TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.1.135.7
Multidrug exporter, EfrAB.  Confers resistance to many structurally unrelated antimicrobial agents, such as norfloxacin, ciprofloxacin, doxycycline, acriflavine, 4,6-diamidino-2-phenylindole, tetraphenylphosphonium chloride, daunorubicin, and doxorubicin (Lee et al. 2003).  Induced by half minimal inhibitory concentrations (MIC) of gentamicin, streptomycin and chloramphenicol which are also exporter (Lavilla Lerma et al. 2014).  In some strains, this system may not be the primary drug exporter (Hürlimann et al. 2016).

Accession Number:E2YHZ7
Protein Name:ABC transporter, ATP-binding protein
Length:589
Molecular Weight:65835.00
Species:Enterococcus faecalis DAPTO 512 [749489]
Number of TMSs:7
Substrate norfloxacin, Ciprofloxacin, Doxycycline, acriflavine, 4,6-diamidino-2-phenylindole, TPP chloride, daunorubicin, doxorubicin

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MKHAFSSMKR IGRYIKPYRV TFYLVILFTI LTVAFNAALP YLTGLPTTEI SRNIAAGESI 
61:	NFDYVIQCLI WILVVGTGYC VAQFLSGFLM TNVVQQSMRD LRRDIEEKIN RLPVSYFDKN 
121:	QQGNILSRVT NDVDAVSNAM QQSFINIVSA VLGIVMAVVM MFLINPLMAI FSVIMIPLSL 
181:	IISRTIVKIS QKYFQGMQNS LGDLNGYVQE NMTGFSVLKL YGREKETLEG FKQVNHRLNG 
241:	FGFKASFISG LMLPLVQMTA YGTYIGVAVL GSYYVVAGVI VVGQLQAFIQ YIWQISQPMG 
301:	NITQLSAALQ SASASTMRIF EILDEPEEEL NEQDVPLPEP ILGSVEFENV SFSYDPEKPL 
361:	IRNLNFKVDA GQMVAIVGPT GAGKTTLINL LMRFYDVTEG AIKIDGIDTK KMNRSDVRSV 
421:	FGMVLQDAWL YKGTIADNIR FGKLDATDYE VVDAAKTANV DHFIRTMPDG YEMEINSEGD 
481:	NVSLGQKQLL TIARAVISDP KILILDEATS SVDTRLEALI QKAMDRVMEG RTSFVIAHRL 
541:	STIREADLIL VMKQGEIIEK GTHHELLEQG GFYEKLYNSQ FAEEGDYEE