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3.A.1.134.4
The bacitracin/vancoresmycin (a tetramic acid antibiotic) resistance exporter (Becker et al. 2009) (most like 3.A.1.134.2)

Accession Number:Q8DQ76
Protein Name:Putative uncharacterized protein ABC-MSD
Length:662
Molecular Weight:74509.00
Species:Streptococcus pneumoniae (strain ATCC BAA-255 / R6) [171101]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Bacitracin, Vancoremycin

Cross database links:

eggNOG: COG0577
HEGENOM: HBG305944
RefSeq: NP_358407.1   
Entrez Gene ID: 934353   
Pfam: PF02687   
BioCyc: SPNE171101:SPR0813-MONOMER   
KEGG: spr:spr0813   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane

References (1)

[1] “Genome of the bacterium Streptococcus pneumoniae strain R6.”  Hoskins J.et.al.   11544234

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MFRLTNKLAV SNLIKNRKLY YPFALAVLLA VTVTYLFYSL TFNPKIAEIR GGTTIQATLG 
61:	FGMFVVTLAS AIIVLYANSF VMKNRSKELG IYGMLGLEKR HLISMTFKEL VVFGILTVGA 
121:	GIGIGALFDK LIFAFLLKLM KLKVELVATF QTKVVITVLV VFGLIFLGLM FLNALRIARM 
181:	NALQLSREKA SGEKKGRFLP LQTILGSISL GIGYYLALTV KDPLTALTTF FIAVLLVIFG 
241:	TYLLFNAGIT VFLQILKKNK KYYYQPNNLI SVSNLIFRMK KNAVGLATIA ILSTMVLVTM 
301:	SAATSIFNSS ESFKKVLNPH DFGVSGQNVE KEDLDKLLSQ FASDKGYKIK EKEVFRYTYF 
361:	AVANQEGTKL TIFEKGQNRV QPKTVFMVFD QKDYENMTGQ KLSLSGNEVG LFAKNEGVKE 
421:	QKALTLNDHQ FSVKEEFTKD FIVNHVPNQF NILTADYNYL VVPDLQAFLD QFPDSAIYNQ 
481:	FYGGMNVNAS EAEQLKVAEE YEKYLQKFNA QLNTEGNYVY GSTLADASAQ MSALFGGVFF 
541:	IGIFLSIIFM VGTVLVIYYK QISEGYEDRE RFIILQKVGL DQKQIKQTIN KQVLTVFFLP 
601:	LLFAFLHLAF AYHMLSLILK VIGVLDTTMM LIVTLSICAI FLIAYVLIFM ITSRSYRKIV 
661:	QM