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3.D.10.1.7
Succinate dehydrogenase complex, or succinate:ubiquinone oxidoreductase (SQR) or  mitochondrial respiratory complex II of four subunits, SdhA, B, C and D.  Does not transport protons across the membrane, but all 4 subunits are homologous to the prokaryotic Sdh subunits that do transport protons.  It is an integral membrane protein complex in both the tricarboxylic acid cycle and aerobic respiration. Sun et al. 2005 reported the first crystal structure of Complex II from porcine heart at 2.4 Å resolution and its complex structure with inhibitors 3-nitropropionate and 2-thenoyltrifluoroacetone (TTFA) at 3.5 Å resolution. Complex II is comprised of two hydrophilic proteins, flavoprotein (Fp) and iron-sulfur protein (Ip), and two transmembrane proteins (CybL and CybS), as well as prosthetic groups required for electron transfer from succinate to ubiquinone. The structure correlates the protein environments around prosthetic groups with their unique midpoint redox potentials. Two ubiquinone binding sites are identified. The structure provides a bona fide model for study of the mitochondrial respiratory system and human mitochondrial diseases related to mutations in this complex (Sun et al. 2005).

Accession Number:P21912
Protein Name:Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Length:280
Molecular Weight:31630.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Peripheral membrane protein2 / Matrix side3
Substrate

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FASTA formatted sequence
1:	MAAVVALSLR RRLPATTLGG ACLQASRGAQ TAAATAPRIK KFAIYRWDPD KAGDKPHMQT 
61:	YEVDLNKCGP MVLDALIKIK NEVDSTLTFR RSCREGICGS CAMNINGGNT LACTRRIDTN 
121:	LNKVSKIYPL PHMYVIKDLV PDLSNFYAQY KSIEPYLKKK DESQEGKQQY LQSIEEREKL 
181:	DGLYECILCA CCSTSCPSYW WNGDKYLGPA VLMQAYRWMI DSRDDFTEER LAKLQDPFSL 
241:	YRCHTIMNCT RTCPKGLNPG KAIAEIKKMM ATYKEKKASV