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3.A.1.15.7
Manganese (Mn2+) (Km=0.1 μM) and iron (Fe2+) (5 μM) porter (inhibited by Cd2+ > Co2+ > Ni2+, Cu2+) (most similar to YfeABCD of Yersinia pestis (TC #3.A.1.15.4)). Important for virulence in Salmonella (Karlinsey et al., 2010).

Accession Number:Q9XCS2
Protein Name:SitA aka T2763 aka STM2861 aka STY2983
Length:305
Molecular Weight:33723.00
Species:Salmonella typhimurium AND Salmonella typhi [90370]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Mn2+, Fe2+

Cross database links:

HEGENOM: HBG731008
RefSeq: NP_457255.1    NP_806464.1   
Entrez Gene ID: 1068914    1249290   
Pfam: PF01297   
BioCyc: SENT209261:T2763-MONOMER    SENT220341:STY2983-MONOMER   
KEGG: stt:t2763    sty:STY2983   

Gene Ontology

GO:0046872 F:metal ion binding
GO:0007155 P:cell adhesion
GO:0030001 P:metal ion transport

References (2)

[1] “Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18.”  Deng W.et.al.   12644504
[2] “Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18.”  Parkhill J.et.al.   11677608

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTNLHRLKTL LIAGIVAILA LSPAYAKEKF KVITTFTVIA DMAKNVAGDA AEVSSITKPG 
61:	AEIHEYQPTP GDIKRAQGAQ LILANGLNLE RWFARFYQHL SGVPEVVVST GVKPMGITEG 
121:	PYNGKPNPHA WMSAENALIY VDNIRDALVK YDPDNAQIYK QNAERYKAKI RQMADPLRAE 
181:	LEKIPADQRW LVTSEGAFSY LARDNDMKEL YLWPINADQQ GTPKQVRKVI DTIKKHHIPA 
241:	IFSESTVSDK PARQVARESG AHYGGVLYVD SLSAADGPVP TYLDLLRVTT ETIVNGINDG 
301:	LRSQQ