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3.A.1.14.7
Iron (Fe3+)-hydroxamate porter (transports Fe3+-ferrichrome and Fe3+-ferrioxamine B with FhuD1, and these compounds plus aerobactin and coprogen with FhuD2).  FhuB may function with FhuG (A6QEV8) together with FhuD2 to form a ferrichrome transporter where FhuB and FhuG have conserved arginine residues (R71 and R61, respectively) that form essential salt bridges with FhuD2 (Vinés et al. 2013).

Accession Number:Q93PN3
Protein Name:FhuD1
Length:303
Molecular Weight:34843.00
Species:Staphylococcus aureus [1280]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Fe3+hydroxamate

Cross database links:

Pfam: PF01497   

Gene Ontology

GO:0005381 F:iron ion transmembrane transporter activity
GO:0004872 F:receptor activity
GO:0006827 P:high-affinity iron ion transport

References (1)

[1] “Identification and characterization of fhuD1 and fhuD2, two genes involved in iron-hydroxamate uptake in Staphylococcus aureus.”  Sebulsky M.T.et.al.   11489851

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKRLIGILLC NLFILTACSA SVDKTSNSTK TTDYKIENGE TLKVPEKPKR VAVLTGFYVG 
61:	DFIKLGIKPI AVSDITKDSS ILKPYLKGVD YIGENDVERV AKAKPDLIVV DAMDKNIKKY 
121:	QKIAPTIPYT YNKYNHKEIL KEIGKLTNNE DKAKKWIEEW DDKTRKDKKE IQSKIGQATA 
181:	SVFEPDEKQI YIYNSTWGRG LDIVHDAFGM PMTKQYKDKL QEDKKGYASI SKENISKYAG 
241:	DYIFLSKPSY GKFDFEKTHT WQNIEAVKKG HVISYKAEDY WFTDPITLEH LRSKLKKEIL 
301:	NKK