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3.A.1.119.1
5-Hydroxystreptomycin and other streptomycin-like aminoglycoside exporter, StrVW

Accession Number:Q54204
Protein Name:StrW
Length:591
Molecular Weight:63481.00
Species:Streptomyces glaucescens [1907]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate 5-Hydroxystreptomycin, Streptomycin-like aminoglycosides

Cross database links:

Pfam: PF00664    PF00005   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0055085 P:transmembrane transport

References (1)

[1] “The str gene cluster for the biosynthesis of 5'-hydroxystreptomycin in Streptomyces glaucescens GLA.0 (ETH 22794): new operons and evidence for pathway-specific regulation by StrR.”  Beyer S.et.al.   8628239

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSRTRLPVAG TAEVRAHGAA LARRHARDLT WMLALHGLAA VCGLLGPWLI GRLLDEVVRG 
61:	TTLSTVDHIG IALLLSLVAQ AVLTYWAVQR SCRFGEKVTA EVREDFVDRV VRLPLPTVED 
121:	AEPGDLITRA SRDTDALTNT VRYGVPETLI ALMTCLFTFA ALVLVGPLTA LPSLVVVPLL 
181:	WAGTRWYLRR SQAAYRRRGA SYTALGDTLA ETVPGARTVE ALRLQAWRRR ALDRDLAEAY 
241:	EAERHTMCWR SSWYLTVELS YVVPVVATLA IGGLLYTQGL ATVGQAVAAT LYVRQLIFPL 
301:	DDVLSWMDEL QIGSASLARV LGVSELPDDR RPSGARPDGR QLTARSAGYS YVPGRDILHG 
361:	VDLDLAPGER LAVVGPSGSG KSTLGKLLAG VYEPVSGTVE LGGVRLVDLG TEELRRRIAL 
421:	VTQDHHIFRG HLRENVTLAR PAADDEVEHA LKAVGAAEWA AALPDGPETV VGSGGHQLTA 
481:	AQAQQIALAR LVLADPHTVV LDEATALVDP ATARHTERAL AAVLSDRTVI AIAHRLHTAQ 
541:	SADRIAVLEN GRIKELGSHQ ELLAANAPTP PCGAYGTAIE LIAEIPRPVL A