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3.A.1.129.1
Thiol (Cysteine/Glutathione) exporter, CydDC; CydC is also called MdrH (periplasmic cysteine is required for cytochrome bd assembly) (Cruz-Ramos et al., 2004).  The purified asymmetric heterodimer exhibits low ATPase activity which is activated by both thiols and heme (e.g., heme b) compounds, suggesting that heme binds to and activates thiol transport (Yamashita et al. 2014).  Bacterial redox homoeostasis during nitrosative stress is influenced by CydDC.  Periplasmic low molecular weight thiols restore haem incorporation into a cytochrome complex (Holyoake et al. 2016).

Accession Number:P29018
Protein Name:Transport ATP-binding protein CydD
Length:588
Molecular Weight:65056.00
Species:Escherichia coli [83333]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Cysteine, Glutathione

Cross database links:

Genevestigator: P29018
EchoBASE: EB1377
EcoGene: EG11405
eggNOG: COG4988
HEGENOM: HBG758042
DIP: DIP-9363N
RefSeq: AP_001517.1    NP_415407.1   
Entrez Gene ID: 949052   
Pfam: PF00664    PF00005   
BioCyc: EcoCyc:CYDD-MONOMER    ECOL168927:B0887-MONOMER   
KEGG: ecj:JW0870    eco:b0887   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0055085 P:transmembrane transport

References (8)

[1] “Cytochrome bd biosynthesis in Escherichia coli: the sequences of the cydC and cydD genes suggest that they encode the components of an ABC membrane transporter.”  Poole R.K.et.al.   7934832
[2] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Isolation and characterization of an Escherichia coli mutant defective in resuming growth after starvation.”  Siegele D.D.et.al.   8276245
[6] “Molecular characterization of the Escherichia coli htrD gene: cloning, sequence, regulation, and involvement with cytochrome d oxidase.”  Delaney J.M.et.al.   8380150
[7] “Isolation and characterization of the Escherichia coli htrD gene, whose product is required for growth at high temperatures.”  Delaney J.M.et.al.   1310500
[8] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNKSRQKELT RWLKQQSVIS QRWLNISRLL GFVSGILIIA QAWFMARILQ HMIMENIPRE 
61:	ALLLPFTLLV LTFVLRAWVV WLRERVGYHA GQHIRFAIRR QVLDRLQQAG PAWIQGKPAG 
121:	SWATLVLEQI DDMHDYYARY LPQMALAVSV PLLIVVAIFP SNWAAALILL GTAPLIPLFM 
181:	ALVGMGAADA NRRNFLALAR LSGHFLDRLR GMETLRIFGR GEAEIESIRS ASEDFRQRTM 
241:	EVLRLAFLSS GILEFFTSLS IALVAVYFGF SYLGELDFGH YDTGVTLAAG FLALILAPEF 
301:	FQPLRDLGTF YHAKAQAVGA ADSLKTFMET PLAHPQRGEA ELASTDPVTI EAEELFITSP 
361:	EGKTLAGPLN FTLPAGQRAV LVGRSGSGKS SLLNALSGFL SYQGSLRING IELRDLSPES 
421:	WRKHLSWVGQ NPQLPAATLR DNVLLARPDA SEQELQAALD NAWVSEFLPL LPQGVDTPVG 
481:	DQAARLSVGQ AQRVAVARAL LNPCSLLLLD EPAASLDAHS EQRVMEALNA ASLRQTTLMV 
541:	THQLEDLADW DVIWVMQDGR IIEQGRYAEL SVAGGPFATL LAHRQEEI