2008). The human TRPV6 channel protein is associated with cyclophilin B in human placenta. J. Biol. Chem. 283: 18086-18098. 18445599

Suzuki, M., J. Sato, K. Kutsuwada, G. Ooki, and M. Imai. (1999). Cloning of a stretch-inhibitable nonselective cation channel. J. Biol. Chem. 274: 6330-6335. 10037722

Thébault, S., G. Cao, H. Venselaar, Q. Xi, R.J. Bindels, and J.G. Hoenderop. (2008). Role of the α-kinase domain in transient receptor potential melastatin 6 channel and regulation by intracellular ATP. J. Biol. Chem. 283: 19999-20007. 18490453

van de Graaf, S.F.J., J.G.J. Hoenderop, D. Gkika, D. Lamers, J. Prenen, U. Rescher, V. Gerke, O. Staub, B. Nilius, and R.J.M. Bindels. (2003). Functional expression of the epithelial Ca²⁺ channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex. EMBO J. 22: 1478-1487. 12660155

Vanden Abeele, F., A. Zholos, G. Bidaux, Y. Shuba, S. Thebault, B. Beck, M. Flourakis, Y. Panchin, R. Skryma, and N. Prevarskaya. (2006). Ca²⁺-independent phospholipase A₂-dependent gating of TRPM8 by lysophospholipids. J. Biol. Chem. 281: 40174-40182. 17082190

Viswanath, V., G.M. Story, A.M. Peier, M.J. Petrus, V.M. Lee, S.W. Hwang, A. Patapoutian, and T. Jegla. (2003). Ion channels: opposite thermosensor in fruitfly and mouse. Nature 423: 822-823. 12815418

Voets, T., B. Nilius, S. Hoefs, A.W.C.M. van der Kemp, G. Droogmans, R.J.M. Bindels, and J.G.J. Hoenderop. (2004). TRPM6 forms the Mg²⁺ influx channel involved in intestinal and renal Mg²⁺ absorption. J. Biol. Chem. 279: 19-25. 14576148

Wang, Y.Y., R.B. Chang, and E.R. Liman. (2010). TRPA1 is a component of the nociceptive response to CO₂. J. Neurosci. 30: 12958-12963. 20881114

Wilkinson, J.A., J.L. Scragg, J.P. Boyle, B. Nilius, and C. Peers. (2008). H₂O 2-stimulated Ca²⁺ influx via TRPM2 is not the sole determinant of subsequent cell death. Pflugers Arch 455: 1141-1151. 18043941

Winn, M.P., P.J. Conlon, K.L. Lynn, M.K. Farrington, T. Creazzo, A.F. Hawkins, N. Daskalakis, S.Y. Kwan, S. Ebersviller, J.L. Burchette, M.A. Pericak-Vance, D.N. Howell, J.M. Vance, and P.B. Rosenberg. (2005). A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science 308: 1801-1804. 15879175

Wong, F., E.L. Schaefer, B.C. Roop, J.N. LaMendola, D. Johnson-Seaton, and D. Shao. (1989). Proper function of the Drosophila trp gene product during pupal development is important for normal visual transduction in the adult. Neuron 3: 81-94. 2482778

Xia, R., Z.Z. Mei, H.J. Mao, W. Yang, L. Dong, H. Bradley, D.J. Beech, and L.H. Jiang. (2008). Identification of pore residues engaged in determining divalent cationic permeation in transient receptor potential melastatin subtype channel 2. J. Biol. Chem. 283: 27426-27432. 18687688

Xiao, B., A.E. Dubin, B. Bursulaya, V. Viswanath, T.J. Jegla, and A. Patapoutian. (2008). Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels. J. Neurosci. 28: 9640-9651. 18815250

Xu, H., I.S. Ramsey, S.A. Kotecha, M.M. Moran, J.A. Chong, D. Lawson, P. Ge, J. Lilly, I. Silos-Santiago, Y. Xie, P.S. DiStefano, R. Curtis, and D.E. Clapham. (2002). TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature 418: 181-186. 12077604

Xu, X.Z., and P.W. Sternberg. (2003). A C. elegans sperm TRP protein required for sperm-egg interactions during fertilization. Cell 114: 285-297. 12914694

Yang, F., Y. Cui, K. Wang, and J. Zheng. (2010). Thermosensitive TRP channel pore turret is part of the temperature activation pathway. Proc. Natl. Acad. Sci. USA 107: 7083-7088. 20351268

Zakharian, E., C. Cao, and T. Rohacs. (2010). Gating of transient receptor potential melastatin 8 (TRPM8) channels activated by cold and chemical agonists in planar lipid bilayers. J. Neurosci. 30: 12526-12534. 20844147

Zhou, X., Z. Su, A. Anishkin, W.J. Haynes, E.M. Friske, S.H. Loukin, C. Kung, and Y. Saimi. (2007). Yeast screens show aromatic residues at the end of the sixth helix anchor transient receptor potential channel gate. Proc. Natl. Acad. Sci. USA. 104: 15555-15559. 17878311

Zimmermann, K., J.K. Lennerz, A. Hein, A.S. Link, J.S. Kaczmarek, M. Delling, S. Uysal, J.D. Pfeifer, A. Riccio, and D.E. Clapham. (2011). Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proc. Natl. Acad. Sci. USA 108: 18114-18119. 22025699

1.A.5

Anyatonwu, G.I. and B.E. Ehrlich. (2005). Organic cation permeation through the channel formed by polycystin-2. J. Biol. Chem. 280: 29488-29493. 15961385

Bai, C.X., S. Kim, W.P. Li, A.J. Streets, A.C. Ong, and L. Tsiokas. (2008). Activation of TRPP2 through mDia1-dependent voltage gating. EMBO. J. 27: 1345-1356. 18388856

Bycroft, M., A. Bateman, J. Clarke, S.J. Hamill, R. Sandford, R.L. Thomas, and C. Chothia. (1999). The structure of a PKD domain from polycystin-1. Implications for polycystic kidney disease. EMBO J. 18: 297-305. 9889186

Chen, X.-Z., P.M. Vassilev, N. Basora, J.-B. Peng, H. Nomura, Y. Segal, E.M. Brown, S.T. Reeders, M.A. Hediger, and J. Zhou. (1999). Polycystin-L is a calcium-regulated cation channel permeable to calcium ions. Nature 401: 383-386. 10517637

Deltas, C.C. (2001). Mutations of the human polycystic kidney disease 2 (PKD2) gene. Hum. Mutat. 18: 13-24. 11438989

Dong, X.P., X. Cheng, E. Mills, M. Delling, F. Wang, T. Kurz, and H. Xu. (2008). The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel. Nature 455: 992-996. 18794901

González-Perrett, S., K. Kim, C. Ibarra, A.E. Damiano, E. Zotta, M. Batelli, P.C. Harris, I.L. Reisin, M.A. Arnaout, and H.F. Cantiello. (2001). Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca²⁺-permeable nonselective cation channel. Proc. Natl. Acad. Sci. USA 98: 1182-1187. 11252306

Gonzalez-Perrett, S., M. Batelli, K. Kim, M. Essafi, G. Timpanaro, N. Moltabetti, I.L. Reisin, M.A. Arnaout, and H.F. Cantiello. (2002). Voltage dependence and pH regulation of human polycystin-2-mediated cation channel activity. J. Biol. Chem. 277: 24959-24966. 11991947

Hoffmeister, H., A.R. Gallagher, A. Rascle, and R. Witzgall. (2010). The human polycystin-2 protein represents an integral membrane protein with six membrane-spanning domains and intracellular N- and C-termini. Biochem. J. 433: 285-294. 21044049

Huang, K., D.R. Diener, A. Mitchell, G.J. Pazour, G.B. Witman, and J.L. Rosenbaum. (2007). Function and dynamics of PKD2 in Chlamydomonas reinhardtii flagella. J. Cell Biol. 179: 501-514. 17984324

Kim H.J., Q. Li, S. Tjon-Kon-Sang, I. So, K. Kiselyov, S. Muallem. (2007). Gain-of-function mutation in TRPML3 causes the mouse Varitint-Waddler phenotype. J Biol Chem. 282: 36138-36142. 17962195

Kim, H.J., S. Yamaguchi, Q. Li, I. So, and S. Muallem. (2010). Properties of the TRPML3 pore and its stable expansion by the varitint-waddler causing mutation. J. Biol. Chem. [Epub: Ahead of Print] 20378547

Kim, I., Y. Fu, K. Hui, G. Moeckel, W. Mai, C. Li, D. Liang, P. Zhao, J. Ma, X.Z. Chen, A.L. George, R.J. Coffey, Z.P. Feng, and G. Wu (2008). Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function. J Am Soc Nephrol 19: 455-68. 18235088

Kiselyov, K., J. Chen, Y. Rbaibi, D. Oberdick, S. Tjon-Kon-Sang, N. Shcheynikov, S. Muallem, and A. Soyombo. (2005). TRP-ML1 is a lysosomal monovalent cation channel that undergoes proteolytic cleavage. J. Biol. Chem. 280: 43218-43223. 16257972

Lev, S., D.A. Zeevi, A. Frumkin, V. Offen-Glasner, G. Bach, and B. Minke. (2010). Constitutive activity of the human TRPML2 channel induces cell degeneration. J. Biol. Chem. 285: 2771-2782. 19940139

Li, Q., X.Q. Dai, P.Y. Shen, Y. Wu, W. Long, C.X. Chen, Z. Hussain, S. Wang, and X.Z. Chen. (2007). Direct binding of α-actinin enhances TRPP3 channel activity. J Neurochem 103(6): 2391-2400. 17944866

Liu, Y., Q. Li, M. Tan, Y.-Y. Zhang, E. Karpinski, J. Zhou, and X.-Z. Chen. (2002). Modulation of the human polycystin-L channel by voltage and divalent cations. FEBS Lett. 525: 71-76. 12163164

Luzio, J.P., N.A. Bright, and P.R. Pryor. (2007). The role of calcium and other ions in sorting and delivery in the late endocytic pathway. Biochem. Soc. Trans. 35: 1088-1091. 17956286

Molland, K.L., A. Narayanan, J.W. Burgner, and D.A. Yernool. (2010). Identification of the structural motif responsible for trimeric assembly of the C-terminal regulatory domains of polycystin channels PKD2L1 and PKD2. Biochem. J. 429: 171-183. 20408813

Somlo, S. and B. Ehrlich. (2001). Human disease: calcium signaling in polycystic kidney disease. Curr. Biol. 11: R356-R360. 11369247

Wilson, P.D. (2001). Polycystin: new aspects of structure, function, and regulation. J. Am. Soc. Nephrol. 12: 834-845. 11274246

Wu, G. (2001). Current advances in molecular genetics of autosomal-dominant polycystic kidney disease. Curr. Opin. Nephrol. Hypertens. 10: 23-31. 11195048

Xu, G.M., S. González-Perrett, M. Essafi, G.A. Timpanaro, N. Montalbetti, M.A. Arnaout, and H.F. Cantiello. (2003). Polycystin-1 activates and stabilizes the polycystin-2 channel. J. Biol. Chem. 278: 1457-1462. 12407099

Yu, Y., M.H. Ulbrich, M.H. Li, Z. Buraei, X.Z. Chen, A.C. Ong, L. Tong, E.Y. Isacoff, and J. Yang. (2009). Structural and molecular basis of the assembly of the TRPP2/PKD1 complex. Proc. Natl. Acad. Sci. USA 106: 11558-11563. 19556541

Zhu, J., Y. Yu, M.H. Ulbrich, M.H. Li, E.Y. Isacoff, B. Honig, and J. Yang. (2011). Structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach. Proc. Natl. Acad. Sci. USA 108: 10133-10138. 21642537

1.A.6

Alvarez de la Rosa, D., C.M. Canessa, G.K. Fyfe, and P. Zhang. (2000). Structure and regulation of amiloride-sensitive sodium channels. Annu. Rev. Physiol. 62: 573-594. 10845103

Arteaga, M.F., T. Coric, C. Straub, and C.M. Canessa. (2008). A brain-specific SGK1 splice isoform regulates expression of ASIC1 in neurons. Proc. Natl. Acad. Sci. U.S.A. 105: 4459-4464. 18334630

Baron, A., L. Schaefer, E. Lingueglia, G. Champigny, and M. Lazdunski. (2001). Zn²⁺ and H⁺ are coactivators of acid-sensing ion channels. J. Biol. Chem. 276: 35361-35367. 11457851

Bianchi L. (2007). Mechanotransduction: touch and feel at the molecular level as modeled in Caenorhabditis elegans. Mol Neurobiol. 36: 254-271. 17955200

Canessa, C.M., L. Schild, G. Buell, B. Thorens, I. Gautschi, J.-D. Horisberger, and B.C. Rossier. (1994). Amiloride-sensitive epithelial Na⁺ channel is made of three homologous subunits. Nature 367: 463-467. 8107805

Carnally, S.M., H.S. Dev, A.P. Stewart, N.P. Barrera, M.X. Van Bemmelen, L. Schild, R.M. Henderson, and J.M. Edwardson. (2008). Direct visualization of the trimeric structure of the ASIC1a channel, using AFM imaging. Biochem. Biophys. Res. Commun. 372: 752-755. 18514062

Chai, S., M. Li, D. Branigan, Z.G. Xiong, and R.P. Simon. (2010). Activation of acid-sensing ion channel 1a (ASIC1a) by surface trafficking. J. Biol. Chem. 285: 13002-13011. 20185828

Chelur, D.S., Ernstrom, G.G., M.B. Goodman, C.A. Yao, L. Chen, R. O'Hagan, and M. Chalfie. (2002). The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel. Nature 420: 669-673. 12478294

Chen, X., G. Polleichtner, I. Kadurin, and S. Gründer. (2007). Zebrafish Acid-sensing Ion Channel (ASIC) 4, Characterization of Homo- and Heteromeric Channels, and Identification of Regions Important for Activation by H⁺. J. Biol. Chem. 282(42): 30406-30413. 17686779

Coscoy, S., J.R. de Weille, E. Lingueglia, and M. Lazdunski. (1999). The pre-transmembrane 1 domain of acid-sensing ion channels participates in the ion pore. J. Biol. Chem. 274: 10129-10132. 10187795

Darboux, I., E. Lingueglia, G. Champigny, S. Coscoy, and P. Barbry. (1998). dGNaC1, a gonad-specific amiloride-sensitive Na⁺ channel. J. Biol. Chem. 273: 9424-9429. 9545267

Deval, E., J. Noël, N. Lay, A. Alloui, S. Diochot, V. Friend, M. Jodar, M. Lazdunski, and E. Lingueglia. (2008). ASIC3, a sensor of acidic and primary inflammatory pain. EMBO. J. 27: 3047-3055. 18923424

Durrnagel, S., A. Kuhn, C.D. Tsiairis, M. Williamson, H. Kalbacher, C.J. Grimmelikhuijzen, T.W. Holstein, and S. Grunder. (2010). Three homologous subunits form a high-affinity peptide-gated ion channel in hydra. J. Biol. Chem. [Epub: Ahead of Print] 20159980

Firsov, D., I. Gautschi, A.-M. Merillat, B.C. Rossier, and L. Schild. (1998). The heterotetrameric architecture of the epithelial sodium channel (ENaC). EMBO J. 17: 344-352. 9430626

García-Ańoveros, J., J.A. García, J.D. Liu, and D.P. Corey. (1998). The nematode degenerin UNC-105 forms ion channels that are activated by degeneration- or hypercontraction-causing mutations. Neuron 20: 1231-1241. 9655510

Garty, H. and L.G. Palmer. (1997). Epithelial sodium channels – function, structure, and regulation. Physiol. Rev. 77: 359-396. 9114818

Golubovic, A., A. Kuhn, M. Williamson, H. Kalbacher, T.W. Holstein, C.J. Grimmelikhuijzen, and S. Gründer. (2007). A peptide-gated ion channel from the freshwater polyp Hydra. J. Biol. Chem. 282: 35098-35103. 17911098

Gonzales, E.B., T. Kawate, and E. Gouaux. (2009). Pore architecture and ion sites in acid-sensing ion channels and P2X receptors. Nature 460: 599-604. 19641589

Henry, P.C., V. Kanelis, M.C. O'Brien, B. Kim, I. Gautschi, J. Forman-Kay, L. Schild, and D. Rotin. (2003). Affinity and specificity of interactions between Nedd4 isoforms and the epithelial Na⁺ channel. J. Biol. Chem. 278: 20019-20028. 12654927

Horisberger, J.-D. (1998). Amiloride-sensitive Na channels. Curr. Opin. Struc. Biol. 10: 443-449. 9719863

Jasti, J., H. Furukawa, E.B. Gonzales, and E. Gouaux. (2007). Structure of acid-sensing ion channel 1 at 1.9 Å resolution and low pH. Nature 449: 316-323. 17882215

Konstas, A.A., L.M. Shearwin-Whyatt, A.B. Fotia, B. Degger, D. Riccardi, D.I. Cook, C. Korbmacher, and S. Kumar. (2002). Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein. J. Biol. Chem. 277: 29406-29416. 12050153

Le, T. and M.H. Saier, Jr. (1996). Phylogenetic characterization of the epithelial Na⁺ channel (ENaC) family. Mol. Membr. Biol. 13: 149-157. 8905643

Lee, I.H., A. Dinudom, A. Sanchez-Perez, S. Kumar, and D.I. Cook. (2007). Akt Mediates the Effect of Insulin on Epithelial Sodium Channels by Inhibiting Nedd4-2. J. Biol. Chem. 282(41):29866-29873. 17715136

Mano, I. and M. Driscoll. (1999). DEG/ENaC channels: a touchy superfamily that watches its salts. BioEssays 21: 568-578. 10472184

Matalon, S. and H. O’Brodovich. (1999). Sodium channels in alveolar epithelial cells: molecular characterization, biophysical properties, and physiological significance. Annu. Rev. Physiol. 61: 627-661. 10099704

McCleskey, E.W. and M.S. Gold. (1999). Ion channels of nociception. Annu. Rev. Physiol. 61: 835-856. 10099712

Mueller, G.M., A.B. Maarouf, C.L. Kinlough, N. Sheng, O.B. Kashlan, S. Okumura, S. Luthy, T.R. Kleyman, and R.P. Hughey. (2010). Cys palmitoylation of the beta subunit modulates gating of the epithelial sodium channel. J. Biol. Chem. 285: 30453-30462. 20663869

Price, M.P., G.R. Lewin, S.L. McIlwrath, C. Cheng, J. Xie, P.A. Heppenstall, C.L. Stucky, A.G. Mannsfeldt, T.J. Brennan, H.A. Drummond, J. Qiao, C.J. Benson, D.E. Tarr, R.F. Hrstka, B. Yang, R.A. Williamson, and M.J. Welsh. (2000). The mammalian sodium channel BNC1 is required for normal touch sensation. Nature 407: 1007-1010. 11069180

Sedensky, M.M., J.M. Siefker, J.Y. Koh, D.M. Miller, 3rd, and P.G. Morgan. (2004). A stomatin and a degenerin interact in lipid rafts of the nervous system of Caenorhabditis elegans. Am. J. Physiol. Cell Physiol. 287: C468-474. 15102610

Sheng, S., J. Li, K.A. McNulty, D. Avery, and T.R. Kleyman. (2000). Characterization of the selectivity filter of the epithelial sodium channel. J. Biol. Chem. 275: 8572-8581. 10722696

Sheng, S., J. Li, K.A. McNulty, T. Kieber-Emmons, and T.R. Kleyman. (2001a). Epithelial sodium channel pore region: structure and role in gating. J. Biol. Chem. 276: 1326-1334. 11022046

Sheng, S., K.A. McNulty, J.M. Harvey, and T.R. Kleyman. (2001b). Second transmembrane domains of ENaC subunits contribute to ion permeation and selectivity. J. Biol. Chem. 276: 44091-44098. 11564745

Snyder, P.M., D.R. Olson, F.J. McDonald, and D.B. Bucher. (2001). Multiple WW domains, but not the C2 domain, are required for inhibition of the epithelial Na⁺ channel by human Nedd4. J. Biol. Chem. 276: 28321-28326. 11359767

Su, X., Q. Li, K. Shrestha, E. Cormet-Boyaka, L. Chen, P.R. Smith, E.J. Sorscher, D.J. Benos, S. Matalon, and H.L. Ji. (2006). Interregulation of proton-gated Na⁺ channel 3 and cystic fibrosis transmembrane conductance regulator. J. Biol. Chem. 281: 36960-36968. 17012229

Takeda, A.N., I. Gautschi, M.X. van Bemmelen, and L. Schild. (2007). Cadmium trapping in an epithelial sodium channel pore mutant. J. Biol. Chem. 282: 31928-31936. 17804416

Ugawa, S., Y. Ishida, T. Ueda, K. Inoue, M. Nagao, and S. Shimada. (2007). Nafamostat mesilate reversibly blocks acid-sensing ion channel currents. Biochem. Biophys. Res. Commun. 363: 203-208. 17826743

Ugawa, S., Y. Ishida, T. Ueda, Y. Yu, and S. Shimada. (2008). Hypotonic stimuli enhance proton-gated currents of acid-sensing ion channel-1b. Biochem. Biophys. Res. Commun. 367: 530-534. 18158916

Waldmann, R., G. Champigny, F. Bassilana, C. Heurteaux, and M. Lazdunski. (1997). A proton-gated cation channel involved in acid-sensing. Nature 386: 173-177. 9062189

Wang, W., B. Duan, H. Xu, L. Xu, and T.-L. Xu. (2006). Calcium-permeable acid-sensing ion channel is a molecular target of the neurotoxic metal ion lead. J. Biol. Chem. 281: 2497-2505. 16319075

Wang, Y., A. Apicella, Jr, S.K. Lee, M. Ezcurra, R.D. Slone, M. Goldmit, W.R. Schafer, S. Shaham, M. Driscoll, and L. Bianchi. (2008). A glial DEG/ENaC channel functions with neuronal channel DEG-1 to mediate specific sensory functions in C. elegans. EMBO. J. 27: 2388-2399. 18701922

Welsh, M.J., M.P. Price, and J. Xie. (2002). Biochemical basis of touch perception: mechanosensory function of degenerin/epithelial Na⁺ channels. J. Biol. Chem. 277: 2369-2372. 11706013

Wiemuth, D. and S. Gründer. (2010). A single amino acid tunes Ca²⁺ inhibition of brain liver intestine Na⁺ channel (BLINaC). J. Biol. Chem. 285: 30404-30410. 20656685

1.A.7

Alexander, S.P.H. and J.A. Peters. (1997). Receptor and ion channel nomenclature supplement. Trends Pharmacol. Sci. 18: 65-68.

Allsopp, R.C. and R.J. Evans. (2011). The Intracellular Amino Terminus Plays a Dominant Role in Desensitization of ATP-gated P2X Receptor Ion Channels. J. Biol. Chem. 286: 44691-44701. 22027824

Aschrafi, A., S. Sadtler, C. Niculescu, J. Rettinger, and G. Schmalzing. (2004). Trimeric architecture of homomeric P2X₂ and heteromeric P2X₁₊₂ receptor subtypes. J. Mol. Biol. 342: 333-343. 15313628

de Souza, C.A., P.C. Teixeira, R.X. Faria, O. Krylova, P. Pohl, and L.A. Alves. (2011). A consensus segment in the M2 domain of the hP2X(7) receptor shows ion channel activity in planar lipid bilayers and in biological membranes. Biochim. Biophys. Acta. 1818: 64-71. [Epub: Ahead of Print] 21958668

Fountain, S.J., K. Parkinson, M.T. Young, L. Cao, C.R. Thompson, and R.A. North. (2007). An intracellular P2X receptor required for osmoregulation in Dictyostelium discoideum. Nature. 448: 200-203. 17625565

Fountain, S.J., L. Cao, M.T. Young, and R.A. North. (2008). Permeation Properties of a P2X Receptor in the Green Algae Ostreococcus tauri. J. Biol. Chem. 283: 15122-15126. 18381285

Jiang, L.H., F. Rassendren, A. Surprenant, and R.A. North. (2000). Identification of amino acid residues contributing to the ATP-binding site of a purinergic P2X receptor. J. Biol. Chem. 275: 34190-34196. 10940304

Jindrichova, M., K. Khafizov, A. Skorinkin, D. Fayuk, G. Bart, H. Zemkova, and R. Giniatullin. (2011). Highly conserved tyrosine 37 stabilizes desensitized states and restricts calcium permeability of ATP-gated P2X3 receptor. J Neurochem 119: 676-685. 21883226

Kawate, T., J.C. Michel, W.T. Birdsong, and E. Gouaux. (2009). Crystal structure of the ATP-gated P2X(4) ion channel in the closed state. Nature 460: 592-598. 19641588

Kracun, S., V. Chaptal, J. Abramson, and B.S. Khakh. (2010). Gated access to the pore of a P2X receptor: Structural implications for closed-open transitions. J. Biol. Chem. [Epub: Ahead of Print] 20093367

Li, Q., X. Luo, and S. Muallem. (2005). Regulation of the P2X7 receptor permeability to large molecules by extracellular Cl^- and Na⁺. J. Biol. Chem. 280: 26922-26927. 15923180

Lu, H., D. Burns, P. Garnier, G. Wei, K. Zhu, and W. Ying. (2007). P2X7 receptors mediate NADH transport across the plasma membranes of astrocytes. Biochem. Biophys. Res. Commun. 362: 946-950. 17803959

Ludlow, M.J., L. Durai, and S.J. Ennion. (2009). Functional characterization of intracellular Dictyostelium discoideum P2X receptors. J. Biol. Chem. 284: 35227-35239. 19833731

McCleskey E.W. and M.S. Gold. (1999). Ion channels of nociception. Annu. Rev. Physiol. 61: 835-856. 10099712

North, R.A. (2002). Molecular physiology of P2X receptors. Physiol. Rev. 82: 1013-1067. 12270951

North, R.A. (1996). Families of ion channels with two hydrophobic segments. Curr. Opin. Cell Biol. 8: 474-483. 8791456

Roger, S., P. Pelegrin, and A. Surprenant. (2008). Facilitation of P2X7 receptor currents and membrane blebbing via constitutive and dynamic calmodulin binding. J. Neurosci. 28: 6393-6401. 18562610

Samways, D.S., B.S. Khakh, and T.M. Egan. (2012). Allosteric modulation of Ca²⁺ flux in a ligand-gated cation channel (P2X4) by actions on lateral portals. J. Biol. Chem. [Epub: Ahead of Print] 22219189

Smart, M.L., B. Gu, R.G. Panchal, J. Wiley, B. Cromer, D.A. Williams, and S. Petrou. (2003). P2X7 receptor cell surface expression and cytolytic pore formation are regulated by a distal C-terminal region. J. Biol. Chem. 278: 8853-8860. 12496266

Soto, F., M. Garcia-Guzman, and W. Stühmer. (1997). Cloned ligand-gated channels activated by extracellular ATP (P2X receptors). J. Membr. Biol. 160: 91-100. 9354701

1.A.8

Bienert, G.P., M.D. Schüssler, and T.P. Jahn. (2008). Metalloids: essential, beneficial or toxic? Major intrinsic proteins sort it out. Trends Biochem. Sci. 33: 20-26. 18068370

Amezcua-Romero, J.C., O. Pantoja, and R. Vera-Estrella. (2010). Ser123 is essential for the water channel activity of McPIP2;1 from Mesembryanthemum crystallinum. J. Biol. Chem. [Epub: Ahead of Print] 20332086

Beese-Sims, S.E., J. Lee, and D.E. Levin. (2011). Yeast Fps1 glycerol facilitator functions as a homotetramer. Yeast 28: 815-819. 22030956

Beitz, E., S. Pavlovic-Djuranovic, M. Yasui, P. Agre, and J.E. Schultz. (2004). Molecular dissection of water and glycerol permeability of the aquaglyceroporin from Plasmodium falciparum by mutational analysis. Proc. Natl. Acad. Sci. USA 101: 1153-1158. 14734807

Bellati, J., K. Alleva, G. Soto, V. Vitali, C. Jozefkowicz, and G. Amodeo. (2010). Intracellular pH sensing is altered by plasma membrane PIP aquaporin co-expression. Plant Mol. Biol. 74: 105-118. 20593222

Bertl, A., and R. Kaldenhoff. (2007). Function of a separate NH3-pore in Aquaporin TIP2;2 from wheat. FEBS Lett. 581: 5413-5417. 17967420

Bienert, G.P., A.L. Moller, K.A. Kristiansen, A. Schulz, I.M. Moller, J.K. Schjoerring, and T.P. Jahn. (2007). Specific aquaporins facilitate the diffusion of hydrogen peroxide across membranes. J. Biol. Chem. 282: 1183-1192. 17105724

Buzhynskyy, N., J.F. Girmens, W. Faigle, S. Scheuring. (2007). Human cataract lens membrane at subnanometer resolution. J. Mol. Biol. 374: 162-169. 17920625

Calamita, G., B. Kempf, M. Bonhivers, W.R. Bishai, E. Bremer, and P. Agre. (1998). Regulation of the Escherichia coli water channel gene aqpZ. Proc. Natl. Acad. Sci. USA 95: 3627-3631. 9520416

Calamita. G. (2000). The Escherichia coli aquaporin-Z water channel. Mol. Microbiol. 37: 254-262. 10931322

Carbrey, J.M., D.A. Gorelick-Feldman, D. Kozono, J. Praetorius, S. Nielsen, and P. Agre. (2003). Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver. Proc. Natl. Acad. Sci. USA 100: 2945-2950. 12594337

Carbrey, J.M., M. Bonhivers, J.D. Boeke, and P. Agre. (2001). Aquaporins in Saccharomyces: characterization of a second functional water channel protein. Proc. Natl. Acad. Sci. USA 98: 1000-1005. 11158584

Chiba, Y., N. Mitani, N. Yamaji, and J.F. Ma. (2009). HvLsi1 is a silicon influx transporter in barley. Plant J. 57: 810-818. 18980663

Choi, W.G., and D.M. Roberts. (2007). Arabidopsis NIP2;1, a major intrinsic protein transporter of lactic acid induced by anoxic stress. J. Biol. Chem. 282: 24209-24218. 17584741

Chrispeels, M.J. and C. Maurel. (1994). Aquaporins: the molecular basis of facilitated water movement through living plant cells? Plant Physiol. 105: 9-13. 7518091

Cui, Y. and D.A. Bastien. (2011). Water transport in human aquaporin-4: Molecular dynamics (MD) simulations. Biochem. Biophys. Res. Commun. 412: 654-659. 21856282

Dai, Y.H., B.R. Liu, H.J. Chiang, and H.J. Lee. (2011). Gene transport and expression by arginine-rich cell-penetrating peptides in Paramecium. Gene 489: 89-97. 21925248

