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3.A.1.5.10
Oligopeptide porter (transports peptides of 4-35) amino acyl residues; di- and tripeptides are not transported; hydrophobic basic peptides are preferred). OppA determines the specificity of the system (Doeven et al., 2004). A large cavity in OppA binds proline-rich peptides preferentially (Berntsson et al., 2009). Two crystal structures of OppA with different nonapeptides show binding in different registers (Berntsson et al., 2011).

Accession Number:P0A4N9
Protein Name:OppC
Length:294
Molecular Weight:32835.00
Species:Lactococcus lactis subsp. lactis (Streptococcus lactis) [1360]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Oligopeptides

Cross database links:

HEGENOM: HBG729429
RefSeq: NP_267995.1    YP_001174732.1   
Entrez Gene ID: 1115503    5077311   
Pfam: PF00528   
BioCyc: LLAC272623:L90358-MONOMER   
KEGG: lla:L90358   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0015833 P:peptide transport
GO:0015031 P:protein transport

References (2)

[1] “Genetic and biochemical characterization of the oligopeptide transport system of Lactococcus lactis.”  Tynkkynen S.et.al.   8244921
[2] “The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403.”  Bolotin A.et.al.   11337471

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTEKKHKNSL SLVHSIKEEL KKDKLAMIST IFLVAVFLIV YIYSMFLKQS NYVDVNIMDQ 
61:	YLAPLTNGHL LGTDNGGRDI IMMLMISARN SFNIAFAVTL ITLVVGNILG VITGYFGGRF 
121:	DLIFMRFTDF VMILPSMMII IVFVTIIPRF NSWSLIGIIS IFSWIGTTRL IRARTMTEVN 
181:	RDYVRASKTS GTSDFKIMFR EIWPNLSTLV IAEATLVFAG NIGLETGLSF LGFGLPAGTP 
241:	SLGTMINEAT NPETMTDKPW TWVPATVVIL IVVLAIIFIG NALRRVADQR QATR