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3.A.1.14.5
Heme (hemin) uptake porter. The receptor, HmuT, binds two parallel stacked heme molecules, and two are transported per reaction cycle (Mattle et al., 2010).

Accession Number:Q56993
Protein Name:HmuV aka YPO0279 aka Y0539
Length:266
Molecular Weight:29658.00
Species:Yersinia pestis [632]
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Peripheral membrane protein2
Substrate Heme

Cross database links:

HEGENOM: HBG758042
RefSeq: NP_991828.1    YP_002345361.1   
Entrez Gene ID: 1173125    2764129   
Pfam: PF00005   
BioCyc: YPES187410:Y0539-MONOMER    YPES214092:YPO0279-MONOMER    YPES229193:YP0434-MONOMER   
KEGG: ype:YPO0279    ypk:y0539    ypm:YP_0434   

Gene Ontology

GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0015439 F:heme-transporting ATPase activity
GO:0015886 P:heme transport

References (4)

[1] “Molecular characterization of the hemin uptake locus (hmu) from Yersinia pestis and analysis of hmu mutants for hemin and hemoprotein utilization.”  Thompson J.M.et.al.   10417152
[2] “Genome sequence of Yersinia pestis, the causative agent of plague.”  Parkhill J.et.al.   11586360
[3] “Genome sequence of Yersinia pestis KIM.”  Deng W.et.al.   12142430
[4] “Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans.”  Song Y.et.al.   15368893
Structure:
4G1U     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVDMAVTPVA LLEASHLHYH VQQQALINDV SLHIASGEMV AIIGPNGAGK STLLRLLTGY 
61:	LSPSHGECHL LGQNLNSWQP KALARTRAVM RQYSELAFPF SVSEVIQMGR APYGGSQDRQ 
121:	ALQQVMAQTD CLALAQRDYR VLSGGEQQRV QLARVLAQLW QPQPTPRWLF LDEPTSALDL 
181:	YHQQHTLRLL RQLTRQEPLA VCCVLHDLNL AALYADRIML LAQGKLVACG TPEEVLNAET 
241:	LTQWYQADLG VSRHPESALP QIYLRQ