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1.A.9.1.13
Neuronal acetylcholine receptor with two subunits, α- and β-subunits, Unc-63 (Lev7; 502 aas) and Acr-2 (575 aas), respectively.  Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion (Jospin et al. 2009). Involved in nAChR sensitivity to nicotine and levamisole (Culetto et al. 2004; Gottschalk et al. 2005). The AcChR subunits in C. elegans have been compared with those of parasitic nematodes (Holden-Dye et al. 2013).

Accession Number:Q9N587
Protein Name:Acetylcholine receptor subunit alpha-type unc-63
Length:502
Molecular Weight:57391.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell junction1 / Multi-pass membrane protein2
Substrate

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGPNDHGFAY ILIFLLLSPP THANRDANRL FEDLIADYNK LVRPVSENGE TLVVTFKLKL 
61:	SQLLDVHEKN QIMTTNVWLQ HSWMDYKLRW DPVEYGGVEV LYVPSDTIWL PDVVLYNNAD 
121:	GNYQVTIMTK AKLTYNGTVE WAPPAIYKSM CQIDVEFFPF DRQQCEMKFG SWTYGGLEVD 
181:	LQHRDKHLEK EIEEDVEGVD GPTKEIVWVV DRGIDLSDYY PSVEWDILNV PGKRHSKRYP 
241:	CCESPFIDIT YEIHLRRKTL FYTVNLIFPS VGISFLTALV FYLPSDGGEK ISLCISILIS 
301:	LTVFFLLLVE IIPSTSLVIP LIGKYLLFTM VLVTLSVVVT VVTLNVHYRS PTTHTMPKWM 
361:	KRLFVDFLPK YLLMTRPQPP GHHSKPNRKF DSRASTFSIG VNHVLGQNSE LLSPGLNSNR 
421:	EESSFTLPRD NSPVRSAVES VAYIADHLKN EEDDKQVIED WKYISVVMDR IFLITFTFAC 
481:	AFGTVVIIAR APSIYDNTPA LA