TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.2.1.1
H+-translocating F-type ATPase

Accession Number:P68699
Protein Name:ATP synthase C chain ATPL aka ATPE aka UNCE aka PAPH aka B3737
Length:79
Molecular Weight:8256.00
Species:Escherichia coli [83333]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2

Cross database links:

Genevestigator: P68699
EchoBASE: EB0100
EcoGene: EG10102
eggNOG: COG0636
HEGENOM: HBG753983
RefSeq: AP_004050.1    NP_418193.1   
Entrez Gene ID: 948253   
Pfam: PF00137   
BioCyc: EcoCyc:ATPE-MONOMER    ECOL168927:B3737-MONOMER    MetaCyc:ATPE-MONOMER   
KEGG: ecj:JW3715    eco:b3737   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0045263 C:proton-transporting ATP synthase complex, c...
GO:0046933 F:hydrogen ion transporting ATP synthase acti...
GO:0008289 F:lipid binding
GO:0015986 P:ATP synthesis coupled proton transport

References (17)

[1] “Nucleotide sequence of genes coding for dicyclohexylcarbodiimide-binding protein and the alpha subunit of proton-translocating ATPase of Escherichia coli.”  Kanazawa H.et.al.   6266400
[2] “The nucleotide sequence of the atp genes coding for the F0 subunits a, b, c and the F1 subunit delta of the membrane bound ATP synthase of Escherichia coli.”  Nielsen J.et.al.   6278247
[3] “The atp operon: nucleotide sequence of the promoter and the genes for the membrane proteins, and the delta subunit of Escherichia coli ATP-synthase.”  Gay N.J.et.al.   6272190
[4] “The F1F0-ATPase of Escherichia coli. Substitution of proline by leucine at position 64 in the c-subunit causes loss of oxidative phosphorylation.”  Fimmel A.L.et.al.   6193778
[5] “DNA sequence around the Escherichia coli unc operon. Completion of the sequence of a 17 kilobase segment containing asnA, oriC, unc, glmS and phoS.”  Walker J.E.et.al.   6395859
[6] “Amino acid replacement in dicyclohexylcarbodiimide-reactive proteins from mutant strains of Escherichia coli defective in the energy-transducing ATPase complex.”  Wachter E.et.al.   6446460
[7] “Mutations in the uncE gene affecting assembly of the c-subunit of the adenosine triphosphatase of Escherichia coli.”  Jans D.A.et.al.   6309138
[8] “DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication.”  Burland V.D.et.al.   7686882
[9] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[10] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[11] “The preferred stoichiometry of c subunits in the rotary motor sector of Escherichia coli ATP synthase is 10.”  Jiang W.et.al.   11320246
[12] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996
[13] “Heteronuclear 1H-15N nuclear magnetic resonance studies of the c subunit of the Escherichia coli F1F0 ATP synthase: assignment and secondary structure.”  Norwood T.J.et.al.   1385726
[14] “Determination of local protein structure by spin label difference 2D NMR: the region neighboring Asp61 of subunit c of the F1F0 ATP synthase.”  Girvin M.E.et.al.   7849023
[15] “Solution structure of the transmembrane H+-transporting subunit c of the F1F0 ATP synthase.”  Girvin M.E.et.al.   9636021
[16] “Structural changes linked to proton translocation by subunit c of the ATP synthase.”  Rastogi V.K.et.al.   10580496
[17] “Model of the c-subunit oligomer in the membrane domain of F-ATPases.”  Groth G.et.al.   9237612
Structure:
1A91   1ATY   1C0V   1C17   1C99   1IJP   1J7F   1L6T   1QO1      [...more]

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MENLNMDLLY MAAAVMMGLA AIGAAIGIGI LGGKFLEGAA RQPDLIPLLR TQFFIVMGLV 
61:	DAIPMIAVGL GLYVMFAVA