Dean, R.M., R.L. Rivers, M.L. Zeide, and D.M. Roberts. (1999). Purification and functional reconstitution of soybean nodulin 26. An aquaporin with water and glycerol transport properties. Biochemistry 38: 347-353. 9890916

Deen, P.M.T. and C.H. van Os. (1998). Epithelial aquaporins. Curr. Opin. Cell Biol. 10: 435-442. 9719862

Dynowski, M., G. Schaaf, D. Loque, O. Moran, and U. Ludewig. (2008). Plant plasma membrane water channels conduct the signalling molecule H₂O2. Biochem. J. 414: 53-61. 18462192

Engel, A., Y. Fujiyoshi, and P. Agre. (2000). The importance of aquaporin water channel protein structures. EMBO J. 19: 800-806. 10698922

Engel, A., Y. Fujiyoshi, T. Gonen, and T. Walz. (2008). Junction-forming aquaporins. Curr. Opin. Struct. Biol. 18: 229-235. 18194855

Fenton, R.A., H.B. Moeller, J.D. Hoffert, M.J. Yu, S. Nielsen, and M.A. Knepper. (2008). Acute regulation of aquaporin-2 phosphorylation at Ser-264 by vasopressin. Proc. Natl. Acad. Sci. U. S. A. 105: 3134-3139. 18287043

Figarella, K., M. Rawer, N.L. Uzcategui, B.K. Kubata, K. Lauber, F. Madeo, S. Wesselborg, and M. Duszenko. (2005). Prostaglandin D2 induces programmed cell death in Trypanosoma brucei bloodstream form. Cell Death Differ. 12: 335-346. 15678148

Figarella, K., N.L. Uzcategui, Y. Zhou, A. LeFurgey, M. Ouellette, H. Bhattacharjee, and R. Mukhopadhyay. (2007). Biochemical characterization of Leishmania major aquaglyceroporin LmAQP1: possible role in volume regulation and osmotaxis. Mol. Microbiol. 65: 1006-1017. 17640270

Froger, A., J.-P. Rolland, P. Bron, V. Lagrée, F. Le Cahérec, S. Deschamps, J.-F. Hubert, I. Pellerin, D. Thomas, and C. Delamarche. (2001). Functional characterization of a microbial aquaglyceroporin. Microbiology 147: 1129-1135. 11320116

Fu, D., A. Libson, L.J.W. Miercke, C. Weitzman, P. Nollert, J. Krucinski, and R.M. Stroud. (2000). Structure of a glycerol-conducting channel and the basis for its selectivity. Science 290: 481-486. 11039922

Gerbeau, P., J. Güçlü, P. Ripoche, and C. Maurel. (1999). Aquaporin Nt-TIPa can account for the high permeability of tobacco cell vacuolar membrane to small neutral solutes. Plant J. 18: 577-587. 10417709

Gonen, T. and T. Walz. (2006). The structure of aquaporins. Q. Rev. Biophys. 39: 361-396. 17156589

Gonen, T., P. Sliz, J. Kistler, Y. Cheng, and T. Walz. (2004b). Aquaporin-0 membrane junctions reveal the structure of a closed water pore. Nature 429: 193-197. 15141214

Gonen, T., Y. Cheng, J. Kistler, and T. Walz. (2004a). Aquaporin-0 membrane junctions form upon proteolytic cleavage. J. Mol. Biol. 342: 1337-1345. 15351655

Gonen, T., Y. Cheng, P. Sliz, Y. Hiroaki, Y. Fujiyoshi, S.C. Harrison, and T. Walz. (2005). Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature 438: 633-638. Erratum in: Nature (2006) 441: 248. 16319884

Gourbal, B., N. Sonuc, H. Bhattacharjee, D. Legare, S. Sundar, M. Ouellette, B.P. Rosen, and R. Mukhopadhyay. (2004). Drug uptake and modulation of drug resistance in Leishmania by an aquaglyceroporin. J. Biol. Chem. 279: 31010-31017. 15138256

Hara-Chikuma, M., and A.S. Verkman. (2008). Prevention of skin tumorigenesis and impairment of epidermal cell proliferation by targeted aquaporin-3 gene disruption. Mol. Cell. Biol. 28: 326-332. 17967887

Heymann, J.B. and A. Engel. (2000). Structural clues in the sequences of the aquaporins. J. Mol. Biol. 295: 1039-1053. 10656809

Horsefield, R., K. Nordén, M. Fellert, A. Backmark, S. Törnroth-Horsefield, A.C. Terwisscha van Scheltinga, J. Kvassman, P. Kjellbom, U. Johanson, and R. Neutze. (2008). High-resolution x-ray structure of human aquaporin 5. Proc. Natl. Acad. Sci. USA 105: 13327-13332. 18768791

Hub, J.S. and B.L. de Groot. (2008). Mechanism of selectivity in aquaporins and aquaglyceroporins. Proc. Natl. Acad. Sci. USA 105: 1198-1203. 18202181

Hwang, J.H., S.R. Ellingson, and D.M. Roberts. (2010). Ammonia permeability of the soybean nodulin 26 channel. FEBS Lett. 584: 4339-4343. 20875821

Ikeda, M., E. Beitz, D. Kozono, W.B. Guggino, P. Agre, and M. Yasui. (2002). Characterization of aquaporin-6 as a nitrate channel in mammalian cells. Requirement of pore-lining residue threonine. J. Biol. Chem. 277: 39873-39879. 12177001

Isayenkov, S.V. and F.J. Maathuis. (2008). The Arabidopsis thaliana aquaglyceroporin AtNIP7;1 is a pathway for arsenite uptake. FEBS Lett. 582: 1625-1628. 18435919

Ishikawa, F., S. Suga, T. Uemura, M.H. Sato, and M. Maeshima. (2005). Novel type aquaporin SIPs are mainly localized to the ER membrane and show cell-specific expression in Arabidopsis thaliana. FEBS Lett. 579: 5814-5820. 16223486

Jiang, J., B.V. Daniels, and D. Fu. (2006). Crystal structure of AqpZ tetramer reveals two distinct Arg-189 conformations associated with water permeation through the narrowest constriction of the water-conducting channel. J. Biol. Chem. 281: 454-460. 16239219

Kikawada, T., A. Saito, Y. Kanamori, M. Fujita, K. Snigórska, M. Watanabe, and T. Okuda. (2008). Dehydration-inducible changes in expression of two aquaporins in the sleeping chironomid, Polypedilum vanderplanki. Biochim. Biophys. Acta. 1778: 514-520. 18082130

Kozono, D., X. Ding, I. Iwasaki, X. Meng, Y. Kamagata, P. Agre, and Y. Kitagawa. (2003). Functional expression and characterization of an archaeal aquaporin. AqpM from Methanothermobacter marburgensis. J. Biol. Chem. 278: 10649-10656. 12519768

Li, H., S. Lee, and B.K. Jap. (1997). Molecular design of aquaporin-1 water channel as revealed by electrocrystallography. Nature Struc. Biol. 4: 263-265. 9095192

Li, J. and A.S. Verkman. (2001). Impaired hearing in mice lacking aquaporin-4 water channels. J. Biol. Chem. 276: 31233-31237. 11406631

Li, R.Y., Y. Ago, W.J. Liu, N. Mitani, J. Feldmann, S.P. McGrath, J.F. Ma, and F.J. Zhao. (2009). The rice aquaporin Lsi1 mediates uptake of methylated arsenic species. Plant Physiol. 150: 2071-2080. 19542298

Loqué, D., U. Ludewig, L. Yuan, and N. von Wirén. (2005). Tonoplast intrinsic proteins AtTIP2;1 and AtTIP2;3 facilitate NH3 transport into the vacuole. Plant Physiology 137: 671-680. 15665250

Lu, D.C., H. Zhang, Z. Zador, and A.S. Verkman. (2008). Impaired olfaction in mice lacking aquaporin-4 water channels. FASEB J. 22: 3216-3223. 18511552

Ma, J.F., K. Tamai, N. Yamaji, N. Mitani, S. Konishi, M. Katsuhara, M. Ishiguro, Y. Murata, and M. Yano. (2007b). A silicon transporter in rice. Nature 440: 688-691. 16572174

Ma, J.F., N. Yamaji, K. Tamai, and N. Mitani. (2007a). Genotypic difference in silicon uptake and expression of silicon transporter genes in rice. Plant Physiol. 145: 919-924. 17905867

Mahdieh, M., A. Mostajeran, T. Horie, and M. Katsuhara. (2008). Drought stress alters water relations and expression of PIP-type aquaporin genes in Nicotiana tabacum plants. Plant Cell Physiol. 49: 801-813. 18385163

Mallo, R.C. and Ashby, M.T. (2006). AqpZ-mediated water permeability in Escherichia coli measured by stopped-flow spectroscopy. J. Bacteriol. 188:820-822. 16385074

McDermott, J.R., X. Jiang, L.C. Beene, B.P. Rosen, and Z. Liu. (2009). Pentavalent methylated arsenicals are substrates of human AQP9. Biometals. [Epub: Ahead of Print] 19802720

Meng, Y.-L., Z. Liu, and B.P. Rosen. (2004). As(III) and Sb(III) uptake by GlpF and efflux by ArsB in Escherichia coli. J. Biol. Chem. 279: 18334-18341. 14970228

Mitani N., N. Yamaji, J.F. Ma. (2008). Characterization of substrate specificity of a rice silicon transporter, Lsi1. Pflugers Arch : . 18214526

Moe, S.E., J.G. Sorbo, R. Sogaard, T. Zeuthen, O. Petter Ottersen, and T. Holen. (2008). New isoforms of rat Aquaporin-4. Genomics 91: 367-377. 18255256

Murata, K., K. Mitsuoka, T. Hirai, T. Walz, P. Agre, J.B. Heymann, A. Engel, and Y. Fujiyoshi. (2000). Structural determinants of water permeation through aquaporin-1. Science 407: 599-605.

Najafabadi, H.S., N. Torabi, and M. Chamankhah. (2008). Designing multiple degenerate primers via consecutive pairwise alignments. BMC Bioinformatics 9: 55. 18221562

Nakazawa, Y., M. Oka, A. Mitsuishi, M. Bando, and M. Takehana. (2011). Quantitative analysis of ascorbic acid permeability of aquaporin 0 in the lens. Biochem. Biophys. Res. Commun. 415: 125-130. 22020074

Nemeth-Cahalan, K.L., K. Kalman, A. Froger, and J. E. Hall. (2007). Zinc Modulation of Water Permeability Reveals that Aquaporin 0 Functions as a Cooperative Tetramer. J. Gen. Physiol. 130(5):457-464. 17938229

Niemietz, C.M. and S.D. Tyerman. (2000). Channel-mediated permeation of ammonia gas through the peribacteroid membrane of soybean nodules. FEBS Lett. 465: 110-114. 10631315

Nozaki, K., D. Ishii, and K. Ishibashi. (2008). Intracellular aquaporins: clues for intracellular water transport? Pflugers Arch 456(4): 701-707. 18034355

Oliveira, R., F. Lages, M. Silva-Graça, and C. Lucas. (2003). Fps1p channel is the mediator of the major part of glycerol passive diffusion in Saccharomyces cerevisiae: artefacts and re-definitions. Biochim. Biophys. Acta. 1613: 57-71. 12832087

Park, J.H. and M.H. Saier, Jr. (1996). Phylogenetic characterization of the MIP family of transmembrane channel proteins. J. Membr. Biol. 153: 171-180. 8849412

Pietrement, C., N. Da Silva, C. Silberstein, M. James, M. Marsolais, A. Van Hoek, D. Brown, N. Pastor-Soler, N. Ameen, R. Laprade, V. Ramesh, and S. Breton. (2008). Role of NHERF1, Cystic Fibrosis transmembrane conductance regulator, and cAMP in the regulation of aquaporin 9. J. Biol. Chem. 283: 2986-2996. 18055461

Pillitteri, L.J., N.L. Bogenschutz, and K.U. Torii. (2008). The bHLH protein, MUTE, controls differentiation of stomata and the hydathode pore in arabidopsis. Plant Cell Physiol. 49: 934-943. 18450784

Reizer, J., A. Reizer, and M.H. Saier, Jr. (1993). The MIP family of integral membrane channel proteins: sequence comparisons, evolutionary relationships, reconstructed pathway of evolution and proposed functional differentiation of the two repeated halves of the proteins. Crit. Rev. Biochem. Mol. Biol. 28: 235-257. 8325040

Saparov, S.M., D. Kozono, U. Rothe, P. Agre, and P. Pohl. (2001). Water and ion permeation of aquaporin-1 in planar lipid bilayers. Major differences in structural determinants and stoichiometry. J. Biol. Chem. 276: 31515-31520. 11410596

Saparov, S.M., K. Liu, P. Agre, and P. Pohl. (2007). Fast and selective ammonia transport by aquaporin-8. J. Biol. Chem. 282: 5296-5301. 17189259

Shukla, V.K. and M.J. Chrispeels. (1998). Aquaporins: their role and regulation in cellular water movement. NATO-ASI Series (subseries H). Cellular integration of signaling pathways in plant development, pp.11-22. Springer-Verlag.

Sidoux-Walter, F., N. Pettersson, and S. Hohmann. (2004). The Saccharomyces cerevisiae aquaporin Aqy1 is involved in sporulation. Proc. Natl. Acad. Sci. USA 101: 17422-17427. 15583134

Soria, L.R., E. Fanelli, N. Altamura, M. Svelto, R.A. Marinelli, and G. Calamita. (2010). Aquaporin-8-facilitated mitochondrial ammonia transport. Biochem. Biophys. Res. Commun. [Epub: Ahead of Print] 20132793

Soto, G., K. Alleva, M.A. Mazzella, G. Amodeo, and J.P. Muschietti. (2008). AtTIP1;3 and AtTIP5;1, the only highly expressed Arabidopsis pollen-specific aquaporins, transport water and urea. FEBS Lett. 582: 4077-4082. 19022253

Soto, G., R. Fox, N. Ayub, K. Alleva, F. Guaimas, E.J. Erijman, A. Mazzella, G. Amodeo, and J. Muschietti. (2010). TIP5;1 is an aquaporin specifically targeted to pollen mitochondria and is probably involved in nitrogen remobilization in Arabidopsis thaliana. Plant J. 64: 1038-1047. 21143683

Suzuki, H., K. Nishikawa, Y. Hiroaki, and Y. Fujiyoshi. (2008). Formation of aquaporin-4 arrays is inhibited by palmitoylation of N-terminal cysteine residues. Biochim. Biophys. Acta. 1778(4): 1181-1189. 18179769

Törnroth-Horsefield, S., Y. Wang, K. Hedfalk, U. Johanson, M. Karlsson, E. Tajkhorshid, R. Neutze, and P. Kjellbom. (2006). Structural mechanism of plant aquaporin gating. Nature 439: 688-694. 16340961

Takano, J., M. Wada, U. Ludewig, G. Schaaf, N. von Wirén, and T. Fujiwara. (2006). The Arabidopsis major intrinsic protein NIP5;1 is essential for efficient boron uptake and plant development under boron limitation. The Plant Cell 18: 1498-1509. 16679457

Tani, K., T. Mitsuma, Y. Hiroaki, A. Kamegawa, K. Nishikawa, Y. Tanimura, and Y. Fujiyoshi. (2009). Mechanism of aquaporin-4's fast and highly selective water conduction and proton exclusion. J. Mol. Biol. 389: 694-706. 19406128

Uehlein, N., B. Otto, D.T. Hanson, M. Fischer, N. McDowell, and R. Kaldenhoff. (2008). Function of Nicotiana tabacum Aquaporins as Chloroplast Gas Pores Challenges the Concept of Membrane CO₂ Permeability. Plant Cell 20: 648-657. 18349152

Uehlein, N., C. Lovisolo, F. Siefritz, and R. Kaldenhoff. (2003). The tobacco aquaporin NtAQP1 is a membrane CO₂ pore with physiological functions. Nature (in press). 14520414

Uzcategui, N.L., A. Szallies, S. Pavlovic-Djuranovic, M. Palmada, K. Figarella, C. Boehmer, F. Lang, E. Beitz, and M. Duszenko. (2004). Cloning, heterologous expression, and characterization of three aquaglyceroporins from Trypanosoma brucei. J. Biol. Chem. 279: 42669-42676. 15294911

Verdoucq, L., A. Grondin, and C. Maurel. (2008). Structure-function analysis of plant aquaporin AtPIP2;1 gating by divalent cations and protons. Biochem. J. 415: 409-416. 18637793

Viadiu, H., T. Gonen, and T. Walz. (2007). Projection map of aquaporin-9 at 7 Å resolution. J. Mol. Biol. 367: 80-88. 17239399

Wysocki, R., C.C. Chéry, D. Wawrzycka, M. Van Hulle, R. Cornelis, J.M. Thevelein, and M.J. Tamás. (2001). The glycerol channel Fps1p mediates the uptake of arsenite and antimonite in Saccharomyces cerevisiae. Mol. Microbiol. 40: 1391-1401. 11442837

Yang, B., Z. Zador, and A.S. Verkman. (2008). Glial cell aquaporin-4 overexpression in transgenic mice accelerates cytotoxic brain swelling. J. Biol. Chem. 283: 15280-15286. 18375385

Yang, H.-C., J. Cheng, T.M. Finan, B.P. Rosen, and H. Bhattacharjee. (2005). Novel pathway for arsenic detoxification in the legume symbiont Sinorhizobium meliloti. J. Bacteriol. 187: 6991-6997. 16199569

Yasui, M., A. Hazama, T.-H. Kwon, S. Nielsen, W.B. Guggino, and P. Agre. (1999). Rapid gating and anion permeability of an intracellular aquaporin. Nature 402: 184-187. 10647010

Yool, A.J. (2007). Dominant-negative suppression of big brain ion channel activity by mutation of a conserved glutamate in the first transmembrane domain. Gene Expr. 13: 329-337. 17708419

Yu, X.S., X. Yin, E.M. Lafer, and J.X. Jiang. (2005). Developmental regulation of the direct interaction between the intracellular loop of connexin 45.6 and the C terminus of major intrinsic protein (aquaporin-0). J. Biol. Chem. 280: 22081-22090. 15802270

Zardoya, R. and S. Villalba. (2001). A phylogenetic framework for the aquaporin family in eukaryotes. J. Mol. Evol. 52: 391-404. 11443343

Zeuthen T., B. Wu, S. Pavlovic-Djuranovic, L.M. Holm, N.L. Uzcategui, M. Duszenko, J.F. Kun, J.E. Schultz, E. Beitz. (2006). Ammonia permeability of the aquaglyceroporins from Plasmodium falciparum, Toxoplasma gondii and Trypansoma brucei. Mol. Microbiol. 61: 1598-1608. 16889642

Zhang, H. and A.S. Verkman. (2010). Aquaporin-1 tunes pain perception by interaction with Na(v)1.8 Na⁺ channels in dorsal root ganglion neurons. J. Biol. Chem. 285: 5896-5906. 20018876

Zhao, X.Q., N. Mitani, N. Yamaji, R.F. Shen, and J.F. Ma. (2010). Involvement of silicon influx transporter OsNIP2;1 in selenite uptake in rice. Plant Physiol. 153: 1871-1877. 20498338

1.A.9

Alexander, S.P.H. and J.A. Peters. (1997). Receptor and ion channel nomenclature supplement. Trends Pharmacol. Sci. 18: 4-6; 36-40; 42-44.

Ashcroft, F.M. (2000). Ion Channels and Disease. San Diego: Academic Press.

Baylis, H.A., K. Matsuda, M.D. Squire, J.T. Fleming, R.J. Harvey, M.G. Darlison, E.A. Barnard, and D.B. Sattelle. (1997). ACR-3, a Caenorhabditis elegans nicotinic acetylcholine receptor subunit. Molecular cloning and functional expression. Receptors Channels 5: 149-58. 9606719

Beg, A.A. and E.M. Jorgensen. (2003). EXP-1 is an excitatory GABA-gated cation channel. Nature Neurosci. (in press). 14555952

Bocquet, N., H. Nury, M. Baaden, C. Le Poupon, J.P. Changeux, M. Delarue, and P.J. Corringer. (2009). X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation. Nature 457: 111-114. 18987633

Bocquet, N., L. Prado de Carvalho, J. Cartaud, J. Neyton, C. Le Poupon, A. Taly, T. Grutter, J.P. Changeux, and P.J. Corringer. (2007). A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family. Nature 445: 116-119. 17167423

Bouzat, C., F. Gumilar, G. Spitzmaul, H.-L. Wang, D. Rayes, S.B. Hansen, P. Taylor, and S.M. Sine. (2004). Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel. Nature 430: 896-900. 15318223

Brejc, K., W.J. van Dijk, R.V. Klaassen, M. Schuurmans, J. van der Oost, A.B. Smit, and T.K. Sixma. (2001). Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors. Nature 411: 269-276. 11357122

Brownlow, S., R. Webster, R. Croxen, M. Brydson, B. Neville, J.P. Lin, A. Vincent, J. Newsom-Davis, and D. Beeson. (2001). Acetylcholine receptor delta subunit mutations underlie a fast-channel myasthenic syndrome and arthrogryposis multiplex congenita. J. Clin. Invest. 108: 125-130. 11435464

Burzomato, V., M. Beato, P.J. Groot-Kormelink, D. Colquhoun, and L.G. Sivilotti. (2004). Single-channel behavior of heteromeric α1β glycine receptors: an attempt to detect a conformational change before the channel opens. J. Neurosci. 24: 10924-10940. 15574743

Cascio M. (2004). Structure and function of the glycine receptor and related nicotinicoid receptors. J. Biol. Chem. 279: 19383-19386. 15023997

Chen, Y., K. Reilly, and Y. Chang. (2006). Evolutionarily conserved allosteric network in the Cys loop family of ligand-gated ion channels revealed by statistical covariance analyses. J. Biol. Chem. 281: 18184-18192. 16595655

Connolly, C.N. (2008). Trafficking of 5-HT(3) and GABA(A) receptors (Review). Mol. Membr. Biol. 25: 293-301. 18446615

Corringer, P.J., M. Baaden, N. Bocquet, M. Delarue, V. Dufresne, H. Nury, M. Prevost, and C. Van Renterghem. (2010). Atomic structure and dynamics of pentameric ligand-gated ion channels: new insight from bacterial homologues. J. Physiol. 588: 565-572. 19995852

Cymes, G.D., Y. Ni, and C. Grosman. (2005). Probing ion-channel pores one proton at a time. Nature 438: 975-980. 16355215

Dent, J.A., M.M. Smith, D.K. Vassilatis, and L. Avery. (2000). The genetics of ivermectin resistance in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 97: 2674-2679. 10716995

Feng, Z., W. Li, A. Ward, B.J. Piggott, E.R. Larkspur, P.W. Sternberg, and X.Z. Xu. (2006). A C. elegans model of nicotine-dependent behavior: regulation by TRP-family channels. Cell 127: 621-633. 17081982

Filippova, N., V.E. Wotring, and D.S. Weiss. (2004). Evidence that the TM1-TM2 loop contributes to the ρ1 GABA receptor pore. J. Biol. Chem. 279: 20906-20914. 15007065

Fritsch, S., I. Ivanov, H. Wang, and X. Cheng. (2011). Ion selectivity mechanism in a bacterial pentameric ligand-gated ion channel. Biophys. J. 100: 390-398. 21244835

Goyal, R., A.A. Salahudeen, and M. Jansen. (2011). Engineering a prokaryotic Cys-loop receptor with a third functional domain. J. Biol. Chem. 286: 34635-34642. 21844195

Hanna, M.C., P.A. Davies, T.G. Hales, and E.F. Kirkness. (2000). Evidence for expression of heteromeric serotonin 5-HT(3) receptors in rodents. J. Neurochem. 75: 240-247. 10854267

Herb, A., W. Wisden, H. Lüddens, G. Puia, S. Vicini, and P.H. Seeburg. (1992). The third γ subunit of the gamma-aminobutyric acid type A receptor family. Proc. Natl. Acad. Sci. U.S.A. 89: 1433-1437. 1311098

Hilf, R.J., and R. Dutzler. (2008). X-ray structure of a prokaryotic pentameric ligand-gated ion channel. Nature 452: 375-379. 18322461

Howard, R.J., S. Murail, K.E. Ondricek, P.J. Corringer, E. Lindahl, J.R. Trudell, and R.A. Harris. (2011). Structural basis for alcohol modulation of a pentameric ligand-gated ion channel. Proc. Natl. Acad. Sci. USA 108: 12149-12154. 21730162

Khiroug, S.S., P.C. Harkness, P.W. Lamb, S.N. Sudweeks, L. Khiroug, N.S. Millar, and J.L. Yakel. (2002). Rat nicotinic ACh receptor alpha7 and beta2 subunits co-assemble to form functional heteromeric nicotinic receptor channels. J. Physiol. 540: 425-434. 11956333

Lummis, S.C., D.L. Beene, L.W. Lee, H.A. Lester, R.W. Broadhurst, and D.A. Dougherty. (2005). Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel. Nature 438: 248-252. 16281040

Luu, T., P.W. Gage, and M.L. Tierney. (2006). GABA increases both the conductance and mean open time of recombinant GABA_A channels co-expressed with GABARAP. J. Biol. Chem. 281: 35699-35708. 16954214

McKinnon, N.K., D.C. Reeves, and M.H. Akabas. (2011). 5-HT3 receptor ion size selectivity is a property of the transmembrane channel, not the cytoplasmic vestibule portals. J Gen Physiol 138: 453-466. 21948949

Menard, C., H.R. Horvitz, and S. Cannon. (2005). Chimeric mutations in the M2 segment of the 5-hydroxytryptamine-gated chloride channel MOD-1 define a minimal determinant of anion/cation permeability. J. Biol. Chem. 280: 27502-27507. 15878844

Mineur, Y.S., A. Abizaid, Y. Rao, R. Salas, R.J. DiLeone, D. Gündisch, S. Diano, M. De Biasi, T.L. Horvath, X.B. Gao, and M.R. Picciotto. (2011). Nicotine decreases food intake through activation of POMC neurons. Science 332: 1330-1332. 21659607

Mitchell K.E., T. Iwamoto, J. Tomich, L.C. Freeman. (2000). A synthetic peptide based on a glycine-gated chloride channel induces a novel chloride conductance in isolated epithelial cells. Biochim. Biophys. Acta. 1466: 47-60. 10825430

Miyazawa, A. Y. Fujiyoshi, and N. Unwin. (2003). Structure and gating mechanism of the acetylcholine receptor pore. Nature 423: 949-955. 12827192

Nury, H., F. Poitevin, C. Van Renterghem, J.P. Changeux, P.J. Corringer, M. Delarue, and M. Baaden. (2010). One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue. Proc. Natl. Acad. Sci. USA 107: 6275-6280. 20308576

Pantazis, A., A. Segaran, C.H. Liu, A. Nikolaev, J. Rister, A.S. Thum, T. Roeder, E. Semenov, M. Juusola, and R.C. Hardie. (2008). Distinct roles for two histamine receptors (HclA and HclB) at the Drosophila photoreceptor synapse. J. Neurosci. 28: 7250-7259. 18632929

Peters, J.A., M.A. Cooper, J.E. Carland, M.R. Livesey, T.G. Hales, and J.J. Lambert. (2010). Novel structural determinants of single channel conductance and ion selectivity in 5-hydroxytryptamine type 3 and nicotinic acetylcholine receptors. J. Physiol. 588: 587-596. 19933751

Purohit, P. and A. Auerbach. (2007). Acetylcholine receptor gating: movement in the α-subunit extracellular domain. J. Gen. Physiol. 130(6):569-579. 18040059

Purohit, P., A. Mitra, and A. Auerbach. (2007). A stepwise mechanism for acetylcholine receptor channel gating. Nature 446: 930-933. 17443187

Ranganathan, R., S.C. Cannon and H.R. Horvitz. (2000). MOD-1 is a serotonin-gated chloride channel that modulates locomotory behavior in C. elegans. Nature 408: 470-473. 11100728

Reeves, D.C. and S.C.R. Lummis. (2002). The molecular basis of the structure and function of the 5-HT₃ receptor: a model ligand-gated ion channel. Mol. Membrane Biol. 19: 11-26. 11989819

Ringstad, N., N. Abe, and H.R. Horvitz. (2009). Ligand-gated chloride channels are receptors for biogenic amines in C. elegans. Science 325: 96-100. 19574391

Sarang, S.S., S.M. Lukyanova, D.D. Brown, B.S. Cummings, S.R. Gullans, and R.G. Schnellmann. (2008). Identification, coassembly, and activity of γ- aminobutyric acid receptor subunits in renal proximal tubular cells. J. Pharmacol. Exp. Ther. 324: 376-382. 17959749

Shivers, B.D., I. Killisch, R. Sprengel, H. Sontheimer, M. Köhler, P.R. Schofield, and P.H. Seeburg. (1989). Two novel GABAA receptor subunits exist in distinct neuronal subpopulations. Neuron. 3: 327-337. 2561970

Sigel, E., R. Baur, I. Rácz, J. Marazzi, T.G. Smart, A. Zimmer, and J. Gertsch. (2011). The major central endocannabinoid directly acts at GABA(A) receptors. Proc. Natl. Acad. Sci. USA 108: 18150-18155. 22025726

Sine, S.M. and A.G. Engel. (2006). Recent advances in Cys-loop receptor structure and function. Nature 440: 448-455. 16554804

Sivilotti, L.G. (2010). What single-channel analysis tells us of the activation mechanism of ligand-gated channels: the case of the glycine receptor. J. Physiol. 588: 45-58. 19770192

Squire, M.D., C. Tornře, H.A. Baylis, J.T. Fleming, E.A. Barnard, and D.B. Sattelle. (1995). Molecular cloning and functional co-expression of a Caenorhabditis elegans nicotinic acetylcholine receptor subunit (acr-2). Receptors Channels 3: 107-115. 8581398

Thompson, A.J., H.A. Lester, and S.C. Lummis. (2010). The structural basis of function in Cys-loop receptors. Q. Rev. Biophys. 43: 449-499. 20849671

Unwin, N. (1995). Acetylcholine receptor channel imaged in the open state. Nature 373: 37-43. 7800037

Wang, H.L., X. Cheng, and S.M. Sine. (2011). Intra-membrane proton binding site linked to activation of a bacterial pentameric ion channel. J. Biol. Chem. [Epub: Ahead of Print] 22084238

Wang, Q. and J.W. Lynch. (2012). A comparison of glycine- and ivermectin-mediated conformational changes in the glycine receptor ligand-binding domain. Int J Biochem. Cell Biol. 44: 335-340. 22094187

Witzemann, V., E. Stein, B. Barg, T. Konno, M. Koenen, W. Kues, M. Criado, M. Hofmann, and B. Sakmann. (1990). Primary structure and functional expression of the α-, β-, γ-, δ- and ε-subunits of the acetylcholine receptor from rat muscle. Eur J Biochem 194: 437-448. 1702709

Xue, H. (1998). Identification of major phylogenetic branches of inhibitory ligand-gated channel receptors. J. Mol. Evol. 47: 323-333. 9732459

Zhu, F. and G. Hummer. (2009). Gating transition of pentameric ligand-gated ion channels. Biophys. J. 97: 2456-2463. 19883588

Zhu, F. and G. Hummer. (2010). Pore opening and closing of a pentameric ligand-gated ion channel. Proc. Natl. Acad. Sci. USA 107: 19814-19819. 21041674

1.A.10

Alexander, S.P.H. and J.A. Peters. (1997). Receptor and ion channel nomenclature supplement. Trends Pharmacol. Sci. 18: 36-40.

