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3.A.1.14.5
Heme (hemin) uptake porter. The receptor, HmuT, binds two parallel stacked heme molecules, and two are transported per reaction cycle (Mattle et al., 2010).

Accession Number:Q56991
Protein Name:HmuT aka YPO0281 aka Y0541
Length:279
Molecular Weight:29574.00
Species:Yersinia pestis [632]
Location1 / Topology2 / Orientation3: Periplasm1
Substrate Heme

Cross database links:

HEGENOM: HBG708630
RefSeq: NP_667878.1    NP_991830.1    YP_002345363.1   
Entrez Gene ID: 1145488    1173127    2766946   
Pfam: PF01497   
BioCyc: YPES187410:Y0541-MONOMER    YPES214092:YPO0281-MONOMER    YPES229193:YP0436-MONOMER   
KEGG: ype:YPO0281    ypk:y0541    ypm:YP_0436   

Gene Ontology

GO:0042597 C:periplasmic space
GO:0005381 F:iron ion transmembrane transporter activity
GO:0006827 P:high-affinity iron ion transport

References (4)

[1] “The hmu locus of Yersinia pestis is essential for utilization of free haemin and haem-protein complexes as iron sources.”  Hornung J.M.et.al.   9026634
[2] “Genome sequence of Yersinia pestis, the causative agent of plague.”  Parkhill J.et.al.   11586360
[3] “Genome sequence of Yersinia pestis KIM.”  Deng W.et.al.   12142430
[4] “Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans.”  Song Y.et.al.   15368893
Structure:
3MD9     

External Searches:

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRLRLLSLPF ILSLCAPLLP LNTLAAERIV TIGGDVTEIA YALGAGDEIV ARDSTSQQPQ 
61:	AAQKLPDVGY MRTLNAEGIL AMKPTMLLVS ELAQPSLVLT QIASSGVNVV TVPGQTTPES 
121:	VAMKINAVAT ALHQTEKGQK LIEDYQQRLA AVNKTPLPVK VLFVMSHGGL TPMAAGQNTA 
181:	ADAMIRAAGG SNAMQGFSRY RPLSQEGVIA SAPDLLLITT DGVKALGSSE NIWKLPGMAL 
241:	TPAGKHKRLL VVDDMALLGF GLETPQVLAQ LREKMEQMQ