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3.A.1.1.9
The oligosaccharide (glucuronate-linked to a xylo-oligosaccharide) ABC uptake porter, GuoEFGK in AguEFGK. GuoE binds with high affinity a four sugar aldotetrouronic
acid [2-O-α-(4-O-methyl-α-D-glucuronosyl)-xylotriose] (Shulami et al., 1999; S.Shulami, personal communication)

Accession Number:Q09LY7
Protein Name:Sugar abc transport system permease component
Length:360
Molecular Weight:39949.00
Species:Bacillus stearothermophilus [1422]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate oligosaccharides

Cross database links:

Pfam: PF00528   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0006810 P:transport

References (5)

[1] “Cloning and DNA sequence of the gene coding for Bacillus stearothermophilus T-6 xylanase.”  Gat O.et.al.   8031084
[2] “The glucuronic acid utilization gene cluster from Bacillus stearothermophilus T-6.”  Shulami S.et.al.   10368143
[3] “Stereochemistry of family 52 glycosyl hydrolases: a beta-xylosidase from Bacillus stearothermophilus T-6 is a retaining enzyme.”  Bravman T.et.al.   11322943
[4] “Biochemical characterization and identification of catalytic residues in alpha-glucuronidase from Bacillus stearothermophilus T-6.”  Zaide G.et.al.   11358519
[5] “A Two-Component System Regulates the Expression of an ABC Transporter for Xylo-Oligosaccharides in Geobacillus stearothermophilus.”  Shulami S.et.al.   17142383

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRKKEQSSGF NDGGVRTGAS SEREFTSMSA PAFLQEMTPE GGNGYAVGRR CQRTNNSGGS 
61:	KESSEKKRNV AVACYVASAL IIVVDFSICS DARTGHGFSS YEPWLGFFAF SLPLVSSIFK 
121:	TMFEYEDARQ VIWNTLVIST LKIIFNLGVP LAFALLLNEV YVMKFKRTVQ TIVYLPHFLS 
181:	WVILGGILID MLSPEGGIVN RFLSIFGVKP IFFLGDNDWF RTVVVVTDVW KECGFNTIVF 
241:	LAALTSIKGS LYEAAIVDGA NRWQQTIYIS LPSMLPIIIV VGTLSLGNIL NAGFDQILNL 
301:	YNPLVYKTGD IIDTYVYRVG LLNGDFSYAT AVGLFKSVIS FILVVTGYRL AYKYANYKIF