Armstrong, N., J. Jasti, M. Beich-Frandsen, and E. Gouaux. (2006). Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor. Cell 127: 85-97. 17018279

Ayalon, G., E. Segev, S. Elgavish, and Y. Stern-Bach. (2005). Two regions in the N-terminal domain of ionotropic glutamate receptor 3 form the subunit oligomerization interfaces that control subtype-specific receptor assembly. J Biol Chem. 280: 15053-15060. 15703162

Bettler B., J. Boulter, I. Hermans-Borgmeyer, A. O'Shea-Greenfield, E.S. Deneris, C. Moll, U. Borgmeyer, M. Hollmann, S. Heinemann. (1990). Cloning of a novel glutamate receptor subunit, GluR5: expression in the nervous system during development. Neuron. 5: 583-595. 1977421

Chaudhry, C., A.J. Plested, P. Schuck, and M.L. Mayer. (2009). Energetics of glutamate receptor ligand binding domain dimer assembly are modulated by allosteric ions. Proc. Natl. Acad. Sci. USA 106: 12329-12334. 19617541

Chen, G.-Q., C. Cui, M.L. Mayer, and E. Gouaux. (1999). Functional characterization of a potassium-selective prokaryotic glutamate receptor. Nature 402: 817-819. 10617203

Das, U., J. Kumar, M.L. Mayer, and A.J. Plested. (2010). Domain organization and function in GluK2 subtype kainate receptors. Proc. Natl. Acad. Sci. USA 107: 8463-8468. 20404149

Furukawa, H., S.K. Singh, R. Mancusso, and E. Gouaux. (2005). Subunit arrangement and function in NMDA receptors. Nature 438: 185-192. 16281028

Gouaux, E. (2004). Structure and function of AMPA receptors. J. Physiol. 554: 249-253. 14645452

Humeau, Y., D. Reisel, A.W. Johnson, T. Borchardt, V. Jensen, C. Gebhardt, V. Bosch, P. Gass, D.M. Bannerman, M.A. Good, Ř. Hvalby, R. Sprengel, and A. Lüthi. (2007). A pathway-specific function for different AMPA receptor subunits in amygdala long-term potentiation and fear conditioning. J. Neurosci. 27: 10947-10956. 17928436

Jin, R., S. Clark, A.M. Weeks, J.T. Dudman, E. Gouaux, and K.M. Partin. (2005). Mechanism of positive allosteric modulators acting on AMPA receptors. J. Neurosci. 25: 9027-9036. 16192394

Kamboj, R.K., D.D. Schoepp, S. Nutt, L. Shekter, B. Korczak, R.A. True, V. Rampersad, D.M. Zimmerman, and M.A. Wosnick MA. (1994). Molecular cloning, expression, and pharmacological characterization of humEAA1, a human kainate receptor subunit. J. Neurochem. 62:1-9. 8263508

Kang, J., and F.J. Turano. (2003). The putative glutamate receptor 1.1 (AtGLR1.1) functions as a regulator of carbon and nitrogen metabolism in Arabidopsis thaliana. Proc. Natl. Acad. Sci. U.S.A. 100: 6872-6877. 12738881

Kim, K.S., D. Yan, and S. Tomita. (2010). Assembly and stoichiometry of the AMPA receptor and transmembrane AMPA receptor regulatory protein complex. J. Neurosci. 30: 1064-1072. 20089915

Mayer, M.L. (2006). Glutamate receptors at atomic resolution. Nature 440: 456-462. 16554805

Mayer, M.L. (2011). Emerging models of glutamate receptor ion channel structure and function. Structure 19: 1370-1380. 22000510

Mayer, M.L., R. Olson, and E. Gouaux. (2001). Mechanisms for ligand binding to GluR0 ion channels: crystal structures of the glutamate and serine complexes and a closed apo state. J. Mol. Biol. 311: 815-836. 11518533

Midgett, C.R., A. Gill, and D.R. Madden. (2012). Domain architecture of a calcium-permeable AMPA receptor in a ligand-free conformation. Front Mol Neurosci 4: 56. 22232575

Monyer H., R. Sprengel, R. Schoepfer, A. Herb, M. Higuchi, H. Lomeli, N. Burnashev, B. Sakmann, P.H. Seeburg. (1992). Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science. 256: 1217-1221. 1350383

Nakanishi, N., N.A. Shneider, and R. Axel. (1990). A family of glutamate receptor genes: Evidence for the formation of heteromultimeric receptors with distinct channel properties. Neuron 5: 569-581. 1699567

Olson, R. and E. Gouaux. (2005). Crystal structure of the Vibrio cholerae cytolysin (VCC) pro-toxin and its assembly into a heptameric transmembrane pore. J. Mol. Biol. 350: 997-1016. 15978620

Retchless, B.S., W. Gao, and J.W. Johnson. (2012). A single GluN2 subunit residue controls NMDA receptor channel properties via intersubunit interaction. Nat Neurosci. [Epub: Ahead of Print] 22246434

Safferling, M., W. Tichelaar, G. Kümmerle, A. Jouppila, A. Kuusinen, K. Keinänen, and D.R. Madden. (2001). First images of a glutamate receptor ion channel: oligomeric state and molecular dimensions of GluRB homomers. Biochemistry 40: 13948-13953. 11705385

Salussolia, C.L., A. Corrales, I. Talukder, R. Kazi, G. Akgul, M. Bowen, and L.P. Wollmuth. (2011). Interaction of the M4 Segment with Other Transmembrane Segments Is Required for Surface Expression of Mammalian α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors. J. Biol. Chem. 286: 40205-40218. 21930708

Schüler, T., I. Mesic, C. Madry, I. Bartholomäus, and B. Laube. (2008). Formation of NR1/NR2 and NR1/NR3 heterodimers constitutes the initial step in N-methyl-D-aspartate receptor assembly. J. Biol. Chem. 283(1): 37-46. 17959602

Slotboom, D.J., I. Sobczak, W.N. Konings, and J.S. Lolkema. (1999). A conserved serine-rich stretch in the glutamate transporter family forms a substrate-sensitive reentrant loop. Proc. Natl. Acad. Sci. USA 96: 14282-14287. 10588697

Stephens, N.R., Z. Qi, and E.P. Spalding. (2008). Glutamate receptor subtypes evidenced by differences in desensitization and dependence on the GLR3.3 and GLR3.4 genes. Plant Physiol. 146: 529-538. 18162597

Straub, C. and S. Tomita. (2011). The regulation of glutamate receptor trafficking and function by TARPs and other transmembrane auxiliary subunits. Curr Opin Neurobiol. [Epub: Ahead of Print] 21993243

Sun, Y., R. Olson, M. Horning, N. Armstrong, M. Mayer, and E. Gouaux. (2002). Mechanism of glutamate receptor desensitization. Nature 417: 245-253. 12015593

Uemura, T., H. Mori, and M. Mishina. (2004). Direct interaction of GluRδ2 with Shank scaffold proteins in cerebellar Purkinje cells. Mol. Cell Neurosci. 26: 330-241. 15207857

Unwin, N. (1993). Neurotransmitter action: Opening of ligand-gated ion channels. Cell 72: 31-41. 7679054

Yan, D. and S. Tomita. (2012). Defined criteria for auxiliary subunits of glutamate receptors. J. Physiol. 590: 21-31. 21946847

Yang, Y.C., C.H. Lee, and C.C. Kuo. (2010). Ionic flow enhances low-affinity binding: a revised mechanistic view into Mg²⁺ block of NMDA receptors. J. Physiol. 588: 633-650. 20026615

1.A.11

Andrade, S.L. and O. Einsle. The Amt/Mep/Rh family of ammonium transport proteins. Mol. Membr. Biol. 24: 357-365. 17710640

Andrade, S.L., A. Dickmanns, R. Ficner, and O. Einsle. (2005). Crystal structure of the archaeal ammonium transporter Amt-1 from Archaeoglobus fulgidus. Proc. Natl. Acad. Sci. USA 102: 14994-14999. 16214888

Bakouh, N., F. Benjelloun, P. Hulin, F. Brouillard, A. Edelman, B. Chérif-Zahar, and G. Planelles. (2004). NH₃ is involved in the NH₄⁺ transport induced by the functional expression of the human RhC glycoprotein. J. Biol. Chem. 279: 15975-15983. 14761968

Barnes, E.M., Jr. and A. Jayakumar. (1993). NH₄⁺ transport systems in Escherichia coli. In: E.P. Bakker (Ed.), Alkali Cation Transport Systems in Prokaryotes, Boca Raton, FL: CRC Press, pp. 397-409.

Blakey, D., A. Leech, G.H. Thomas, G. Coutts, K. Findlay, and M. Merrick. (2002). Purification of the Escherichia coli ammonium transporter AmtB reveals a trimeric stoichiometry. Biochem. J. 364: 527-535. 12023896

Blauwkamp, T.A. and A.J. Ninfa. (2003). Antagonism of PII signalling by the AmtB protein of Escherichia coli. Mol. Microbiol. 48: 1017-1028. 12753193

Boeckstaens, M., B. André, and A.M. Marini. (2008). Distinct transport mechanisms in yeast ammonium transport/sensor proteins of the mep/amt/rh family and impact on filamentation. J. Biol. Chem. 283: 21362-21370. 18508774

Cherif-Zahar, B., A. Durand, I. Schmidt, N. Hamdaoui, I. Matic, M. Merrick, and G. Matassi. (2007). Evolution and functional characterization of the RH50 gene from the ammonia-oxidizing bacterium Nitrosomonas europaea. J. Bacteriol. 189: 9090-9100. 17921289

Conroy, M.J., P.A. Bullough, M. Merrick, and N.D. Avent. (2005). Modelling the human rhesus proteins: implications for structure and function. Br J Haematol 131: 543-551. 16281947

Dabas, N., S. Schneider, and J. Morschhäuser. (2009). Mutational analysis of the Candida albicans ammonium permease Mep2p reveals residues required for ammonium transport and signaling. Eukaryot. Cell. 8: 147-160. 19060183

Durand A. and M. Merrick. (2006). In Vitro Analysis of the Escherichia coli AmtB-GlnK Complex Reveals a Stoichiometric Interaction and Sensitivity to ATP and 2-Oxoglutarate. J. Biol. Chem. 281: 29558-29567. 16864585

Fong, R.N., K.S. Kim, C. Yoshihara, W.B. Inwood, and S. Kustu. (2007). The W148L substitution in the Escherichia coli ammonium channel AmtB increases flux and indicates that the substrate is an ion. Proc. Natl. Acad. Sci. USA 104: 18706-18711. 17998534

Gruswitz, F., J. O'Connell 3rd, and R.M. Stroud. (2007). Inhibitory complex of the transmembrane ammonia channel, AmtB, and the cytosolic regulatory protein, GlnK, at 1.96 A. Proc. Natl. Acad. Sci. U.S.A. 104: 42-47. 17190799

Gruswitz, F., S. Chaudhary, J.D. Ho, A. Schlessinger, B. Pezeshki, C.M. Ho, A. Sali, C.M. Westhoff, and R.M. Stroud. (2010). Function of human Rh based on structure of RhCG at 2.1 Ĺ. Proc. Natl. Acad. Sci. USA 107: 9638-9643. 20457942

Hall, J.A. and S. Kustu. (2011). The pivotal twin histidines and aromatic triad of the Escherichia coli ammonium channel AmtB can be replaced. Proc. Natl. Acad. Sci. USA 108: 13270-13274. 21775672

Huergo, L.F., M. Merrick, F.O. Pedrosa, L.S. Chubatsu, L.M. Araujo, and E.M. Souza. (2007). Ternary complex formation between AmtB, GlnZ and the nitrogenase regulatory enzyme DraG reveals a novel facet of nitrogen regulation in bacteria. Mol. Microbiol. 66: 1523-1535. 18028310

Inwood, W.B., J.A. Hall, K.S. Kim, R. Fong, and S. Kustu. (2009). Genetic evidence for an essential oscillation of transmembrane-spanning segment 5 in the Escherichia coli ammonium channel AmtB. Genetics 183: 1341-1355. 19884311

Ishikita, H. and E.W. Knapp. (2007). Protonation states of ammonia/ammonium in the hydrophobic pore of ammonia transporter protein AmtB. J. Am. Chem. Soc. 129(5):1210-1215. 17263403

Javelle, A., B. André, A.-M. Marini, and M. Chalot. (2003a). High-affinity ammonium transporters and nitrogen sensing in mycorrhizas. Trends Microbiol. 11: 53-55. 12598122

Javelle, A., B.-R. Rodríguez-Pastrana, C. Jacob, B. Botton, A. Brun, B. André, A.-M. Marini, and M. Chalot. (2001). Molecular characterization of two ammonium transporters from the ectomycorrhizal fungus Hebeloma cylindrosporum. FEBS Lett. 505: 393-398. 11576535

Javelle, A., D. Lupo, L. Zheng, X.D. Li, F.K. Winkler, and M. Merrick. (2006). An unusual twin-his arrangement in the pore of ammonia channels is essential for substrate conductance. J. Biol. Chem. 281: 39492-39498. 17040913

Javelle, A., M. Morel, B.-R. Rodríguez-Pastrana, B. Botton, B. André, A.-M. Marini, A. Brun, and M. Chalot. (2003b). Molecular characterization, function and regulation of ammonium transporters (Amt) and ammonium-metabolizing enzymes (GS, NADP-GDH) in the ectomycorrhizal fungus Hebeloma cylindrosporum. Mol. Microbiol. 47: 411-430. 12519192

Khademi, S., J. O'Connell, III, J. Remis, Y. Robles-Colmenares, L.J.W. Miercke, and R.M. Stroud. (2004). Mechanism of ammonia transport by Amt/MEP/Rh: Structure of AmtB at 1.35 Ĺ. Science 305: 1587-1594. 15361618

Kleiner, D. (1993). NH₄⁺ transport systems. In: E.P. Bakker (Ed.), Alkali Cation Transport Systems in Prokaryotes. Boca Raton, FL: CRC Press, pp. 378-396.

Knepper, M.A. and P. Agre. (2004). Structural biology. The atomic architecture of a gas channel. Science 305: 1573-1574. 15361612

Lalonde, S., D.W. Ehrhardt, D. Loqué, J. Chen, S.Y. Rhee, and W.B. Frommer. (2008). Molecular and cellular approaches for the detection of protein-protein interactions: latest techniques and current limitations. Plant J. 53: 610-635. 18269572

Lanquar, V., D. Loqué, F. Hörmann, L. Yuan, A. Bohner, W.R. Engelsberger, S. Lalonde, W.X. Schulze, N. von Wirén, and W.B. Frommer. (2009). Feedback inhibition of ammonium uptake by a phospho-dependent allosteric mechanism in Arabidopsis. Plant Cell 21: 3610-3622. 19948793

Li, X., S. Jayachandran, H.H. Nguyen, and M.K. Chan. (2007). Structure of the Nitrosomonas europaea Rh protein. Proc. Natl. Acad. Sci. U.S.A. 104: 19279-19284. 18040042

Liu, Z., Y. Chen, R. Mo, C. Hui, J.F. Cheng, N. Mohandas, and C.H. Huang. (2000). Characterization of human RhCG and mouse RhCG as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis. J. Biol. Chem. 275: 25641-25651. 10852913

Lopez, C., S. Métral, D. Eladari, S. Drevensek, P. Gane, R. Chambreys, V. Bennett, J.-P. Cartron, C.L. Kim, and Y. Colin. (2005). The ammonium transporter RhBG. Requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells. J. Biol. Chem. 280: 8221-8228. 15611082

Loqué, D., S. Lalonde, L.L. Looger, N. von Wirén, and W.B. Frommer. (2007). A cytosolic trans-activation domain essential for ammonium uptake. Nature 446: 195-198. 17293878

Loqué, D., S.I. Mora, S.L. Andrade, O. Pantoja, and W.B. Frommer. (2009). Pore mutations in ammonium transporter AMT1 with increased electrogenic ammonium transport activity. J. Biol. Chem. 284: 24988-24995. 19581303

Lorenz, M.C. and J. Heitman. (1998). The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae. EMBO J. 17: 1236-1247. 9482721

Ludewig, U., B. Neuhäuser, and M. Dynowski. (2007). Molecular mechanisms of ammonium transport and accumulation in plants. FEBS Lett. 581: 2301-2308. 17397837

Ludewig, U., N. von Wirén, and W.B. Frommer. (2002). Uniport of NH₄⁺ by the root hair plasma membrane ammonium transporter LeAMT1;1. J. Biol. Chem. 277: 13548-13555. 11821433

Lupo, D., X.D. Li, A. Durand, T. Tomizaki, B. Cherif-Zahar, G. Matassi, M. Merrick, and F.K. Winkler. (2007). The 1.3-A resolution structure of Nitrosomonas europaea Rh50 and mechanistic implications for NH3 transport by Rhesus family proteins. Proc. Natl. Acad. Sci. U.S.A. 104: 19303-19308. 18032606

Marini, A. and B. André. (2000). In vivo N-glycosylation of the Mep2 high-affinity ammonium transporter of Saccharomyces cerevisiae reveals an extracytosolic N-terminus. Mol. Microbiol. 38: 552-564. 11069679

Marini, A., J. Springael, W.B. Frommer, and B. André. (2000). Cross-talk between ammonium transporters in yeast and interference by the soybean SAT1 protein. Mol. Microbiol. 35: 378-385. 10652098

Marini, A., S. Vissers, A. Urrestarazu, and B. André. (1994). Cloning and expression of the MEP1 gene encoding an ammonium transporter in Saccharomyces cerevisiae. EMBO J. 13: 3456-3463. 8062822

Marini, A.-M., G. Matassi, V. Raynal, B. Andre, J.P. Cartron, and B. Cherif-Zahar. (2000). The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast. Nat. Genet. 26: 341-344. 11062476

Meier-Wagner, J., L. Nolden, M. Jakoby, R. Siewe, R. Krämer, and A. Burkovski. (2001). Multiplicity of ammonium uptake systems in Corynebacterium glutamicum: role of Amt and AmtB. Microbiology 147: 135-143. 11160807

Musa-Aziz, R., L.M. Chen, M.F. Pelletier, and W.F. Boron. (2009). Relative CO₂/NH₃ selectivities of AQP1, AQP4, AQP5, AmtB, and RhAG. Proc. Natl. Acad. Sci. USA 106: 5406-5411. 19273840

Nakhoul, N.L., S.M. Abdulnour-Nakhoul, E. Schmidt, R. Doetjes, E. Rabon, and L.L. Hamm. (2010). pH sensitivity of ammonium transport by Rhbg. Am. J. Physiol. Cell Physiol. 299: C1386-1397. 20810915

Neuhäuser, B., M. Dynowski, and U. Ludewig. (2009). Channel-like NH₃ flux by ammonium transporter AtAMT2. FEBS Lett. 583: 2833-2838. 19635480

Ninnemann, O., J. Jauniaux, and W.B. Frommer. (1994). Identification of a high affinity NH₄⁺ transporter from plants. EMBO J. 13: 3464-3471. 8062823

Ortiz-Ramirez, C., S.I. Mora, J. Trejo, and O. Pantoja. (2011). PvAMT1;1, a Highly Selective Ammonium Transporter That Functions as H⁺/NHFormula Symporter. J. Biol. Chem. 286: 31113-31122. 21757699

Pau, V.P., Y. Zhu, Z. Yuchi, Q.Q. Hoang, and D.S. Yang. (2007). Characterization of the C-terminal domain of a potassium channel from Streptomyces lividans (KcsA). J. Biol. Chem. 282: 29163-29169.

Paz-Yepes, J., A. Herrero, and E. Flores. (2007). The NtcA-regulated amtB gene is necessary for full methylammonium uptake activity in the cyanobacterium Synechococcus elongatus. J. Bacteriol. 189: 7791-7798. 17704220

Rutherford, J.C., G. Chua, T. Hughes, M.E. Cardenas, and J. Heitman. (2008). A Mep2-dependent Transcriptional Profile Links Permease Function to Gene Expression during Pseudohyphal Growth in Saccharomyces cerevisiae. Mol. Biol. Cell 19: 3028-3039. 18434596

Rutherford, J.C., X. Lin, K. Nielsen, and J. Heitman. (2008). Amt2 permease is required to induce ammonium-responsive invasive growth and mating in Cryptococcus neoformans. Eukaryot. Cell. 7(2): 237-246. 18055915

Saier, M.H., Jr., B.H. Eng, S. Fard, J. Garg, D.A. Haggerty, W.J. Hutchinson, D.L. Jack, E.C. Lai, H.J. Liu, D.P. Nusinew, A.M. Omar, S.S. Pao, I.T. Paulsen, J.A. Quan, M. Sliwinski, T.-T. Tseng, S. Wachi, and G.B. Young. (1999). Phylogenetic characterization of novel transport protein families revealed by genome analyses. Biochim. Biophys. Acta 1422: 1-56. 10082980

Salussolia, C.L., A. Corrales, I. Talukder, R. Kazi, G. Akgul, M. Bowen, and L.P. Wollmuth. (2011). Interaction of the M4 Segment with Other Transmembrane Segments Is Required for Surface Expression of Mammalian α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors. J. Biol. Chem. 286: 40205-40218. 21930708

Siewe, R.M., B. Weil, A. Burkovski, B.J. Eikmanns, M. Eikmanns, and R. Krämer. (1995). Functional and genetic characterization of the (Methyl)ammonium uptake carrier of Corynebacterium glutamicum. J. Biol. Chem. 271: 5398-5403. 8621394

Sohlenkamp, C., M. Shelden, S. Howitt, and M. Udvardi. (2000). Characterization of Arabidopsis AtAMT2, a novel ammonium transporter in plants. FEBS Lett. 467: 273-278. 10675553

Soupene, E., H. Lee, and S. Kustu. (2002b). Ammonium/methylammonium transport (Amt) proteins facilitate diffusion of NH₃ bidirectionally. Proc. Natl. Acad. Sci. U.S.A. 99(6):3926-3931. 11891327

Soupene, E., L. He, D. Yan, and S. Kustu. (1998). Ammonia acquisition in enteric bacteria: physiological role of the ammonium/methylammonium transport B (AmtB) protein. Proc. Natl. Acad. Sci. USA 95: 7030-7034. 9618533

Soupene, E., N. King, E. Feild, P. Liu, K.K. Niyogi, C.-H. Huang, and S. Kustu. (2002d). Rhesus expression in a green alga is regulated by CO₂. Proc. Natl. Acad. Sci. USA 99: 7769-7773. 12032358

Soupene, E., R.M. Ramirez, and S. Kustu. (2002c). Evidence that fungal MEP proteins mediate diffusion of the uncharged species NH₃ across the cytoplasmic membrane. Mol. Cell Biol. 21(17):5733-5741.

Soupene, E., T. Chu, R.W. Corbin, D.F. Hunt, and S. Kustu. (2002a). Gas channels for NH₃: proteins from hyperthermophiles complement an Escherichia coli mutant. J. Bacteriol. 184(12):3396-3400.

Soupene, E., W. Inwood, and S. Kustu. (2004). Lack of the Rhesus protein Rh1 impairs growth of the green alga Chlamydomonas reinhardtii at high CO₂. Proc. Natl. Acad. Sci. USA 101: 7787-7792. 15096599

Teichert, S., J.C. Rutherford, M. Wottawa, J. Heitman, and B. Tudzynski. (2008). Impact of ammonium permeases mepA, mepB, and mepC on nitrogen-regulated secondary metabolism in Fusarium fujikuroi. Eukaryot. Cell. 7(2): 187-201. 18083831

Thomas, G.H., J.G.L. Mullins, and M. Merrick. (2000). Membrane topology of the Mep/Amt family of ammonium transporters. Mol. Microbiol. 37: 331-344. 10931328

Vázquez-Bermúdez, M.F., J. Paz-Yepes, A. Herrero, and E. Flores. (2002). The NtcA-activated amt1gene encodes a permease required for uptake of low concentrations of ammonium in the cyanobacterium Synechococcus sp. PCC7942. Microbiology 148: 861-869. 11882722

Walter, B., M. Küspert, D. Ansorge, R. Krämer, and A. Burkovski. (2008). Dissection of ammonium uptake systems in Corynebacterium glutamicum : mechanism of action and energetics of AmtA and AmtB. J. Bacteriol. 190: 2611-2614. 18245289

Weidinger, K., B. Neuhäuser, S. Gilch, U. Ludewig, O. Meyer, and I. Schmidt. (2007). Functional and physiological evidence for a rhesus-type ammonia transporter in Nitrosomonas europaea. FEMS Microbiol. Lett. 273: 260-267. 17608700

Westhoff, C.M., D.L. Siegel, C.G. Burd, and J.K. Foskett. (2004). Mechanism of genetic complementation of ammonium transport in yeast by human erythrocyte Rh-associated glycoprotein. J. Biol. Chem. 279: 17443-17448. 14966114

Westhoff, C.M., M. Ferreri-Jacobia, D.O. Mak, and J.K. Foskett. (2002). Identification of the erythrocyte Rh blood group glycoprotein as a mammalian ammonium transporter. J. Biol. Chem. 277: 12499-12502. 11861637

Worrell, R.T., L. Merk, and J.B. Matthews. (2008). Ammonium transport in the colonic crypt cell line, T84: role for Rhesus glycoproteins and NKCC1. Am. J. Physiol. Gastrointest Liver Physiol 294: G429-440. 18032481

Yakunin, A.F. and P.C. Hallenbeck. (2002). AmtB is necessary for NH₄⁺-induced nitrogenase switch-off and ADP-ribosylation in Rhodobacter capsulatus. J. Bacteriol. 184: 4081-4088. 12107124

Yoshino, R., T. Morio, Y. Yamada, H. Kuwayama, M. Sameshima, Y. Tanaka, H. Sesaki, and M. Iijima. (2007). Regulation of Ammonia Homeostasis by the Ammonium Transporter AmtA in Dictyostelium discoideum. Eukaryot. Cell. 6: 2419-2428. 17951519

Yuan, L., D. Loqué, F. Ye, W.B. Frommer, and N. von Wirén. (2007). Nitrogen-dependent posttranscriptional regulation of the ammonium transporter AtAMT1;1. Plant Physiol. 143: 732-744. 17172286

Yuan, L., L. Graff, D. Loqué, S. Kojima, Y.N. Tsuchiya, H. Takahashi, and N. von Wirén. (2009). AtAMT1;4, a pollen-specific high-affinity ammonium transporter of the plasma membrane in Arabidopsis. Plant Cell Physiol. 50: 13-25. 19073648

Zidi-Yahiaoui, N., I. Callebaut, S. Genetet, C. Le Van Kim, J.P. Cartron, Y. Colin, P. Ripoche, and I. Mouro-Chanteloup. (2009). Functional analysis of human RhCG: a comparison with E.coli ammonium transporter reveals similarities in the pore and differences in the vestibule. Am. J. Physiol. Cell Physiol. [Epub: Ahead of Print] 19553567

1.A.12

Berryman, M., J. Bruno, J. Price, and J.C. Edwards. (2004). CLIC-5A functions as a chloride channel in vitro and associates with the cortical actin cytoskeleton in vitro and in vivo. J. Biol. Chem. 279: 34794-34801. 15184393

Cromer, B.A., M.A. Gorman, G. Hansen, J.J. Adams, M. Coggan, D.R. Littler, L.J. Brown, M. Mazzanti, S.N. Breit, P.M. Curmi, A.F. Dulhunty, P.G. Board, and M.W. Parker MW. (2007). Structure of the Janus protein human CLIC2. J. Mol. Biol. 374: 719-731. 17945253

Duncan, R.R., P.K. Westwood, A. Boyd, and R.H. Ashley. (1997). Rat brain p64H1, expression of a new member of the p64 chloride channel protein family in endoplasmic reticulum. J. Biol. Chem. 272: 23880-23886. 9295337

Edwards, J.C., C. Cohen, W. Xu, and P.H. Schlesinger. (2006). c-Src control of chloride channel support for osteoclast HCl transport and bone resorption. J. Biol. Chem. 281: 28011-28022. 16831863

Elter, A., A. Hartel, C. Sieben, B. Hertel, E. Fischer-Schliebs, U. Lüttge, A. Moroni, and G. Thiel. (2007). A plant homolog of animal chloride intracellular channels (CLICs) generates an ion conductance in heterologous systems. J. Biol. Chem. 282: 8786-8792. 17267397

Goodchild, S.C., C.N. Angstmann, S.N. Breit, P.M. Curmi, and L.J. Brown. (2011). Transmembrane Extension and Oligomerization of the CLIC1 Chloride Intracellular Channel Protein upon Membrane Interaction. Biochemistry 50: 10887-10897. 22082111

Harrop, S.J., M.Z. DeMaere, W.D. Fairlie, T. Reztsova, S.M. Valenzuela, M. Mazzanti, R. Tonini, M.R. Qiu, L. Jankova, K. Warton, A.R. Bauskin, W.M. Wu, S. Pankhurst, T.J. Campbell, S.N. Breit, and P.M. Curmi. (2001). Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-Ĺ resolution. J. Biol. Chem. 276: 44993-5000. 11551966

Kleba, B., T.R. Clark, E.I. Lutter, D.W. Ellison, and T. Hackstadt. (2010). Disruption of the Rickettsia rickettsii Sca2 autotransporter inhibits actin-based motility. Infect. Immun. 78: 2240-2247. 20194597

Landry, D, S. Sullivan, M. Nicolaides, C. Redhead, A. Edelman, M. Field, Q. al-Awqati, and J. Edwards. (1993). Molecular cloning and characterization of p64, a chloride channel protein from kidney microsomes. J. Biol. Chem. 268: 14948-14955. 7686908

Meng, X., G. Wang, C. Viero, Q. Wang, W. Mi, X.D. Su, T. Wagenknecht, A.J. Williams, Z. Liu, and C.C. Yin. (2009). CLIC2-RyR1 interaction and structural characterization by cryo-electron microscopy. J. Mol. Biol. 387: 320-334. 19356589

