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1.A.1.3.3
Ca2+-activated K+ channel Slo-1 (Maxi K; BK channel) (ethanol-activated; responsible for intoxication) (Davies et al., 2003); tyrosyl phosphorylation regulates BK channels via cortactin (Tian et al. 2008a), but palmitoylation gates phosphorylation-dependent regulation of BK potassium channels (Tian et al., 2008b). Also regulated by Mg2+ which mediates interaction between the voltage sensor and cytosolic domain to activate BK channels (Yang et al., 2007). Modulated by the ss2 subunit (Lee et al., 2010). The structure of the gating ring from the human large-conductance Ca2+-gated K+ channel has been reported (Wu et al., 2010). Four pairs of RCK1 and RICK2 domains form the Ca2+-sensing apparatus known as the "gating ring" in BK channel proteins (Savalli et al., 2012).  The dystrophin (Q9TW65) dystrobrevin (Q9Y048) complex controls BK channel localization and muscle activity as well as neurotroansmitter release (Kim et al. 2009, Chen et al. 2011).  Syntrophin (Q93646) links various receptors and transporters to the actin cytoskeleton and the dystrophin glycoprotein complex (DGC), and α-catulin (CTN-1; 759 aas, 0 TMSs) facilitates targeting.

Accession Number:Q95V25
Protein Name:BK channel
Length:1140
Molecular Weight:129530.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

eggNOG: meNOG05590
HEGENOM: HBG386987
RefSeq: NP_001024259.1    NP_001024260.1    NP_001024261.1   
Entrez Gene ID: 180203   
Pfam: PF03493    PF00520   
KEGG: cel:Y51A2D.19   

Gene Ontology

GO:0008076 C:voltage-gated potassium channel complex
GO:0005488 F:binding
GO:0015269 F:calcium-activated potassium channel activity
GO:0003824 F:catalytic activity
GO:0005249 F:voltage-gated potassium channel activity
GO:0008152 P:metabolic process
GO:0006813 P:potassium ion transport
GO:0055085 P:transmembrane transport

References (3)

[1] “SLO-1 potassium channels control quantal content of neurotransmitter release at the C. elegans neuromuscular junction.”  Wang Z.-W.et.al.   11738032
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916
[3] “A central role of the BK potassium channel in behavioral responses to ethanol in C. elegans.”  Davies A.G.et.al.   14675531

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGEIYSPSQS KGFNQPYGYP MNCNLSRVFM EMTEEDRKCL EERKYWCFLL SSITTFCASM 
61:	ILVVIWRVVT HLCCQRREKE FVEPIPAPEA VQINMNGSKH APSETDPFLK QQEEKHLGWM 
121:	TEAKDWAGEL ISGQSLTGRF LVLLVFILSI GSLIIYFYDA SFQNFQVETC IPWQDSPSQQ 
181:	IDLGFNIFFL VYFFIRFIAA SDKVWFLLEM YSWIDFFTIP PSFVAIYLQR NWLGFRFLRA 
241:	LRLMTVPDIL QYLNILKTSS SIRLTQLVTI FVAVCLTGAG LVHLLENSGD FFKGFINPHR 
301:	ITYADSVYFV LVTMSTVGYG DIYCTTLCGR LFMIFFILFG LAMFASYVPE IADLIGNRQK 
361:	YGGEYKGEHG KKHIVVCGHI TYDSVSHFLQ DFLHEDRDDV DVEVVFLHRV VPDLELEGLF 
421:	KRHFTKVEFF TGTVMDSLDL SRVKIGDADA CLVLANKYST NPDAEDAANI MRVISIKNYS 
481:	SDIRVIVQLM QYHNKAYLLN IPSWDWKRGD DVICLAELKL GFIAQSCLAP GFSTMMANLF 
541:	AMRSFKTSQT TPDWLNLYLC GAGMEMYTDT LSHSFVGMTF PEAVDLLFNR LGLLLLAIEL 
601:	KDEENKECNI AINPGPHIVI QPQTQGFFIA QSADEVKRAF FWCKQCHDDI KDVSLIKKCK 
661:	CKNLALFRRN TKHSTAARAR ATDVLQQFQP QAPAGPMGHL GQQVQLRMIN QQSSTSDTHL 
721:	NTKSLRFAYE IKKLMPSSGG RRNSMSIPPD GRGVDFSKDF EQQFQDMKYD STGMFHWCPS 
781:	RNLEDCVLER HQAAMTVLNG HVVVCLFADQ DSPLIGLRNF IMPLRSSNFH YHELKHVVIV 
841:	GDLEYLRKEW KTLYNLPKIS ILNGSPLSRA DLRAVNINLC DMCVIISARV PNTEDTTLAD 
901:	KEAILASLNI KAMQFDDTLG FFPMRHQTGD RSPLGSPISM QKKGAKFGTN VPMITELVND 
961:	SNVQFLDQDD DDDPDTELYL TQPFACGTAF AISVLDSLMS TTYFNDSALT LIRTLVTGGA 
1021:	TPELELILAE GAGLRGGYST PETLSNRDRC RIAQISLQDN PYDGVVHNTT YGAMFTIALR 
1081:	RYGQLCIGLY RLHDQDNPDS MKRYVITNPP AELRIKNTDY VYVLEQFDPG LEYEPGKRHF