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3.A.1.4.1
Leucine; leucine/isoleucine/valine porter (also transports phenylalanine and tyrosine; Koyanagi et al., 2004)

Accession Number:P22731
Protein Name:LivF aka B3454
Length:237
Molecular Weight:26310.00
Species:Escherichia coli [83333]
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate phenylalanine, Valine, Isoleucine, Leucine, tyrosine

Cross database links:

Genevestigator: P22731
EchoBASE: EB0531
EcoGene: EG10536
eggNOG: COG0410
HEGENOM: HBG758042
RefSeq: AP_004338.1    NP_417911.4   
Entrez Gene ID: 947961   
Pfam: PF00005   
BioCyc: EcoCyc:LIVF-MONOMER    ECOL168927:B3454-MONOMER   
KEGG: ecj:JW3419    eco:b3454   

Gene Ontology

GO:0005524 F:ATP binding
GO:0016887 F:ATPase activity
GO:0005515 F:protein binding
GO:0006865 P:amino acid transport

References (4)

[1] “Nucleotide sequence and genetic characterization reveal six essential genes for the LIV-I and LS transport systems of Escherichia coli.”  Adams M.D.et.al.   2195019
[2] “Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes.”  Sofia H.J.et.al.   8041620
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEKVMLSFDK VSAHYGKIQA LHEVSLHINQ GEIVTLIGAN GAGKTTLLGT LCGDPRATSG 
61:	RIVFDDKDIT DWQTAKIMRE AVAIVPEGRR VFSRMTVEEN LAMGGFFAER DQFQERIKWV 
121:	YELFPRLHER RIQRAGTMSG GEQQMLAIGR ALMSNPRLLL LDEPSLGLAP IIIQQIFDTI 
181:	EQLREQGMTI FLVEQNANQA LKLADRGYVL ENGHVVLSDT GDALLANEAV RSAYLGG