Nishizawa, T., T. Nagao, T. Iwatsubo, J.G. Forte, and T. Urushidani. (2000). Molecular cloning and characterization of a novel chloride intracellular channel-related protein, parchorin, expressed in water-secreting cells. J. Biol. Chem. 275: 11164-11173. 10753923

Ponsioen, B., L. van Zeijl, M. Langeslag, M. Berryman, D. Littler, K. Jalink, and W.H. Moolenaar. (2009). Spatiotemporal Regulation of Chloride Intracellular Channel protein CLIC4 by RhoA. Mol. Biol. Cell. [Epub: Ahead of Print] 19776349

Singh, H. (2010). Two decades with dimorphic Chloride Intracellular Channels (CLICs). FEBS Lett. [Epub: Ahead of Print] 20226783

Singh, H. and R.H. Ashley. CLIC4 (p64H1) and its putative transmembrane domain form poorly selective, redox-regulated ion channels. Mol. Membr. Biol. 24: 41-52. 17453412

Tulk, B.M., P.H. Schlesinger, S.A. Kapadia, and J.C. Edwards. (2000). CLIC-1 functions as a chloride channel when expressed and purified from bacteria. J. Biol. Chem. 275: 26986-26993. 10874038

Valenzuela, S., D.K. Martin, S.B. Por, J.M. Robbins, K. Warton, M.R. Bootcov, P.R. Schofield, T.J. Campbell, and S.N. Breit. (1997). Molecular cloning and expression of a chloride ion channel of cell nuclei. J. Biol. Chem. 272: 12575-12582. 9139710

Warton, K., R. Tonini, W.D. Fairlie, J.M. Matthews, S.M. Valenzuela, M.R. Qiu, W.M. Wu, S. Pankhurst, A.R. Bauskin, S.J. Harrop, T.J. Campbell, P.M.G. Curmi, S.N. Breit, and M. Mazzanti. (2002). Recombinant CLIC1 (NCC27) assembles in lipid bilayers via a pH-dependent two-state process to form chloride ion channels with identical characteristics to those observed in Chinese hamster ovary cells expressing CLIC1. J. Biol. Chem. 277: 26003-26011. 11978800

1.A.13

Agnel, M., T. Vermat, and J. Culouscou. (1999). Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea. FEBS Lett. 455: 295-301. 10437792

Barrett, K.E. and S.J. Keely. (2000). Chloride secretion by the intestinal epithelium: molecular basis and regulatory aspects. Annu. Rev. Physiol. 62: 535-572. 10845102

Elble, R.C., G. Ji, K. Nehrke, J. DeBiasio, P.D. Kingsley, M.I. Kotlikoff, and B.U. Pauli. (2002). Molecular and functional characterization of a murine calcium-activated chloride channel expressed in smooth muscle. J. Biol. Chem. 277: 18586-18591. 11896056

Evans, S.R., W.B. Thoreson, and C.L. Beck. (2004). Molecular and functional analyses of two new calcium-activated chloride channel family members from mouse eye and intestine. J. Biol. Chem. 279: 41792-41800. 15284223

Fuller, C.M., I.I. Ismailov, D.A. Keeton, and D.J. Benos. (1994). Phosphorylation and activation of a bovine tracheal anion channel by Ca²⁺/calmodulin-dependent protein kinase II. J. Biol. Chem. 269: 26642-26650. 7929397

Gibson, A., A.P. Lewis, K. Affleck, A.J. Aitken, E. Meldrum, and N. Thompson. (2005). hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels. J. Biol. Chem. 280: 27205-27212. 15919655

Ran, S. and D.J. Benos. (1992). Immunopurification and structural analysis of a putative epithelial Cl^- channel protein isolated from bovine trachea. J. Biol. Chem. 267: 3618-3625. 1371273

Ran, S., C.M. Fuller, M. Pia Arrate, R. Latorre, and D.J. Benos. (1992). Functional reconstitution of a chloride channel protein from bovine trachea. J. Biol. Chem. 267: 20630-20637. 1383206

Yoon, I.S., S.M. Jeong, S.N. Lee, J.H. Lee, J.H. Kim, M.K. Pyo, J.H. Lee, B.H. Lee, S.H. Choi, H. Rhim, H. Choe, and S.Y. Nah. (2006). Cloning and heterologous expression of a Ca²⁺-activated chloride channel isoform from rat brain. Biol Pharm Bull 29: 2168-2173. 17077509

1.A.14

Bultynck, G., S. Kiviluoto, N. Henke, H. Ivanova, L. Schneider, V. Rybalchenko, T. Luyten, K. Nuyts, W. De Borggraeve, I. Bezprozvanny, J.B. Parys, H. De Smedt, L. Missiaen, and A. Methner. (2011). The C-terminus of bax inhibitor-1 forms a Ca²⁺-permeable channel pore. J. Biol. Chem. [Epub: Ahead of Print] 22128171

van Stelten, J., F. Silva, D. Belin, and T.J. Silhavy. (2009). Effects of antibiotics and a proto-oncogene homolog on destruction of protein translocator SecY. Science 325: 753-756. 19661432

1.A.15

Egido, W., V. Castrejón, B. Antón, and M. Martínez. (2008). Maitotoxin induces two dose-dependent conductances in Xenopus oocytes. Comparison with nystatin effects as a pore inductor. Toxicon. 51: 797-812. 18255116 18255116 18255116

Bihler, H., C.L. Slayman, and A. Bertl. (1998). NSC1: a novel high-current inward rectifier for cations in the plasma membrane of Saccharomyces cerevisiae. FEBS Lett. 432: 59-64. 9710251 9710251

Estacion, M., H. B. Nguyen and J.J. Gargus (1996). Calcium is permeable through a maitotoxin-activated nonselective cation channel in mouse L cells. Am. J. Physiol. 270: C1145-C1152. 8928742

Fantino, E., D. Church, U. Bengtsson and J.J. Gargus (1997). Mammalian gene encoding growth factor-activated cation channel is homologue to yeast microsomal protein SEC62 and maps to human chromosome 3. J. Gen. Physiol. 110: 44a.

Frace, A.M. and J.J. Gargus (1989). Activation of single-channel currents in mouse fibroblasts by platelet-derived growth factor. Proc. Natl. Acad. Sci. USA 86: 2511-2515. 2467305

Gargus, J.J., A.M. Frace and F. Jung (1993). The role of a PDGF-activated nonselective cation channel in the proliferative response. In "Nonselective cation channels: pharmacology, physiology and biophysics" (D. Siemen and J. Hescheler, eds.), Birkhäuser Verlag, Basel, Switzerland, pp. 289-295. 7505659

Jung, F., S. Selvaraj and J.J. Gargus (1992). Blockers of platelet-derived growth factor-activated nonselective cation channel inhibit cell proliferation. Am. J. Physiol. 262: C1464-C1470. 1377445

1.A.16

Iida, H., H. Nakamara, T. Ono, M.S. Okumura, and Y. Anraku. (1994). MID1, a novel Saccharomyces cerevisiae gene encoding a plasma membrane protein, is required for Ca²⁺ influx and mating. Mol. Cell. Biol. 14: 8259-8271. 7526155

Kanzaki, M., M. Nagasawa, I. Kojima, C. Sato, K. Naruse, M. Sokabe, and H. Iida. (1999). Molecular identification of a eukaryotic, stretch-activated nonselective cation channel. Science 285: 882-886. 10436155

Lew, R.R., Z. Abbas, M.I. Anderca, and S.J. Free. (2008). Phenotype of a mechanosensitive channel mutant, mid-1, in a filamentous fungus, Neurospora crassa. Eukaryot. Cell. 7: 647-655. 18296620

Nagasawa, M., M. Kanzaki, Y. Iino, Y. Morishita, and I. Kojima. (2001). Identification of a novel chloride channel expressed in the endoplasmic reticulum, Golgi apparatus, and nucleus. J. Biol. Chem. 276: 20413-20418. 11279057

Tada, T., M. Ohmori, and H. Iida. (2003). Molecular dissection of the hydrophobic segments H3 and H4 of the yeast Ca²⁺ channel component Mid1. J. Biol. Chem. 278: 9647-9654. 12514173

1.A.17

Almaça, J., Y. Tian, F. Aldehni, J. Ousingsawat, P. Kongsuphol, J.R. Rock, B.D. Harfe, R. Schreiber, and K. Kunzelmann. (2009). TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A. J. Biol. Chem. 284: 28571-28578. 19654323

Caputo, A., E. Caci, L. Ferrera, N. Pedemonte, C. Barsanti, E. Sondo, U. Pfeffer, R. Ravazzolo, O. Zegarra-Moran, and L.J. Galietta. (2008). TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity. Science 322: 590-594. 18772398

Ferrera, L., A. Caputo, I. Ubby, E. Bussani, O. Zegarra-Moran, R. Ravazzolo, F. Pagani, and L.J. Galietta. (2009). Regulation of TMEM16A chloride channel properties by alternative splicing. J. Biol. Chem. 284: 33360-33368. 19819874

Galietta, L.J. (2009). The TMEM16 protein family: a new class of chloride channels? Biophys. J. 97: 3047-3053. 20006941

Huang, F., J.R. Rock, B.D. Harfe, T. Cheng, X. Huang, Y.N. Jan, and L.Y. Jan. (2009). Studies on expression and function of the TMEM16A calcium-activated chloride channel. Proc. Natl. Acad. Sci. USA 106: 21413-21418. 19965375

Huang, F., X. Wong, and L.Y. Jan. (2012). International Union of Basic and Clinical Pharmacology. LXXXV: calcium-activated chloride channels. Pharmacol Rev 64: 1-15. 22090471

Hwang, S.J., P.J. Blair, F.C. Britton, K.E. O'Driscoll, G. Hennig, Y.R. Bayguinov, J.R. Rock, B.D. Harfe, K.M. Sanders, and S.M. Ward. (2009). Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles. J. Physiol. 587: 4887-4904. 19687122

Martins, J.R., D. Faria, P. Kongsuphol, B. Reisch, R. Schreiber, and K. Kunzelmann. (2011). Anoctamin 6 is an essential component of the outwardly rectifying chloride channel. Proc. Natl. Acad. Sci. USA 108: 18168-18172. 22006324

Ousingsawat, J., J.R. Martins, R. Schreiber, J.R. Rock, B.D. Harfe, and K. Kunzelmann. (2009). Loss of TMEM16A causes a defect in epithelial Ca²⁺-dependent chloride transport. J. Biol. Chem. 284: 28698-28703. 19679661

Planells-Cases, R. and T.J. Jentsch. (2009). Chloride channelopathies. Biochim. Biophys. Acta. [Epub: Ahead of Print] 19419694

Schreiber, R., I. Uliyakina, P. Kongsuphol, R. Warth, M. Mirza, J.R. Martins, and K. Kunzelmann. (2010). Expression and function of epithelial anoctamins. J. Biol. Chem. 285: 7838-7845. 20056604

Scudieri, P., E. Sondo, L. Ferrera, and L.J. Galietta. (2011). The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. Exp Physiol. [Epub: Ahead of Print] 21984732

Suzuki, J., M. Umeda, P.J. Sims, and S. Nagata. (2010). Calcium-dependent phospholipid scrambling by TMEM16F. Nature 468: 834-838. 21107324

Yang, Y.D., H. Cho, J.Y. Koo, M.H. Tak, Y. Cho, W.S. Shim, S.P. Park, J. Lee, B. Lee, B.M. Kim, R. Raouf, Y.K. Shin, and U. Oh. (2008). TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature 455: 1210-1215. 18724360

1.A.18

Kessler, F. and G. Blobel (1996). Interaction of the protein import and folding machineries in the chloroplast. Proc. Natl. Acad. Sci. USA 93: 7684-7689. 8755536

Lübeck, J., J. Soll, M. Akita, E. Nielsen and K. Keegstra (1996). Topology of IEP110, a component of the chloroplastic protein import machinery present in the inner envelope membrane. J. EMBO 15: 4230-4238. 8861951

van den Wijngaard, P.W.J. and W.J. Vredenberg (1999). The envelope anion channel involved in chloroplast protein import is associated with Tic110. J. Biol. Chem. 274: 25201-25204. 10464239

1.A.19

Acharya, R., V. Carnevale, G. Fiorin, B.G. Levine, A.L. Polishchuk, V. Balannik, I. Samish, R.A. Lamb, L.H. Pinto, W.F. DeGrado, and M.L. Klein. (2010). Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus. Proc. Natl. Acad. Sci. USA 107: 15075-15080. 20689043

Balannik, V., V. Carnevale, G. Fiorin, B.G. Levine, R.A. Lamb, M.L. Klein, W.F. Degrado, and L.H. Pinto. (2010). Functional studies and modeling of pore-lining residue mutants of the influenza a virus M2 ion channel. Biochemistry 49: 696-708. 20028125

Cady, S.D., C. Goodman, C.D. Tatko, W.F. DeGrado, and M. Hong. (2007). Determining the orientation of uniaxially rotating membrane proteins using unoriented samples: a ²H, ¹³C, and ¹⁵N solid-state NMR investigation of the dynamics and orientation of a transmembrane helical bundle. J. Am. Chem. Soc. 129: 5719-5729. 17417850

Duong-Ly, K.C., V. Nanda, W.F. Degrado, and K.P. Howard. (2005). The conformation of the pore region of the M2 proton channel depends on lipid bilayer environment. Protein Sci. 14: 856-861. 15741338

Fischer, W.B. and M.S. Sansom. (2002). Viral ion channels: structure and function. Biochim. Biophys. Acta 1561: 27-45. 11988179

Fischer, W.B., M. Pitkeathly, B.A. Wallace, L.R. Forrest, G.R. Smith, and M.S.P. Sansom. (2000). Transmembrane peptide NB of influenza B: a simulation, structure and conductance study. Biochemistry 41: 12708-12716. 11027151

Jing, X., C. Ma, Y. Ohigashi, F.A. Oliveira, T.S. Jardetzky, L.H. Pinto, and R.A. Lamb. (2008). Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel. Proc. Natl. Acad. Sci. USA 105: 10967-10972. 18669647

Kukol, A., P.D. Adams, L.M. Rice, A.T. Brunger, and I.T. Arkin. (1999). Experimentally based orientational refinement of membrane protein models: a structure for the influenza A M2 H⁺ channel. J. Mol. Biol. 286: 951-962. 10024461

Leiding, T., J. Wang, J. Martinsson, W.F. DeGrado, and S.P. Arsköld. (2010). Proton and cation transport activity of the M2 proton channel from influenza A virus. Proc. Natl. Acad. Sci. USA 107: 15409-15414. 20713739

Ma, C., A.L. Polishchuk, Y. Ohigashi, A.L. Stouffer, A. Schön, E. Magavern, X. Jing, J.D. Lear, E. Freire, R.A. Lamb, W.F. DeGrado, and L.H. Pinto. (2009). Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel. Proc. Natl. Acad. Sci. USA 106: 12283-12288. 19590009

Moffat, J.C., V. Vijayvergiya, P.F. Gao, T.A. Cross, D.J. Woodbury, and D.D. Busath. (2008). Proton transport through influenza A virus M2 protein reconstituted in vesicles. Biophys. J. 94: 434-445. 17827230

Mould, J.A., H. Li, C.S. Dudlak, J.D. Lear, A. Pekosz, R.A. Lamb, and L.H. Pinto. (2000). Mechanism for proton conduction of the M2 ion channel of influenza A virus. J. Biol. Chem. 275: 8592-8599. 10722698

Mould, J.A., J.E. Drury, S.M. Frings, U.B. Kaupp, A. Pekosz, R.A. Lamb, and L.H. Pinto. (2000). Permeation and activation of the M2 ion channel of influenza A virus. J. Biol. Chem. 75: 31038-31050. 10913133

Pinto, L.H., G.R. Dieckmann, C.S. Gandhi, C.G. Papworth, J. Braman, M.A. Shaughnessy. J.D. Lear, R.A. Lamb, and W.F. DeGrado. (1997). A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity. Proc. Natl. Acad. Sci. USA 94: 11301-11306. 9326604

Schnell, J.R., and J.J. Chou (2008). Structure and mechanism of the M2 proton channel of influenza A virus. Nature 451: 591-5. 18235503

Stouffer, A.L., R. Acharya, D. Salom, A.S. Levine, L. Di Costanzo, C.S. Soto, V. Tereshko, V. Nanda, S. Stayrook, and W.F. DeGrado (2008). Structural basis for the function and inhibition of an influenza virus proton channel. Nature 451: 596-9. 18235504

Tang, Y., F. Zaitseva, R.A. Lamb, and L.H. Pinto. (2002). The gate of the influenza virus M₂ proton channel is formed by a single tryptophan residue. J. Biol. Chem. 277: 39880-39886. 12183461

Tian, C. K. Tobler, R.A. Lamb, L.H. Pinto, and T.A. Cross. (2002). Expression and initial structural insights from solid-stage NMR of the M2 proton channel from influenza A virus. Biochemistry 41: 11294-11300. 12220196

Witter, R., F. Nozirov, U. Sternberg, T.A. Cross, A.S. Ulrich, and R. Fu. (2008). Solid-state 19F NMR spectroscopy reveals that Trp41 participates in the gating mechanism of the M2 proton channel of influenza A virus. J. Am. Chem. Soc. 130: 918-924. 18163621

1.A.20

Bocharov, E.V., Y.E. Pustovalova, K.V. Pavlov, P.E. Volynsky, M.V. Goncharuk, Y.S. Ermolyuk, D.V. Karpunin, A.A. Schulga, M.P. Kirpichnikov, R.G. Efremov, I.V. Maslennikov, and A.S. Arseniev. (2007). Unique dimeric structure of BNip3 transmembrane domain suggests membrane permeabilization as a cell death trigger. J. Biol. Chem. 282: 16256-16266. 17412696

1.A.21

Adams, J.M. and S. Cory. (1998). The Bcl-2 protein family: arbiters of cell survival. Science 281: 1322-1326. 9735050

Antonsson, B., S. Montessuit, S. Lauper, R. Eskes, and J. Martinou. (2000). Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria. Biochem. J. 345: 271-278. 10620504

Arbel, N. and V. Shoshan-Barmatz. (2010). Voltage-dependent anion channel 1-based peptides interact with Bcl-2 to prevent antiapoptotic activity. J. Biol. Chem. 285: 6053-6062. 20037155

Boise, L., M. Gonzalez-Garcia, C. Postema, L. Ding, T. Lindsten, L. Turka, X. Mao, G. Nunez, and C. Thompson. (1993). bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74: 597-608. 8358789

Faustin, B., Y. Chen, D. Zhai, G. Le Negrate, L. Lartigue, A. Satterthwait, and J.C. Reed. (2009). Mechanism of Bcl-2 and Bcl-X(L) inhibition of NLRP1 inflammasome: loop domain-dependent suppression of ATP binding and oligomerization. Proc. Natl. Acad. Sci. USA 106: 3935-3940. 19223583

Grinberg, M., M. Schwarz, Y. Zaltsman, T. Eini, H. Niv, S. Pietrokovski, and A. Gross. (2005). Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha. Mol. Cell. Biol. 25(11):4579-4590. 15899861

Gross, A. (2005). Mitochondrial carrier homolog 2: a clue to cracking the BCL-2 family riddle? J. Bioenerg. Biomembr. 37(3):113-119.

Kuwana, T., M.R. Mackey, G. Perkins, M.H. Ellisman, M. Latterich, R. Schneiter, D.R. Green, and D.D. Newmeyer. (2002). Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell 111: 331-342. 12419244

Muchmore, S.W., M. Sattler, H. Liang, R.P. Meadows, J.E. Harlan, H.S. Yoon, D. Nettesheim, B.S. Chang, C.B. Thompson, S.L. Wong, S.L. Ng, and S.W. Fesik. (1996). X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature 381: 335-341. 8692274

Narita, M., S. Shimizu, T. Ito, T. Chittenden, R.J. Lutz, H. Matsuda and Y. Tsujimoto (1998). Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc. Natl. Acad. Sci. USA 95: 14681-14686. 9843949

Qian, S., W. Wang, L. Yang, and H.W. Huang. (2008). Structure of transmembrane pore induced by Bax-derived peptide: evidence for lipidic pores. Proc. Natl. Acad. Sci. USA 105: 17379-17383. 18987313

Shimizu, S., M. Narita, and Y. Tsujimoto. (1999). Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 399: 483-487. 10365962

Siskind, L.J., L. Feinstein, T. Yu, J.S. Davis, D. Jones, J. Choi, J.E. Zuckerman, W. Tan, R.B. Hill, J.M. Hardwick, and M. Colombini. (2008). Anti-apoptotic Bcl-2 Family proteins disassemble ceramide channels. J. Biol. Chem. 283: 6622-6630. 18171672

Siskind, L.J., R.N. Kolesnick, and M. Colombini. (2002). Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins. J. Biol. Chem. 277: 26796-26803. 12006562

Siskind, L.J., R.N. Kolesnick, and M. Colombini. (2006). Ceramide forms channels in mitochondrial outer membranes at physiologically relevant concentrations. Mitochondrion 6: 118-125. 16713754

Tsujimoto, T. and S. Shimizu. (2000). Bcl-2 family: life-or-death switch. FEBS Lett. 466: 6-10. 10648802

Wei, M.C., W.-X. Zong, E.H.-Y. Cheng, T. Lindsten, V. Panoutsakopoulou, A.J. Ross, K.A. Roth, G.R. MacGregor, C.B. Thompson, and S.J. Korsmeyer. (2001). Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292: 727-730. 11326099

Willis, S.N., J.I. Fletcher, T. Kaufmann, M.F. van Delft, L. Chen, P.E. Czabotar, H. Ierino, E.F. Lee, W.D. Fairlie, P. Bouillet, A. Strasser, R.M. Kluck, J.M. Adams, and D.C. Huang. (2007). Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science 315: 856-859. 17289999

1.A.22

Ajouz, B., C. Berrier, A. Garrigues, M. Besnard, and A. Ghazi. (1998). Release of thioredoxin via the mechanosensitive channel MscL during osmotic downshock of Escherichia coli cells. J. Biol. Chem. 273: 26670-26674. 9756908

Balleza, D., F. Gómez-Lagunas, and C. Quinto. (2010). Cloning and functional expression of an MscL ortholog from Rhizobium etli: characterization of a mechanosensitive channel. J. Membr. Biol. 234: 13-27. 20177670

Blount, P., M.J. Schroeder, and C. Kung. (1997). Mutations in a bacterial mechanosensitive channel change the cellular response to osmotic stress. J. Biol. Chem. 272: 32150-32157. 9405414

Blount, P., S.I. Sukharev, M.J. Schroeder, S.K. Nangle, and C. Kung. (1996b). Single residue substitutions that change the gating properties of a mechanosensitive channel in Escherichia coli. Proc. Natl. Acad. Sci. USA 93: 11652-11657. 8876191

Blount, P., S.I. Sukharev, P.C. Moe, M.J. Schroeder, H.R. Guy, and C. Kung. (1996a). Membrane topology and multimeric structure of a mechanosensitive channel protein of Escherichia coli. EMBO J. 15: 4798-4805. 8890153

Chang, G., R.H. Spencer, A.T. Lee, M.T. Barclay, and D.C. Rees. (1998). Structure of the MscL homolog from Mycobacterium tuberculosis: a gated mechanosensitive ion channel. Science 282: 2220-2226. 9856938

Hase, C.C., A.C. Le Dain, and B. Martinac. (1995). Purification and functional reconstitution of the recombinant large mechanosensitive ion channel (MscL) of Escherichia coli. J. Biol. Chem. 270: 18329-18334. 7543101

Haswell, E.S., R. Phillips, and D.C. Rees. (2011). Mechanosensitive channels: what can they do and how do they do it? Structure 19: 1356-1369. 22000509

Hoffmann, T., C. Boiangiu, S. Moses, and E. Bremer. (2008). Responses of Bacillus subtilis to hypotonic challenges: physiological contributions of mechanosensitive channels to cellular survival. Appl. Environ. Microbiol. 74: 2454-2460. 18310427

Iscla, I., R. Wray, and P. Blount. (2011). The oligomeric state of the truncated mechanosensitive channel of large conductance shows no variance in vivo. Protein. Sci. 20: 1638-1642. 21739498

Kloda, A. and Martinac, B. (2002). Common evolutionary origins of mechanosensitive ion channels in archaea, bacteria and cell-walled eukarya. Archaea 1: 35-44. 15803657

Kung, C., B. Martinac, and S. Sukharev. (2010). Mechanosensitive channels in microbes. Annu. Rev. Microbiol. 64: 313-329. 20825352

Nakamaru, Y., Y. Takahashi, T. Unemoto, and T. Nakamura. (1999). Mechanosensitive channel functions to alleviate the cell lysis of marine bacterium, Vibrio alginolyticus, by osmotic downshock. FEBS Lett. 444: 170-172. 10050752

Perozo, E., A. Kloda, D.M. Cortes, and B. Martinac. (2001). Site-directed spin-labeling analysis of reconstituted Mscl in the closed state. J Gen Physiol 118: 193-206. 11479346

Pivetti, C.D., M.-R. Yen, S. Miller, W. Busch, Y.-H. Tseng, I.R. Booth, and M.H. Saier, Jr. (2003). Two families of mechanosensitive channel proteins. Microbiol. Mol. Biol. Rev. 67: 66-85. 12626684

Price, C.E., A. Kocer, S. Kol, J.P. van der Berg, and A.J. Driessen. (2011). In vitro synthesis and oligomerization of the mechanosensitive channel of large conductance, MscL, into a functional ion channel. FEBS Lett. 585: 249-254. 21134371

Saier, M.H., Jr., B.H. Eng, S. Fard, J. Garg, D.A. Haggerty, W.J. Hutchinson, D.L. Jack, E.C. Lai, H.J. Liu, D.P. Nusinew, A.M. Omar, S.S. Pao, I.T. Paulsen, J.A. Quan, M. Sliwinski, T.-T. Tseng, S. Wachi, and G.B. Young. (1999). Phylogenetic characterization of novel transport protein families revealed by genome analyses. Biochim. Biophys. Acta 1422: 1-56. 10082980

Sukharev, S. (1999). Mechanosensitive channels in bacteria as membrane tension reporters. FASEB J. 13: 55-61. 10352145

Sukharev, S., M. Betanzos, C.S. Chiang, and H.R. Guy. (2001). The gating mechanism of the large mechanosensitive channel MscL. Nature 409: 720-724. 11217861

Sukharev, S., M.J. Schroeder, and D.R. McCaslin. (1999). Stoichiometry of the large conductance bacterial mechanosensitive channel of E. coli. A biochemical study. J. Memb. Biol. 171: 183-193. 10501827

Sukharev, S.I., P. Blount, B. Martinac, F.R. Blattner, and C. Kung. (1994). A large-conductance mechanosensitive channel in E. coliencoded by mscL alone. Nature 368: 265-268. 7511799

Sukharev, S.I., P. Blount, B. Martinac, H.R. Guy, and C. Kung. (1996). MscL: a mechanosensitive channel in Escherichia coli. In: Organellar Ion Channels and Transporters, The Rockefeller University Press, pp. 133-141. 8809939

Wahome, P.G., A.E. Cowan, B. Setlow, and P. Setlow. (2009). Levels and localization of mechanosensitive channel proteins in Bacillus subtilis. Arch. Microbiol. 191: 403-414. 19252899

Yoshimura, K., J. Usukura, and M. Sokabe. (2008). Gating-associated conformational changes in the mechanosensitive channel MscL. Proc. Natl. Acad. Sci. USA 105: 4033-4038. 18310324

1.A.23

Bass, R.B., P. Strop, M. Barclay, and D.C. Rees. (2002). Crystal structure of Escherichia coli MscS, a voltage-modulated and mechanosensitive channel. Science 298: 1582-1587. 12446901

Biggin, P.C. and M.S. Sansom. (2003). Mechanosensitive channels: stress relief. Curr. Biol. 13: R183-185. 12620208

Booth, I.R. and P. Louis (1999). Managing hypoosmotic stress: aquaporins and mechanosensitive channels in Escherichia coli. Curr. Opin. Microbiol. 2: 166-169. 10322175

Caldwell, D.B., H.R. Malcolm, D.E. Elmore, and J.A. Maurer. (2010). Identification and experimental verification of a novel family of bacterial cyclic nucleotide-gated (bCNG) ion channels. Biochim. Biophys. Acta. 1798: 1750-1756. 20529663

Haswell, E.S. and E.M. Meyerowitz. (2006). MscS-like proteins control plastid size and shape in Arabidopsis thaliana. Curr. Biol. 16: 1-11. 16401419

Haswell, E.S., R. Peyronnet, H. Barbier-Brygoo, E.M. Meyerowitz, and J.M. Frachisse. (2008). Two MscS homologs provide mechanosensitive channel activities in the Arabidopsis root. Curr. Biol. 18: 730-734. 18485707

Kloda, A. and B. Martinac. (2001a). Molecular identification of a mechanosensitive channel in archaea. Biophys. J. 80: 229–240. 11159397

Kloda, A. and B. Martinac. (2001b). Structural and functional differences between two homologous mechanosensitive channels of Methanococcus jannaschii. EMBO J. 20: 1888–1896. 11296222

Koprowski, P. and A. Kubalski. (2003). C termini of the Escherichia coli mechanosensitive ion channel (MscS) move apart upon the channel opening. J. Biol. Chem. 278: 11237-11245. 12551944

Koprowski, P., W. Grajkowski, E.Y. Isacoff, and A. Kubalski. (2011). Genetic screen for potassium leaky small mechanosensitive channels (MscS) in Escherichia coli: recognition of cytoplasmic β domain as a new gating element. J. Biol. Chem. 286: 877-888. 20978126

Kung, C., B. Martinac, and S. Sukharev. (2010). Mechanosensitive channels in microbes. Annu. Rev. Microbiol. 64: 313-329. 20825352

Le Dain, A.C., N. Saint, A. Kloda, A. Ghazi and B. Martinac (1998). Mechanosensitive ion channels of the archeon Haloferax volcanii. J. Biol. Chem. 273: 12116-12119. 9575156

Levina, N., S. Tötemeyer, N.R. Stokes, P. Louis, M.A. Jones and I.R. Booth (1999). Protection of E. coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity. EMBO J. 18: 1730-1737. 10202137

Martinac, B., J. Adler and C. Kung (1990). Mechanosensitive channels of E. coli activated by amphipaths. Nature 348: 261-263. 1700306

Martinac, B., M. Buechner, A.H. Delcour, J. Adler and C. Kung (1987). Pressure-sensitive ion channel in Escherichia coli. Proc. Natl. Acad. Sci. USA 84: 2297-2301. 2436228

Miller, S., M.D. Edwards, C. Ozdemir, and I.R. Booth. (2003b). The closed structure of the MscS mechanosensitive channel. Cross-linking of single cysteine mutants. J. Biol. Chem. 278: 32246-32250. 12767977

Miller, S., W. Bartlett, S. Chandrasekaran, S. Simpson, M. Edwards, and I.R. Booth. (2003a). Domain organization of the MscS mechanosensitive channel of Escherichia coli. EMBO J. 22: 36-46. 12505982

Nakayama, Y., K. Fujiu, M. Sokabe, and K. Yoshimura. (2007). Molecular and electrophysiological characterization of a mechanosensitive channel expressed in the chloroplasts of Chlamydomonas. Proc. Natl. Acad. Sci. USA 104: 5883-5888. 17389370

Ochoa de Alda, J. and J. Houmard (2000). Genomic survey of cAMP and cGMP signalling components in the cyanobacterium Synechocystis PCC 6803. Microbiology 146: 3183-3194. 11101676

Perozo, E. and D.C. Rees. (2003). Structure and mechanism in prokaryotic mechanosensitive channels. Curr. Opin. Struct. Biol. 13: 432-442. 12948773

Pivetti, C.D., M.-R. Yen, S. Miller, W. Busch, Y.-H. Tseng, I.R. Booth, and M.H. Saier, Jr. (2003). Two families of mechanosensitive channel proteins. Microbiol. Mol. Biol. Rev. 67: 66-85. 12626684

Schumann, U., M.D. Edwards, T. Rasmussen, W. Bartlett, P. van West, and I.R. Booth. (2010). YbdG in Escherichia coli is a threshold-setting mechanosensitive channel with MscM activity. Proc. Natl. Acad. Sci. USA 107: 12664-12669. 20616037

Sukharev, S.I., P. Blount, B. Martinac, H.R. Guy and C. King (1996). MscL: a mechanosensitive channel in Escherichia coli. In: Organellar Ion Channels and Transporters (D. E. Clapham and B. E. Ehrlich, eds.). Rockefeller University Press, New York, pp. 133-141. 8809939

Touzé, T., G. Gouesbet, C. Boiangiu, M. Jebbar, S. Bonnassie, and C. Blanco. (2001). Glycine betaine loses its osmoprotective activity in a bspAstrain of Erwinia chrysanthemi. Mol. Microbiol. 42: 87-99. 11679069

Wahome, P.G., A.E. Cowan, B. Setlow, and P. Setlow. (2009). Levels and localization of mechanosensitive channel proteins in Bacillus subtilis. Arch. Microbiol. 191: 403-414. 19252899

Wang, W., S. Black, M.D. Edwards, S. Miller, E.L. Morrision, W. Bartlett, C. Dong, J.H. Naismith, and I.R. Booth. (2008).  The structure of an open form of an E. coli mechanosensitive channel at 3.45 A Resoluton.  Science 321: 1179-1214. 

