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1.N.1.1.1
The Osteoclast fusion complex including DC-STAMP (470 aas; 7 TMSs), OC-STAMP (566 aas and 7 TMSs) and Leucocyte surface antigen, CD47 of 323 aas and 5 TMSs (Chiu et al. 2016; Møller et al. 2016; Zhang et al. 2014).  CD47 is homologous to the first 5 TMSs of Presenilin-1 of Homo sapiens (1.A.54.1.1).  It is therefore a presenilin homologue (unpublished observation). Sulforaphene (SFE) downregulates mRNA expression of DC-STAMP, OC-STAMP, and Atp6v0d2, which encode cell-cell fusion molecules (Takagi et al. 2017). SFE attenuates pre-osteoclast multinucleation via suppression of cell-cell fusion. ITIM on DC-STAMP is a functional motif that regulates osteoclast differentiation through the NFATc1/Ca2+ axis (Chiu et al. 2017).

Accession Number:Q9BR26
Protein Name:Osteoclast stimulatory transmembrane protein
Length:566
Molecular Weight:61579.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate small molecules

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPGHPGAAEQ LVKTGWRSWH LGFWKALAPL QAAWDAFSQP VPASCGQLLT QLLLCASLAA 
61:	AAAGLVYHWL ASLLLYPPGP SAMVATVCGL LVFLSLGLVP PVRCLFALSV PTLGMEQGRR 
121:	LLLSYSTATL AIAVVPNVLA NVGAAGQVLR CVTEGSLESL LNTTHQLHAA SRALGPTGQA 
181:	GSRGLTFEAQ DNGSAFYLHM LRVTQQVLED FSGLESLARA AALGTQRVVT GLFMLGLLVE 
241:	SAWYLHCYLT DLRFDNIYAT QQLTQRLAQA QATHLLAPPP TWLLQAAQLR LSQEELLSCL 
301:	LRLGLLALLL VATAVAVATD HVAFLLAQAT VDWAQKLPTV PITLTVKYDV AYTVLGFIPF 
361:	LFNQLAPESP FLSVHSSYQW ELRLTSARCP LLPARRPRAA APLAAGALQL LAGSTVLLEA 
421:	YARRLRHAIA ASFFTAQEAR RVRHLHARLQ RRHDRHQGQQ LPLGDPSCVP TPRPACKPPA 
481:	WIDYRLDALR TESSEGEGKE LWSCRDLSCN LGPVPPPCVT LGKSLHLSEP RFLHLHNDSI 
541:	FTIDVTYFPR RDVVRMEGNT GHDRPG