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1.N.1.1.1
The Osteoclast fusion complex including DC-STAMP (470 aas; 7 TMSs), OC-STAMP (566 aas and 7 TMSs) and Leucocyte surface antigen, CD47 of 323 aas and 5 TMSs (Chiu et al. 2016; Møller et al. 2016; Zhang et al. 2014).  CD47 is homologous to the first 5 TMSs of Presenilin-1 of Homo sapiens (1.A.54.1.1).  It is therefore a presenilin homologue (unpublished observation). Sulforaphene (SFE) downregulates mRNA expression of DC-STAMP, OC-STAMP, and Atp6v0d2, which encode cell-cell fusion molecules (Takagi et al. 2017). SFE attenuates pre-osteoclast multinucleation via suppression of cell-cell fusion. ITIM on DC-STAMP is a functional motif that regulates osteoclast differentiation through the NFATc1/Ca2+ axis (Chiu et al. 2017).

Accession Number:Q9H295
Protein Name:Dendritic cell-specific transmembrane protein
Length:470
Molecular Weight:53393.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate small molecules

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGIWTSGTDI FLSLWEIYVS PRSPGWMDFI QHLGVCCLVA LISVGLLSVA ACWFLPSIIA 
61:	AAASWIITCV LLCCSKHARC FILLVFLSCG LREGRNALIA AGTGIVILGH VENIFHNFKG 
121:	LLDGMTCNLR AKSFSIHFPL LKKYIEAIQW IYGLATPLSV FDDLVSWNQT LAVSLFSPSH 
181:	VLEAQLNDSK GEVLSVLYQM ATTTEVLSSL GQKLLAFAGL SLVLLGTGLF MKRFLGPCGW 
241:	KYENIYITRQ FVQFDERERH QQRPCVLPLN KEERRKYVII PTFWPTPKER KNLGLFFLPI 
301:	LIHLCIWVLF AAVDYLLYRL IFSVSKQFQS LPGFEVHLKL HGEKQGTQDI IHDSSFNISV 
361:	FEPNCIPKPK FLLSETWVPL SVILLILVML GLLSSILMQL KILVSASFYP SVERKRIQYL 
421:	HAKLLKKRSK QPLGEVKRRL SLYLTKIHFW LPVLKMIRKK QMDMASADKS