1.A.24

Ayad, W.A., D. Locke, I.V. Koreen, and A.L. Harris. (2006). Heteromeric, but not homomeric, connexin channels are selectively permeable to inositol phosphates. J. Biol. Chem. 281: 16727-16739. 16601118

Bevans, C.G., M. Kordel, S.K. Rhee, and A.L. Harris. (1998). Isoform composition of connexin channels determines selectivity among second messengers and uncharged molecules. J. Biol. Chem. 273: 2808-2816. 9446589

Beyer, E.C., D.L. Paul, and D.A. Goodenough. (1987). Connexin43: a protein from rat heart homologous to a gap junction protein from liver. J. Cell Biol. 105: 2621-2629. 2826492

Bosco, D., J.A. Haefliger, and P. Meda. (2011). Connexins: key mediators of endocrine function. Physiol. Rev. 91: 1393-1445. 22013215

Derosa, A.M., C.H. Xia, X. Gong, and T.W. White. (2007). The cataract-inducing S50P mutation in Cx50 dominantly alters the channel gating of wild-type lens connexins. J. Cell. Sci. 120:4107-4116. 18003700

Goldberg, G.S., A.P. Moreno, and P.D. Lampe. (2002). Gap junctions between cells expressing connexon 43 or 32 show inverse permselectivity to adenosine and ATP. J. Biol. Chem. 277: 36725-36730. 12119284

Hervé, J.C., M. Derangeon, D. Sarrouilhe, B.N. Giepmans, and N. Bourmeyster. (2011). Gap junctional channels are parts of multiprotein complexes. Biochim. Biophys. Acta. [Epub: Ahead of Print] 22197781

Hervé, J.C., P. Phelan, R. Bruzzone, and T.W. White. (2005). Connexins, innexins and pannexins: bridging the communication gap. Biochim. Biophys. Acta. 1719: 3-5. 16359939

Hua, V.B., A.B. Chang, J.H. Tchieu, P.A. Nielsen, and M.H. Saier, Jr. (2003). Sequence and phylogenetic analysis of 4 TMS junctional proteins: Connexins, innexins, claudins and occludins. J. Mem. Biol. 194: 59-76. 14502443

Iovine, M.K., A.M. Gumpert, M.M. Falk, and T.C. Mendelson. (2008). Cx23, a connexin with only four extracellular-loop cysteines, forms functional gap junction channels and hemichannels. FEBS Lett. 582: 165-170. 18068130

Kang, J., N. Kang, D. Lovatt, A. Torres, Z. Zhao, J. Lin, and M. Nedergaard. (2008). Connexin 43 hemichannels are permeable to ATP. J. Neurosci. 28: 4702-4711. 18448647

Kim, D.Y., Y. Kam, S.K. Koo, and C.O. Joe. (1998). Gating connexin 43 channels reconstituted in lipid vesicles by mitogen-activated protein kinase phosphorylation. J. Biol. Chem. 274: 5581-5587. 10026174

Kyle, J.W., V.M. Berthoud, J. Kurutz, P.J. Minogue, M. Greenspan, D.A. Hanck, and E.C. Beyer. (2009). The N-terminus of connexin37 contains an α-helix that is required for channel function. J. Biol. Chem. [Epub: Ahead of Print] 19478091

Leithe, E. and E. Rivedal. (2007). Ubiquitination of gap junction proteins. J. Membr. Biol. 217: 43-51. 17657522

Liu, F., F.T. Arce, S. Ramachandran, and R. Lal. (2006). Nanmechanics of hemichannel conformations. Connexin flexibility underlying channel opening and closing. J. Biol. Chem. 281: 23207-23217. 16769719

Maeda, S., S. Nakagawa, M. Suga, E. Yamashita, A. Oshima, Y. Fujiyoshi, and T. Tsukihara. (2009). Structure of the connexin 26 gap junction channel at 3.5 Ĺ resolution. Nature 458: 597-602. 19340074

Nakagawa, S., S. Maeda, and T. Tsukihara. (2010). Structural and functional studies of gap junction channels. Curr. Opin. Struct. Biol. 20: 423-430. 20542681

Orthmann-Murphy, J.L., M. Freidin, E. Fischer, S.S. Scherer, and C.K. Abrams. (2007). Two distinct heterotypic channels mediate gap junction coupling between astrocyte and oligodendrocyte connexins. J. Neurosci. 27: 13949-13957. 18094232

Stridh, M.H., M. Tranberg, S.G. Weber, F. Blomstrand, and M. Sandberg. (2008). Stimulated efflux of amino acids and glutathione from cultured hippocampal slices by omission of extracellular calcium: likely involvement of connexin hemichannels. J. Biol. Chem. 283(16): 10347-10356. 18272524

Teubner B., B. Odermatt, M. Guldenagel, G. Sohl, J. Degen, F. Bukauskas, J. Kronengold, V.K. Verselis, Y.T. Jung, C.A. Kozak, K. Schilling, K. Willecke. (2001). Functional expression of the new gap junction gene connexin47 transcribed in mouse brain and spinal cord neurons. J. Neurosci. 21: 1117-1126. 11160382

Unger, V.M., N.M. Kumar, N.B. Gilula, and M. Yeager. (1999). Three-dimensional structure of a recombinant gap junction membrane channel. Science 283: 1176-1180. 10024245

Valiunas V., R. Mui, E. McLachlan, G. Valdimarsson, P.R. Brink, T.W. White. (2004). Biophysical characterization of zebrafish connexin35 hemichannels. Am J Physiol. Cell Physiol. 287: C1596-1604 15282192

White, T.W. and D.L. Paul. (1999). Genetic diseases and gene knockouts reveal diverse connexin functions. Annu. Rev. Physiol. 61: 283-310. 10099690

White, T.W., H. Wang, R. Mui, J. Litteral, and P.R. Brink. (2004). Cloning and functional expression of invertebrate connexins from Halocynthia pyriformis. FEBS Lett. 577: 42-48. 15527759

Yeager, M. and N.B. Gilula. (1992). Membrane topology and quaternary structure of cardiac gap junction ion channels. J. Mol. Biol. 223: 929-948. 1371548

Yeager, M., V.M. Unger, and M.M. Falk. (1998). Synthesis, assembly and structure of gap junction intercellular channels. Curr. Opin. Struct. Biol. 8: 517-524. 9729745

1.A.25

Ambrosi, C., O. Gassmann, J.N. Pranskevich, D. Boassa, A. Smock, J. Wang, G. Dahl, C. Steinem, and G.E. Sosinsky. (2010). Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other. J. Biol. Chem. 285: 24420-24431. 20516070

Bao, L., S. Samuels, S. Locovei, E.R. Macagno, K.J. Muller, and G. Dahl. (2007). Innexins form two types of channels. FEBS Lett. 581: 5703-5708. 18035059

Baranova, A., D. Ivanov, N. Petrash, A. Pestova, M. Skoblov, I. Kelmanson, D. Shagin, S. Nazarenko, E. Geraymovych, O. Litvin, A. Tiunova, T.L. Born, N. Usman, D. Staroverov, S. Lukyanov, and Y. Panchin. (2004). The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. Genomics 83: 706-716. 15028292

Bargiotas, P., A. Krenz, S.G. Hormuzdi, D.A. Ridder, A. Herb, W. Barakat, S. Penuela, J. von Engelhardt, H. Monyer, and M. Schwaninger. (2011). Pannexins in ischemia-induced neurodegeneration. Proc. Natl. Acad. Sci. USA 108: 20772-20777. 22147915

Chuang, C.F., M.K. VanHoven, R.D. Fetter, V.K. Verselis and C.I. Bargmann (2007). An Innexin-Dependent Cell Network Establishes Left-Right Neuronal Asymmetry in C. elegans. Cell 129: 787-799 17512411

Curtin, K.D., Z. Zhang and R.J. Wyman (1999). Drosophila has several genes for gap junction proteins. Gene 232: 191-201. 10352230

Ganfornina, M.D., D. Sanchez, M. Herrera and M.J. Bastiani (1999). Developmental expression and molecular characterization of two gap junction channel proteins during embryogenesis in the grasshopper Schistocerca americana. Dev. Genet. 24: 137-150. 10079517

Hua, V.B., A.B. Chang, J.H. Tchieu, P.A. Nielsen, and M.H. Saier, Jr. (2003). Sequence and phylogenetic analysis of 4 TMS junctional proteins: Connexins, innexins, claudins and occludins. J. Mem. Biol. 194: 59-76. 14502443

Huang, Y.A. and S.D. Roper. (2010). Intracellular Ca²⁺ and TRPM5-mediated membrane depolarization produce ATP secretion from taste receptor cells. J. Physiol. 588: 2343-2350. 20498227

Kienitz, M.C., K. Bender, R. Dermietzel, L. Pott, and G. Zoidl. (2011). Pannexin 1 constitutes the large conductance cation channel of cardiac myocytes. J. Biol. Chem. 286: 290-298. 21041301

Landesman, Y., T.W. White, T.A. Starich, J.E. Shaw, D.A. Goodenough and D.L. Paul (1999). Innexin-3 forms connexin-like intercellular channels. J. Cell Sci. 112: 2391-2396. 10381394

Llobet, E., J.M. Tomás, and J.A. Bengoechea. (2008). Capsule polysaccharide is a bacterial decoy for antimicrobial peptides. Microbiology 154: 3877-3886. 19047754

Locovei, S., E. Scemes, F. Qiu, D.C. Spray, and G. Dahl. (2007). Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex. FEBS Lett. 581: 483-488. 17240370

Oviedo, N.J., and M. Levin. (2007). Gap junctions provide new links in left-right patterning. Cell. 129: 787-799. 17512395

Penuela, S., R. Bhalla, X.Q. Gong, K.N. Cowan, S.J. Celetti, B.J. Cowan, D. Bai, Q. Shao, and D.W. Laird. (2007). Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins. J. Cell Sci. 120: 3772-3783. 17925379

Scemes, E. (2011). Nature of plasmalemmal functional "hemichannels" Biochim. Biophys. Acta. [Epub: Ahead of Print] 21703226

Shestopalov, V.I. and Y. Panchin. (2008). Pannexins and gap junction protein diversity. Cell Mol Life Sci 65: 376-394. 17982731

Silverman, W., S. Locovei, and G. Dahl. (2008). Probenecid, a gout remedy, inhibits pannexin 1 channels. Am. J. Physiol. Cell Physiol. 295: C761-767. 18596212

White, T.W. and D.L. Paul (1999). Genetic diseases and gene knockouts reveal diverse connexin functions. Annu. Rev. Physiol. 61: 283-310. 10099690

Yen, M.R. and M.H. Saier, Jr. (2007). Gap junctional proteins of animals: the innexin/pannexin superfamily. Prog. Biophys. Mol. Biol. (945-14). 17507077

1.A.26

Amari, K., E. Boutant, C. Hofmann, C. Schmitt-Keichinger, L. Fernandez-Calvino, P. Didier, A. Lerich, J. Mutterer, C.L. Thomas, M. Heinlein, Y. Mély, A.J. Maule, and C. Ritzenthaler. (2010). A family of plasmodesmal proteins with receptor-like properties for plant viral movement proteins. PLoS Pathog 6: e1001119. 20886105

Benitez-Alfonso, Y., C. Faulkner, C. Ritzenthaler, and A.J. Maule. (2010). Plasmodesmata: gateways to local and systemic virus infection. Mol. Plant Microbe Interact. 23: 1403-1412. 20687788

Benitez-Alfonso, Y., D. Jackson, and A. Maule. (2011). Redox regulation of intercellular transport. Protoplasma 248: 131-140. 21107619

Faulkner, C. and A. Maule. (2011). Opportunities and successes in the search for plasmodesmal proteins. Protoplasma 248: 27-38. 20922549

Maule, A.J. (2008). Plasmodesmata: structure, function and biogenesis. Curr. Opin. Plant Biol. 11: 680-686. 18824402

Meiners, S., A. Xu and M. Schindler (1991). Gap junctions protein homologue from Arabidopsis thaliana: evidence for connexins in plants. Proc. Natl. Acad. Sci. 88: 4119-4122. 1851993

1.A.27

Attali B., H. Latter, N. Rachamim, H. Garty. (1995). A corticosteroid-induced gene expressing an 'IsK-like' K+ channel activity in Xenopus oocytes. Proc. Natl. Acad. Sci. U.S.A. 92: 6092-6096 7597086

Chen, L.S.K., C.F. Lo, R. Numann and M. Cuddy (1997). Characterization of the human and rat phospholemman (PLM) cDNAs and localization of the human PLM gene to chromosome 19q13.1. Genomics 41: 435-443. 9169143

Foskett, J.K. (1998). ClC and CFTR chloride channel gating. Annu. Rev. Physiol. 60: 689-717. 9558482

Kirk, K. and K. Strange (1998). Functional properties and physiological roles of organic solute channels. Annu. Rev. Physiol. 60: 719-739. 9558483

Lifshitz, Y., M. Lindzen, H. Garty, and S.J. Karlish. (2006). Functional interactions of phospholemman (PLM) (FXYD1) with Na⁺,K⁺-ATPase. Purification of alpha1/beta1/PLM complexes expressed in Pichia pastoris. J. Biol. Chem. 281: 15790-15799. 16608841

Lubarski, I., K. Pihakaski-Maunsbach, S.J. Karlish, A.B. Maunsbach, and H. Garty. (2005). Interaction with the Na,K-ATPase and tissue distribution of FXYD5 (related to ion channel). J. Biol. Chem. 280: 37717-37724. 16148001

Wang, J., X.Q. Zhang, B.A. Ahlers, L.L. Carl, J. Song, L.I. Rothblum, R.C. Stahl, D.J. Carey, and J.Y. Cheung. (2006). Cytoplasmic tail of phospholemman interacts with the intracellular loop of the cardiac Na⁺/Ca²⁺ exchanger. J. Biol. Chem. 281: 32004-32014. 16921169

1.A.28

Bagnasco, S.M. (2006). The erythrocyte urea transporter UT-B. J. Membr. Biol. 212: 133-138. 17264984

Bosse, J.T., H.D. Gilmour, and J.I. MacInnes. (2001). Novel genes affecting urease activity in Actinobacillus pleuropneumoniae. J. Bacteriol. 183: 1242-1247. 11157936

Couriaud, C., C. Leroy, M. Simon, C. Silberstein, P. Bailly, P. Ripoche, and G. Rousselet. (1999). Molecular and functional characterization of an amphibian urea transporter. Biochim. Biophys. Acta 1421: 347-352. 10518704

Couriaud, C., P. Ripoche, and G. Rousselet. (1998). Cloning and functional characterization of a rat urea transporter-expression in the brain. Biochim. Biophys. Acta 1309: 197-199. 8982255

Levin, E.J., M. Quick, and M. Zhou. (2009). Crystal structure of a bacterial homologue of the kidney urea transporter. Nature. [Epub: Ahead of Print] 19865084

Lucien, N. F. Sidoux-Walter, N. Roudier, P. Ripoche, M. Huet, M.-M. Trinh-Trang-Tan, J.-P. Cartron, and P. Bailly. (2002). Antigenic and functional properties of the human red blood cell urea transporter hUT-B1. J. Biol. Chem. 277: 34101-34108. 12093813

Lucien, N., F. Sidoux-Walter, B. Olives, J. Moulds, P.-Y. Le Pennec, J.-P. Cartron, and P. Bailly. (1998). Characterization of the gene encoding the human Kidd blood group/urea transporter protein. J. Biol. Chem. 273: 12973-12980. 9582331

Minocha, R., K. Studley, and M.H. Saier, Jr. (2003). The urea transporter (UT) family: bioinformatic analyses leading to structural, functional, and evolutionary predictions. Receptors & Channels 9: 345-352. 14698962

Mistry, A.C., R. Mallick, O. Fröhlich, J.D. Klein, A. Rehm, G. Chen, and J.M. Sands. (2007). The UT-A1 urea transporter interacts with snapin, a SNARE-associated protein. J. Biol. Chem. 282: 30097-30106. 17702749

Olives, B., P. Neau, P. Bailly, M.A. Hediger, G. Rousselet, J.P. Cartron, and P. Ripoche. (1994). Cloning and functional expression of a urea transporter from human bone marrow cells. J. Biol. Chem. 269: 31649-31652. 7989337

Raunser, S., J.C. Mathai, P.D. Abeyrathne, A.J. Rice, M.L. Zeidel, and T. Walz. (2009). Oligomeric structure and functional characterization of the urea transporter from Actinobacillus pleuropneumoniae. J. Mol. Biol. 387: 619-627. 19361419

Sands, J.M. (2003). Molecular mechanisms of urea transport. J. Membrane Biol. 191: 149-163. 12571750

Shayakul, C., A. Steel, and M.A. Hediger. (1996). Molecular cloning and characterization of the vasopressin-regulated urea transporter of rat kidney collecting ducts. J. Clin. Invest. 98: 2580-2587. 8958221

Smith, C.P. and G. Rousselet. (2001). Facilitative urea transporters. J. Membrane Biol. 183: 1-14. 11547347

Yang, B. and A.S. Verkman. (1998). Urea transporter UT3 functions as an efficient water channel. J. Bacteriol. 272: 9369-9372. 9545259

Yang, B. and A.S. Verkman. (2002). Analysis of double knockout mice lacking aquaporin-1 and urea transporter UT-B. Evidence for UT-B-facilitated water transport in erythrocytes. J. Biol. Chem. 277: 36782-36786. 12133842

Zhao, D., N.D. Sonawane, M.H. Levin, and B. Yang. (2007). Comparative transport efficiencies of urea analogues through urea transporter UT-B. Biochim. Biophys. Acta. 1768: 1815-1821. 17506977

1.A.29

Gray, L.R., S.X. Gu, M. Quick, and S. Khademi. (2011). Transport kinetics and selectivity of HpUreI, the urea channel from Helicobacter pylori. Biochemistry 50: 8656-8663. 21877689

Sachs, G., J.A. Kraut, Y. Wen, J. Feng, and D.R. Scott. (2006). Urea transport in bacteria: acid acclimation by gastric Helicobacter spp. J. Membr. Biol. 212: 71-82. 17264989

Scott, D.R., E.A. Marcus, Y. Wen, S. Singh, J. Feng, and G. Sachs. (2010). Cytoplasmic histidine kinase (HP0244)-regulated assembly of urease with UreI, a channel for urea and its metabolites, CO₂, NH₃, and NH₄⁺, is necessary for acid survival of Helicobacter pylori. J. Bacteriol. 192: 94-103. 19854893

Weeks, D.L. and G. Sachs. (2001). Sites of pH regulation of the urea channel of Helicobacter pylori. Mol. Microbiol. 40: 1249-1259. 11442825

Weeks, D.L., G. Gushansky, D.R. Scott, and G. Sachs. (2004). Mechanism of proton gating of a urea channel. J. Biol. Chem. 279: 9944-9950. 14701805

Weeks, D.L., S. Eskandari, D.R. Scott, and G. Sachs. (2000). A H⁺-gated urea channel: the link between Helicobacter pylori urease and gastric colonization. Science 287: 482-485. 10642549

Wilson, S.A., R.J. Williams, L.H. Pearl, and R.E. Drew. (1995). Identification of two new genes in the Pseudomonas aeruginosa amidase operon, encoding an ATPase (AmiB) and a putative integral membrane protein (AmiS). J. Biol. Chem. 270: 18818-18824. 7642533

1.A.30

Ito, M., D.B. Hicks, T.M. Henkin, A.A. Guffanti, B.D. Powers, L. Zvi, K. Uematsu, and T.A. Krulwich. (2004). MotPS is the stator-force generator for motility of alkaliphilic Bacillus, and its homologue is a second functional Mot in Bacillus subtilis. Mol. Microbiol. 53: 1035-1049. 15306009

Koerdt, A., A. Paulick, M. Mock, K. Jost, and K.M. Thormann. (2009). MotX and MotY are required for flagellar rotation in Shewanella oneidensis MR-1. J. Bacteriol. 191: 5085-5093. 19502394

Kojima, S., K. Imada, M. Sakuma, Y. Sudo, C. Kojima, T. Minamino, M. Homma, and K. Namba. (2009). Stator assembly and activation mechanism of the flagellar motor by the periplasmic region of MotB. Mol. Microbiol. 73: 710-718. 19627504

O'Neill, J., M. Xie, M. Hijnen, and A. Roujeinikova. (2011). Role of the MotB linker in the assembly and activation of the bacterial flagellar motor. Acta Crystallogr D Biol Crystallogr 67: 1009-1016. 22120737

O'Neill, J., M. Xie, M. Hijnen, and A. Roujeinikova. (2011). Role of the MotB linker in the assembly and activation of the bacterial flagellar motor. Acta Crystallogr D Biol Crystallogr 67: 1009-1016. 18540076

Okabe, M., T. Yakushi, and M. Homma. (2005). Interactions of MotX with MotY and with the PomA/PomB sodium ion channel complex of the Vibrio alginolyticus polar flagellum. J. Biol. Chem. 280: 25659-25664. 15866878

Yonekura, K., S. Maki-Yonekura, and M. Homma. (2011). Structure of the flagellar motor protein complex PomAB: implications for the torque-generating conformation. J. Bacteriol. 193: 3863-3870. 21642461

1.A.31

De Seranno, S., C. Benaud, N. Assard, S. Khediri, V. Gerke, J. Baudier, and C. Delphin. (2006). Identification of an AHNAK binding motif specific for the Annexin2/S100A10 tetramer. J. Biol. Chem. 281: 35030-35038. 16984913

Isas, J.M., J.P. Cartailler, Y. Sokolov, D.R. Patel, R. Langen, H. Luecke, J.E. Hall and H.T. Haigler (2000). Annexins V and XII insert into bilayers at mildly acidic pH and form ion channels. Biochem. 39:3015-3022. 10715122

Kourie, J.I. and H.B. Wood (2000). Biophysical and molecular properties of annexin-formed channels. Prog. Biophys. Mol. Biol. 73: 91-134. 10958928

Langen, R., J.M. Isas, W.L. Hubbell and H.T. Haigler (1998). A transmembrane form of annexin XII detected by site-directed spin labeling. Proc. Natl. Acad. Sci. USA 95: 14060-14065. 9826653

McNeil, A.K., U. Rescher, V. Gerke, and P.L. McNeil. (2006). Requirement for annexin A1 in plasma membrane repair. J. Biol. Chem. 281: 35202-35207. 16984915

Oling, F., J. Sopkova-de Oliviera Santos, N. Govorukhina, C. Mazères-Dubut, W. Bergsma-Schutter, G. Oostergetel, W. Keegstra, O. Lambert, A. Lewit-Bentley and A. Brisson (2000). Structure of membrane-bound annexin A5 trimers: a hybrid cryo-EM - X-ray crystallography study. J. Mol. Bio. 304: 561-573. 11099380

Riquelme, G., P. Llanos, E. Tischner., J. Neil, and B. Campos. (2004). Annexin 6 modulates the maxi-chloride channel of the apical membrane of syncytiotrophoblast isolated from human placenta. J. Biol. Chem. 279: 50601-50608. 15355961

Seaton, B.A. (1996). Annexins: Molecular structure to cellular function. R.G. Landes Company, Austin, Texas.

1.A.32

Fischer, W.B. and M.S. Sansom. (2002). Viral ion channels: structure and function. Biochim. Biophys. Acta 1561: 27-45. 11988179

Fischer, W.B., M. Pitkeathly, B.A. Wallace, L.R. Forrest, G.R. Smith, and M.S. Sansom. (2000). Transmembrane peptide NB of influenza B: a simulation, structure, and conductance study. Biochemistry 41: 12708-12716. 11027151

1.A.33

Arispe, N. and A. DeMaio. (2000). ATP and ADP modulate a cation channel formed by Hsc70 in acidic phospholipid membranes. J. Biol. Chem. 275: 30839-30843. 10899168

Gross, C., W. Koelch, A. DeMaio, N. Arispe, and G. Multhoff. (2003). Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B. J. Biol. Chem. 278: 41173-41181. 12874291

1.A.34

Camp, A.H. and R. Losick. (2008). A novel pathway of intercellular signalling in Bacillus subtilis involves a protein with similarity to a component of type III secretion channels. Mol. Microbiol. 69: 402-417. 18485064

Camp, A.H. and R. Losick. (2009). A feeding tube model for activation of a cell-specific transcription factor during sporulation in Bacillus subtilis. Genes Dev. 23: 1014-1024. 19390092

Kroos, L. (2009). Bacterial development: evidence for very short umbilical cords. Curr. Biol. 19: R452-453. 19515352

Meisner, J., X. Wang, M. Serrano, A.O. Henriques, and C.P. Moran, Jr. (2008). A channel connecting the mother cell and forespore during bacterial endospore formation. Proc. Natl. Acad. Sci. USA 105: 15100-15105. 18812514

1.A.35

Bui, D.M., J. Gregan, E. Jarosch, A. Ragnini and R.J. Schweyen. (1999). The bacterial magnesium transporter CorA can functionally substitute for its putative homologue Mrs2p in the yeast inner mitochondrial membrane. J. Biol. Chem. 274: 20438-20443. 10400670

Da Costa, B.M., K. Cornish, and J.D. Keasling. (2007). Manipulation of intracellular magnesium levels in Saccharomyces cerevisiae with deletion of magnesium transporters. Appl. Microbiol. Biotechnol. 77: 411-425. 17926032

Graschopf, A., J.A. Stadler, M.K. Hoellerer, S. Eder, M. Sieghardt, S.D. Kohlwein, and R.J. Schweyen. (2001). The yeast plasma membrane protein Alr1 controls Mg²⁺ homeostasis and is subject to Mg²⁺-dependent control of its synthesis and degradation. J. Biol. Chem. 276: 16216-16222. 11279208

Hantke, K. (1997). Ferrous iron uptake by a magnesium transport system is toxic for Escherichia coli and Salmonella typhimurium. J. Bacteriol. 179: 6201-6204. 9324273

Kehres, D.G., C.H. Lawyer, and M.E. Maguire. (1998). The CorA magnesium transporter gene family. Microbial Comp. Genom. 3: 151-169. 9775386

Kolisek, M., G. Zsurka, J. Samaj, J. Weghuber, R.J. Schweyen, and M. Schweigel. (2003). Mrs2p is an essential component of the major electrophoretic Mg²⁺ influx system in mitochondria. EMBO J. 22: 1235-1244. 12628916

Lunin, V.V., E. Dobrovetsky, G. Khutoreskaya, R. Zhang, A. Joachimiak, D.A. Doyle, A. Bochkarev, M.E. Maguire, A.M. Edwards, and C.M. Koth. (2006). Crystal structure of the CorA Mg²⁺ transporter. Nature 440: 833-837. 16598263

MacDiarmid, C.W. and R.C. Gardner. (1998). Overexpression of the Saccharomyces cerevisiae magnesium transport system confers resistance to aluminum ion. J. Biol. Chem. 273: 1727-1732. 9430719

Moomaw, A.S. and M.E. Maguire. (2010). Cation selectivity by the CorA Mg²⁺ channel requires a fully hydrated cation. Biochemistry 49: 5998-6008. 20568735

Papp, K.M. and M.E. Maguire. (2004). The CorA Mg²⁺ transporter does not transport Fe²⁺. J. Bacteriol. 186: 7653-7658. 15516579

Payandeh, J., C. Li, M. Ramjeesingh, E. Poduch, C.E. Bear, and E.F. Pai. (2008). Probing structure-function relationships and gating mechanisms in the CorA Mg²⁺ transport system. J. Biol. Chem. 283: 11721-11733. 18276588

Schindl, R., J. Weghuber, C. Romanin, and R.J. Schweyen. (2007). Mrs2p forms a high conductance Mg²⁺ selective channel in mitochondria. Biophys. J. 93: 3872-3883. 17827224

Smith, R.L. and M.E. Maguire. (1998). Microbial magnesium transport: unusual transporters searching for identity. Mol. Microbiol. 28: 217-226. 9622348

Smith, R.L., E. Gottlieb, L.M. Kucharski, and M.E. Maguire. (1998). Functional similarity between archaeal and bacterial CorA magnesium transporters. J. Bacteriol. 180: 2788-2791. 9573171

