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1.A.1.10.19
Sodium channel Nav1.4-beta complex of 1820 and 209 aas, respectively.  Voltage-gated sodium (Nav) channels initiate and propagate action potentials. Yan et al. 2017 presented the cryo-EM structure of EeNav1.4, the Nav channel from electric eel, in complex with the beta1 subunit at 4.0 Å resolution. The immunoglobulin domain of beta1 docks onto the extracellular L5I and L6IV loops of EeNav1.4 via extensive polar interactions, and the single transmembrane helix interacts with the third voltage-sensing domain (VSDIII). The VSDs exhibit "up" conformations, while the intracellular gate of the pore domain is kept open by a digitonin-like molecule. Structural comparison with closed NavPaS shows that the outward transfer of gating charges is coupled to the iris-like pore domain dilation through intricate force transmissions involving multiple channel segments. The IFM fast inactivation motif on the III-IV linker is plugged into the corner enclosed by the outer S4-S5 and inner S6 segments in repeats III and IV, suggesting a potential allosteric blocking mechanism for fast inactivation (Yan et al. 2017). The PDB# for the complex is 5XSY, and that for the two subunits are 5XSY_A and 5XSY_B.

Accession Number:P02719
Protein Name:Sodium channel protein
Length:1820
Molecular Weight:208332.00
Species:Electrophorus electricus (Electric eel) [8005]
Number of TMSs:23
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

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FASTA formatted sequence
1:	MARKFSSARP EMFRRFTPDS LEEIEAFTEL KKSCTLEKKE PESTPRIDLE AGKPLPMIYG 
61:	DPPEDLLNIP LEDLDPFYKT QKTFIVISKG NIINRFNAER ALYIFSPFNP IRRGAIRVFV 
121:	NSAFNFFIMF TIFSNCIFMT ISNPPAWSKI VEYTFTGIYT FEVIVKVLSR GFCIGHFTFL 
181:	RDPWNWLDFS VVTMTYITEF IDLRNVSALR TFRVLRALKT ITIFPGLKTI VRALIESMKQ 
241:	MGDVVILTVF SLAVFTLAGM QLFMGNLRHK CIRWPISNVT LDYESAYNTT FDFTAYIENE 
301:	ENQYFLDGAL DALLCGNNSD AGKCPEGYTC MKAGRNPNYG YTNYDNFAWT FLCLFRLMLQ 
361:	DYWENLYQMT LRAAGKSYMV FFIMVIFLGS FYLINLILAV VAMAYEEQNQ ATLAEAQEKE 
421:	AEFQRAVEQL RIQQEQINDE RKASLASQLT QNQEAEITDD GDDAIKECNG KAFPLANIRE 
481:	PSSVKLSTEE QRSDSKSMDS KHSVDKPSLK HKAASTMSVF TLEDLEAARR PCPPVWYKFA 
541:	GFVFKWNCCG PWVFLKKWVH FVMMDPFTDL FITLCIILNT LFMSIEHHPM NESFQSLLSA 
601:	GNLVFTTIFA AEMVLKIIAL DPYYYFQQTW NIFDSIIVSL SLLELGLSNM QGMSVLRSLR 
661:	LLRIFKLAKS WPTLNILIKI ICNSVGALGN LTIVLAIIVF IFALVGFQLF GKNYKEYVCK 
721:	ISDDCELPRW HMNDFFHSFL IVFRALCGEW IETMWDCMEV GGVPMCLAVY MMVIIIGNLV 
781:	MLNLFLALLL SSFSSDNLSS IEEDDEVNSL QVASERISRA KNWVKIFITG TVQALVLWIQ 
841:	GKKPPSDDVV GEEGDNEGKK DTLPLNYLDG EKIVDGITNC VESPTLNLPI VKGESEIEEE 
901:	GLVDSSDEED TNKKKHALND EDSSVCSTVD YSPSEQDPLA KEEEEEEEEE PEELESKDPE 
961:	ACFTEKCIWR FPFLDVDITQ GKGKIWWNLR RTCYTIVEHD YFETFIIFMI LLSSGVLAFE 
1021:	DIYIWRRRVI KVILEYADKV FTYVFIVEML LKWVAYGFKR YFTDAWCWLD FVIVGASIMG 
1081:	ITSSLLGYEE LGAIKNLRTI RALRPLRALS RFEGMKVVVR ALLGAIPSIM NVLLVCLMFW 
1141:	LIFSIMGVNL FAGKFYRCIN TTTDEILPVE EVNNRSDCMA LMYTNEVRWV NLKVNYDNAG 
1201:	MGYLSLLQVS TFKGWMDIMY AAVDSREVED QPIYEINVYM YLYFVIFIVF GAFFTLNLFI 
1261:	GVIIDNFNRQ KQKLGGEDLF MTEEQKKYYN AMKKLGSKKA AKCIPRPSNV VQGVVYDIVT 
1321:	QPFTDIFIMA LICINMVAMM VESEDQSQVK KDILSQINVI FVIIFTVECL LKLLALRQYF 
1381:	FTVGWNVFDF AVVVISIIGL LLSDIIEKYF VSPTLFRVIR LARIARVLRL IRAAKGIRTL 
1441:	LFALMMSLPA LFNIGLLLFL IMFIFSIFGM SNFAYVKKQG GVDDIFNFET FGNSMICLFE 
1501:	ITTSAGWDGL LLPTLNTGPP DCDPDVENPG TDVRGNCGNP GKGITFFCSY IILSFLVVVN 
1561:	MYIAIILENF GVAQEESSDL LCEDDFVMFD ETWHKFDVHG TQFLDYNDLP RFVNALQEPM 
1621:	RIPNPNRHKL AKMDMYVVME DKISYLDVLL AVTQEVLGDT TEMEAMRLSI QAKFKKDNPS 
1681:	PTFFEPVVTT LRRKEEEWAS VVIQRAFRQY LLMRAVSHAS FLSQIKHMNE GPKDGVGSQD 
1741:	SLITQKMNAL YRGNPELTMP LEQQIKPMLD KPRMPSLSVP ETYPIQIPKE VTNEVILHSA 
1801:	PMVRQNYSYS GAIVVRESIV