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3.A.1.5.10
Oligopeptide porter (transports peptides of 4-35) amino acyl residues; di- and tripeptides are not transported; hydrophobic basic peptides are preferred). OppA determines the specificity of the system (Doeven et al., 2004). A large cavity in OppA binds proline-rich peptides preferentially (Berntsson et al., 2009). Two crystal structures of OppA with different nonapeptides show binding in different registers (Berntsson et al., 2011).

Accession Number:P0A2V4
Protein Name:OppF
Length:319
Molecular Weight:35976.00
Species:Lactococcus lactis subsp. lactis (Streptococcus lactis) [1360]
Location1 / Topology2 / Orientation3: Cell membrane1 / Peripheral membrane protein2
Substrate Oligopeptides

Cross database links:

HEGENOM: HBG758042
RefSeq: NP_267997.1   
Entrez Gene ID: 1115505   
Pfam: PF00005    PF08352   
BioCyc: LLAC272623:L92192-MONOMER   
KEGG: lla:L92192   

Gene Ontology

GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0016887 F:ATPase activity
GO:0015833 P:peptide transport
GO:0015031 P:protein transport

References (2)

[1] “Genetic and biochemical characterization of the oligopeptide transport system of Lactococcus lactis.”  Tynkkynen S.et.al.   8244921
[2] “The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403.”  Bolotin A.et.al.   11337471

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSEILNLKDL KVYYPIRSGF FNRVTDNVLA VDGVDLTIHE GETVGLVGES GSGKSTIGKT 
61:	IVGLEQMTSG QLIYKGQDVS KKKIRNQLKY NKDVQMIFQD AFSSLNPRKT IYDIIAEPIR 
121:	NFEKIDANTE NKRIHELLDI VGLPKQALEQ YPFQFSGGQQ QRIGIARAVA TNPKLIVADE 
181:	PVSALDLSVQ AQVLNFMKLI QKDLGIAFLF ISHDLGVVRH MTDNIAVMHN GRIVEKGTRR 
241:	DIFDEPQHIY TKRLLSAIPS IDVTRRAENR KNRLKVEQDF EDKKANFYDK DGHALPLKKL 
301:	SESHWAALPK GGENVESNY