Smith, R.L., J.L. Banks, M.D. Snavely, and M.E. Maguire. (1993). Sequence and topology of the CorA magnesium transport systems of Salmonella typhimurium and Escherichia coli. Identification of a new class of transport protein. J. Biol. Chem. 268: 14071-14080. 8314774

Smith, R.L., M.A. Szegedy, L.M. Kucharski, C. Walker, R.M. Wiet, A. Redpath, M.T. Kaczmarek, and M.E. Maguire. (1998). The CorA Mg²⁺ transport protein of Salmonella typhimurium. Mutagenesis of conserved residues in the third membrane domain identifies a Mg²⁺ pore. J. Biol. Chem. 273: 28663-28669. 9786860

Tan, K., A. Sather, J.L. Robertson, S. Moy, B. Roux, and A. Joachimiak. (2009). Structure and electrostatic property of cytoplasmic domain of ZntB transporter. Protein. Sci. 18: 2043-2052. 19653298

ter Huurne, A.A., S. Muir, M. van Houten, B.A. van der Zeijst, W. Gaastra, and J.G. Kusters. (1994). Characterization of three putative Serpulina hyodysenteriae hemolysins. Microb Pathog. 16: 269-282. 7968456

Wang, S.Z., Y. Chen, Z.H. Sun, Q. Zhou, and S.F. Sui. (2006). Escherichia coli CorA periplasmic domain functions as a homotetramer to bind substrate. J. Biol. Chem. 281: 26813-26820. 16835234

Warren, M.A., L.M. Kucharski, A. Veenstra, L. Shi, P.F. Grulich, and M.E. Maguire. (2004). The CorA Mg²⁺ transporter is a homotetramer. J. Bacteriol. 186: 4605-4612. 15231793

Worlock, A.J. and R.L. Smith. (2002). ZntB is a novel Zn²⁺ transporter in Salmonella enterica serovar typhimurium. J. Bacteriol. 184: 4369-4373. 12142406

1.A.36

Nagasawa, M., M. Kanzaki, Y. Iino, Y. Morishita, and I. Kojima. (2001). Identification of a novel chloride channel expressed in the endoplasmic reticulum, Golgi apparatus, and nucleus. J. Biol. Chem. 276: 20413-20418. 11279057

1.A.37

Bubien, J.K., L.J. Zhou, P.D. Bell, R.A. Frizzell, and T.F. Tedder. (1993). Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca²⁺ conductance found constitutively in B lymphocytes. J. Cell Biol. 121: 1121-1132. 7684739

Kanzaki, M., L. Nie, H. Shibata, and I. Kojima. (1997a). Activation of a calcium-permeable cation channel CD20 expressed in Balb/c3T3 cells by insulin-like growth factor-I. J. Biol. Chem. 272: 4964-4969. 9030557

Kanzaki, M., M.A. Lindorfer, J.C. Garrison, and I. Kojima. (1997b). Activation of the calcium-permeable cation channel CD20 by alpha subunits of the Gi protein. J. Biol. Chem. 272: 14733-14739. 9169438

Tedder, T.F., G. Klejman, S.F. Schlossman, and H. Saito. (1989). Structure of the gene encoding the human B lymphocyte differentiation antigen CD20 (B1). J. Immunol. 142: 2560-2568. 2466899

1.A.38

Edwards, J.C. and C.R. Kahl. (2010). Chloride channels of intracellular membranes. FEBS Lett. [Epub: Ahead of Print] 20100480

Maeda, Y., T. Ide, M. Koike, Y. Uchiyama, and T. Kinoshita. (2008). GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. Nat. Cell Biol. 10: 1135-1145. 18794847

1.A.39

Fischer, W.B. and M.S. Sansom. (2002). Viral ion channels: structure and function. Biochim. Biophys. Acta 1561: 27-45. 11988179

1.A.40

Becker, C.F.W., M. Oblatt-Montal, G.G. Kochendoerfer, and M. Montal. (2004). Chemical synthesis and single channel properties of tetrameric and pentameric TASPs (template-assembled synthetic proteins) derived from the transmembrane domain of HIV virus protein u (Vpu). J. Biol. Chem. 279: 17483-17489. 14752102

Fischer, W.B. and M.S. Sansom. (2002). Viral ion channels: structure and function. Biochim. Biophys. Acta 1561: 27-45. 11988179

Hsu, K., J. Seharaseyon, P. Dong, S. Bour, and E. Marbán. (2004). Mutual functional destruction of HIB-1 Vpu and host TASK-1 channel. Mol. Cell 14: 259-267. 15099524

Lu, J.X., S. Sharpe, R. Ghirlando, W.M. Yau, and R. Tycko. (2010). Oligomerization state and supramolecular structure of the HIV-1 Vpu protein transmembrane segment in phospholipid bilayers. Protein. Sci. 19: 1877-1896. 20669237

Sharma, M., C. Li, D.D. Busath, H.X. Zhou, and T.A. Cross. (2011). Drug sensitivity, drug-resistant mutations, and structures of three conductance domains of viral porins. Biochim. Biophys. Acta. 1808: 538-546. 20655872

1.A.41

Bodelón, G., L. Labrada, J. Martínez-Costas, and J. Benavente. (2002). Modification of late membrane permeability in avian reovirus-infected cells. J. Biol. Chem. 277: 17789-17796. 11893756

1.A.42

Coeytaux, E., D. Coulaud, E. Le Cam, O. Danos, and A. Kichler. (2003). The cationic amphipathic α-helix of HIV-1 viral protein R (Vpr) binds to nucleic acids, permeabilizes membranes, and efficiently transfects cells. J. Biol. Chem. 278: 18110-18116. 12639957

1.A.43

Grahn, A.M., R. Daugelavicius, and D.H. Bamford. (2002). Sequential model of phage PRD1 DNA delivery: active involvement of the viral membrane. Mol. Microbiol. 46: 1199-1209. 12453208

Poranen, M.M., R. Daugelavicius, and D.H. Bamford. (2002). Common principles in viral entry. Annu. Rev. Microbiol. 56: 521-538. 12142475

1.A.44

Boulanger, P., P. Jacquot, L. Plançon, M. Chami, A. Engel, C. Parquet, C. Herbeuval, and L. Letellier. (2008). Phage T5 straight tail fiber is a multifunctional protein acting as a tape measure and carrying fusogenic and muralytic activities. J. Biol. Chem. 283: 13556-13564. 18348984

Feucht, A., A. Schmid, R. Benz, H. Schwarz, and K.J. Heller. (1990). Pore formation associated with the tail-tip protein pb2 of bacteriophage T5. J. Biol. Chem. 265: 18561-18567. 1698788

Poranen, M.M., R. Daugelavicius, and D.H. Bamford. (2002). Common principles in viral entry. Annu. Rev. Microbiol. 56: 521-538. 12142475

1.A.45

Israel, V. (1977). E proteins of bacteriophage P22. I. Identification and ejection from wild-type and defective particles. J. Virol. 23: 91-97. 328927

Perez, G.L. and S. Maloy, personal communication.

Perez, G.L., B. Huynh, M. Slater, and S. Maloy. (2009). Transport of phage P22 DNA across the cytoplasmic membrane. J. Bacteriol. 191: 135-140. 18978055

1.A.46

Burgess, R., I.D. Millar, B.P. Leroy, J.E. Urquhart, I.M. Fearon, E. De Baere, P.D. Brown, A.G. Robson, G.A. Wright, P. Kestelyn, G.E. Holder, A.R. Webster, F.D. Manson, and G.C. Black. (2008). Biallelic mutation of BEST1 causes a distinct retinopathy in humans. Am. J. Hum. Genet. 82: 19-31. 18179881

Hagen, A.R., R.D. Barabote, and M.H. Saier. (2005). The bestrophin family of anion channels: identification of prokaryotic homologues. Mol. Membr. Biol. 22: 291-302. 16154901

O'Driscoll, K.E., W.J. Hatton, H.R. Burkin, N. Leblanc, and F.C. Britton. (2008). Expression, localization, and functional properties of Bestrophin 3 channel isolated from mouse heart. Am. J. Physiol. Cell Physiol. 295: C1610-1624. 18945938

Petrukhin, K., M.J. Koisti, B. Bakall, W. Li, G. Xie, T. Marknell, O. Sandgren, K. Forsman, G. Holmgren, S. Andreasson, M. Vujic, A.A. Bergen, V. McGarty-Dugan, D. Figueroa, C.P. Austin, M.L. Metzker, C.T. Caskey, and C. Wadelius. (1998). Identification of the gene responsible for Best macular dystrophy. Nat. Genet. 19: 241-247. 9662395

Qu, Z. and H.C. Hartzell. (2008). Bestrophin Cl^- channels are highly permeable to HCO₃^-. Am. J. Physiol. Cell Physiol. 294: C1371-1377. 18400985

Qu, Z., W. Cheng, Y. Cui, Y. Cui, and J. Zheng. (2009). Human disease-causing mutations disrupt an N-C-terminal interaction and channel function of bestrophin 1. J. Biol. Chem. 284: 16473-16481. 19372599

Qu, Z., Y. Cui, and C. Hartzell. (2006). A short motif in the C-terminus of mouse bestrophin 3 [corrected] inhibits its activation as a Cl channel. FEBS Lett. 580: 2141-2146. 16563389

Roberts, S.K., J. Milnes, and M. Caddick. (2011). Characterisation of AnBEST1, a functional anion channel in the plasma membrane of the filamentous fungus, Aspergillus nidulans. Fungal Genet Biol 48: 928-938. 21596151

Sun, H., T. Tsunenari, K.-W. Yau, and J. Nathans. (2002). The vitelliform macular dystrophy protein defines a new family of chloride channels. Proc. Natl. Acad. Sci. USA 99: 4008-4013. 11904445

Tsunenari, T., H. Sun, J. Williams, H. Cahill, P. Smallwood, K.-W. Yau, and J. Nathans. (2003). Structure-function analysis of the Bestrophin family of anion channels. J. Biol. Chem. 278: 41114-41125. 12907679

Xiao, Q., A. Prussia, K. Yu, Y.Y. Cui, and H.C. Hartzell. (2008). Regulation of bestrophin Cl channels by calcium: role of the C terminus. J Gen Physiol 132: 681-692. 19029375

Xiao, Q., K. Yu, Y.Y. Cui, and H.C. Hartzell. (2009). Dysregulation of human bestrophin-1 by ceramide-induced dephosphorylation. J. Physiol. 587: 4379-4391. 19635817

Yu, K., Q. Xiao, G. Cui, A. Lee, and H.C. Hartzell. (2008). The best disease-linked Cl^- channel hBest1 regulates Ca V 1 (L-type) Ca²⁺ channels via src-homology-binding domains. J. Neurosci. 28: 5660-5670. 18509027

Yu, K., Y. Cui, and H.C. Hartzell. (2006). The bestrophin mutation A243V, linked to adult-onset vitelliform macular dystrophy, impairs its chloride channel function. Invest Ophthalmol Vis Sci 47: 4956-4961. 17065513

1.A.47

Ritter, M., A. Ravasio, M. Jakab, S. Chwatal, J. Fürst, A. Laich, M. Gschwenter, S. Signorelli, C. Burtscher, S. Eichmüller, and M. Paulmichl. (2003). Cell swelling stimulates cytosol to membrane transposition of ICln. J. Biol. Chem. 278: 50163-50174. 12970357

1.A.48

He, Y., A.J. Ramsay, M.L. Hunt, A.K. Whitbread, S.A. Myers, and J.D. Hooper. (2008). N-glycosylation analysis of the human Tweety family of putative chloride ion channels supports a penta-spanning membrane arrangement: impact of N-glycosylation on cellular processing of Tweety homologue 2 (TTYH2). Biochem. J. 412: 45-55. 18260827

Suzuki, M. and A. Mizuno. (2004). A novel human Cl^- channel family related to Drosophila flightless locus. J. Biol. Chem. 279: 22461-22468. 15010458

1.A.49

Griffiths, E.J., D. Balaska, and W.H. Cheng. (2010). The ups and downs of mitochondrial calcium signalling in the heart. Biochim. Biophys. Acta. 1797: 856-864. 20188059

Hoppe, U.C. (2010). Mitochondrial calcium channels. FEBS Lett. 584: 1975-1981. 20388514

Kirichok, Y., G. Krapivinsky, and D.E. Clapham. (2004). The mitochondrial calcium uniporter is a highly selective ion channel. Nature 427: 360-364. 14737170

Mironova, G.D., M. Baumann, O. Kolomytkin, Z. Krasichkova, A. Berdimuratov, T. Sirota, I. Virtanen, and N.E. Saris. (1994). Purification of the channel component of the mitochondrial calcium uniporter and its reconstitution into planar lipid bilayers. J. Bioenerg. Biomembr. 26: 231-238. 8056790

1.A.50

Asahi, M., N.M. Green, K. Kurzydlowski, M. Tada, and D.H. MacLennan. (2001). Phospholamban domain IB forms an interaction site with the loop between transmembrane helices M6 and M7 of sarco(endo)plasmic reticulum Ca²⁺ ATPases. Proc. Natl. Acad. Sci. USA 98: 10061-10066. 11526231

Asahi, M., Y. Kimura, K. Kurzydlowski, M. Tada and D.H. MacLennan (1999). Transmembrane helix M6 in Sarco(endo)plasmic reticulum Ca²⁺-ATPase forms a functional interaction site. J. Biol. Chem. 274: 32855-32862. 10551848

Babu, G.J., P. Bhupathy, N.N. Petrashevskaya, H. Wang, S. Raman, D. Wheeler, G. Jagatheesan, D. Wieczorek, A. Schwartz, P.M. Janssen, M.T. Ziolo, and M. Periasamy. (2006). Targeted overexpression of sarcolipin in the mouse heart decreases sarcoplasmic reticulum calcium transport and cardiac contractility. J. Biol. Chem. 281: 3972-3979. 16365042

Becucci, L., A. Cembran, C.B. Karim, D.D. Thomas, R. Guidelli, J. Gao, and G. Veglia. (2009). On the function of pentameric phospholamban: ion channel or storage form? Biophys. J. 96: L60-62. 19450461

Chu, G., L. Li, Y. Sato, J.M. Harrer, V.J. Kadambi, B.D. Hoit, D.M. Bers and E.G. Kranias (1998). Pentameric assembly of phospholamban facilitates inhibition of cardiac function in vivo. J. Biol. Chem. 273: 33674-33680. 9837953

Fujii, J., A. Zarain-Herzberg, H.F. Willard, M. Tada and D.H. MacLennan (1991). Structure of the rabbit phospholamban gene, cloning of the human cDNA, and assignment of the gene to human chromosome 6. J. Biol. Chem. 266: 11669-11675. 1828805

Hughes, E. and D.A. Middleton. (2003). Solid-state NMR reveals structural changes in phospholamban accompanying the functional regulation of Ca²⁺-ATPase. J. Biol. Chem. 278: 20835-20842. 12556441

Hughes, E., J.C. Clayton, A. Kitmitto, M. Esmann, and D.A. Middleton. (2007). Beta-sheet pore-forming peptides selected from a rational combinatorial library: mechanism of pore formation in lipid vesicles and activity in biological membranes. J. Biol. Chem. 282(36):26603-26613.

Hughes, E., R. Edwards, and D.A. Middleton. (2010). Heparin-derived oligosaccharides interact with the phospholamban cytoplasmic domain and stimulate SERCA function. Biochem. Biophys. Res. Commun. 401: 370-375. 20851101

Kovacs, R.J., M.T. Nelson, H.K. Simmerman, and L.R. Jones. (1988). Phospholamban forms Ca²⁺-selective channels in lipid bilayers. J. Biol. Chem. 263: 18364-18368. 2848034

Mall, S., R. Broadbridge, S.L. Harrison, M.G. Gore, A.G. Lee, and J.M. East. (2006). The presence of sarcolipin results in increased heat production by Ca²⁺-ATPase. J. Biol. Chem. 281: 36597-36602. 17018526

Minamisawa, S., M. Hoshijima, G. Chu, C.A. Ward, K. Frank, Y. Gu, M.E. Martone, Y. Wang, J. Ross, Jr., E.G. Kranias, W.R. Giles and K.R. Chien (1999). Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. Cell 99: 313-322. 10555147

Shannon, T.R., G. Chu, E.G. Kranias and D.M. Bers (2001). Phospholamban decreases the energetic efficiency of the sarcoplasmic reticulum Ca pump. J. Biol. Chem. 276: 7195-7201. 11087739

1.A.51

Chanda, B., and F. Bezanilla (2008). A common pathway for charge transport through voltage-sensing domains. Neuron 57: 345-51. 18255028

DeCoursey, T.E. (2008). Voltage-gated proton channels: what's next? J. Physiol. 586: 5305-5324. 18801839

Demaurex, N. and A. El Chemaly. (2010). Physiological roles of voltage-gated proton channels in leukocytes. J. Physiol. 588: 4659-4665. 20693294

Koch, H.P., T. Kurokawa, Y. Okochi, M. Sasaki, Y. Okamura, and H.P. Larsson. (2008). Multimeric nature of voltage-gated proton channels. Proc. Natl. Acad. Sci. USA 105: 9111-9116. 18583477

Lee, S.Y., J.A. Letts, and R. Mackinnon. (2008). Dimeric subunit stoichiometry of the human voltage-dependent proton channel Hv1. Proc. Natl. Acad. Sci. USA 105: 7692-7695. 18509058

Lee, S.Y., J.A. Letts, and R. MacKinnon. (2009). Functional reconstitution of purified human Hv1 H⁺ channels. J. Mol. Biol. 387: 1055-1060. 19233200

Musset, B., M. Capasso, V.V. Cherny, D. Morgan, M. Bhamrah, M.J. Dyer, and T.E. DeCoursey. (2010). Identification of Thr29 as a critical phosphorylation site that activates the human proton channel Hvcn1 in leukocytes. J. Biol. Chem. 285: 5117-5121. 20037153

Nelson, R.D., G. Kuan, M.H. Saier, Jr., and M. Montal. (1999). Modular assembly of voltage-gated channel proteins: a sequence analysis and phylogenetic study. J. Mol. Microbiol. Biotechnol. 2: 281-287. 10943557

Ramsey, I.S., M.M. Moran, J.A. Chong, and D.E. Clapham. (2006). A voltage-gated proton-selective channel lacking the pore domain. Nature 440: 1213-1216. 16554753

Sasaki, M., M. Takagi, and Y. Okamura. (2006). A voltage sensor-domain protein is a voltage-gated proton channel. Science 312: 589-592. 16556803

Smith, S.M., D. Morgan, B. Musset, V.V. Cherny, A.R. Place, J.W. Hastings, and T.E. Decoursey. (2011). Voltage-gated proton channel in a dinoflagellate. Proc. Natl. Acad. Sci. USA 108: 18162-18167. 22006335

Tombola, F., M.H. Ulbrich, and E.Y. Isacoff. (2008). The voltage-gated proton channel Hv1 has two pores, each controlled by one voltage sensor. Neuron. 58: 546-556. 18498736

Tombola, F., M.H. Ulbrich, and E.Y. Isacoff. (2009). Architecture and gating of Hv1 proton channels. J. Physiol. 587: 5325-5329. 19915215

1.A.52

Baba, Y., K. Hayashi, Y. Fujii, A. Mizushima, H. Watarai, M. Wakamori, T. Numaga, Y. Mori, M. Iino, M. Hikida, and T. Kurosaki. (2006). Coupling of STIM1 to store-operated Ca²⁺ entry through its constitutive and inducible movement in the endoplasmic reticulum. Proc. Natl. Acad. Sci. U.S.A. 103(45):16704-16709.

Bird, G.S., S.Y. Hwang, J.T. Smyth, M. Fukushima, R.R. Boyles, and J.W. Putney, Jr. (2009). STIM1 is a calcium sensor specialized for digital signaling. Curr. Biol. 19: 1724-1729. 19765994

Bolotina, V.M. (2008). Orai, STIM1 and iPLA2beta: a view from a different perspective. J. Physiol. 586: 3035-3042. 18499724

Cahalan, M.D. (2009). STIMulating store-operated Ca²⁺ entry. Nat. Cell Biol. 11: 669-677. 19488056

Cheng, K.T., X. Liu, H.L. Ong, and I.S. Ambudkar. (2008). Functional requirement for Orai1 in store-operated TRPC1-STIM1 channels. J. Biol. Chem. 283: 12935-12940. 18326500

Clapham, D.E. (2009). A STIMulus Package puts orai calcium channels to work. Cell 136: 814-816. 19269360

DeHaven, W.I., J.T. Smyth, R.R. Boyles, G.S. Bird, and J.W. Putney, Jr. (2008). Complex actions of 2-aminoethyldiphenyl borate on store-operated calcium entry. J. Biol. Chem. 283: 19265-19273. 18487204

Demuro, A., A. Penna, O. Safrina, A.V. Yeromin, A. Amcheslavsky, M.D. Cahalan, and I. Parker. (2011). Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states. Proc. Natl. Acad. Sci. USA 108: 17832-17837. 21987805

Feske, S., Y. Gwack, M. Prakriya, S. Srikanth, S.H. Puppel, B. Tanasa, P.G. Hogan, R.S. Lewis, M. Daly, and A. Rao. (2006). A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature 441: 179-185. 16582901

Gross, S.A., U. Wissenbach, S.E. Philipp, M. Freichel, A. Cavalié, and V. Flockerzi. (2007). Murine ORAI2 splice variants form functional Ca²⁺ release-activated Ca²⁺ (CRAC) channels. J. Biol. Chem. 282: 19375-19384. 17463004

Hogan, P.G., and A. Rao. (2007). Dissecting ICRAC, a store-operated calcium current. Trends Biochem. Sci. 32: 235-245. 17434311

Ji, W., P. Xu, Z. Li, J. Lu, L. Liu, Y. Zhan, Y. Chen, B. Hille, T. Xu, and L. Chen. (2008). Functional stoichiometry of the unitary calcium-release-activated calcium channel. Proc. Natl. Acad. Sci. USA 105: 13668-13673. 18757751

Lee, K.P., J.P. Yuan, W. Zeng, I. So, P.F. Worley, and S. Muallem. (2009). Molecular determinants of fast Ca²⁺-dependent inactivation and gating of the Orai channels. Proc. Natl. Acad. Sci. USA 106: 14687-14692. 19706554

Lis, A., C. Peinelt, A. Beck, S. Parvez, M. Monteilh-Zoller, A. Fleig, and R. Penner. (2007). CRACM1, CRACM2, and CRACM3 are store-operated Ca²⁺ channels with distinct functional properties. Curr. Biol. 17: 794-800. 17442569

Lis, A., S. Zierler, C. Peinelt, A. Fleig, and R. Penner. (2010). A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating. J Gen Physiol 136: 673-686. 21115697

Maruyama, Y., T. Ogura, K. Mio, K. Kato, T. Kaneko, S. Kiyonaka, Y. Mori, and C. Sato. (2009). Tetrameric Orai1 Is a Teardrop-shaped Molecule with a Long, Tapered Cytoplasmic Domain. J. Biol. Chem. 284: 13676-13685. 19289460

Matias, M.G., K.M. Gomolplitinant, D.G. Tamang, and M.H. Saier, Jr. (2010). Animal Ca²⁺ release-activated Ca²⁺ (CRAC) channels appear to be homologous to and derived from the ubiquitous cation diffusion facilitators. BMC Res Notes 3: 158-159. 20525303

McNally, B.A., M. Yamashita, A. Engh, and M. Prakriya. (2009). Structural determinants of ion permeation in CRAC channels. Proc. Natl. Acad. Sci. USA 106: 22516-22521. 20018736

Mercer, J.C., W.I. Dehaven, J.T. Smyth, B. Wedel, R.R. Boyles, G.S. Bird, and J.W. Putney, Jr. (2006). Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. J. Biol. Chem. 281: 24979-24990. 16807233

Mignen, O., J.L. Thompson, and T.J. Shuttleworth. (2008a). Orai1 subunit stoichiometry of the mammalian CRAC channel pore. J. Physiol. 586: 419-425. 18006576

Mignen, O., J.L. Thompson, and T.J. Shuttleworth. (2008b). Both Orai1 and Orai3 are essential components of the arachidonate-regulated Ca²⁺-selective (ARC) channels. J. Physiol. 586: 185-195. 17991693

Mignen, O., J.L. Thompson, and T.J. Shuttleworth. (2009). The molecular architecture of the arachidonate-regulated Ca²⁺-selective ARC channel is a pentameric assembly of Orai1 and Orai3 subunits. J. Physiol. [Epub: Ahead of Print] 19622606

Motiani, R.K., I.F. Abdullaev, and M. Trebak. (2010). A novel native store-operated calcium channel encoded by Orai3: selective requirement of Orai3 versus Orai1 in estrogen receptor-positive versus estrogen receptor-negative breast cancer cells. J. Biol. Chem. 285: 19173-19183. 20395295

Park, C.Y., P.J. Hoover, F.M. Mullins, P. Bachhawat, E.D. Covington, S. Raunser, T. Walz, K.C. Garcia, R.E. Dolmetsch, and R.S. Lewis. (2009). STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1. Cell 136: 876-890. 19249086

Peinelt, C., A. Lis, A. Beck, A. Fleig, and R. Penner. (2008). 2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels. J. Physiol. 586: 3061-3073. 18403424

Peinelt, C., M. Vig, D.L. Koomoa, A. Beck, M.J. Nadler, M. Koblan-Huberson, A. Lis, A. Fleig, R. Penner, and J.P. Kinet. (2006). Amplification of CRAC current by STIM1 and CRACM1 (Orai1). Nat. Cell. Biol. 8: 771-773. 16733527

Penna, A., A. Demuro, A.V. Yeromin, S.L. Zhang, O. Safrina, I. Parker, and M.D. Cahalan. (2008). The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers. Nature 456: 116-120. 18820677

Schindl, R., J. Bergsmann, I. Frischauf, I. Derler, M. Fahrner, M. Muik, R. Fritsch, K. Groschner, and C. Romanin. (2008). 2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size. J. Biol. Chem. 283: 20261-20267. 18499656

Soboloff, J., M.A. Spassova, X.D. Tang, T. Hewavitharana, W. Xu, and D.L. Gill. (2006). Orai1 and STIM reconstitute store-operated calcium channel function. J. Biol. Chem. 281: 20661-20665. 16766533

Srikanth, S., H.J. Jung, B. Ribalet, and Y. Gwack. (2010). The intracellular loop of Orai1 plays a central role in fast inactivation of Ca²⁺ release-activated Ca²⁺ channels. J. Biol. Chem. 285: 5066-5075. 20007711

Vig, M., C. Peinelt, A. Beck, D.L. Koomoa, D. Rabah, M. Koblan-Huberson, S. Kraft, H. Turner, A. Fleig, R Penner, and J.P. Kinet. (2006). CRACM1 is a plasma membrane protein essential for store-operated Ca²⁺ entry. Science 312: 1220-1223. 16645049

Yamashita, M., L. Navarro-Borelly, B.A. McNally, and M. Prakriya. (2007). Orai1 mutations alter ion permation and Ca²⁺-dependent fast inactivation of CRAC channels: evidence for coupling of permeation and gating. J. Gen. Physiol. 130(5):525-540.

