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1.F.1.1.3
The worm SNARE complex and it's regulators for vesicle neurotransmetter and neuropeptide release (Gracheva et al. 2007).  The SNARE complex consists of Syntaxin, SNAP and Synaptobrevin and mediates the synaptic vesicle cycle (Rathore et al. 2010).  Synaptotagmin I is a Ca2+ sensor triggering vesicle fusion (Yu et al. 2013).  Regulators include Snapin dimers (Yu et al. 2013), Complexin, a presynaptic protein that interacts with the SNARE complex; the C-terminal domain binds lipids to inhibit exocytosis (Hobson et al. 2011; Wragg et al. 2013), Unc-18, which binds syntaxin and regluates synaptic vesicle (neurotransmitter) docking (Graham et al. 2011), Unc13 which also regluates docking of the synaptic vescicles to the plasma membrane by interacting with syntaxin, CAPS or Unc31, a Ca2+-activated protein for secretion that is required for dense core vesicle docking for neuropeptide release (Lin et al. 2010), and Tomosyn or Tom-1, a negative regluator of both neurotransmitter and neuropeptide release (Gracheva et al. 2007).

Accession Number:P27715
Protein Name:Phorbol ester/diacylglycerol-binding protein unc-13
Length:2155
Molecular Weight:245231.00
Species:Caenorhabditis elegans [6239]
Substrate neurotransmitter

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDDVGDYNDD QLSDGMSMRL LCITIKKARL QGAVDEFNSY VTVKLQTVKS TTVAVRGNLP 
61:	CWEQEFIFET NRPDDGMVLE LWAKGVLWDK LIGVHYMPLS EIRYSNAAGS GQWLQMDHEL 
121:	ETRNGQTVGT RGPTGHNLLT DVRFELPFDV QGHDEDIQSR LLALNGLIEH DQLGPNNHHR 
181:	APFNHSGLSE DSDYTSDVSV PVNHHQLHPN SSAHQYESHL HPHRTRQLLH TREGAASYED 
241:	EEDAYHARHQ PESDDYNHQD TYDQHSSYYN DEYAPSGSSS QYQRQGYQDQ DQQHQNIYED 
301:	TVTPVREFGE SAVPPAASSS RRQFDQVYGY ASSSEERYDT PMSSGRLPRD EPILEHSEPE 
361:	YVYDQNGYPE EDNYGINPTY SEDHFEGQTN DYSTTHQEPN DFRNDYNSSY QREYWNESEP 
421:	LSYNSRPPNG HIRTGANTWR EPSTSSRPTS SQAWNYQDDT HQYDEVDRGS RVSFTRTPSV 
481:	DRTDRPSESG GGFYDEMSES GRPGRPDSHH NWRYDSIQEE DNEKDNWKQH VEGYEEGQEE 
541:	KQKDNQKPND HSAASPQDHY HRSDSTAQQD FGNNIVRQTI QEEEEKRNYQ ELWHNAYKRV 
601:	CADLGIKSSQ ASLVATTGGT LLQNLFLYRP KLAPAGHGAT ASQFQSPAGA TRFYANHNNN 
661:	NNNVSKNELD STTETPPDPS RTPSTSSMNP VPSLAVPMSP GPYLNSDPPS PVSPNPQIKR 
721:	SIYRIKESYE DRNGGRERIY TTNLVSVYLE KMKPPDELEE GSSGSMRETQ NEIKNGTQLH 
781:	NAESNIFFPQ DSVPKSISYN AGNLKNTSIT TSKTSSAITN HSSLPPQPPS KPASRDSDPM 
841:	KQLLTFSKSF KKVRRVRSAM PRRRKRKRVK IKKSRSCPIL WKTEKTPHPM KSKSMTCIRI 
901:	PKKTVIAPLR KEIKIVRMKP PAARCESDSK AHKKKNLLDV YKDMGKSTVL DGNGSSAANA 
961:	FYKSIDAAPN MNVARTKTSI PLVSELVLKT MATKRAQAGL ANAARTTFSD TELKTHVYKK 
1021:	TLQALIYPIS ATTPHNFATT TFQTPTFCYE CEGLLWGLAR QGLRCTQCQV KVHDKCRELL 
1081:	SADCLQRAAE KSTKHGEADR TQSLVNVIRD RMKIQEQNKP EVFQMIRTVF DVDENIQKET 
1141:	LKTVKASILE GSSKWSAKIT LTVLCAQGLI AKDKTGKSDP YVTAQVGKTK RRTRTIHQEL 
1201:	NPVWNEKFHF ECHNSTDRIK VRVWDEDNDL KSKLRQKLTR ESDDFLGQTV IEVRTLSGEM 
1261:	DVWYNLEKRT DKSAVSGAIR LHINVEIKGE EKLAPYHVQY TCLHEHLFAA HCVDEEVKLP 
1321:	KVRGEDSWKV CFQETGQEIA EEFAMRYGIE SIYQAMTHFA CLCTRYMCAG VPAVLSTLLA 
1381:	NINAYYAHTT ATSAVSAPDR FAASNFGKER FVKLLDQLHN SLRIDLSAYR NHFPSSSPAK 
1441:	LQDLKSTVDL LTSITFFRMK VLELASPPRA STVVRECAKA CMQQTYQLMF ESCAEQFPIL 
1501:	DTSVQFWYEF IDYIMRVIEE DQKNYTPALN QFPQELNVGN LSAETLWSMY KNDLKMALEE 
1561:	HAQKKRCKTP EYMNLYFKVK GFYFKYVADL STYKSSIPEF PAWFIPFVMD WLNENDEHSM 
1621:	DILRNAYNVD KADNFPQTSE HTKFSNSVVD VFTQLNAALK LLKQMDCPNP EVAADMMKRF 
1681:	SKTLNKVLLA YADMVQKDFP KFAHDEKLAC ILMNNVQQLR VQLEKIYETM GGAELDEHIG 
1741:	QVLTVLQKKL NSVLDRLSAE FVTTLEPHIH EQTIKLGMLL VKIKGPQLQK TQVQPEADAV 
1801:	LEPLMDLLEG SLRRYADQCE KTVLKYILKE LWKITIVNME KRVVLPPLSD KALLKQLPNA 
1861:	KIGDVTKLMS TNIQSIKGMN SVKDMMDMAR ESEKSLTPRQ CTVLDCALDA IKDSFHASGK 
1921:	GLKKSFFEKS PELQSLKYAL SLYTQTTEQL IKTFITSQRQ QDLPSQEQPV GEVSVQVDLF 
1981:	SHPGTGEQKV TVKILAANDL RWQTSSAFKP FVEVHLVGPH LSDKKRKWST KTKAGNWAPK 
2041:	FNETFHFFLG NEGEPEHYEL MFQVKDYCFA RDDRVVGVGV LQLSSVVDQA GSCAMWVQLG 
2101:	TRLHIDETGL ILLRILSQRQ TDEVAKDFVR LKTECRYETE TVMAASASSQ NINRT