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3.A.1.5.10
Oligopeptide porter (transports peptides of 4-35) amino acyl residues; di- and tripeptides are not transported; hydrophobic basic peptides are preferred). OppA determines the specificity of the system (Doeven et al., 2004). A large cavity in OppA binds proline-rich peptides preferentially (Berntsson et al., 2009). Two crystal structures of OppA with different nonapeptides show binding in different registers (Berntsson et al., 2011).

Accession Number:P0A4N7
Protein Name:OppB
Length:319
Molecular Weight:35962.00
Species:Lactococcus lactis subsp. lactis (Streptococcus lactis) [1360]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Oligopeptides

Cross database links:

HEGENOM: HBG724229
RefSeq: NP_267996.1   
Entrez Gene ID: 1115504   
Pfam: PF00528   
BioCyc: LLAC272623:L91252-MONOMER   
KEGG: lla:L91252   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0015833 P:peptide transport
GO:0015031 P:protein transport

References (2)

[1] “Genetic and biochemical characterization of the oligopeptide transport system of Lactococcus lactis.”  Tynkkynen S.et.al.   8244921
[2] “The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403.”  Bolotin A.et.al.   11337471

External Searches:

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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MWKVIIRRIL LMIPQLFILS ILVFFFAKLM PGDPFSGLIG PHTDPHEVEA LRRAAGLYDP 
61:	WWEQYLRWLG NAIHGNLGMS YNLKEPVMTV IGHRAINTFW MSLLSVILTY LFAIPMSIVA 
121:	ARNEGKWQDQ LWLTYNSITF GIPPYVFYLL IIFIFGYSLN WFPTGGTVSP DAMGIIPVFF 
181:	SKIYHMILPA FSLAVFGTVG IFTYFRSGIL DEQTQDYVRT ARAKGVKEKV IFRRHILRNA 
241:	SLPIASNFGF VITGLLGGAI FAETIFGYPG LGQLFITSIS GRDYSMITAL ILLNGFLGLL 
301:	GALLSDIIMA MVDPRIRIQ