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1.F.1.1.3
The worm SNARE complex and it's regulators for vesicle neurotransmetter and neuropeptide release (Gracheva et al. 2007).  The SNARE complex consists of Syntaxin, SNAP and Synaptobrevin and mediates the synaptic vesicle cycle (Rathore et al. 2010).  Synaptotagmin I is a Ca2+ sensor triggering vesicle fusion (Yu et al. 2013).  Regulators include Snapin dimers (Yu et al. 2013), Complexin, a presynaptic protein that interacts with the SNARE complex; the C-terminal domain binds lipids to inhibit exocytosis (Hobson et al. 2011; Wragg et al. 2013), Unc-18, which binds syntaxin and regluates synaptic vesicle (neurotransmitter) docking (Graham et al. 2011), Unc13 which also regluates docking of the synaptic vescicles to the plasma membrane by interacting with syntaxin, CAPS or Unc31, a Ca2+-activated protein for secretion that is required for dense core vesicle docking for neuropeptide release (Lin et al. 2010), and Tomosyn or Tom-1, a negative regluator of both neurotransmitter and neuropeptide release (Gracheva et al. 2007).

Accession Number:Q23658
Protein Name:Calcium-dependent secretion activator
Length:1378
Molecular Weight:156188.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cytoplasmic vesicle membrane1
Substrate neurotransmitter

Cross database links:

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
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  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLGASSSEEE DDDFQEDHDS LPIAQVKKRS LLSGAMTPRS SSPAPSDSVS QTNSLKRNNS 
61:	SSQGRRKDSV QSQTPARSAR IMSNVSKPIM QNSQEFDGDE EEGEEGSTTV VGSGDECGGP 
121:	ALSKEEQERM KAEREEEDHK KNLQMYMFLA RCIAYPFNGQ QTGDMARRQM KVNKQELARI 
181:	RERFTLFLKG ETNIAADEAF TKAIQSYFEV FLKSERVQKV VHAGGFSQHD FREVFRLNIE 
241:	KRVRSLPDIE GLSKDTVLNS WLAKFDAIIK GDETDQNRNA RGRSRNPQNA MSADAVLGKE 
301:	QLYDVFQQIL GVKKFEHQII FNALQLDNPD EQAAAIRREF ATREEALKDP IKMKRLTPKF 
361:	VVKDMETLYM DEVRMSINTL IGNLETVPVT TRGATVGKRK DKSRSRSIED LSLFNSLKRR 
421:	TSSGSLNKGD SEDGDVTLTK SDVSLALSME VVVMEVQGLK SVQPSKIVYC TMEVDGHKLQ 
481:	TDHAEASKPK WDTQGDFSTK NPLPVVKVKL YTEVKSMIAF EDKELGKVII QPTPNCARSP 
541:	EWYTMTLPKS SQDQNLKIRI AIRVEKPPNL KYCGYCYCIG RNAWKKWKKR FFCLVQVSQY 
601:	AFAVCSFRQK KADPTEFIQL DGFTIDYMPE SDPELSAQGG KHFFTAIKEG DELKFATDDE 
661:	NERHLWVQAL YRATGQAYKP VPPKQSTIAP KAQGFQDKAS KHGMDAMIQA DSINFDHDHF 
721:	YSDVQRLTLD FRINEPICSL GWFSPGQAFV LEEYSARYMV RGCFRHVTLL SNLLDKADDG 
781:	LLIDPALIHY SFAFCASHVH GNRCMPDRQG PEGVGTVTLE EKEKFQEIKE RLRVLLEKQI 
841:	TNFRYCFPFG RPEGALKGTL GLLERVLMKD VVSPVPPEEV RAVIRKCLED AALVNYTRIC 
901:	NEAKIEQRMG IDVSPAQRIE DMIRVTEFCI DLLKENEEHH GEAFAWFSDL LSDHSEIFWS 
961:	LYSVDLDSAL EVQPHDSWDS FPLFQMLNDF LLSESSLKGG IFHNKIVQQF QPLVVRYIDL 
1021:	MEHSIAQAID KGFSKEKWES RKEGCATSED IYWKLDALHT FVIDLNWPEE DFRKYLQTKM 
1081:	KSLTSDMISK VSDCTFTAFD SWMQRAKKST DYMLPSEVCV QINVMFSSKS RAVRVTVDSG 
1141:	EYKYQSKLDE TLETMLKTME SCIQEKLHGV LESVLSRLAR YDEGNPIGAI LNIAPKPASI 
1201:	FNKLKTMAGD TSAQATTTAR QPLTAQQSSG QIGNSYVTFF HGCTELLRQV IIDEIWVNGL 
1261:	FEHWYDNQMK SINEWLTERL QQSLSATQYI SLSTIVKKVY QDFSLQGIDE ERLNSKTYQS 
1321:	ISRRLQLEES NSHIQEAAIN GSAQGSVFPT SLGNATAAVS NMSSMVEGAG AKMFSLFK