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3.A.1.1.25
The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose.  The structures have been solved to a resolution range of 1.6-2.0 Å (Chandravanshi et al. 2019). D

Accession Number:Q72H67
Protein Name:Maltose transport system permease protein malF aka TT_C1628
Length:291
Molecular Weight:32564.00
Species:Thermus thermophilus [262724]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Trehalose, Maltose, Sucrose, Palatinose

Cross database links:

eggNOG: COG1175
HEGENOM: HBG739365
RefSeq: YP_005597.1   
Entrez Gene ID: 2775068   
Pfam: PF00528   
BioCyc: TTHE262724:TT_C1628-MONOMER   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0006810 P:transport

References (1)

[1] “The genome sequence of the extreme thermophile Thermus thermophilus.”  Henne A.et.al.   15064768

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLTLRQVRLA WILVLPTLLV VVLVAGYPLA QVFYWSFFKA DIAFVEPPEF VGLENYAYLF 
61:	QDPDFRQALW NTLKFTVVSV SLETVLGLAI ALIIHSNFRG RGLVRTAILI PWAIPTVVSA 
121:	KMWQWMLNDV YGVINVLGVK LGLLSQKVAF LARPELLLPS IIAVDVWKTT PFMALLLLAG 
181:	LQMIPEELYE AASIDGASRW QQFWSITLPL LTPALVVALI FRTLDALRVF DVVFVMSGVN 
241:	PATRTLAVYN RQTLVDFQDL GYGSAISVAI LVIIFAFVLL YMRTVGKEAL K