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3.A.1.127.1
Exporter of AmfS extracellular peptidic morphogen (Chater and Horinouchi, 2003; Ueda et al., 2002)

Accession Number:Q07638
Protein Name:AmfA
Length:634
Molecular Weight:66529.00
Species:Streptomyces griseus [1911]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Secreted1
Substrate peptides

Cross database links:

Pfam: PF00005   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0055085 P:transmembrane transport

References (2)

[1] “A gene cluster involved in aerial mycelium formation in Streptomyces griseus encodes proteins similar to the response regulators of two-component regulatory systems and membrane translocators.”  Ueda K.et.al.   8458843
[2] “Characterization of an A-factor-responsive repressor for amfR essential for onset of aerial mycelium formation in Streptomyces griseus.”  Ueda K.et.al.   9748440

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKAGRAPGRD EQAPGARPRQ AGQRHDARPA RDGKRHGARG RRDTSLRRVG REARPFLRAR 
61:	TGAILRLAGW SLLEFAQTFL GGFGVARALD DGFLAGRPTT GLLWLAVAAA AVLPSVPAAR 
121:	GVFGRLADLV EPLRDGLVRR AVSRALSGAL DRAGDVSTRS LSQVTHQSEI ARDGWAGLVL 
181:	TLRSFVFTAA GAVTGLLALS PALLLIVLPP LLLGAALFLA TLPPMAARQR DYLAADEAYA 
241:	AHAGRLAASV RDIAAAGAAE RTVTESRTLA EEQLAASRSL ARWSGVRVLA LAVCGRFPPL 
301:	LLLLGAPWLL RNGLTPGALV GALTYLTQAL APAVQALMTM LGTAGGRLVV VLDRFTDAPP 
361:	PPADDPPPAR EAAPPHRGTP VAELHEVSFA YGPGAQPVLD RLSLTIEAGE HLAVVGPSGS 
421:	GKSTLAAVLA GTERPTGGAV RWRGRPVRPA DATAVRVLLP QHAYVFSGSL RDNLRYHRPG 
481:	ARDREIAAMA DTLGLDPLLS RLGSLDAAVE PDRLSQGERQ LIALGRAYLA APPLLILDEA 
541:	TSRLDPAAET RVEHAFGALP GALVVVAHRL SSARRAGRTL VMDGPRTQCG THGELLDSCA 
601:	LYRDLAGLWE PADGRGEGSG RREGNGRGAE RGRG