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1.A.1.3.8
SLOwpoke K+ channel, SLO-2 or Slo2, of 1107 aas and 6 TMSs, present in motor neurons.  It has six putative TMSs with a K+-selective pore and a large C-terminal cytosolic domain (Lim et al. 1999). Its requirements for both Cl- and Ca2+ are synergistic and associated with the same functional domain (Yuan et al. 2000) which serves to counteract hypoxia stress when cytoplasmic Cl- and Ca2+ concentrations increase (Yuan et al. 2003; Santi et al. 2003).  SLO2 protects from hypoxic injury by increasing the permeability of the mitochondrial inner membrane to K+ (Wojtovich et al. 2011). SLO-2 is functionally coupled with CaV1 and regulates neurotransmitter release (Liu et al. 2014).  Partially responsible for action potential repolarization during synaptic transmission (Ford and Davis 2014).

Accession Number:G5EDJ1
Protein Name:SLO-2 potassium channel
Length:1107
Molecular Weight:127393.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:4
Substrate K+

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSDDTNNRTD RCTMKHRERR VDSCHSLPSD YRIPNKHVAR MQYGEKKNIK HKLQQWFIEN 
61:	PSISARIRSC NVLIKLLTCI LYCIRVVNDE RSYPDDFPFS EEEAGKQDVT LYKYLLWVDF 
121:	DFKIWFLQTM FACISMVYTI LVFYLSYSGS VVRLLINIHF LLELITSFPF IISIFIPSLT 
181:	YLYVPVFLNC WLAKGALQAM MNDLNRKSFI SSSALFRQLL LLFSVLACLI FTGMCSIEHL 
241:	QRARGKRIDL FTSFYFVMVT FSTVGYGDWY PDYWASQLCV VILICVALGL IPKQLDELGQ 
301:	TWSERQKSGT DFSSWNGVES HVVVTITTLE VEFIRDFLEE FYAHPENQRI QIVLLSPAEL 
361:	DNQTRMLLKI PLWNNRVHYV RGSSLRDEDL ERANVATSKA CFILSARHVN RKVATDEHTI 
421:	LRSWAIKDFA PNVKQYVQIF RAETKMHIEH AEVLICEDEF KYALLANNCI CPGISTFITL 
481:	LMHTSRGEEG QKSTEPWHKV YGFHSGNEMY QIKVQDSKFF CEYVGKSFSS TSFHAHKEYG 
541:	IGLIAVSPDG DTSRMKLNPG SSHIIQPTDT VYYMGLTNEE SLTDFRKGIR SQQKRANVAS 
601:	TIANIGTVAV DVPRSDKTEL VGRKKKKRKE KAADEIHLIE VGEHVQSSRR PSIAMVTEGK 
661:	IDSSSDSDQE EICDKCRGPC IQHKLQRTYP QVRTYIGTSN TVCHMMKERR SLCCLKLDEK 
721:	CAHKSATSAH EYQWRNRPII LAADRTSSGM YNLVIPLRAY YRPVHDLHPI IILLELEEQD 
781:	SLNDAFLDAI SYFPDVYWMK GKVGNLDCLL RAGVSSAEHV VVVKETAVMA EEHTADCNTI 
841:	ITVQKIHRMF PRLRMITELT HATNMRFVQF NPHNAYSLAQ SRFEKKERKR GSHMPFMFRL 
901:	PFAQGGVFSA NMLDRLLYQA IIKPFVVDLV RLLLGIDQHS DGGYLTSFVI TSDDLWIRNY 
961:	GRLYQKLCSS VADIPIGIFR TKKMDTKTVS LDLQEQCKDF ENTEMGRNKD MYDHVKNRMR 
1021:	LLNIKDTHTL LEGSDEKSQI SYVIINPAQD LELESGDIVY VIRSPIRKDA TNARINPRRG 
1081:	LRRSKNVSET IDSTNQVPTI VIDENNL