TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.1.135.7
Multidrug exporter, EfrAB.  Confers resistance to many structurally unrelated antimicrobial agents, such as norfloxacin, ciprofloxacin, doxycycline, acriflavine, 4,6-diamidino-2-phenylindole, tetraphenylphosphonium chloride, daunorubicin, and doxorubicin (Lee et al. 2003).  Induced by half minimal inhibitory concentrations (MIC) of gentamicin, streptomycin and chloramphenicol which are also exporter (Lavilla Lerma et al. 2014).  In some strains, this system may not be the primary drug exporter (Hürlimann et al. 2016).

Accession Number:J6RCW6
Protein Name:ABC transporter, ATP-binding protein
Length:567
Molecular Weight:63446.00
Species:Enterococcus faecalis ERV85 [1134799]
Number of TMSs:7
Substrate norfloxacin, Ciprofloxacin, Doxycycline, acriflavine, 4,6-diamidino-2-phenylindole, TPP chloride, daunorubicin, doxorubicin

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MRYKKLLFAD FICVFGFILI ELGLPTILAR MIDKGIIPKD MDYIYQQGIW MVVITIIGVA 
61:	MNILLGYFGA RITTNIVRDI RDDLFEKIQT FSHSEYESIG VSSLITRTTN DAYQIMLFMG 
121:	NILRLGFMTP VMFIASLYMV MRTSPSLGMY VLGALPFLLL AVVGIARLSE PLSKKQQKNL 
181:	DGINGILREN LSGLRVIRAF VNEKFEESRF NKVNETYTKS SKSLFRLMAA AQPGFFFLFN 
241:	IVMVLIIWSG TVQISHGDLE VGNLIAFIEY IFHALFSFML FASVFMMYPR AAVSASRIQE 
301:	ALDMEPAIRE EEGVTETATK GYLEFKNVTF AYPGHAESPV IRNVSFKASP GETVAFIGST 
361:	GSGKSTLIQL IPRFYDVSEG EILIDGVNVK DYQLSALRNK IGYIPQKALL FTGTIADNLR 
421:	YGKEDATLEE MERAIDIAQA TEFVSQKPQG YDEPLSEGGT NFSGGQKQRL AIARAIIRNP 
481:	EIYIFDDSFS ALDYQTDANL RARLKKETTE STVLIVAQRV GTIMHADRIV VLNEGDVVGI 
541:	GTHRELLETC PIYYDIAASQ LSEEELA