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3.A.1.14.7
Iron (Fe3+)-hydroxamate porter (transports Fe3+-ferrichrome and Fe3+-ferrioxamine B with FhuD1, and these compounds plus aerobactin and coprogen with FhuD2).  FhuB may function with FhuG (A6QEV8) together with FhuD2 to form a ferrichrome transporter where FhuB and FhuG have conserved arginine residues (R71 and R61, respectively) that form essential salt bridges with FhuD2 (Vinés et al. 2013).

Accession Number:Q99RY8
Protein Name:FhuD2
Length:302
Molecular Weight:34011.00
Species:Staphylococcus aureus [158878]
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Fe3+hydroxamate

Cross database links:

eggNOG: COG0614
HEGENOM: HBG692908
RefSeq: NP_372808.1   
Entrez Gene ID: 1122309   
Pfam: PF01497   
BioCyc: SAUR158878:SAV2284-MONOMER   
KEGG: sav:SAV2284   

Gene Ontology

GO:0005381 F:iron ion transmembrane transporter activity
GO:0004872 F:receptor activity
GO:0006827 P:high-affinity iron ion transport

References (1)

[1] “Whole genome sequencing of meticillin-resistant Staphylococcus aureus.”  Kuroda M.et.al.   11418146

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKKLLLPLII MLLVLAACGN QGEKNNKAET KSYKMDDGKT VDIPKDPKRI AVVAPTYAGG 
61:	LKKLGANIVA VNQQVDQSKV LKDKFKGVTK IGDGDVEKVA KEKPDLIIVY STDKDIKKYQ 
121:	KVAPTVVVDY NKHKYLEQQE MLGKIVGKED KVKAWKKDWE ETTAKDGKEI KKAIGQDATV 
181:	SLFDEFDKKL YTYGDNWGRG GEVLYQAFGL KMQPEQQKLT AKAGWAEVKQ EEIEKYAGDY 
241:	IVSTSEGKPT PGYESTNMWK NLKATKEGHI VKVDAGTYWY NDPYTLDFMR KDLKEKLIKA 
301:	AK