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1.F.1.1.3
The worm SNARE complex and it's regulators for vesicle neurotransmetter and neuropeptide release (Gracheva et al. 2007).  The SNARE complex consists of Syntaxin, SNAP and Synaptobrevin and mediates the synaptic vesicle cycle (Rathore et al. 2010).  Synaptotagmin I is a Ca2+ sensor triggering vesicle fusion (Yu et al. 2013).  Regulators include Snapin dimers (Yu et al. 2013), Complexin, a presynaptic protein that interacts with the SNARE complex; the C-terminal domain binds lipids to inhibit exocytosis (Hobson et al. 2011; Wragg et al. 2013), Unc-18, which binds syntaxin and regluates synaptic vesicle (neurotransmitter) docking (Graham et al. 2011), Unc13 which also regluates docking of the synaptic vescicles to the plasma membrane by interacting with syntaxin, CAPS or Unc31, a Ca2+-activated protein for secretion that is required for dense core vesicle docking for neuropeptide release (Lin et al. 2010), and Tomosyn or Tom-1, a negative regluator of both neurotransmitter and neuropeptide release (Gracheva et al. 2007).

Accession Number:Q49HI3
Protein Name:Protein TOM-1, isoform a
Length:1124
Molecular Weight:123692.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:2
Substrate neurotransmitter

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDRAKKKFAS AIDGLRSLHN RTEINVDEKI QSEHCRFTRV VRHGLPEDPR CFAYDPVQRL 
61:	IAIGTGRGHI RIIGDAGVDY LLKHESGEPV LHMQFLVNEG GLITSCGTDS IHLWNYRQKT 
121:	AEIVHTVQLS KESVSCIHLP VAGKWLFIGT DKGNVYFLCL NSFLLSPYVI NWNKAIDLSC 
181:	RVHPGPVRQL AVSPAENTKL LIVYDKGIVV QWNLGTREVD RYPLDPPIKS VNWHFDGRQI 
241:	LTGNVDGSIS LYNHKKSTEA IQRTTPHGSG PCRPIQQVEW KHMSETESII MFSGGMPTDD 
301:	GLPMPALTIL KGGKSATVLE MDWPIIQFIP LNQNIWNSIP QCPHSVAVLL KHDFMVLDLN 
361:	QNGHPVIESP HAMNIHESPV TCMAYYSDCP LDLIGALTLV GTKQRNKEFS ARSWPVTGGL 
421:	GRECATGHQE LVVTGHKDGS LKFWQETGEH LQILYKLKSS SHFERLEEME TSDKVSHAVK 
481:	YIELCLESRQ LLVAGISGQV TLFRFTKQEI CGTIAVVNIP LLGNLSSNLP NNDFDKSPVP 
541:	NGPGKEIRRQ RKIVSRESTN SLDTSDSGDE RIVPFKVRGA PVKRPPGFVP ELACFVPWHS 
601:	HAKVDQITTI CLNSSYGIIA IGTSSGLALV DTTQCALIYS WTTNELYGSD PTPAIQLSMQ 
661:	LSDAASPLES PISLEAPKRI ISEQKQRSFD ARRPQLFKTQ SVVENGSLSR GDSQRESPSS 
721:	GRQLNTSSPS TSSQSLERSM STQPQESITS LSFIHSYSKK NDSKMSPCLW VGTSAGASLA 
781:	LNLILPEDRF TSTIVVAPSG TVVRLKGQVI SQSFMDNTFC IISPASESYK EAAKEQSATS 
841:	PDRSLLNRVN TKASLAPQYS SSIDSNDEIS QILIVAAENE VKVVALPTFS QLYVQKFDEI 
901:	PLVKATPTHI RGYPCLMCLS AAGQIIMLSL PSLRILQTST IFPHSVEIDD PLCQKTAFSD 
961:	HGLGVYMASQ TEMEKYTMCS EIAEQTGESL GELFVPCEMP EQPKNNSFLK GVSSIFGGTP 
1021:	RNDPNDIDAI LSENMGVKNS SGVNPMRSVA RTIPGPSVQM DRAQAGGVSA GQAAAMALQN 
1081:	LNERTEKLNA TVDATENLKN NAMSLSSRTG KLVEKYEKKK WYNF