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1.A.1.4.1
K+ channel, AKT1; may form heteromeric channels with KC1 (TC # 1.A.1.4.9) (Geiger et al., 2009).  Required for seed development and postgermination growth in low potassium (Pyo et al. 2010).  Functions optimally with intermediate potassium concentrations (~1 mM) (Nieves-Cordones et al. 2014).

Accession Number:Q38998
Protein Name:AKT1 or F18A8.2
Length:857
Molecular Weight:96990.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

Genevestigator: Q38998
eggNOG: KOG0498
HEGENOM: HBG318539
DIP: DIP-36762N
RefSeq: NP_180233.1   
Entrez Gene ID: 817206   
Pfam: PF00023    PF00027    PF11834    PF00520   
BioCyc: MetaCyc:MONOMER-14552   
KEGG: ath:AT2G26650   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005242 F:inward rectifier potassium channel activity
GO:0005515 F:protein binding
GO:0006813 P:potassium ion transport
GO:0009651 P:response to salt stress
GO:0048767 P:root hair elongation
GO:0055085 P:transmembrane transport

References (12)

[1] “Cloning and expression in yeast of a plant potassium ion transport system.”  Sentenac H.et.al.   1585180
[2] “Organization and expression of the gene coding for the potassium transport system AKT1 of Arabidopsis thaliana.”  Basset M.et.al.   8555458
[3] “Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.”  Lin X.et.al.   10617197
[4] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[5] “Tissue-specific expression of Arabidopsis AKT1 gene is consistent with a role in K+ nutrition.”  Lagarde D.et.al.   8820606
[6] “Tetramerization of the AKT1 plant potassium channel involves its C-terminal cytoplasmic domain.”  Daram P.et.al.   9218788
[7] “A role for the AKT1 potassium channel in plant nutrition.”  Hirsch R.E.et.al.   9572739
[8] “Phylogenetic relationships within cation transporter families of Arabidopsis.”  Maeser P.et.al.   11500563
[9] “Regulated expression of Arabidopsis shaker K(+) channel genes involved in K(+) uptake and distribution in the plant.”  Pilot G.et.al.   12678562
[10] “A protein kinase, interacting with two calcineurin B-like proteins, regulates K+ transporter AKT1 in Arabidopsis.”  Xu J.et.al.   16814720
[11] “A Ca(2)+ signaling pathway regulates a K(+) channel for low-K response in Arabidopsis.”  Li L.et.al.   16895985
[12] “A protein phosphorylation/dephosphorylation network regulates a plant potassium channel.”  Lee S.-C.et.al.   17898163

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRGGALLCGQ VQDEIEQLSR ESSHFSLSTG ILPSLGARSN RRVKLRRFVV SPYDHKYRIW 
61:	EAFLVVLVVY TAWVSPFEFG FLRKPRPPLS ITDNIVNAFF AIDIIMTFFV GYLDKSTYLI 
121:	VDDRKQIAFK YLRSWFLLDL VSTIPSEAAM RISSQSYGLF NMLRLWRLRR VGALFARLEK 
181:	DRNFNYFWVR CAKLVCVTLF AVHCAACFYY LIAARNSNPA KTWIGANVAN FLEESLWMRY 
241:	VTSMYWSITT LTTVGYGDLH PVNTKEMIFD IFYMLFNLGL TAYLIGNMTN LVVHGTSRTR 
301:	NFRDTIQAAS NFAHRNHLPP RLQDQMLAHL CLKYRTDSEG LQQQETLDAL PKAIRSSISH 
361:	FLFYSLMDKV YLFRGVSNDL LFQLVSEMKA EYFPPKEDVI LQNEAPTDFY ILVNGTADLV 
421:	DVDTGTESIV REVKAGDIIG EIGVLCYRPQ LFTVRTKRLC QLLRMNRTTF LNIIQANVGD 
481:	GTIIMNNLLQ HLKEMNDPVM TNVLLEIENM LARGKMDLPL NLCFAAIRED DLLLHQLLKR 
541:	GLDPNESDNN GRTPLHIAAS KGTLNCVLLL LEYHADPNCR DAEGSVPLWE AMVEGHEKVV 
601:	KVLLEHGSTI DAGDVGHFAC TAAEQGNLKL LKEIVLHGGD VTRPRATGTS ALHTAVCEEN 
661:	IEMVKYLLEQ GADVNKQDMH GWTPRDLAEQ QGHEDIKALF REKLHERRVH IETSSSVPIL 
721:	KTGIRFLGRF TSEPNIRPAS REVSFRIRET RARRKTNNFD NSLFGILANQ SVPKNGLATV 
781:	DEGRTGNPVR VTISCAEKDD IAGKLVLLPG SFKELLELGS NKFGIVATKV MNKDNNAEID 
841:	DVDVIRDGDH LIFATDS