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3.A.2.2.4
The ubiquitous 14 subunit vacuolar H+-ATPase, V1/V0, has been implicated in various human diseases including osteopetrosis, renal tubule acidosis, and cancer (Hinton et al., 2009).  The transmembrane enzyme, Ribonuclease kappa, RNASEK (137 aas; 2 TMSs; UniProt acc# Q6P5S7), closely associates with the V-ATPase and is required for its function; its loss prevents the early events of endocytosis and the replication of multiple pathogenic viruses (Perreira et al. 2015).

Accession Number:P61421
Protein Name:V-ATPase subunit d1
Length:351
Molecular Weight:40329.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Endomembrane system1 / Peripheral membrane protein2
Substrate H+

Cross database links:

Genevestigator: P61421
eggNOG: prNOG16262
HEGENOM: HBG317755
RefSeq: NP_004682.2   
Entrez Gene ID: 9114   
Pfam: PF01992   
Drugbank: Drugbank Link   
OMIM: 607028  gene
KEGG: hsa:9114   

Gene Ontology

GO:0033179 C:proton-transporting V-type ATPase, V0 domain
GO:0016471 C:vacuolar proton-transporting V-type ATPase ...
GO:0015986 P:ATP synthesis coupled proton transport

References (4)

[1] “Cloning and tissue distribution of subunits C, D, and E of the human vacuolar H(+)-ATPase.”  van Hille B.et.al.   8250920
[2] “Structure of the VPATPD gene encoding subunit D of the human vacuolar proton ATPase.”  Agarwal A.K.et.al.   11118322
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis.”  Smith A.N.et.al.   12384298

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FASTA formatted sequence
1:	MSFFPELYFN VDNGYLEGLV RGLKAGVLSQ ADYLNLVQCE TLEDLKLHLQ STDYGNFLAN 
61:	EASPLTVSVI DDRLKEKMVV EFRHMRNHAY EPLASFLDFI TYSYMIDNVI LLITGTLHQR 
121:	SIAELVPKCH PLGSFEQMEA VNIAQTPAEL YNAILVDTPL AAFFQDCISE QDLDEMNIEI 
181:	IRNTLYKAYL ESFYKFCTLL GGTTADAMCP ILEFEADRRA FIITINSFGT ELSKEDRAKL 
241:	FPHCGRLYPE GLAQLARADD YEQVKNVADY YPEYKLLFEG AGSNPGDKTL EDRFFEHEVK 
301:	LNKLAFLNQF HFGVFYAFVK LKEQECRNIV WIAECIAQRH RAKIDNYIPI F