Yeromin, A.V., S.L. Zhang, W. Jiang, Y. Yu, O. Safrina, and M.D. Cahalan. (2006). Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai. Nature 443: 226-229. 16921385

Zhang, S.L., A.V. Yeromin, J. Hu, A. Amcheslavsky, H. Zheng, and M.D. Cahalan. (2011). Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91. Proc. Natl. Acad. Sci. USA 108: 17838-17843. 21987804

Zhang, S.L., J.A. Kozak, W. Jiang, A.V. Yeromin, J. Chen, Y. Yu, A. Penna, W. Shen, V. Chi, and M.D. Cahalan. (2008). Store-dependent and -independent modes regulating Ca²⁺ release-activated Ca²⁺ channel activity of human Orai1 and Orai3. J. Biol. Chem. 283: 17662-17671. 18420579

Zhou, Y., S. Ramachandran, M. Oh-Hora, A. Rao, and P.G. Hogan. (2010). Pore architecture of the ORAI1 store-operated calcium channel. Proc. Natl. Acad. Sci. USA 107: 4896-4901. 20194792

1.A.53

Clarke, D., Griffin, S., Beales, L., Gelais, C.S., Burgess, S., Harris, M., and Rowlands, D. (2006). Evidence for the formation of a heptameric ion channel complex by the hepatitis C virus p7 protein in vitro. J. Biol. Chem. 281: 37057-37068. 17032656

Madan, V., S. Sánchez-Martínez, N. Vedovato, G. Rispoli, L. Carrasco, and J.L. Nieva. (2007). Plasma membrane-porating domain in poliovirus 2B protein. A short peptide mimics viroporin activity. J. Mol. Biol. 374(4):951-964. 17963782

1.A.54

Annaert, W. and B. De Strooper. (2002). A cell biological perspective on Alzheimer's disease. Annu. Rev. Cell Dev. Biol. 18: 25-51. 12142279

Cheung, K.H., D. Shineman, M. Müller, C. Cárdenas, L. Mei, J. Yang, T. Tomita, T. Iwatsubo, V.M. Lee, and J.K. Foskett. (2008). Mechanism of Ca²⁺ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating. Neuron. 58: 871-883. 18579078

Cipolat, S., T. Rudka, D. Hartmann, V. Costa, L. Serneels, K. Craessaerts, K. Metzger, C. Frezza, W. Annaert, L. D'Adamio, C. Derks, T. Dejaegere, L. Pellegrini, R. D'Hooge, L. Scorrano, and B. De Strooper. (2006). Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell 126: 163-175. 16839884

Eckert, G.P. and W.E. Müller. (2009). Presenilin 1 modifies lipid raft composition of neuronal membranes. Biochem. Biophys. Res. Commun. 382: 673-677. 19292975

Kim, J. and R. Schekman. (2004). The ins and outs of presenilin 1 membrane topology. Proc. Natl. Acad. Sci. USA 101: 905-906. 14732690

Laudon, H., E.M. Hansson, K. Melen, A. Bergman, M.R. Farmery, B. Winblad, U. Lendahl, G. von Heijne, and J. Naslund. (2005). A nine-transmembrane domain topology for presenilin 1. J. Biol. Chem. 280: 35352-35360. 16046406

Smith, I.F., K.N. Green, and F.M. LaFerla. ((2005)). Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animals. Cell Calcium 38: 427-437. 16125228

Spasic, D., A. Tolia, K. Dillen, V. Baert, B. De Strooper, S. Vrijens, and W. Annaert. (2006). Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway. J. Biol. Chem. 281: 26569-26577. 16846981

Takagi, S., A. Tominaga, C. Sato, T. Tomita, and T. Iwatsubo. (2010). Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase. J. Neurosci. 30: 15943-15950. 21106832

Tandon, A. and P. Fraser. (2002). The presenilins. Genome Biol. 3: (E-pub). 12429067

Tu, H., O. Nelson, A. Bezprozvanny, Z. Wang, S.F. Lee, Y.H. Hao, L. Serneels, B. De Strooper, G. Yu, and I. Bezprozvanny. (2006). Presenilins form ER Ca²⁺ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell 126: 981-993. 16959576

Wolfe, M.S. and R. Kopan. (2004). Intramembrane proteolysis: theme and variations. Science 305: 1119-1123. 15326347

1.A.55

Yao, C.K., Y.Q. Lin, C.V. Ly, T. Ohyama, C.M. Haueter, V.Y. Moiseenkova-Bell, T.G. Wensel, and H.J. Bellen. (2009). A synaptic vesicle-associated Ca²⁺ channel promotes endocytosis and couples exocytosis to endocytosis. Cell 138: 947-960. 19737521

1.A.56

Aller, S.G. and V.M. Unger. (2006). Projection structure of the human copper transporter CTR1 at 6 Ĺ resolution reveals a compact trimer with a novel channel-like architecture. Proc. Natl. Acad. Sci. USA 103: 3627-3632. 16501047

Andrews, N.C. (2001). Mining copper transport genes. Proc. Natl. Acad. Sci. USA 98: 6543-6545. 11390990

Barhoom, S., M. Kupiec, X. Zhao, J.R. Xu, and A. Sharon. (2008). Functional characterization of CgCTR2, a putative vacuole copper transporter that is involved in germination and pathogenicity in Colletotrichum gloeosporioides. Eukaryot. Cell. 7: 1098-1108. 18456860

Beaudoin, J., D.J. Thiele, S. Labbé, and S. Puig. (2011). Dissection of the relative contribution of the Schizosaccharomyces pombe Ctr4 and Ctr5 proteins to the copper transport and cell surface delivery functions. Microbiology. [Epub: Ahead of Print] 21273250

Bellemare, D.R., L. Shaner, K.A. Morano, J. Beaudoin, R. Langlois, and S. Labbé. (2002). Ctr6, a vacuolar membrane copper transporter in Schizosaccharomyces pombe. J. Biol. Chem. 277: 46676-46686. 12244050

Bertinato, J., E. Swist, L.J. Plouffe, S.P. Brooks, and M.R. L'abbé. (2008). Ctr2 is partially localized to the plasma membrane and stimulates copper uptake in COS-7 cells. Biochem. J. 409(3): 731-740. 17944601

Bertinato, J., N. Hidiroglou, R. Peace, K.A. Cockell, K.D. Trick, P. Jee, A. Giroux, R. Madère, G. Bonacci, M. Iskandar, S. Hayward, N. Giles, and M.R. L'Abbé. (2007). Sparing effects of selenium and ascorbic acid on vitamin C and E in guinea pig tissues. Nutr J 6: 7. 17386096

Dancis, A., D. Haile, D.S. Yuan, and R.D. Klausner. (1994a). The Saccharomyces cerevisiae copper transport protein (Ctrlp). Biochemical characterization, regulation by copper, and physiologic role in copper uptake. J. Biol. Chem. 269: 25660-25667. 7929270

Dancis, A., D.S. Yuan, D. Haile, C. Askwith, D. Eide, C. Moehle, J. Kaplan, and R.D. Klausner. (1994b). Molecular characterization of a copper transport protein in S. cerevisiae: An unexpected role for copper in iron transport. Cell 76: 393-402. 8293472

De Feo, C.J., S. Mootien, and V.M. Unger. (2010). Tryptophan scanning analysis of the membrane domain of CTR-copper transporters. J. Membr. Biol. 234: 113-123. 20224886

De Feo, C.J., S.G. Aller, and V.M. Unger. (2007). A structural perspective on copper uptake in eukaryotes. Biometals 20: 705-716. 17211682

De Feo, C.J., S.G. Aller, G.S. Siluvai, N.J. Blackburn, and V.M. Unger. (2009). Three-dimensional structure of the human copper transporter hCTR1. Proc. Natl. Acad. Sci. USA 106: 4237-4242. 19240214

Dumay, Q.C., A.J. Debut, N.M. Mansour, and M.H. Saier, Jr. (2006). The copper transporter (Ctr) family of Cu⁺ uptake systems. J. Mol. Microbiol. Biotechnol. 11: 10-19. 16825786

Eide, D. and M. L. Guerinot. (1997). Metal ion uptake in eukaryotes. ASM News 63: 199-205.

Eisses, J.F. and J.H. Kaplan. (2002). Molecular characterization of hCTR1, the human copper uptake protein. J. Biol. Chem. 277: 29162-29171. 12034741

Eisses, J.F. and Kaplan, J.H. (2005). The mechanism of copper uptake mediated by human CTR1: a mutational analysis. J. Biol. Chem. 280: 37159-37168. 16135512

Guo, Y., K. Smith, and M.J. Petris. (2004). Cisplatin stabilizes a multimeric complex of the human Ctr1 copper transporter. Requirement for the extracellular methionine-rich clusters. J. Biol. Chem. 279: 46393-46399. 15326162

Harris, E.D. (2000). Cellular copper transport and metabolism. Annu. Rev. Nutr. 20: 291-310. 10940336

Kaplan, J.H. and S. Lutsenko. (2009). Copper transport in mammalian cells: special care for a metal with special needs. J. Biol. Chem. 284: 25461-25465. 19602511

Kuo, Y.-M., B. Zhou, D. Cosco, and J. Gitschier. (2001). The copper transporter CTR1 provides an essential function in mammalian embryonic development. Proc. Natl. Acad. Sci. USA 98: 6836-6841. 11391004

Lee, J., J.R. Prohaska, and D.J. Thiele. (2001). Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development. Proc. Natl. Acad. Sci. USA 98: 6842-6847. 11391005

Lee, J., M.M.O. Peńa, Y. Nose, and D.J. Thiele. (2002). Biochemical characterization of the human copper transporter Ctr1. J. Biol. Chem. 277: 4380-4387. 11734551

Lee, S., S.B. Howell, and S.J. Opella. (2007). NMR and mutagenesis of human copper transporter 1 (hCtr1) show that Cys-189 is required for correct folding and dimerization. Biochim. Biophys. Acta. 1768: 3127-3134. 17959139

Marvin, M.E., R.P. Mason, and A.M. Cashmore. (2004). The CaCTR1 gene is required for high-affinity iron uptake and is transcriptionally controlled by a copper-sensing transactivator encoded by CaMAC1. Microbiology 150: 2197-2208. 15256562

Molloy, S.A. and J.H. Kaplan. (2009). Copper-dependent recycling of hCTR1, the human high affinity copper transporter. J. Biol. Chem. 284: 29704-29713. 19740744

Nose, Y., E.M. Rees, and D.J. Thiele. (2006). Structure of the Ctr1 copper trans'PORE'ter reveals novel architecture. Trends Biochem. Sci. 31: 604-607. 16982196

Page, M.D., J. Kropat, P.P. Hamel, and S.S. Merchant. (2009). Two Chlamydomonas CTR Copper Transporters with a Novel Cys-Met Motif Are Localized to the Plasma Membrane and Function in Copper Assimilation. Plant Cell 21: 928-943. 19318609

Puig, S., J. Lee, M. Lau, and D.J. Thiele. (2002). Biochemical and genetic analyses of yeast and human high affinity copper transporters suggest a conserved mechanism for copper uptake. J. Biol. Chem. 277: 26021-26030. 11983704

Rees, E.M. and D.J. Thiele. (2007). Identification of a vacuole-associated metalloreductase and its role in Ctr2-mediated intracellular copper mobilization. J. Biol. Chem. 282: 21629-21638. 17553781

Rubino, J.T., M.P. Chenkin, M. Keller, P. Riggs-Gelasco, and K.J. Franz. (2011). A comparison of methionine, histidine and cysteine in copper(I)-binding peptides reveals differences relevant to copper uptake by organisms in diverse environments. Metallomics 3: 61-73. 21553704

Rubino, J.T., P. Riggs-Gelasco, and K.J. Franz. (2010). Methionine motifs of copper transport proteins provide general and flexible thioether-only binding sites for Cu(I) and Ag(I). J Biol Inorg Chem 15: 1033-1049. 20437064

Sancenón, V., S. Puig, I. Nateu-Andrés, E. Dorcey, D.J. Thiele, and L. Peńarrubia. (2004). The Arabidopsis copper transporter COPT1 functions in root elongation and pollen development. J. Biol. Chem. 279: 15348-15355. 14726516

Sinani, D., D.J. Adle, H. Kim, and J. Lee. (2007). Distinct mechanisms for Ctr1-mediated copper and cisplatin transport. J. Biol. Chem. 282: 26775-26785. 17627943

Soll, S.J., S.J. Neil, and P.D. Bieniasz. (2010). Identification of a receptor for an extinct virus. Proc. Natl. Acad. Sci. USA 107: 19496-19501. 20974973

Turski, M.L., and D.J. Thiele. (2007). Drosophila Ctr1A functions as a copper transporter essential for development. J. Biol. Chem. 282: 24017-24026. 17573340

Wu, X., D. Sinani, H. Kim, and J. Lee. (2009). Copper transport activity of yeast Ctr1 is down-regulated via its C terminus in response to excess copper. J. Biol. Chem. 284: 4112-4122. 19088072

Zhou H., K.M. Cadigan, D.J. Thiele. (2003) A copper-regulated transporter required for copper acquisition, pigmentation, and specific stages of development in Drosophila melanogaster. J. Biol. Chem. 278:48210-48218. 12966081

Zhou, B. and J. Gitschier. (1997). hCTR1: a human gene for copper uptake identified by complementation in yeast. Proc. Natl. Acad. Sci. USA 94: 7481-7486. 9207117

Zhou, H. and D.J. Thiele. (2001). Identification of a novel high affinity copper transport complex in the fission yeast Schizosaccharomyces pombe. J. Biol. Chem. 276: 20529-20535. 11274192

Zimnicka, A.M., E.B. Maryon, and J.H. Kaplan. (2007). Human copper transporter hCTR1 mediates basolateral uptake of copper into enterocytes: implications for copper homeostasis. J. Biol. Chem. 282: 26471-26480. 17627945

1.A.57

Lu W., B.J. Zheng, K. Xu, W. Schwarz, L. Du, C.K. Wong, J. Chen, S. Duan, V. Deubel, B. Sun. (2006). Severe acute respiratory syndrome-associated coronavirus 3a protein forms an ion channel and modulates virus release. Proc. Natl. Acad. Sci. U.S.A. 103: 12540-12545. 16894145

1.A.58

Balannik, V., R.A. Lamb, and L.H. Pinto. (2008). The oligomeric state of the active BM2 ion channel protein of influenza B virus. J. Biol. Chem. 283(8): 4895-4904. 18073201

Imai, M., K. Kawasaki, and T. Odagiri. (2008). Cytoplasmic domain of influenza B virus BM2 protein plays critical roles in production of infectious virus. J. Virol. 82: 728-739. 17989175

Ma, C., C.S. Soto, Y. Ohigashi, A. Taylor, V. Bournas, B. Glawe, M.K. Udo, W.F. Degrado, R.A. Lamb, and L.H. Pinto. (2008). Identification of the Pore-lining Residues of the BM2 Ion Channel Protein of Influenza B Virus. J. Biol. Chem. 283: 15921-15931. 18408016

Mould J.A., R.G. Paterson, M. Takeda, Y. Ohigashi, P. Venkataraman, R.A. Lamb, L.H. Pinto. (2003). Influenza B virus BM2 protein has ion channel activity that conducts protons across membranes. Dev Cell. 5: 175-184. 12852861

Paterson R.G., M. Takeda, Y. Ohigashi, L.H. Pinto, R.A. Lamb. (2003). Influenza B virus BM2 protein is an oligomeric integral membrane protein expressed at the cell surface. Virology. 306: 7-17. 12620792

1.A.59

Galloux M., S. Libersou, N. Morellet, S. Bouaziz, B.D. Costa, M. Ouldali, J. Lepault, and B. Delmas. (2007). Infectious Bursal Disease Virus, a Non-Enveloped Virus, Possesses a Capsid-Associated Peptide that Deforms and Perforates Biological Membranes. J. Biol. Chem. 282 (28):20774-20784. 17488723

1.A.60

Agosto, M.A., T. Ivanovic, and M.L. Nibert. (2006). Mammalian reovirus, a nonfusogenic nonenveloped virus, forms size-selective pores in a model membrane. Proc. Natl. Acad. Sci. U.S.A. 103: 16496-16501. 17053074

1.A.61

Bong D.T., C. Steinem, A. Janshoff, J.E. Johnson, M. Reza Ghadiri. (1999). A Highly Membrane-Active Peptide in Flock House Virus: Implications for the Mechanism of Nodavirus Infection. Chem Biol. 6(7):473-481. 10381406

Janshoff A., D.T. Bong, C. Steinem, J.E. Johnson, and M.R. Ghadiri. (1999). An Animal Virus-Derived Peptide Switches Membrane Morphology: Possible Relevance to Nodaviral Transfection Processes. Biochemistry. 38(17):5328-5336. 10220319

1.A.62

Silverio, A.L. and M.H. Saier, Jr. (2011). Bioinformatic characterization of the trimeric intracellular cation-specific channel protein family. J. Membr. Biol. 241: 77-101. 21519847

Yazawa M., C. Ferrante, J. Feng, K. Mio, T. Ogura, M. Zhang, P. Lin, Z. Pan, S. Komazaki, K. Kato, M. Nishi, X. Zhao, N. Weisleder, C. Sato., J. Ma and H. Takeshima. (2007). TRIC channels are essential for Ca²⁺ handling in intracellular stores. Nature. 448:78-82. 17611541

1.A.63

Burghardt, T., D.J. Näther, B. Junglas, H. Huber, and R. Rachel. (2007). The dominating outer membrane protein of the hyperthermophilic Archaeum Ignicoccus hospitalis: a novel pore-forming complex. Mol. Microbiol. 63: 166-176. 17163971

1.A.64

Carmosino, M., F. Rizzo, G. Procino, D. Basco, G. Valenti, B. Forbush, N. Schaeren-Wiemers, M.J. Caplan, and M. Svelto. (2010). MAL/VIP17, a New Player in the Regulation of NKCC2 in the Kidney. Mol. Biol. Cell 21: 3985-3997. 20861303

Cui W., L. Yu, H. He, Y. Chu, J. Gao, B. Wan, L. Tang, S. Zhao. (2001). Cloning of human myeloid-associated differentiation marker (MYADM) gene whose expression was up-regulated in NB4 cells induced by all-trans retinoic acid. Mol Biol Rep. 28(3): 123-138.

Fischer I. and V.S. Sapirstein. (1994). Molecular cloning of plasmolipin. Characterization of a novel proteolipid restricted to brain and kidney. J. Biol. Chem. 269: 24912-24919. 7929173

Hartzell, H.C., Z. Qu, K. Yu, Q. Xiao, and L.T. Chien. (2008). Molecular physiology of bestrophins: multifunctional membrane proteins linked to best disease and other retinopathies. Physiol. Rev. 88: 639-672. 18391176

Tosteson, M.T. and V.S. Sapirstein. (1981). Protein interactions with lipid bilayers: the channels of kidney plasma membrane proteolipids. J. Membr. Biol. 63: 77-84. 6273572

1.A.65

Madan, V., J. García Mde, M.A. Sanz, and L. Carrasco. (2005). Viroporin activity of murine hepatitis virus E protein. FEBS Lett. 579(17):3607-3612. 15963987

Torres, J., U. Maheswari, K. Parthasarathy, L. Ng, D.X. Liu, and X. Gong. (2007). Conductance and amantadine binding of a pore formed by a lysine-flanked transmembrane domain of SARS coronavirus envelope protein. Protein. Sci. 16: 2065-2071. 17766393

1.A.66

Bhunia, A., P.N. Domadia, J. Torres, K.J. Hallock, A. Ramamoorthy, and S. Bhattacharjya. (2010). NMR structure of pardaxin, a pore-forming antimicrobial peptide, in lipopolysaccharide micelles: mechanism of outer membrane permeabilization. J. Biol. Chem. 285: 3883-3895. 19959835

Bonza, M.C., H. Martin, M. Kang, G. Lewis, T. Greiner, S. Giacometti, J.L. Van Etten, M.I. De Michelis, G. Thiel, and A. Moroni. (2010). A functional calcium-transporting ATPase encoded by chlorella viruses. J Gen Virol 91: 2620-2629. 20573858

1.A.67

Goytain, A. and G.A. Quamme. (2008). Identification and characterization of a novel family of membrane magnesium transporters, MMgT1 and MMgT2. Am. J. Physiol. Cell Physiol. 294(2): C495-502. 18057121

Saier, M.H., Jr. (2003). Tracing pathways of transport protein evolution. Mol. Microbiol. 48: 1145-1156. 12787345

1.A.68

Gan, S.W., L. Ng, X. Lin, X. Gong, and J. Torres. (2008). Structure and ion channel activity of the human respiratory syncytial virus (hRSV) small hydrophobic protein transmembrane domain. Protein. Sci. 17: 813-820. 18369195

1.A.69

Ramdya, P. and R. Benton. (2010). Evolving olfactory systems on the fly. Trends Genet. 26: 307-316. 20537755

Sato, K., M. Pellegrino, T. Nakagawa, T. Nakagawa, L.B. Vosshall, and K. Touhara. (2008). Insect olfactory receptors are heteromeric ligand-gated ion channels. Nature. 452: 1002-1006. 18408712

Touhara, K. (2009). Insect olfactory receptor complex functions as a ligand-gated ionotropic channel. Ann. N.Y. Acad. Sci. 1170: 177-180. 19686133

Wicher, D., R. Schäfer, R. Bauernfeind, M.C. Stensmyr, R. Heller, S.H. Heinemann, and B.S. Hansson. (2008). Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels. Nature. 452: 1007-1011. 18408711

1.A.70

Fedders, H., M. Michalek, J. Grötzinger, and M. Leippe. (2008). An exceptional salt-tolerant antimicrobial peptide derived from a novel gene family of haemocytes of the marine invertebrate Ciona intestinalis. Biochem. J. 416: 65-75. 18598239

1.A.71

Ostroumova, O.S., L.V. Schagina, M.I. Mosevitsky, and V.V. Zakharov. (2011). Ion channel activity of brain abundant protein BASP1 in planar lipid bilayers. FEBS J. 278: 461-469. 21156029

1.A.72

Yamaguchi, A., Tamang D., and Saier M. (2007). Mercury Transport in Bacteria. [DOI: 10.1007/s11270-007-9334-z] 0

Barkay, T., S.M. Miller, and A.O. Summers. (2003). Bacterial mercury resistance from atoms to ecosystems. FEMS Microbiol. Rev. 27: 355-384. 12829275

Inoue, C., K. Sugawara, and T. Kusano. (1990). Thiobacillus ferrooxidans mer operon: sequence analysis of the promoter and adjacent genes. Gene 96: 115-120. 2265748

Kusano, T., G.Y. Ji, C. Inoue, and S. Silver. (1990). Constitutive synthesis of a transport function encoded by the Thiobacillus ferrooxidans merC gene cloned in Escherichia coli. J. Bacteriol. 172: 2688-2692. 2185229

Miller, S.M. (1999). Bacterial detoxification of Hg(II) and organomercurials. Essays Biochem 34: 17-30. 10730186

Morby, A.P., J.L. Hobman, and N.L. Brown. (1995). The role of cysteine residues in the transport of mercuric ions by the Tn501 MerT and MerP mercury-resistance proteins. Mol. Microbiol. 17: 25-35. 7476206

Peters, S.E., J.L. Hobman, P. Strike, and D.A. Ritchie. (1991). Novel mercury resistance determinants carried by IncJ plasmids pMERPH and R391. Mol. Gen. Genet. 228: 294-299. 1886614

Qian, H., L. Sahlman, P.O. Eriksson, C. Hambraeus, U. Edlund, and I. Sethson. (1998). NMR solution structure of the oxidized form of MerP, a mercuric ion binding protein involved in bacterial mercuric ion resistance. Biochemistry 37: 9316-9322. 9649312

Schué, M., L.G. Dover, G.S. Besra, J. Parkhill, and N.L. Brown. (2009). Sequence and analysis of a plasmid-encoded mercury resistance operon from Mycobacterium marinum identifies MerH, a new mercuric ion transporter. J. Bacteriol. 191: 439-444. 18931130

Serre, L., E. Rossy, E. Pebay-Peyroula, C. Cohen-Addad, and J. Covčs. (2004). Crystal structure of the oxidized form of the periplasmic mercury-binding protein MerP from Ralstonia metallidurans CH34. J. Mol. Biol. 339: 161-171. 15123428

Sugio, T., T. Komoda, Y. Okazaki, Y. Takeda, S. Nakamura, and F. Takeuchi. (2010). Volatilization of metal mercury from Organomercurials by highly mercury-resistant Acidithiobacillus ferrooxidans MON-1. Biosci. Biotechnol. Biochem. 74: 1007-1012. 20460735

Velasco, A., P. Acebo, N. Flores, and J. Perera. (1999). The mer operon of the acidophilic bacterium Thiobacillus T3.2 diverges from its Thiobacillus ferrooxidans counterpart. Extremophiles 3: 35-43. 10086843

Venturi, E., K. Mio, M. Nishi, T. Ogura, T. Moriya, S.J. Pitt, K. Okuda, S. Kakizawa, R. Sitsapesan, C. Sato, and H. Takeshima. (2011). Mitsugumin 23 forms a massive bowl-shaped assembly and cation-conducting channel. Biochemistry 50: 2623-2632. 21381722

Wilson, J.R., C. Leang, A.P. Morby, J.L. Hobman, and N.L. Brown. (2000). MerF is a mercury transport protein: different structures but a common mechanism for mercuric ion transporters? FEBS Lett. 472: 78-82. 10781809

1.A.73

Cavard, D. (2002). Assembly of colicin A in the outer membrane of producing Escherichia coli cells requires both phospholipase A and one porin, but phospholipase A is sufficient for secretion. J. Bacteriol. 184: 3723-3733. 12057969

Chen, Y.R., T.Y. Yang, G.S. Lei, L.J. Lin, and K.F. Chak. (2011). Delineation of the translocation of colicin E7 across the inner membrane of Escherichia coli. Arch. Microbiol. 193: 419-428. 21387181

1.A.74

Venturi, E., K. Mio, M. Nishi, T. Ogura, T. Moriya, S.J. Pitt, K. Okuda, S. Kakizawa, R. Sitsapesan, C. Sato, and H. Takeshima. (2011). Mitsugumin 23 forms a massive bowl-shaped assembly and cation-conducting channel. Biochemistry 50: 2623-2632. 21381722

1.A.76

Perocchi, F., V.M. Gohil, H.S. Girgis, X.R. Bao, J.E. McCombs, A.E. Palmer, and V.K. Mootha. (2010). MICU1 encodes a mitochondrial EF hand protein required for Ca²⁺ uptake. Nature 467: 291-296. 20693986

1.A.77

De Stefani, D., A. Raffaello, E. Teardo, I. Szabň, and R. Rizzuto. (2011). A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. Nature 476: 336-340. 21685888

Drago, I., P. Pizzo, and T. Pozzan. (2011). After half a century mitochondrial calcium in- and efflux machineries reveal themselves. EMBO. J. 30: 4119-4125. 21934651

Hicks, D.B., Z. Wang, Y. Wei, R. Kent, A.A. Guffanti, H. Banciu, D.H. Bechhofer, and T.A. Krulwich. (2003). A tenth atp gene and the conserved atpI gene of a Bacillus atp operon have a role in Mg²⁺ uptake. Proc. Natl. Acad. Sci. USA 100: 10213-10218. 12917488

1.B

Jarosławski, S., K. Duquesne, J.N. Sturgis, and S. Scheuring. (2009). High-resolution architecture of the outer membrane of the Gram-negative bacterium, Roseobacter denitrificans. Mol. Microbiol. [Epub: Ahead of Print] 19843216

1.B.1

Andersen, C., E. Maier, G. Kemmer, J. Blass, A.-K. Hilpert, R. Benz, and J. Reidl. (2003). Porin OmpP2 of Haemophilus influenzae shows specificity for nicotinamide-derived nucleotide substrates. J. Biol. Chem. 278: 24269-24276. 12695515

Benz, R., R.P. Darveau, and R.E.W. Hancock. (1984). Outer-membrane protein PhoE from Escherichia coli forms anion-selective pores in lipid-bilayer membranes. Eur. J. Biochem. 140: 319-324. 6325185

Cervera, J., A.G. Komarov, and V.M. Aguilella. (2008). Rectification properties and pH-dependent selectivity of meningococcal class 1 porin. Biophys. J. 94: 1194-1202. 17965131

Chang, H.K., J.J. Dennis, and G.J. Zylstra. (2009). Involvement of Two Transport Systems and a Specific Porin in the Uptake of Phthalate by Burkholderia spp. J. Bacteriol. [Epub: Ahead of Print] 19429613

Chatfield, C.H., B.J. Mulhern, D.M. Burnside, and N.P. Cianciotto. (2011). Legionella pneumophila LbtU acts as a novel, TonB-independent receptor for the legiobactin siderophore. J. Bacteriol. 193: 1563-1575. 21278293

Cowan, S.W., T. Schirmer, G. Rummel, M. Steiert, R. Ghosh, R.A. Pauptit, J.N. Jansonius, and J.P. Rosenbusch. (1992). Crystal structures explain functional properties of two E. coli porins. Nature 358: 727-733. 1380671

Delcour, A.H. (1997). Function and modulation of bacterial porins: insights from electrophysiology. FEMS Microbiol. Lett. 152: 115-123. 9228742

Duret, G. and A.H. Delcour. (2010). Size and dynamics of the Vibrio cholerae porins OmpU and OmpT probed by polymer exclusion. Biophys. J. 98: 1820-1829. 20441745

Easton, D.M., A. Smith, S.G. Gallego, A.R. Foxwell, A.W. Cripps, and J.M. Kyd. (2005). Characterization of a novel porin protein from Moraxella catarrhalis and identification of an immunodominant surface loop. J. Bacteriol. 187: 6528-6535. 16159786

Elazar, M., D. Halfon, I. Pechatnikov, and Y. Nitzan. (2007). Porin isolated from the outer membrane of Erwinia amylovora and its encoding gene. Curr. Microbiol. 54: 155-161. 17211539

Gensberg, K., A.W. Smith, F.S. Brinkman, and R.E. Hancock. (1999). Identification of oprG, a gene encoding a major outer membrane protein of Pseudomonas aeruginosa. J. Antimicrob. Chemother. 43: 607-608. 10350397

Gromiha, M.M., and M. Suwa (2007). Current developments on β- barrel membrane proteins: sequence and structure analysis, discrimination and prediction. Curr. Protein Pept. Sci. 8: 580-599. 18220845

Housden, N.G., J.A. Wojdyla, J. Korczynska, I. Grishkovskaya, N. Kirkpatrick, A.M. Brzozowski, and C. Kleanthous. (2010). Directed epitope delivery across the Escherichia coli outer membrane through the porin OmpF. Proc. Natl. Acad. Sci. USA 107: 21412-21417. 21098297

Jeanteur, D., J.H. Lakey, and F. Pattus. (1991). The bacterial porin superfamily: sequence alignment and structure prediction. Mol. Microbiol. 5: 2153-2164. 1662760

Jeanteur, D., J.H. Lakey, and F. Pattus. (1994). The porin superfamily: diversity and common features. In: Bacterial Cell Wall (J.M.Ghuysen and R. Hakenbeck, eds.). Elsevier, Amsterdam, pp. 363-380.

Keyhani, N.O., X.B. Li, and S. Roseman. (2000). Chitin catabolism in the marine bacterium Vibrio furnissii. Identification and molecular cloning of a chitoporin. J. Biol. Chem. 275: 33068-33076. 10913115

Massari, P., C.A. King, A.Y. Ho, and L.M. Wetzler. (2003). Neisserial PorB is translocated to the mitochondria of HeLa cells infected with Neisseria meningitidis and protects cells from apoptosis. Cell. Microbiol. 5: 99-109. 12580946

Nikaido, H. (1992). Porins and specific channels of bacterial outer membranes. Mol. Microbiol. 6: 435-442. 1373213

Pagel, M., V. Simonet, J. Li, M. Lallemand, B. Lauman, and A.H. Delcour. (2007). Phenotypic Characterization of Pore Mutants of the Vibrio cholerae Porin OmpU. J. Bacteriol. 189(23): 8593-8600. 17905973

Santiviago, C.A., J.A. Fuentes, S.M. Bueno, A.N. Trombert, A.A. Hildago, L.T. Socias, P. Youderian, and G.C. Mora. (2002). The Salmonella enterica sv. Typhimurium smvA, yddG and ompD (porin) genes are required for the efficient efflux of methyl viologen. Mol. Microbiol. 46: 687-698. 12410826

Schulz, G.E. (1996). Porins: general to specific, native to engineered passive pores. Curr. Opin. Struc. Biol. 6: 485-490. 8794162

Simonet, V.C., A. Baslé, K.E. Klose, and A.H. Delcour. (2003). The Vibrio cholerae porins OmpU and OmpT have distinct channel properties. J. Biol. Chem. 278: 17539-17545. 12606562

Tanabe, M., C.M. Nimigean, and T.M. Iverson. (2010). Structural basis for solute transport, nucleotide regulation, and immunological recognition of Neisseria meningitidis PorB. Proc. Natl. Acad. Sci. USA 107: 6811-6816. 20351243

Tsugawa, H., A. Ogawa, S. Takehara, M. Kimura, and Y. Okawa. (2008). Primary structure and function of a cytotoxic outer-membrane protein (ComP) of Plesiomonas shigelloides . FEMS Microbiol. Lett. 281: 10-16. 18318838

Wang, S.Y., J. Lauritz, J. Jass, and D.L. Milton. (2003). Role for the major outer-membrane protein from Vibrio anguillarum in bile resistance and biofilm formation. Microbiology 149: 1061-1071. 12686648

Ward, M.J., P.R. Lambden, and J.E. Heckels. (1992). Sequence analysis and relationships between meningococcal class 3 serotype proteins and porins from pathogenic and non-pathogenic Neisserial species. FEMS Microbiol. Lett. 73: 283-289. 1330818

1.B.2

Jeanteur, D., J.H. Lakey, and F. Pattus. (1991). The bacterial porin superfamily: sequence alignment and structure prediction. Mol. Microbiol. 5: 2153-2164. 1662760

Jeanteur, D., J.H. Lakey, and F. Pattus. (1994). The porin superfamily: diversity and common features. In: Bacterial Cell Wall. Edited by Ghuysen, J.M., Hakenbeck, R. Elsevier, Amsterdam, pp. 363-380.

