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3.A.2.2.4
The ubiquitous 14 subunit vacuolar H+-ATPase, V1/V0, has been implicated in various human diseases including osteopetrosis, renal tubule acidosis, and cancer (Hinton et al., 2009).  The transmembrane enzyme, Ribonuclease kappa, RNASEK (137 aas; 2 TMSs; UniProt acc# Q6P5S7), closely associates with the V-ATPase and is required for its function; its loss prevents the early events of endocytosis and the replication of multiple pathogenic viruses (Perreira et al. 2015).

Accession Number:Q16864
Protein Name:V-ATPase subunit F
Length:119
Molecular Weight:13370.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Endomembrane system1 / Peripheral membrane protein2
Substrate H+

Cross database links:

Genevestigator: Q16864
HEGENOM: HBG402579
RefSeq: NP_004222.2   
Entrez Gene ID: 9296   
Pfam: PF01990   
Drugbank: Drugbank Link   
OMIM: 607160  gene
KEGG: hsa:9296   

Gene Ontology

GO:0005624 C:membrane fraction
GO:0033180 C:proton-transporting V-type ATPase, V1 domain
GO:0016471 C:vacuolar proton-transporting V-type ATPase ...
GO:0042624 F:ATPase activity, uncoupled
GO:0046933 F:hydrogen ion transporting ATP synthase acti...
GO:0005515 F:protein binding
GO:0046961 F:proton-transporting ATPase activity, rotati...
GO:0015986 P:ATP synthesis coupled proton transport

References (2)

[1] “Cloning, sequencing and expression of a novel cDNA encoding human vacuolar ATPase (14-kDa subunit).”  Fujiwara T.et.al.   8581736
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

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FASTA formatted sequence
1:	MAGRGKLIAV IGDEDTVTGF LLGGIGELNK NRHPNFLVVE KDTTINEIED TFRQFLNRDD 
61:	IGIILINQYI AEMVRHALDA HQQSIPAVLE IPSKEHPYDA AKDSILRRAR GMFTAEDLR