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3.A.1.27.4
The cholesterol uptake porter (Mohn et al., 2008). Takes up cholesterol, 5-α-cholestanol, 5-α-cholestanone, β-sitosterol, etc. (It is not established that all of these proteins comprise the system or that other gene products are not involved.)

Accession Number:Q0S7K1
Protein Name:MCE family protein
Length:338
Molecular Weight:36293.00
Species:rhodococcus sp. (strain rha1) [101510]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Peripheral membrane protein2 / Cytoplasmic side3
Substrate cholesterol

Cross database links:

eggNOG: COG1463
HEGENOM: HBG658533
RefSeq: YP_704643.1   
Entrez Gene ID: 4222250   
Pfam: PF02470   
BioCyc: RSP101510:RHA1_RO04699-MONOMER   
KEGG: rha:RHA1_ro0469   

References (1)

[1] “The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse.”  McLeod M.P.et.al.   17030794

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRATTVKLLI FATVMSVIFA GLALVFSQYR FSSSDGYHAT FTDVSGLKPG DKVRIAGVPV 
61:	GAVEKVSIDD DNLADVDFTV DTKYSLFDGT KATVRYENLV GDRYMELLEG AGSVEPLPDG 
121:	GSIPVENTSP ALDLDLLLGG FKPLLRALDP QQVNDLSQAL VQVFQGQGGT LVSLLGSTSS 
181:	FTNTLADRDQ LIGEVITNLN QVLGTINDRG DQFRSTLDQL QQLVSGLSQD RDQIGDAIPR 
241:	IAGATGDLAN LLEGARPPLQ STIAEANRTA TQLQAGEDDL DWVFQNLPDA YRRLIRIGTY 
301:	GSFFQMYVCT VKFKFSGPDG SDLLLNMPGG QTAGRCAP