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3.D.4.6.1
Cytochrome oxidase (CtaBD/CycA)

Accession Number:P98002
Protein Name:CX1B aka CtaDII
Length:558
Molecular Weight:62439.00
Species:Paracoccus denitrificans [266]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate H+

Cross database links:

DIP: DIP-6088N
RefSeq: YP_915727.1   
Entrez Gene ID: 4581060   
Pfam: PF00115   
Drugbank: Drugbank Link   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0070469 C:respiratory chain
GO:0005507 F:copper ion binding
GO:0004129 F:cytochrome-c oxidase activity
GO:0009055 F:electron carrier activity
GO:0020037 F:heme binding
GO:0009060 P:aerobic respiration
GO:0022900 P:electron transport chain
GO:0015992 P:proton transport

References (5)

[1] “Are there isoenzymes of cytochrome c oxidase in Paracoccus denitrificans?”  Raitio M.et.al.   2155830
[2] “Structure at 2.8-A resolution of cytochrome c oxidase from Paracoccus denitrificans.”  Iwata S.et.al.   7651515
[3] “Structure at 2.7-A resolution of the Paracoccus denitrificans two-subunit cytochrome c oxidase complexed with an antibody FV fragment.”  Ostermeier C.et.al.   9380672
[4] “Evidence for a copper-coordinated histidine-tyrosine cross-link in the active site of cytochrome oxidase.”  Buse G.et.al.   10338009
[5] “Cytochrome c oxidase.”  Ostermeier C.et.al.   8794157
Structure:
1AR1   1QLE   1ZYY   3EHB   3HB3     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MADAAVHGHG DHHDTRGFFT RWFMSTNHKD IGILYLFTAG IVGLISVCFT VYMRMELQHP 
61:	GVQYMCLEGA RLIADASAEC TPNGHLWNVM ITYHGVLMMF FVVIPALFGG FGNYFMPLHI 
121:	GAPDMAFPRL NNLSYWMYVC GVALGVASLL APGGNDQMGS GVGWVLYPPL STTEAGYSMD 
181:	LAIFAVHVSG ASSILGAINI ITTFLNMRAP GMTLFKVPLF AWSVFITAWL ILLSLPVLAG 
241:	AITMLLMDRN FGTQFFDPAG GGDPVLYQHI LWFFGHPEVY IIILPGFGII SHVISTFAKK 
301:	PIFGYLPMVL AMAAIGILGF VVWAHHMYTA GMSLTQQAYF MLATMTIAVP TGIKVFSWIA 
361:	TMWGGSIEFK TPMLWAFGFL FLFTVGGVTG VVLSQAPLDR VYHDTYYVVA HFHYVMSLGA 
421:	VFGIFAGVYY WIGKMSGRQY PEWAGQLHFW MMFIGSNLIF FPQHFLGRQG MPRRYIDYPV 
481:	EFAYWNNISS IGAYISFASF LFFIGIVFYT LFAGKRVNVP NYWNEHADTL EWTLPSPPPE 
541:	HTFETLPKRE DWDRAHAH