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3.A.1.135.2
The heterodimeric putative multidrug exporter, RscA/RscB; probably orthologous to YdaG/YbdA (TC #3.A.1.117.4) [Transcription is activated by stress conditions (heat, acid) and repressed by a 2-component system, CovRS (Dalton et al., 2006)]

Accession Number:Q9A1K5
Protein Name:RscA
Length:568
Molecular Weight:62978.00
Species:Streptococcus pyogenes serotype M1 [301447]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate drugs

Cross database links:

HEGENOM: HBG758042
RefSeq: NP_268591.1    YP_281560.1   
Entrez Gene ID: 3572702    900537   
Pfam: PF00664    PF00005   
BioCyc: SPYO160490:SPY0229-MONOMER    SPYO293653:M5005_SPY0196-MONOMER   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0055085 P:transmembrane transport

References (2)

[1] “Complete genome sequence of an M1 strain of Streptococcus pyogenes.”  Ferretti J.J.et.al.   11296296
[2] “Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events.”  Sumby P.et.al.   16088826

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MLKDAILRYK WYALGSFFMV IGVVASSLLQ PHYLKSVLSA VIQNNQEKIY EVGKPLLIIA 
61:	LLGLMSGAIN TVLAAKIAQG VSADMREKTF RKIQDFSYAN IEAFNAGNLV VRLTNDINQI 
121:	QSLVMMMFQI LFRLPILFIG AFIMAVQTFP QLWWVIVVMV ILIALIMGLV MRQMGPRFGK 
181:	FQRLMDKINR IAKENLRGVR VVKSFVQEQQ QYTKFKETSN DLLALNLSIG YGFSLMQPAL 
241:	MLVSYLAVYV SINVVSTMVE TDPTVIGNIA SFMTYMMQIM FSIIVVGSMG MQVSRAFVSM 
301:	ARIRQILSTE PAMTFENEKE ETISGSIVFD DVSFTYPNDD EPTLKHISFA IEPGQMVGIV 
361:	GATGSGKSTL AQLIPRLFDP QDGQILLGGK PIKTLSQTTL RQSVSIVLQK AILFSGTIAD 
421:	NLRQGSAKAD IDAMQKAAQI AQAKEFIDRM DSRYESQVEE RGSNLSGGQK QRLSIARGVI 
481:	NHPKILILDD STSALDAKSE KRVQEALSHK LEGTTTVIVA QKISSVVKAD KILVLDQGQL 
541:	IGEGTHAELV ANNAIYREIY ETQKGREE