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8.A.142.1.1
PAT heterodimeric complex consisting of two proteins, coiled-coil domain-containing (CCDC) protein, (CDCC47) of 483 aas and 1 N-terminal TMS, and possibly another TMS towards the C-terminus, and Asterix of 106 aas and 2 TMSs. Together they form the PAT chaparone complex in the endoplasmic reticulum (ER) that helps to properly insert multispanning membrane proteins into the ER membranes of eukaryotes (Chitwood and Hegde 2020). It is involved in the regulation of calcium ion homeostasis in the ER (Morimoto et al. 2018) and is required for proper protein degradation via the ERAD pathway (Yamamoto et al. 2014). It plays an essential role in the maintenance of ER organization during embryogenesis.

Accession Number:Q96A33
Protein Name:Coiled-coil domain-containing protein 47
Length:483
Molecular Weight:55874.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1
Substrate

Cross database links:

Structure:
6W6L     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKAFHTFCVV LLVFGSVSEA KFDDFEDEED IVEYDDNDFA EFEDVMEDSV TESPQRVIIT 
61:	EDDEDETTVE LEGQDENQEG DFEDADTQEG DTESEPYDDE EFEGYEDKPD TSSSKNKDPI 
121:	TIVDVPAHLQ NSWESYYLEI LMVTGLLAYI MNYIIGKNKN SRLAQAWFNT HRELLESNFT 
181:	LVGDDGTNKE ATSTGKLNQE NEHIYNLWCS GRVCCEGMLI QLRFLKRQDL LNVLARMMRP 
241:	VSDQVQIKVT MNDEDMDTYV FAVGTRKALV RLQKEMQDLS EFCSDKPKSG AKYGLPDSLA 
301:	ILSEMGEVTD GMMDTKMVHF LTHYADKIES VHFSDQFSGP KIMQEEGQPL KLPDTKRTLL 
361:	FTFNVPGSGN TYPKDMEALL PLMNMVIYSI DKAKKFRLNR EGKQKADKNR ARVEENFLKL 
421:	THVQRQEAAQ SRREEKKRAE KERIMNEEDP EKQRRLEEAA LRREQKKLEK KQMKMKQIKV 
481:	KAM