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3.A.1.15.7
Manganese (Mn2+) (Km=0.1 μM) and iron (Fe2+) (5 μM) porter (inhibited by Cd2+ > Co2+ > Ni2+, Cu2+) (most similar to YfeABCD of Yersinia pestis (TC #3.A.1.15.4)). Important for virulence in Salmonella (Karlinsey et al., 2010).

Accession Number:Q9XCR9
Protein Name:SitD aka STM2864
Length:282
Molecular Weight:30100.00
Species:Salmonella typhimurium [90371]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Mn2+, Fe2+

Cross database links:

HEGENOM: HBG733179
RefSeq: NP_461785.1   
Entrez Gene ID: 1254387   
Pfam: PF00950   
BioCyc: STYP99287:STM2864-MONOMER   
KEGG: stm:STM2864   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0006810 P:transport

References (2)

[1] “Salmonella typhimurium encodes a putative iron transport system within the centisome 63 pathogenicity island.”  Zhou D.et.al.   10085045
[2] “Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.”  McClelland M.et.al.   11677609

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MFLTTLLEPF QFDFMVNALM VSVIVAIPCA LLSVFLVLKG WALMGDAMSH AVFPGVVLAY 
61:	IVGIPLAIGA FIAGLFCAIA TGYLDDNSRI KRDTVMGIVF SGMFGAGLVL YVSIQSEVHL 
121:	DHILFGDMLG VSLGDIVQTS VIALGIALII GLKWKDLLLH AFDPHQAKAS GLNTTLLHYG 
181:	LLCMIALTIV ATLKSVGIIL SISLLIAPGA IAILLTRRFA RALGLAVSLS VITAFAGVYL 
241:	SFYLDSAPAP TIVVLFAIVF IAAFIYATWR DRRNEIVPEA QG