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1.F.1.1.3
The worm SNARE complex and it's regulators for vesicle neurotransmetter and neuropeptide release (Gracheva et al. 2007).  The SNARE complex consists of Syntaxin, SNAP and Synaptobrevin and mediates the synaptic vesicle cycle (Rathore et al. 2010).  Synaptotagmin I is a Ca2+ sensor triggering vesicle fusion (Yu et al. 2013).  Regulators include Snapin dimers (Yu et al. 2013), Complexin, a presynaptic protein that interacts with the SNARE complex; the C-terminal domain binds lipids to inhibit exocytosis (Hobson et al. 2011; Wragg et al. 2013), Unc-18, which binds syntaxin and regluates synaptic vesicle (neurotransmitter) docking (Graham et al. 2011), Unc13 which also regluates docking of the synaptic vescicles to the plasma membrane by interacting with syntaxin, CAPS or Unc31, a Ca2+-activated protein for secretion that is required for dense core vesicle docking for neuropeptide release (Lin et al. 2010), and Tomosyn or Tom-1, a negative regluator of both neurotransmitter and neuropeptide release (Gracheva et al. 2007).

Accession Number:P34693
Protein Name:Synaptotagmin-1
Length:441
Molecular Weight:49904.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cytoplasmic vesicle1 / Single-pass membrane protein2
Substrate neurotransmitter

Cross database links:

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVKLDFSSQD EENDEDLTKE FVRDEAPMEE TTSEAVKQIA TTTKETLKDV VVNKVIDVKD 
61:	VVKEKVMQQT GMPEWAFVFL GFVFILLVLA CAFCLIRKLF GKKRHGEKNK KGGLKGFFGK 
121:	GQDVVDGKNI QGMAQDLEEL GDAMEQNEKE QAEEKEEVKL GRIQYKLDYD FQQGQLTVTV 
181:	IQAEDLPGMD MSGTSDPYVK LYLLPEKKKK VETKVHRKTL NPVFNETFIF KVAFNEITAK 
241:	TLVFAIYDFD RFSKHDQIGQ VLIPLGKIDL GAVIEEWKDI APPPDDKEAE KSLGDICFSL 
301:	RYVPTAGKLT VVILEAKNLK KMDVGGLSDP YVKIVLMQGG KRLKKKKTSI KKCTLNPYYN 
361:	ESFSFEVPFE QIQKVSLMIT VMDYDKLGSN DAIGRCLLGC NGTGAELRHW MDMLASPRRP 
421:	IAQWHTLGPV EEEGDKKDDK K