TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.1.134.3
The putative bacitracin exporter, BceAB (BarAB; YtsCD) (Bernard et al., 2003; Ohki et al., 2003).  Functions in both signaling to the two component system, BceRS, and in export of the antimicrobial peptide (Dintner et al. 2014).  BceB interacts directly with BceS, and BceB binds bacitracin (Dintner et al. 2014).  Specific regions and residues are invollved in signalling or transport (Kallenberg et al. 2013).  More recent studies suggest taht BceAB may cause bacitracin resistance by transferring undecaprenyl pyrophosphate from the exteral to the internal leaflet of the inner membrane where it can't bind bacitracin and other lantibiotics that use Lipid II as a receptor (Draper et al. 2015).

Accession Number:O34741
Protein Name:BceB aka YtsD
Length:646
Molecular Weight:72186.00
Species:Bacillus subtilis [1423]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Bacitracin

Cross database links:

HEGENOM: HBG693049
RefSeq: NP_390915.1   
Entrez Gene ID: 938178   
Pfam: PF02687   
BioCyc: SUBTI:BSU30370-MONOMER   
KEGG: bsu:BSU30370   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0046677 P:response to antibiotic
GO:0006810 P:transport

References (5)

[1] “Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region.”  Lapidus A.et.al.   9387221
[2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[3] “YtsCD and YwoA, two independent systems that confer bacitracin resistance to Bacillus subtilis.”  Bernard R.et.al.   14612242
[4] “The BceRS two-component regulatory system induces expression of the bacitracin transporter, BceAB, in Bacillus subtilis.”  Ohki R.et.al.   12890034
[5] “Cell wall stress responses in Bacillus subtilis: the regulatory network of the bacitracin stimulon.”  Mascher T.et.al.   14651641

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MNINQLILRN LKKNLRNYYL YVFALIFSVA LYFAFVTLQY DPAINEVKAS IKGAAAIKTA 
61:	SILLVAVVAI FILYANTIFI KRRSKEIGLF QLIGMTKHKI FRILSAENVM LYFGSLAIGV 
121:	AAGFSISKLV LMILFKIVDV KADAKLHFSE QALVQTVIVF CGIYLLIMIM NYTFIKKQSI 
181:	LSLFKVTSST EDKVKKISFF QMLIGALGIV LILTGYYVSS ELFGGKFKTI NELFVAMSFI 
241:	LGSVIIGTFL FYKGSVTFIS NIIRKSKGGY LNISEVLSLS SIMFRMKSNA LLLTIITTVS 
301:	ALAIGLLSLA YISYYSSEKT AEQNVAADFS FMNEKDAKLF ENKLRESNIS FVKKATPVLQ 
361:	ANVDIANIMD GTPKEMQGDP GNMQLAVVSD KDVKGVDVAA GEAVFSGYTD LLQKIMVFKD 
421:	SGVIKVKSKH ETQPLKYKGL REEFLVSYTF TSGGMPAVIV DDSLFKQLDK DKDPRIQLAQ 
481:	STFIGVNVKH DDQMEKANEL FQQVNKKNEH LSRLDTSAAQ KSLFGMVMFI VGFLGLTFLI 
541:	TSGCILYFKQ MGESEDEKPS YTILRKLGFT QGDLIKGIRI KQMYNFGIPL VVGLFHSYFA 
601:	VQSGWFLFGS EVWAPMIMVM VLYTALYSIF GFLSVLYYKK VIKSSL