TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.1.152.9
Lipopolysaccharide transporter that exports LPS from the external surface of the cytoplasmic membrane to the outer membrane, LptB2FG. The 134-kDa protein complex is unique among ABC transporters because it extracts lipopolysaccharide from the external leaflet of the inner membrane and propels it along a filament that extends across the periplasm to directly deliver lipopolysaccharide into the external leaflet of the outer membrane. Dong et al. 2017 reported the crystal structure of this transporter in which both LptF and LptG are composed of a beta-jellyroll-like periplasmic domain and six TMSs. LptF and LptG together form a central cavity containing highly conserved hydrophobic residues. Structural and functional studies suggest that LptB2FG uses an alternating lateral access mechanism to extract lipopolysaccharide and traffic it along the hydrophobic cavity toward the transporter's periplasmic domains. The structure has been presented by Dong et al. 2017. LPS transport involves long-ranging bi- directional coupling across cellular compartments between cytoplasmic LptB and periplasmic regions of the Lpt transporter (Lundstedt et al. 2020).  

Accession Number:A6THI4
Protein Name:Putative transmembrane protein, transport
Length:360
Molecular Weight:39630.00
Species:Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) [272620]
Number of TMSs:6
Substrate

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MQAFGVLDRY IGKTIFNTIM MTLFMLVSLS GIIKFVDQLK KSGQGSYDAL GAGLYTILSV 
61:	PKDIQIFFPM AALLGALLGL GMLAQRSELV VMQASGFTRL QVALAVMKTA IPLVLLTMAI 
121:	GEWVAPQGEQ MARNYRAQQM YGGSLLSTQQ GLWAKDGHNF VYIERVKGND ELGGVSIYAF 
181:	NPERRLQSVR YAASAKFDSE NKVWRLSQVD ESDLTDPKQV TGSQMVSGTW KTNLTPDKLG 
241:	VVALDPDALS ISGLHNYVKY LKSSGQDPGR YQLNMWSKIF QPLSVAVMML MALSFIFGPL 
301:	RSVPMGVRVV TGISFGFIFY VLDQIFGPLT LVYGIPPIIG ALLPSASFFL ISLWLMMRKA