PAT heterodimeric complex consisting of two proteins, coiled-coil domain-containing (CCDC) protein, (CDCC47) of 483 aas and 1 N-terminal TMS, and possibly another TMS towards the C-terminus, and Asterix of 106 aas and 2 TMSs. Together they form the PAT chaparone complex in the endoplasmic reticulum (ER) that helps to properly insert multispanning membrane proteins into the ER membranes of eukaryotes (Chitwood and Hegde 2020). It is involved in the regulation of calcium ion homeostasis in the ER (Morimoto et al. 2018) and is required for proper protein degradation via the ERAD pathway (Yamamoto et al. 2014). It plays an essential role in the maintenance of ER organization during embryogenesis.
|Protein Name:||Protein Asterix|
|Species:||Homo sapiens (Human)  |
|Number of TMSs:||2|
|Location1 / Topology2 / Orientation3:
Membrane1 / Multi-pass membrane protein2
1: MSTNNMSDPR RPNKVLRYKP PPSECNPALD DPTPDYMNLL GMIFSMCGLM LKLKWCAWVA
61: VYCSFISFAN SRSSEDTKQM MSSFMLSISA VVMSYLQNPQ PMTPPW