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3.A.1.134.5
The MDR exporter, YvcRS. Possibly linked to regulation by a sensor kinase/response regulator system (YvcQP) (Joseph et al., 2002; Bernard et al., 2007).

Accession Number:O06981
Protein Name:Uncharacterized ABC transporter permease yvcS
Length:646
Molecular Weight:73398.00
Species:Bacillus subtilis [1423]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate drugs

Cross database links:

HEGENOM: HBG339962
Entrez Gene ID: 938473   
Pfam: PF02687   
KEGG: bsu:BSU34690   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0006810 P:transport

References (1)

[1] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNLRTIARKN ILGNLQRYVA YFLSCVFAVS VFFVFTSFIF HPDVNEDNIY GGSLVKTCLS 
61:	AALVVIIVFC IFFITYSNSA FLQARKKEFG LLTLFGTSKQ QLRKMIYYEQ SLISLAAIAA 
121:	GIGAGLLFSK LFFMIMTWML SVKVPISFAI VPKAFVMTIA GFLILFQTLL ILSLGRIRKL 
181:	EIIELIKSAK KPKSLPVYSK WLTVLSLLCL GSGYYLSATA NAIDMMFRVF PILILVLIGT 
241:	YFFFTQSSVA FFRMLYRKKH SFYKGTNIIV RSNMIFRLKD HARMLFLTSV ITAVILTATG 
301:	VIYMFYSDLQ RQEEQSIPQS VSWVEKDASR FQVMKPETAE NTLKKAHAVI TYKVDATGIP 
361:	VTFQSDLPYG NKKMEAEALL ISEKVYNQVA KEKGFPVIHL QENEAFINVS FQMMVKDTFG 
421:	EGETAAFHMK SGKTLSYVMK KQQNKGILMS VDGVSRLLVV SEKSFDSLSQ DVPLKEQMRM 
481:	VGYELEHWQE TVDVSEKLEN MVPKEHTSDF QTRAPSYQIV KQGVALMLFI GLFVSVLFFI 
541:	VQGSMLYLRM FTEIEDTGVQ VLALKRIGVT DKEIHSILGK QIGFLFFIPF IAGTIHAGFA 
601:	YAALSNMLNS NLFLEAVIVI FIYFVFQALY YIVTRHIYKR AVLQRM