TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.1.14.5
Heme (hemin) uptake porter. The receptor, HmuT, binds two parallel stacked heme molecules, and two are transported per reaction cycle (Mattle et al., 2010).

Accession Number:Q56992
Protein Name:HmuU aka YPO0280 aka Y0540
Length:334
Molecular Weight:35540.00
Species:Yersinia pestis [632]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Heme

Cross database links:

HEGENOM: HBG700016
RefSeq: NP_667877.1    NP_991829.1    YP_002345362.1   
Entrez Gene ID: 1145487    1173126    2764130   
Pfam: PF01032   
BioCyc: YPES187410:Y0540-MONOMER    YPES214092:YPO0280-MONOMER    YPES229193:YP0435-MONOMER   
KEGG: ype:YPO0280    ypk:y0540    ypm:YP_0435   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0006826 P:iron ion transport

References (4)

[1] “The hmu locus of Yersinia pestis is essential for utilization of free haemin and haem-protein complexes as iron sources.”  Hornung J.M.et.al.   9026634
[2] “Genome sequence of Yersinia pestis, the causative agent of plague.”  Parkhill J.et.al.   11586360
[3] “Genome sequence of Yersinia pestis KIM.”  Deng W.et.al.   12142430
[4] “Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans.”  Song Y.et.al.   15368893
Structure:
4G1U     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MNGRVQPRLM LGFLLILLVI LALGSANMGA LSLSFRTLWN TSTNDAMWHI WLNIRLPRVL 
61:	LAVVVGCALA VSGTIMQGLF RNPLADPGLL GISSGAALCV GLIIVMPFSL PPLLALYSHM 
121:	VGAFIGSLAI STIIFTLSRW GHGNLARLLL AGIAINALCG AAVGVLTYIS DDQQLRQFSL 
181:	WSMGSLGQAQ WSTLLVASSL ILPTCILGLL QARQLNLLQL GDEEAHYLGV NVRQAKLRLL 
241:	LLSAILIGAA VAVSGVIGFI GLVVPHLIRM RIGADHRWLL PGAALGGACL LLTADTLART 
301:	LVAPAEMPVG LLTSLLGGPY FLWLILRQRE QRSG