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3.A.1.14.7
Iron (Fe3+)-hydroxamate porter (transports Fe3+-ferrichrome and Fe3+-ferrioxamine B with FhuD1, and these compounds plus aerobactin and coprogen with FhuD2).  FhuB may function with FhuG (A6QEV8) together with FhuD2 to form a ferrichrome transporter where FhuB and FhuG have conserved arginine residues (R71 and R61, respectively) that form essential salt bridges with FhuD2 (Vinés et al. 2013).

Accession Number:Q9X665
Protein Name:FhuC aka FhuA
Length:265
Molecular Weight:29496.00
Species:Staphylococcus aureus [1280]
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Fe3+hydroxamate

Cross database links:

Pfam: PF00005   

Gene Ontology

GO:0005524 F:ATP binding
GO:0016887 F:ATPase activity

References (2)

[1] “Molecular characterization of the ferric-uptake regulator, Fur, from Staphylococcus aureus.”  Xiong A.et.al.   10746769
[2] “Identification and characterization of a membrane permease involved in iron-hydroxamate transport in Staphylococcus aureus.”  Sebulsky M.T.et.al.   10913070

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNRLHGQQVK IGYGDNTIIN KLDVEIPDGK VTSIIGPNGC GKSTLLKALS RLLAVKEGEV 
61:	FLDGENIHTQ STKEIAKKIA ILPQSPEVAD GLTVGELVSY GRFPHQKGFG RLTAEDKKEI 
121:	DWAMEVTGTD TFRHRSINDL SGGQRQRVWI AMALAQRTDI IFLDEPTTYL DICHQLEILE 
181:	LVQKLNQEQG CTIVMVLHDI NQAIRFSDHL IAMKEGDIIA TGSTEDVLTQ EILEKVFNID 
241:	VVLSKDPKTG KPLLVTYDLC RRAYS