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1.F.1.1.3
The worm SNARE complex and it's regulators for vesicle neurotransmetter and neuropeptide release (Gracheva et al. 2007).  The SNARE complex consists of Syntaxin, SNAP and Synaptobrevin and mediates the synaptic vesicle cycle (Rathore et al. 2010).  Synaptotagmin I is a Ca2+ sensor triggering vesicle fusion (Yu et al. 2013).  Regulators include Snapin dimers (Yu et al. 2013), Complexin, a presynaptic protein that interacts with the SNARE complex; the C-terminal domain binds lipids to inhibit exocytosis (Hobson et al. 2011; Wragg et al. 2013), Unc-18, which binds syntaxin and regluates synaptic vesicle (neurotransmitter) docking (Graham et al. 2011), Unc13 which also regluates docking of the synaptic vescicles to the plasma membrane by interacting with syntaxin, CAPS or Unc31, a Ca2+-activated protein for secretion that is required for dense core vesicle docking for neuropeptide release (Lin et al. 2010), and Tomosyn or Tom-1, a negative regluator of both neurotransmitter and neuropeptide release (Gracheva et al. 2007).

Accession Number:O01596
Protein Name:Protein FERL-1
Length:898
Molecular Weight:103047.00
Species:Caenorhabditis elegans [6239]
Substrate neurotransmitter

Cross database links:

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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTDKEKLLKV KQKFKRGDSS SDVDSGPERD RDEDDSDNES RNTSKTSKSS KNGKSGKSTG 
61:	TSEMTELLND GGSDIELLPD NGKNFEKRKL QDTDKSCTWN VLVRIIEAKG VSTGSARVRT 
121:	IFDGKSKMTR TVTHAIPKWR QNILYTMKNQ PLEKLAAKVL TFRLVRPTAL GESSVGEFSC 
181:	YLSEVIRSPD RSLIAKWVAL GFPGMSDEEP DDIAYENCGF LKVTLSVYRI DESPPTLIDD 
241:	GGKEQIWSGI RVFSVEQLIR KMINERKIKK KQRFYVMVQC GAHKTKTTME SAFLDEDANI 
301:	ASIIFSLFDK KGRGKTCIGK ATLPMKMIYE PGVAGYLPTF GPAFLNVFDC ERVSRFSIFS 
361:	RKMRGSQLDG SRFVGRLFIA IDCVEYMEKA NAQIMHLDYS QIMEAESICK NLKWYNCFCS 
421:	MSLVNKIDPQ FASDPVCIMM SIGSFGSTSN EDKKCNSSTV PTYPERDEHE CCSFAWGNLR 
481:	PVAEVNAPWE VIDRRIEMSN VLMKMTNMLD SMISEIRHIS SGAVDQIASV GIESLECLEQ 
541:	QIESASKFLR RINHVNSNAL DRHILDYRKE KILKLREHFE KEAFSIDYSD GEVDAKLLRM 
601:	LLQIRSMTLE LAEDVQMTIP PVLIKMMSHG KLIGFAKIPI SEIFQSDDEA QSGEWCGRTR 
661:	AINIQWPTLV DQRNRKREHV AVLHAKMWFG RTDQLTKWKE HVQPADIERF IVLYEVQTKE 
721:	PTLKWKDESD IYDGKWVKTK EVPPLENEWN AVGPWIVMNT RQTFVPKLGQ HTAHDKAFEI 
781:	QKRAETGTWK HFQYTDCYAD ELKPKDLDKH VKGWQVGSWD QDKFRNNGDE KGCVYSTNGV 
841:	FIGSGVLPDR EEKVHHNFRK RCIERPRKHE GYNKEFEDFA RFRKLIGNDK WEVSWNFE