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1.A.1.3.4
The intracellularly Na+ and Cl--activated delayed rectifier K+ channel, rSlo2 (Slack) (provides protection against ischemia (Yuan et al., 2003). The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels (Chen et al., 2009).

Accession Number:Q9Z258
Protein Name:Potassium channel subfamily T member 1 aka Kcnt1 aka rSlo2
Length:1237
Molecular Weight:139615.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

Genevestigator: Q9Z258
eggNOG: maNOG09106
RefSeq: NP_068625.1   
Entrez Gene ID: 60444   
Pfam: PF03493    PF07885   
KEGG: rno:60444   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005488 F:binding
GO:0015269 F:calcium-activated potassium channel activity
GO:0003824 F:catalytic activity
GO:0008152 P:metabolic process
GO:0006813 P:potassium ion transport

References (5)

[1] “Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits.”  Joiner W.J.et.al.   10196543
[2] “Localization of the Slack potassium channel in the rat central nervous system.”  Bhattacharjee A.et.al.   12442315
[3] “The sodium-activated potassium channel is encoded by a member of the Slo gene family.”  Yuan A.et.al.   12628167
[4] “Identification and functional characterization of cereblon as a binding protein for large-conductance calcium-activated potassium channel in rat brain.”  Jo S.et.al.   16045448
[5] “Opposite regulation of Slick and Slack K+ channels by neuromodulators.”  Santi C.M.et.al.   16687497

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MARAKLPRSP SEGKAGPGDT PAGSAAPEEP HGLSPLLPTR GGGSVGSDVG QRLHVEDFSL 
61:	DSSLSQVQVE FYVNENTFKE RLKLFFIKNQ RSSLRIRLFN FSLKLLTCLL YIVRVLLDNP 
121:	DQGIGCWGCT KYNYTFNGSS SEFHWAPILW VERKMALWVI QVIVATISFL ETMLLIYLSY 
181:	KGNIWEQIFH VSFVLEMINT LPFIITVFWP PLRNLFIPVF LNCWLAKHAL ENMINDFHRA 
241:	ILRTQSAMFN QVLILFCTLL CLVFTGTCGI QHLERAGGNL NLLTSFYFCI VTFSTVGFGD 
301:	VTPKIWPSQL LVVILICVTL VVLPLQFEEL VYLWMERQKS GGNYSRHRAR TEKHVVLCVS 
361:	SLKIDLLMDF LNEFYAHPRL QDYYVVILCP SEMDVQVRRV LQIPLWSQRV IYLQGSALKD 
421:	QDLMRAKMDN GEACFILSSR NEVDRTAADH QTILRAWAVK DFAPNCPLYV QILKPENKFH 
481:	VKFADHVVCE EECKYAMLAL NCICPATSTL ITLLVHTSRG QEGQESPEQW QRMYGRCSGN 
541:	EVYHIRMGDS KFFREYEGKS FTYAAFHAHK KYGVCLIGLK REENKSILLN PGPRHILAAS 
601:	DTCFYINITK EENSAFIFKQ EEKQNRRGLA GQALYEGPSR LPVHSIIASM VAMDLQNTDC 
661:	RPSQGGSGGG GGKLTLPTEN GSGSRRPSIA PVLELADSSA LLPCDLLSDQ SEDEVTPSDD 
721:	EGLSVVEYVK GYPPNSPYIG SSPTLCHLLP VKAPFCCLRL DKGCKHNSYE DAKAYGFKNK 
781:	LIIVSAETAG NGLYNFIVPL RAYYRSRREL NPIVLLLDNK PDHHFLEAIC CFPMVYYMEG 
841:	SVDNLDSLLQ CGIIYADNLV VVDKESTMSA EEDYMADAKT IVNVQTMFRL FPSLSITTEL 
901:	THPSNMRFMQ FRAKDSYSLA LSKLEKQERE NGSNLAFMFR LPFAAGRVFS ISMLDTLLYQ 
961:	SFVKDYMITI TRLLLGLDTT PGSGYLCAMK VTEDDLWIRT YGRLFQKLCS SSAEIPIGIY 
1021:	RTECHVFSSE PHDLRAQSQI SVNMEDCEDT REAKGPWGTR AASGGGSTHG RHGGSADPVE 
1081:	HPLLRRKSLQ WARKLSRKSS KQAGKAPMTT DWITQQRLSL YRRSERQELS ELVKNRMKHL 
1141:	GLPTTGYEDV ANLTASDVMN RVNLGYLQDE MNDHHQNTLS YVLINPPPDT RLEPNDIVYL 
1201:	IRSDPLAHVT SSSQSRKSSC SNKLSSCNPE TRDETQL