Kubo, A. and R.S. Stephens. (2001). Substrate-specific diffusion of select dicarboxylates through Chlamydia trachomatis PorB. Microbiology 147: 3135-3140. 11700364

Kubo, A. and R.S. Stephens. (2000). Characterization and functional analysis of PorB, a Chlamydia porin and neutralizing target. Mol. Microbiol. 38: 772-780. 11115112

Nikaido, H. (1992). Porins and specific channels of bacterial outer membranes. Mol. Microbiol. 6: 435-442. 1373213

Pickett, M.A., M.E. Ward, and I.N. Clarke. (1988b). High-level expression and epitope localization of the major outer membrane protein of Chlamydia trachomatis serovar L1. Mol. Microbiol. 2: 681-685. 2460720

Pickett, M.A., S.J. Everson, and I.N. Clarke. (1988a). Chlamydia psittaci ewe abortion agent: complete nucleotide sequence of the major outer membrane protein gene. FEMS Microbiol. Lett. 55: 229-234.

Rodríguez-Marańón, M.J., R.M. Bush, E.M. Peterson, T. Schirmer, and L.M. de la Maza. (2002). Prediction of the membrane-spanning β-strands of the major outer membrane protein of Chlamydia. Protein. Sci. 11: 1854-1861. 12070338

Schulz, G.E. (1996). Porins: general to specific, native to engineered passive pores. Curr. Opin. Struc. Biol. 6: 485-490. 8794162

Sun, G., S. Pal, A.K. Sarcon, S. Kim, E. Sugawara, H. Nikaido, M.J. Cocco, E.M. Peterson, and L.M. de la Maza. (2007). Structural and Functional Analyses of the Major Outer Membrane Protein of Chlamydia trachomatis. J. Bacteriol. 189:6222-6235. 17601785

1.B.3

Andersen, C., B. Rak, and R. Benz. (1999). The gene bglH present in the bgl operon of Escherichia coli, responsible for uptake and fermentation of β-glucosides encodes for a carbohydrate-specific outer membrane porin. Mol. Microbiol. 31: 499-510. 10027967

Dutzler, R., Y.F. Wang, P.J. Rizkallah, J.P. Rosenbusch and T. Schirmer (1996). Crystal structures of various maltooligosaccharides bound to maltoporin reveal a specific sugar translocation pathway. Structure 4: 127-134. 8805519

Hardesty, C., C. Ferran and J.M. DiRenzo (1991). Plasmid-mediated sucrose metabolism in Escherichia coli: characterization of scrY, the structural gene for a phosphoenolpyruvate-dependent sucrose phosphotransferase system outer membrane porin. J. Bacteriol. 173: 449-456. 1846143

Jeanteur, D., J.H. Lakey and F. Pattus (1991). The bacterial porin superfamily: sequence alignment and structure prediction. Mol. Microbiol. 5: 2153-2164. 1662760

Jeanteur, D., J.H. Lakey and F. Pattus (1994). The porin superfamily: diversity and common features. In: Bacterial Cell Wall. Edited by Ghuysen, J.M., Hakenbeck, R. Elsevier, Amsterdam, pp. 363-380.

Meyer, J.E.W., M. Hofnung and G.E. Schulz (1997). Structure of maltoporin from Salmonella typhimurium ligated with a nitrophenyl-maltotrioside. J. Mol. Biol. 266: 761-775. 9102468

Nikaido, H. (1992). Porins and specific channels of bacterial outer membranes. Mol. Microbiol. 6: 435-442. 1373213

Schirmer, T., T.A. Keller, Y.F. Wang and J.P. Rosenbusch (1995). Structural basis for sugar translocation through maltoporin channels at 3.1 Å resolution. Science 267: 512-514.

Schulz, G.E. (1996). Porins: general to specific, native to engineered passive pores. Curr. Opin. Struc. Biol. 6: 485-490. 8794162

Wang, Y.F., R. Dutzler, P.J. Rizkallah, J.P. Rosenbusch and T. Schirmer (1997). Channel specificity: structural basis for sugar discrimination and differential flux rates in maltoporin. J. Mol. Biol. 272: 56-63. 9299337

1.B.4

Cheng, N.H., J.K. Pittman, T. Shigaki, and K.D. Hirschi. (2002). Characterization of CAX4, an Arabidopsis H⁺/cation antiporter. Plant Physiol. 128: 1245-1254. 11950973

Cloeckaert, A., H.S. Debbarh, N. Vizcaino, E. Saman, G. Dubray, and M.S. Zygmunt. (1996). Cloning, nucleotide sequence, and expression of the Brucella melitensis bp26 gene coding for a protein immunogenic in infected sheep. FEMS Microbiol. Lett. 140: 139-144. 8764475

Cloeckaert, A., J.M. Verger, M. Grayon, and N. Vizcaino. (1996). Molecular and immunological characterization of the major outer membrane proteins of Brucella. FEMS Microbiol Lett. 145: 1-8. 8931319

Hohle, T.H. and M.R. O'Brian. (2009). The mntH gene encodes the major Mn²⁺ transporter in Bradyrhizobium japonicum and is regulated by manganese via the Fur protein. Mol. Microbiol. 72: 399-409. 19298371

Hohle, T.H., W.L. Franck, G. Stacey, and M.R. O'Brian. (2011). Bacterial outer membrane channel for divalent metal ion acquisition. Proc. Natl. Acad. Sci. USA 108: 15390-15395. 21880957

Jeanteur, D., J.H. Lakey, and F. Pattus. (1991). The bacterial porin superfamily: sequence alignment and structure prediction. Mol. Microbiol. 5: 2153-2164. 1662760

Jeanteur, D., J.H. Lakey, and F. Pattus. (1994). The porin superfamily: diversity and common features. In: Bacterial Cell Wall. Edited by Ghuysen, J.M., Hakenbeck, R. Elsevier, Amsterdam, pp. 363-380.

Mei, H., N.H. Cheng, J. Zhao, S. Park, R.A. Escareno, J.K. Pittman, and K.D. Hirschi. (2009). Root development under metal stress in Arabidopsis thaliana requires the H⁺/cation antiporter CAX4. New Phytol 183: 95-105. 19368667

Nikaido, H. (1992). Porins and specific channels of bacterial outer membranes. Mol. Microbiol. 6: 435-442. 1373213

Paquet, J-.Y., M.A. Diaz, S. Genevrois, M. Grayon, J-.M. Verger, X. DeBolle, J.H. Lakey, J-.J. Letesson, and A. Cloeckaert. (2001). Molecular, antigenic, and functional analyses of Omp2b porin size variants of Brucella spp. J. Bacteriol. 183: 4839-4847. 11466287

Schulz, G.E. (1996). Porins: general to specific, native to engineered passive pores. Curr. Opin. Struc. Biol. 6: 485-490. 8794162

Vizcaino, N., A. Cloeckaert, M.S. Zygmunt, and G. Dubray. (1996). Cloning, nucleotide sequence, and expression of the Brucella melitensis omp31 gene coding for an immunogenic major outer membrane protein. Infect Immun. 64: 3744-3751. 8751924

1.B.5

Hancock, R.E.W., R. Siehnel and N. Martin (1990). Outer membrane proteins of Pseudomonas. Mol. Microbiol. 4: 1069-1075. 1700255

Jeanteur, D., J.H. Lakey and F. Pattus (1991). The bacterial porin superfamily: sequence alignment and structure prediction. Mol. Microbiol. 5: 2153-2164. 1662760

Jeanteur, D., J.H. Lakey and F. Pattus (1994). The porin superfamily: diversity and common features. In: Bacterial Cell Wall. Edited by Ghuysen, J.M., Hakenbeck, R. Elsevier, Amsterdam, pp. 363-380.

Nikaido, H. (1992). Porins and specific channels of bacterial outer membranes. Mol. Microbiol. 6: 435-442. 1373213

Schulz, G.E. (1996). Porins: general to specific, native to engineered passive pores. Curr. Opin. Struc. Biol. 6: 485-490. 8794162

Siehnel, R., N.L. Martin and R.E.W. Hancock (1990). Sequence and relatedness in other bacteria of the Pseudomonas aeruginosa oprP gene coding for the phosphate-specific porin P. Mol. Microbiol. 4: 831-838. 1697017

1.B.6

Arnold, T., M. Poynor, S. Nussberger, A.N. Lupas, and D. Linke. (2007). Gene duplication of the eight-stranded β-barrel OmpX produces a functional pore: a scenario for the evolution of transmembrane β-barrels. J. Mol. Biol. 366: 1174-1184. 17217961

Arora, A., D. Rinehart, G. Szabo, and L.K. Tamm. (2000). Refolded outer membrane protein A of Escherichia coli forms ion channels with two conductance states in planar lipid bilayers. J. Biol. Chem. 275: 1594-1600. 10636850

Baldermann, C., A. Lupas, J. Lubieniecki, and H. Engelhardt. (1998). The regulated outer membrane protein Omp21 from Comamonas acidovorans is identified as a member of a new family of eight-stranded β-sheet proteins by its sequence and properties. J. Bacteriol. 180: 3741-3749. 9683466

Bartra, S.S., K.L. Styer, D.M. O'Bryant, M.L. Nilles, B.J. Hinnebusch, A. Aballay, and G.V. Plano. (2008). Resistance of Yersinia pestis to complement-dependent killing is mediated by the Ail outer membrane protein. Infect. Immun. 76: 612-622. 18025094

Brinkman, F.S., M. Bains, and R.E.W. Hancock. (2000). The amino terminus of Pseudomonas aeruginosa outer membrane protein OprF forms channels in lipid bilayer membranes: correlation with a three-dimensional model. J. Bacteriol. 182: 5251-5255. 10960112

Gribun, A., D.J. Katcoff, G. Hershkovits, I. Pechatnikov, and Y. Nitzan. (2004). Cloning and characterization of the gene encoding for OMP-PD porin: the major Photobacterium damsela outer membrane protein. Curr. Microbiol. 48: 167-174. 15057460

Gribun, A., Y. Nitzan, I. Pechatnikov, G. Hershkovits, and D.J. Katcoff. (2003). Molecular and structural characterization of the HMP-AB gene encoding a pore-forming protein from a clinical isolate of Actinetobacter baumannii. Curr. Microbiol. 47: 434-443. 14669924

Grizot, S. and S.K. Buchanan. (2004). Structure of the OmpA-like domain of RmpM from Neisseria meningitidis. Mol. Microbiol. 51: 1027-1037. 14763978

Hancock, R.E.W. and F.S.L. Brinkman. (2002). Function of Pseudomonas porins in uptake and efflux. Annu. Rev. Microbiol. 56: 17-38. 12142471

Iida, A., Y. Ohnishi, and S. Horinouchi. (2008). An OmpA family protein, a target of the GinI/GinR quorum-sensing system in Gluconacetobacter intermedius, controls acetic acid fermentation. J. Bacteriol. 190: 5009-5019. 18487322

Jeanteur, D., J.H. Lakey, and F. Pattus. (1991). The bacterial porin superfamily: sequence alignment and structure prediction. Mol. Microbiol. 5: 2153-2164. 1662760

Jeanteur, D., J.H. Lakey, and F. Pattus. (1994). The porin superfamily: diversity and common features. In: Bacterial Cell Wall (Ghuysen, J.M. and R. Hakenbeck,eds.). Elsevier, Amsterdam, pp. 363-380.

Kleinschmidt, J.H. and L.K. Tamm. (1996). Folding intermediates of a β-barrel membrane protein. Kinetic evidence for a multi-step membrane insertion mechanism. Biochemistry 35: 12993-13000. 8855933

Mahalakshmi, R. and F.M. Marassi. (2008). Orientation of the Escherichia coli Outer Membrane Protein OmpX in Phospholipid Bilayer Membranes Determined by Solid-State NMR. Biochemistry. [Epub: Ahead of Print] 18512961

Mahalakshmi, R., C.M. Franzin, J. Choi, and F.M. Marassi. (2007). NMR structural studies of the bacterial outer membrane protein OmpX in oriented lipid bilayer membranes. Biochim. Biophys. Acta. 1768: 3216-3224. 17916325

Molle, V., N. Saint, S. Campagna, L. Kremer, E. Lea, P. Draper, and G. Molle. (2006). pH-dependent pore-forming activity of OmpATb from Mycobacterium tuberculosis and characterization of the channel by peptidic dissection. Mol. Microbiol. 61: 826-837. 16803587

Nestorovich, E.M., E. Sugawara, H. Nikaido, and S.M. Bezrukov. (2006). Pseudomonas aeruginosa porin OprF: properties of the channel. J. Biol. Chem. 281: 16230-16237. 16617058

Niederweis, M. (2003). Mycobacterial porins – new channel proteins in unique outer membranes. Mol. Microbiol. 49: 1167-1177. 12940978

Nikaido, H. (1992). Porins and specific channels of bacterial outer membranes. Mol. Microbiol. 6: 435-442. 1373213

Pautsch, A. and G.E. Schulz. (2000). High-resolution structure of the OmpA membrane domain. J. Mol. Biol. 298: 273-282. 10764596

Schulz, G.E. (1996). Porins: general to specific, native to engineered passive pores. Curr. Opin. Struc. Biol. 6: 485-490. 8794162

Senaratne, R.H., J. Mobasheri, K.G. Papavinasasundaram, P. Jenner, E.D.A. Lea, and P. Draper. (1998). Expression of a gene for a porin-like protein of the OmpA family from Mycobacterium tuberculosis H37Rv. J. Bacteriol. 180: 3541-3547. 9657995

Sugawara, E. and H. Nikaido. (1992). Pore-forming activity of OmpA protein of Escherichia coli. J. Biol. Chem. 267: 2507-2511. 1370823

Sugawara, E. and H. Nikaido. (1994). OmpA protein of Escherichia coli outer membrane occurs in open and closed channel forms. J. Biol. Chem. 269: 17981-17987. 7517935

Sugawara, E., E.M. Nestorovich, S.M. Bezrukov, and H. Nikaido. (2006). Pseudomonas aeruginosa porin OprF exists in two different conformations. J. Biol. Chem. 281: 16220-16229. 16595653

Sugawara, E., M. Steiert, S. Rouhani, and H. Nikaido. (1996). Secondary structure of the outer membrane proteins OmpA of Escherichia coli and OprF of Pseudomonas aeruginosa. J. Bacteriol. 178: 6067-6069. 8830709

Teriete, P., Y. Yao, A. Kolodzik, J. Yu, H. Song, M. Niederweis, and F.M. Marassi. (2010). Mycobacterium tuberculosis Rv0899 Adopts a Mixed alpha/β-Structure and Does Not Form a Transmembrane β-Barrel. Biochemistry 49: 2768-2777. 20199110

1.B.7

Burdman, S., R. De Mot, J. Vanderleyden, Y. Okon, and E. Jurkevitch. (2000). Identification and characterization of the omaA gene encoding the major outer membrane protein of Azospirillum brasilense. DNA Seq 11: 225-237. 11092733

Jeanteur, D., J.H. Lakey and F. Pattus (1991). The bacterial porin superfamily: sequence alignment and structure prediction. Mol. Microbiol. 5: 2153-2164. 1662760

Jeanteur, D., J.H. Lakey and F. Pattus (1994). The porin superfamily: diversity and common features. In: Bacterial Cell Wall. Edited by Ghuysen, J.M., Hakenbeck, R. Elsevier, Amsterdam, pp. 363-380.

Kreusch, A. and G.E. Schultz (1994). Refined structure of the porin from Rhodopseudomonas blastica and comparison with the porin from Rhodobacter capsulatus. J. Mol. Biol. 243: 891-905. 7525973

Nikaido, H. (1992). Porins and specific channels of bacterial outer membranes. Mol. Microbiol. 6: 435-442. 1373213

Pauptit, R.A., T. Schirmer, J.N. Jansonius, J.P. Rosenbusch, M.W. Parker, A.D. Tucker, D. Tsernoglou, M.S. Weiss, and G.E. Schultz. (1991). A common channel-forming motif in evolutionarily distant porins. J Struct Biol 107: 136-145. 1725488

Schiltz, E., A. Kreusch, U. Nestel and G.E. Schulz (1991). Primary structure of porin from Rhodobacter capsulatus. Eur. J. Biochem. 199: 587-594. 1651239

Schulz, G.E. (1996). Porins: general to specific, native to engineered passive pores. Curr. Opin. Struc. Biol. 6: 485-490. 8794162

Weiss, M.S., T. Wacker, J. Weckesser, W. Welte and G.E. Schulz (1990). The three-dimensional structure of porin from Rhodobacter capsulatus at 3 Å resolution. FEBS Lett. 267: 268-272. 2165921

1.B.8

Aiello R., A. Messina, B. Schiffler, R. Benz, G. Tasco, R. Casadio, V. De Pinto. (2004). Functional characterization of a second porin isoform in Drosophila melanogaster. DmPorin2 forms voltage-independent cation-selective pores. J Biol Chem. 279:25364-25373. 15054101

Aram, L., S. Geula, N. Arbel, and V. Shoshan-Barmatz. (2010). VDAC1 cysteine residues: Topology and function in channel activity and apoptosis. Biochem. J. [Epub: Ahead of Print] 20192921

Bahamonde, M.I., J.M. Fernández-Fernández, F.X. Guix, E. Vázquez, and M.A. Valverde. (2003). Plasma membrane voltage-dependent anion channel mediates antiestrogen-activated Maxi Cl^- currents in C1300 neuroblastoma cells. J. Biol. Chem. 278: 33284-33289. 12794078

Blachly-Dyson, E., S. Peng, M. Colombini, and M. Forte. (1990). Selectivity changes in the site-directed mutants of the VDAC ion channel: structural implications. Science 247: 1233-1236. 1690454

Buettner, R., G. Papoutsoglou, E. Scemes, D.C. Spray, and R. Dermietzel. (2000). Evidence for secretory pathway localization of a voltage-dependent anion channel isoform. Proc. Natl. Acad. Sci. USA 97: 3201-3206. 10716730

Casadio, R., I. Jacoboni, A. Messina, and V. De Pinto. (2002). A 3D model of the voltage-dependent anion channel (VDAC). FEBS Lett. 520: 1-7. 12044860

Cesura, A.M., E. Pinard, R. Schubenel, V. Goetschy, A. Friedlein, H. Langen, P. Polcic, M.A. Forte, P. Bernardi, and J.A. Kemp. (2003). The voltage-dependent anion channel is the target for a new class of inhibitors of the mitochondrial permeability transition pore. J. Biol. Chem. 278: 49812-49818. 12952973

Craigen, W.J. and B.H. Graham. (2008). Genetic strategies for dissecting mammalian and Drosophila voltage-dependent anion channel functions. J. Bioenerg. Biomembr. 40: 207-212. 18622693

De Pinto, V., A. Messina, D.J. Lane, and A. Lawen. (2010). Voltage-dependent anion-selective channel (VDAC) in the plasma membrane. FEBS Lett. 584: 1793-1799. 20184885

Fischer, K., A. Weber, S. Brink, B. Arbinger, D. Schünemann, S. Borchert, H.W. Heldt, B. Popp, R. Benz, T.A. Link, C. Eckerskorn, and U.-I. Flügge. (1994). Porins from plants: molecular cloning and functional characterization of two new members of the porin family. J. Biol. Chem. 269: 25754-25760. 7523392

Graham, B.H., Z. Li, E.P. Alesii, P. Versteken, C. Lee, J. Wang, and W.J. Craigen. (2010). Neurologic dysfunction and male infertility in Drosophila porin mutants: a new model for mitochondrial dysfunction and disease. J. Biol. Chem. 285: 11143-11153. 20110367

Hiller, S., J. Abramson, C. Mannella, G. Wagner, and K. Zeth. (2010). The 3D structures of VDAC represent a native conformation. Trends. Biochem. Sci. 35: 514-521. 20708406

Hiller, S., R.G. Garces, T.J. Malia, V.Y. Orekhov, M. Colombini, and G. Wagner. (2008). Solution structure of the integral human membrane protein VDAC-1 in detergent micelles. Science 321: 1206-1210. 18755977

Israelson, A., N. Arbel, S. Da Cruz, H. Ilieva, K. Yamanaka, V. Shoshan-Barmatz, and D.W. Cleveland. (2010). Misfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS. Neuron. 67: 575-587. 20797535

Jeanteur, D., J.H. Lakey, and F. Pattus. (1991). The bacterial porin superfamily: sequence alignment and structure prediction. Mol. Microbiol. 5: 2153-2164. 1662760

Jeanteur, D., J.H. Lakey, and F. Pattus. (1994). The porin superfamily: diversity and common features. In Bacterial Cell Wall, J.M. Ghuysen and R. Hakenbeck (Eds.), Amsterdam, Elsevier, pp. 363-380.

Leung, A.W. and A.P. Halestrap. Recent progress in elucidating the molecular mechanism of the mitochondrial permeability transition pore. Biochim. Biophys. Acta. 1777: 946-952. 18407825

Messina, A., S. Reina, F. Guarino, and V. De Pinto. (2011). VDAC isoforms in mammals. Biochim. Biophys. Acta. [Epub: Ahead of Print] 22020053

Nikaido, H. (1992). Porins and specific channels of bacterial outer membranes. Mol. Microbiol. 6: 435-442. 1373213

Rauch, G. and O. Moran. (1994). On the structure of mitochondrial porins and its homologies with bacterial porins. Biochem. Biophys. Res. Commun. 200: 908-915. 8179626

Roosens, N., F. Al Bitar, M. Jacobs, and F. Homblé. (2000). Characterization of a cDNA encoding a rice mitochondrial voltage-dependent anion channel and its gene expression studied upon plant development and osmotic stress. Biochim. Biophys. Acta 1463: 470-476. 10675523

Röhl, T., M. Motzkus, and J. Soll. (1999). The outer envelope protein OEP24 from pea chloroplasts can functionally replace the mitochondrial VDAC in yeast. FEBS Lett. 460: 491-494. 10556523

Schulz, G.E. (1996). Porins: general to specific, native to engineered passive pores. Curr. Opin. Struc. Biol. 6: 485-490. 8794162

Song, J., C. Midson, E. Blachly-Dyson, M. Forte, and M. Colombini. (1998). The topology of VDAC as probed by biotin modification. J. Biol. Chem. 273: 24406-24413. 9733730

Sridharan, M., E.A. Bowles, J.P. Richards, M. Krantic, K.L. Davis, K.A. Dietrich, A.H. Stephenson, M.L. Ellsworth, and R.S. Sprague. (2011). Prostacyclin Receptor-Mediated ATP Release from Erythrocytes Requires the Voltage-Dependent Anion Channel (VDAC). Am. J. Physiol. Heart Circ Physiol. [Epub: Ahead of Print] 22159995

Troll, H., D. Malchow, A. Müller-Taubenberger, B. Humbel, F. Lottspeich, M. Ecke, G. Gerisch, A. Schmid, and R. Benz. (1992). Purification, functional characterization, and cDNA sequencing of mitochondrial porin from Dictyostelium discoideum. J. Biol. Chem. 267: 21072-21079. 1328220

Ujwal, R., D. Cascio, J.P. Colletier, S. Faham, J. Zhang, L. Toro, P. Ping, and J. Abramson. (2008). The crystal structure of mouse VDAC1 at 2.3 Ĺ resolution reveals mechanistic insights into metabolite gating. Proc. Natl. Acad. Sci. USA 105: 17742-17747. 18988731

Yagoda N., M. von Rechenberg, E. Zaganjor, A.J. Bauer, W.S. Yang, D.J. Fridman, A.J. Wolpaw, I. Smukste, J.M. Peltier, J.J. Boniface, R. SmitH, S.L. Lessnick, S. Sahasrabudhe, B.R. Stockwell. (2007). RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature. 447: 864-868 17568748

Yehezkel, G., Hadad, N., Zaid, H., Sivan, S., and Shoshan-Barmatz, V. (2006). Nucleotide-binding sites in the voltage-dependent anion channel: characterization and localization. J. Biol. Chem. 281: 5938-5946. 16354668

1.B.9

Black, P.N. (1991). Primary sequence of the Escherichia coli fadL gene encoding an outer membrane protein required for long-chain fatty acid transport. J. Bacteriol. 173: 435-442. 1987139

Hearn, E.M., D.R. Patel, and B. van den Berg. (2008). Outer-membrane transport of aromatic hydrocarbons as a first step in biodegradation. Proc. Natl. Acad. Sci. USA 105: 8601-8606. 18559855

Hearn, E.M., D.R. Patel, B.W. Lepore, M. Indic, and B. van den Berg. (2009). Transmembrane passage of hydrophobic compounds through a protein channel wall. Nature 458: 367-370. 19182779

Jones, R.M., L.S. Collier, E.L. Neidle, and P.A. Williams. (1999). areABC genes determine the catabolism of aryl esters in Acinetobacter sp. strain ADPI. J. Bacteriol. 181: 4568-4575. 10419955

Jones, R.M., V. Pagmantidis, and P.A. Williams. (2000). sal genes determining the catabolism of salicylate esters are part of a supraoperonic cluster of catabolic genes in Acinetobacter sp. strain ADPI. J. Bacteriol. 182: 2018-2025. 10715011

Kasai, Y., J. Inoue, and S. Harayama. (2001). The TOL plasmid pWWO xylN gene product from Pseudomonas putida is involved in m-xylene uptake. J. Bacteriol. 183: 6662-6666. 11673437

Kumar, G.B. and P.N. Black. (1993). Bacterial long-chain fatty acid transport. Identification of amino acid residues within the outer membrane protein FadL required for activity. J. Biol. Chem. 268: 15469-15476. 8340375

Lepore, B.W., M. Indic, H. Pham, E.M. Hearn, D.R. Patel, and B. van den Berg. (2011). Ligand-gated diffusion across the bacterial outer membrane. Proc. Natl. Acad. Sci. USA 108: 10121-10126. 21593406

van den Berg, B. (2010). Going forward laterally: transmembrane passage of hydrophobic molecules through protein channel walls. Chembiochem 11: 1339-1343. 20533493

van den Berg, B., P.N. Black, W.M. Clemons, Jr., and T.A. Rapoport. (2004). Crystal structure of the long-chain fatty acid transporter FadL. Science 304: 1506-1509. 15178802

Verardi, R., L. Shi, N.J. Traaseth, N. Walsh, and G. Veglia. (2011). Structural topology of phospholamban pentamer in lipid bilayers by a hybrid solution and solid-state NMR method. Proc. Natl. Acad. Sci. USA 108: 9101-9106. 21576492

Wang, Y., M. Rawlings, D.T. Gibson, D. Labbe, H. Bergeron, R. Brousseau, and P.C. Lau. (1995). Identification of a membrane protein and a truncated LysR-type regulator associated with the toluene degradation pathway in Pseudomonas putida Fl. Mol. Gen. Genet. 246: 570-579. 7535376

1.B.10

Inoue, T., S. Matsuzaki and S. Tanaka (1995). Cloning and sequence analysis of Vibrio parahaemolyticus ompK gene encoding a 26 kDa outer membrane protein, OmpK, that serves as receptor for a broad-host-range vibriophage, KVP40. FEMS. Microbiol. Lett. 134: 245-249. 8586275

Nieweg, A. and E. Bremer (1997). The nucleoside-specific Tsx channel from the outer membrane of Salmonella typhimurium, Klebsiella pneumoniae and Enterobacter aerogenes: functional characterization and DNA sequence analysis of the tsx genes. Microbiology 143: 603-615. 9043137

Ye, J. and B. van den Berg. (2004). Crystal structure of the bacterial nucleoside transporter Tsx. EMBO J. 23: 3187-3195. 15272310

1.B.11

Burmølle, M., M.I. Bahl, L.B. Jensen, S.J. Sørensen, and L.H. Hansen. (2008). Type 3 fimbriae, encoded by the conjugative plasmid pOLA52, enhance biofilm formation and transfer frequencies in Enterobacteriaceae strains. Microbiol. 154: 187-195. 18174137

Cao, J., A.S. Khan, M.E. Bayer, and D.M. Schifferli. (1995). Ordered translocation of 987P fimbrial subunits through the outer membrane of Escherichia coli. J. Bacteriol. 177: 3704-3713. 7601834

Daniels, R. and S. Normark. (2008). Twin ushers guide pili across the bacterial outer membrane. Cell 133: 574-576. 18485865

Dodson, K.W., F. Jacob-Dubuisson, R.T. Striker, and S.J. Hultgren. (1993). Outer-membrane PapC molecular usher discriminately recognizes periplasmic chaperone-pilus subunit complexes. Proc. Natl. Acad. Sci. USA 90: 3670-3674. 8097321

Henderson, N.S., S.S.K. So, C. Martin, R. Kulkarni, and D.G. Thanassi. (2004). Topology of the outer membrane usher PapC determined by site-directed fluorescence labeling. J. Biol. Chem. 279: 53747-53754. 15485883

Huang, Y., B.S. Smith, L.X. Chen, R.H. Baxter, and J. Deisenhofer. (2009). Insights into pilus assembly and secretion from the structure and functional characterization of usher PapC. Proc. Natl. Acad. Sci. USA 106: 7403-7407. 19380723

Li, H., L. Qian, Z. Chen, D. Thibault, G. Liu, T. Liu, and D.G. Thanassi. (2004). The outer membrane usher forms a twin-pore secretion complex. J. Mol. Biol. 344: 1397-1407. 15561151

Mapingire, O.S., N.S. Henderson, G. Duret, D.G. Thanassi, and A.H. Delcour. (2009). Modulating effects of the plug, helix and N- and C-terminal domains on channel properties of the PapC usher. J. Biol. Chem. [Epub: Ahead of Print] 19850919

Mol, O. and B. Oudega. (1996).. Molecular and structural aspects of fimbriae biosynthesis and assembly in Escherichia coli. FEMS Microbiol. Rev. 19: 25-52. 8916554

Nuccio, S.P. and A.J. Bäumler. (2007). Evolution of the chaperone/usher assembly pathway: fimbrial classification goes Greek. Microbiol. Mol. Biol. Rev. 71: 551-575. 18063717

Remaut, H., C. Tang, N.S. Henderson, J.S. Pinkner, T. Wang, S.J. Hultgren, D.G. Thanassi, G. Waksman, and H. Li. (2008). Fiber formation across the bacterial outer membrane by the chaperone/usher pathway. Cell 133: 640-652. 18485872

Ronald, L.S., O. Yakovenko, N. Yazvenko, S. Chattopadhyay, P. Aprikian, W.E. Thomas, and E.V. Sokurenko. (2008). Adaptive mutations in the signal peptide of the type 1 fimbrial adhesin of uropathogenic Escherichia coli. Proc. Natl. Acad. Sci. USA 105: 10937-10942. 18664574

Rudel, D., H. Tian, and R.J. Sommer. (2008). Wnt signaling in Pristionchus pacificus gonadal arm extension and the evolution of organ shape. Proc. Natl. Acad. Sci. USA 105: 10826-10831. 18664575