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3.A.1.27.4
The cholesterol uptake porter (Mohn et al., 2008). Takes up cholesterol, 5-α-cholestanol, 5-α-cholestanone, β-sitosterol, etc. (It is not established that all of these proteins comprise the system or that other gene products are not involved.)

Accession Number:Q0SFA1
Protein Name:Probable bifunctional ABC transport system
Length:363
Molecular Weight:39472.00
Species:rhodococcus sp. (strain rha1) [101510]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type III membrane protein2
Substrate cholesterol

Cross database links:

eggNOG: COG1127
HEGENOM: HBG758042
RefSeq: YP_701943.1   
Entrez Gene ID: 4218191   
Pfam: PF00005   
BioCyc: RSP101510:RHA1_RO01974-MONOMER   
KEGG: rha:RHA1_ro0197   

Gene Ontology

GO:0005524 F:ATP binding
GO:0016887 F:ATPase activity

References (1)

[1] “The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse.”  McLeod M.P.et.al.   17030794

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MGVEVSVEGL TKSFGSQRIW QDVTLTLPAG EVSALLGPSG TGKSVFLKSL IGLLRPEQGS 
61:	IVIDGTNILE CSSKELYEIR KLFGVLFQDG ALFGSMNLFD NVAFPLREHT KKSESEIRKI 
121:	VMEKMELVGL LGAEDKLPGE ISGGMRKRAG LARALVLDPQ IILVDEPDSG LDPVRTTYIS 
181:	QTLIDINAEI DATILIVSHN INLARTVPDN IGMLFRRHLV MFGPREVLLT SEEPVVKQFL 
241:	NGTMIGPIGM SEEKDEATMA QEQAMVDAGH HAGGVDDVEG IVPQMKATPG MPFRQAVARR 
301:	QERVRHIMHT LPENAQIAIQ ESLDETSGGN GGGGYDYAYS QEDTQVIPAY RGEGYENTTH 
361:	GQG