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3.A.1.135.2
The heterodimeric putative multidrug exporter, RscA/RscB; probably orthologous to YdaG/YbdA (TC #3.A.1.117.4) [Transcription is activated by stress conditions (heat, acid) and repressed by a 2-component system, CovRS (Dalton et al., 2006)]

Accession Number:Q9A1K4
Protein Name:RscB
Length:594
Molecular Weight:66788.00
Species:Streptococcus pyogenes serotype M1 [301447]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate drugs

Cross database links:

HEGENOM: HBG758042
RefSeq: NP_268592.1    YP_281561.1   
Entrez Gene ID: 3572703    900538   
Pfam: PF00664    PF00005   
BioCyc: SPYO160490:SPY0230-MONOMER    SPYO293653:M5005_SPY0197-MONOMER   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0055085 P:transmembrane transport

References (2)

[1] “Complete genome sequence of an M1 strain of Streptococcus pyogenes.”  Ferretti J.J.et.al.   11296296
[2] “Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events.”  Sumby P.et.al.   16088826

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MKTARFFWFY FKRYRFSFTV IAVAVILATY LQVKAPVFLG ESLTELGKIG QAYYVAKMSG 
61:	QTHFSPDLSA FNAVMFKLLM TYFFTVLANL IYSFLLTRVV SHSTNRMRKG LFGKLERLTV 
121:	AFFDRHKDGE ILSRFTSDLD NIQNSLNQSL IQVVTNIALY IGLVWMMFRQ DSRLALLTIA 
181:	STPVALIFLV INIRLARKYT NIQQQEVSAL NAFMDETISG QKAIIVQGVQ EDTMTAFLKH 
241:	NERVRQATFK RRLFSGQLFP VMNGMSLINT AIVIFVGSTI VLSDKSMPAA AALGLVVTFV 
301:	QYSQQYYQPM MQIASSWGEL QLAFTGAHRI QEMFDETEEV RPQNAPAFTS LKEAVAINHV 
361:	DFGYLPGQKV LSDVSIVAPK GKMIAVVGPT GSGKTTIMNL INRFYDVDAG SITFDGRDIR 
421:	DYDLDSLRQK VGIVLQESVL FSGTITDNIR FGDQTISQDM VETAARATHI HDFIMSLPKG 
481:	YNTYVSDDDN VFSTGQKQLI SIARTLLTDP EVLILDEATS NVDTVTESKI QRAMEAIVAG 
541:	RTSFVIAHRL KTILNADHII VLKDGKVIEQ GNHHELLHQK GFYAELYHNQ FVFE