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1.A.1.3.4
The one or two component intracellularly Na+ and Cl--activated delayed rectifier K+ channel, rSlo2.2 (Slack; KCNT1)/r Slo2.1 (Slick; KCNT2; TC# 1.A.1.3.6) provides protection against ischemia (Yuan et al., 2003). The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels (Chen et al., 2009). Slick and Slack can also form separate homooligomeric channels. These channels are widely distributed in the mammalian CNS and they play roles in slow afterhyperpolarization, generation of depolarizing afterpotentials and in setting and stabilizing the resting potential (Rizzi et al. 2015). The small cytoplasmic protein beta-synuclein TC# 1.C.77.1.2) and the transmembrane protein 263 (TMEM 263; TC# 8.A.101.1.1) are interaction partners of both Slick and Slack channels. The inactive dipeptidyl-peptidase (DPP 10) and the synapse associated protein 102 (SAP 102) are constituents of the Slick and Slack channel complexes (Rizzi et al. 2015).

Accession Number:Q9Z258
Protein Name:Potassium channel subfamily T member 1 aka Kcnt1 aka rSlo2
Length:1237
Molecular Weight:139615.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

Genevestigator: Q9Z258
eggNOG: maNOG09106
RefSeq: NP_068625.1   
Entrez Gene ID: 60444   
Pfam: PF03493    PF07885   
KEGG: rno:60444   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005488 F:binding
GO:0015269 F:calcium-activated potassium channel activity
GO:0003824 F:catalytic activity
GO:0008152 P:metabolic process
GO:0006813 P:potassium ion transport

References (5)

[1] “Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits.”  Joiner W.J.et.al.   10196543
[2] “Localization of the Slack potassium channel in the rat central nervous system.”  Bhattacharjee A.et.al.   12442315
[3] “The sodium-activated potassium channel is encoded by a member of the Slo gene family.”  Yuan A.et.al.   12628167
[4] “Identification and functional characterization of cereblon as a binding protein for large-conductance calcium-activated potassium channel in rat brain.”  Jo S.et.al.   16045448
[5] “Opposite regulation of Slick and Slack K+ channels by neuromodulators.”  Santi C.M.et.al.   16687497

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MARAKLPRSP SEGKAGPGDT PAGSAAPEEP HGLSPLLPTR GGGSVGSDVG QRLHVEDFSL 
61:	DSSLSQVQVE FYVNENTFKE RLKLFFIKNQ RSSLRIRLFN FSLKLLTCLL YIVRVLLDNP 
121:	DQGIGCWGCT KYNYTFNGSS SEFHWAPILW VERKMALWVI QVIVATISFL ETMLLIYLSY 
181:	KGNIWEQIFH VSFVLEMINT LPFIITVFWP PLRNLFIPVF LNCWLAKHAL ENMINDFHRA 
241:	ILRTQSAMFN QVLILFCTLL CLVFTGTCGI QHLERAGGNL NLLTSFYFCI VTFSTVGFGD 
301:	VTPKIWPSQL LVVILICVTL VVLPLQFEEL VYLWMERQKS GGNYSRHRAR TEKHVVLCVS 
361:	SLKIDLLMDF LNEFYAHPRL QDYYVVILCP SEMDVQVRRV LQIPLWSQRV IYLQGSALKD 
421:	QDLMRAKMDN GEACFILSSR NEVDRTAADH QTILRAWAVK DFAPNCPLYV QILKPENKFH 
481:	VKFADHVVCE EECKYAMLAL NCICPATSTL ITLLVHTSRG QEGQESPEQW QRMYGRCSGN 
541:	EVYHIRMGDS KFFREYEGKS FTYAAFHAHK KYGVCLIGLK REENKSILLN PGPRHILAAS 
601:	DTCFYINITK EENSAFIFKQ EEKQNRRGLA GQALYEGPSR LPVHSIIASM VAMDLQNTDC 
661:	RPSQGGSGGG GGKLTLPTEN GSGSRRPSIA PVLELADSSA LLPCDLLSDQ SEDEVTPSDD 
721:	EGLSVVEYVK GYPPNSPYIG SSPTLCHLLP VKAPFCCLRL DKGCKHNSYE DAKAYGFKNK 
781:	LIIVSAETAG NGLYNFIVPL RAYYRSRREL NPIVLLLDNK PDHHFLEAIC CFPMVYYMEG 
841:	SVDNLDSLLQ CGIIYADNLV VVDKESTMSA EEDYMADAKT IVNVQTMFRL FPSLSITTEL 
901:	THPSNMRFMQ FRAKDSYSLA LSKLEKQERE NGSNLAFMFR LPFAAGRVFS ISMLDTLLYQ 
961:	SFVKDYMITI TRLLLGLDTT PGSGYLCAMK VTEDDLWIRT YGRLFQKLCS SSAEIPIGIY 
1021:	RTECHVFSSE PHDLRAQSQI SVNMEDCEDT REAKGPWGTR AASGGGSTHG RHGGSADPVE 
1081:	HPLLRRKSLQ WARKLSRKSS KQAGKAPMTT DWITQQRLSL YRRSERQELS ELVKNRMKHL 
1141:	GLPTTGYEDV ANLTASDVMN RVNLGYLQDE MNDHHQNTLS YVLINPPPDT RLEPNDIVYL 
1201:	IRSDPLAHVT SSSQSRKSSC SNKLSSCNPE TRDETQL