TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.2.2.1
H+-translocating V-type ATPase. The 3-D structure is known (Lau and Rubinstein, 2012). More recently, Zhou and Sazanov 2019 solved cryo-EM structures of the intact Thermus thermophilus V/A-ATPase in three rotational states with two substates. These structures indicate substantial flexibility between V1 and Vo in a working enzyme, which results from mechanical competition between central shaft rotation and resistance from the peripheral stalks.

Accession Number:Q56403
Protein Name:V-type ATP synthase alpha chain
Length:578
Molecular Weight:63632.00
Species:Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [300852]
Substrate H+

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MIQGVIQKIA GPAVIAKGML GARMYDICKV GEEGLVGEII RLDGDTAFVQ VYEDTSGLKV 
61:	GEPVVSTGLP LAVELGPGML NGIYDGIQRP LERIREKTGI YITRGVVVHA LDREKKWAWT 
121:	PMVKPGDEVR GGMVLGTVPE FGFTHKILVP PDVRGRVKEV KPAGEYTVEE PVVVLEDGTE 
181:	LKMYHTWPVR RARPVQRKLD PNTPFLTGMR ILDVLFPVAM GGTAAIPGPF GSGKTVTQQS 
241:	LAKWSNADVV VYVGCGERGN EMTDVLVEFP ELTDPKTGGP LMHRTVLIAN TSNMPVAARE 
301:	ASIYVGVTIA EYFRDQGFSV ALMADSTSRW AEALREISSR LEEMPAEEGY PPYLAARLAA 
361:	FYERAGKVIT LGGEEGAVTI VGAVSPPGGD MSEPVTQSTL RIVGAFWRLD ASLAFRRHFP 
421:	AINWNGSYSL FTSALDPWYR ENVAEDYPEL RDAISELLQR EAGLQEIVQL VGPDALQDAE 
481:	RLVIEVGRII REDFLQQNAY HEVDAYCSMK KAYGIMKMIL AFYKEAEAAI KRGVSIDEIL 
541:	QLPVLERIGR ARYVSEEEFP AYFEEAMKEI QGAFKALA