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1.A.9.1.13
Neuronal acetylcholine receptor with two subunits, α- and β-subunits, Unc-63 (Lev7; 502 aas) and Acr-2 (575 aas), respectively.  Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion (Jospin et al. 2009). Involved in nAChR sensitivity to nicotine and levamisole (Culetto et al. 2004; Gottschalk et al. 2005). The AcChR subunits in C. elegans have been compared with those of parasitic nematodes (Holden-Dye et al. 2013).

Accession Number:P48182
Protein Name:Acetylcholine receptor subunit beta-type acr-2
Length:575
Molecular Weight:65595.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell junction1 / Multi-pass membrane protein2
Substrate

Cross database links:

eggNOG: meNOG06680
HEGENOM: HBG387619
RefSeq: NP_509128.1   
Entrez Gene ID: 180936   
Pfam: PF02931    PF02932   
KEGG: cel:K11G12.2   

Gene Ontology

GO:0030054 C:cell junction
GO:0016021 C:integral to membrane
GO:0045211 C:postsynaptic membrane
GO:0004889 F:nicotinic acetylcholine-activated cation-se...
GO:0004872 F:receptor activity
GO:0006811 P:ion transport

References (2)

[1] “Molecular cloning and functional co-expression of a Caenorhabditis elegans nicotinic acetylcholine receptor subunit (acr-2).”  Squire M.D.et.al.   8581398
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MKKTVKILLI LITVFLKVHC NGGHDDEAAD FLSHTNIDDP NNSSDPNKNS DQGDTMGEDE 
61:	DRLVIDLFRE YNFLIRPVKN VSSPPVVVDF GVAMILLINV DEKNQILQTN VWLTMKWNDF 
121:	QLAWNPAEYG NISNLHVPSD RVWLPDIVLF NNADGNYEVS FKSNVFVDHH GDVTWVPPAM 
181:	FKSSCRIDVE WFPFDEQCCT LVFGSWTYNS EEVRLHWYNN IQAVQLHDYS YSGIWDVIDV 
241:	PGQLVHKPDL KENKMVFNVV IRRKTLFYTV ILIIPTVLMA FLSVMAFYLP VDSGEKVSLT 
301:	ISLLLALVVF LLLVSKILPP TSNIPLMGKY LLLAFVLNIT AVVGTVVIVN IYFRSALSHK 
361:	MPTWVRKVFL EFLPHLLVMK RPERIPIFNG YFVEEYCASE IFDASLVMPS MTATMLPFLQ 
421:	VTTNLKAASS TSSGQSSEHH ENCSKWKKRL SIRMSKRRAP RARLDDDSED IIDDTNGNHV 
481:	DSLQEKISKE MKTTVEAIAY IAEHMKREMS LKKMRDDWKY VAMVLDRLIL LIFFGVTLGG 
541:	TLGIICSAPH VFDFVDQEAI ISKLNAKYLP SDMYS